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The role of the small intestine in modulating metabolism and inflammation in atherosclerosis and cancer.

Mukherjee P, Chattopadhyay A, Fogelman AM.

Curr Opin Lipidol. 2019 Oct;30(5):383-387. doi: 10.1097/MOL.0000000000000629.


Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.

Meriwether D, Sulaiman D, Volpe C, Dorfman A, Grijalva V, Dorreh N, Solorzano-Vargas RS, Wang J, O'Connor E, Papesh J, Larauche M, Trost H, Palgunachari MN, Anantharamaiah GM, Herschman HR, Martin MG, Fogelman AM, Reddy ST.

J Clin Invest. 2019 Jun 11;130:3670-3685. doi: 10.1172/JCI123700.


Noggin depletion in adipocytes promotes obesity in mice.

Blázquez-Medela AM, Jumabay M, Rajbhandari P, Sallam T, Guo Y, Yao J, Vergnes L, Reue K, Zhang L, Yao Y, Fogelman AM, Tontonoz P, Lusis AJ, Wu X, Boström KI.

Mol Metab. 2019 Jul;25:50-63. doi: 10.1016/j.molmet.2019.04.004. Epub 2019 Apr 10.


Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway.

Sulaiman D, Li J, Devarajan A, Cunningham CM, Li M, Fishbein GA, Fogelman AM, Eghbali M, Reddy ST.

J Mol Cell Cardiol. 2019 Apr;129:154-164. doi: 10.1016/j.yjmcc.2019.02.008. Epub 2019 Feb 23.


PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity.

Shih DM, Meng Y, Sallam T, Vergnes L, Shu ML, Reue K, Tontonoz P, Fogelman AM, Lusis AJ, Reddy ST.

Antioxidants (Basel). 2019 Jan 11;8(1). pii: E19. doi: 10.3390/antiox8010019.


Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice.

Mukherjee P, Hough G, Chattopadhyay A, Grijalva V, O'Connor EI, Meriwether D, Wagner A, Ntambi JM, Navab M, Reddy ST, Fogelman AM.

J Lipid Res. 2018 Oct;59(10):1818-1840. doi: 10.1194/jlr.M083527. Epub 2018 Aug 23.


Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer.

Chattopadhyay A, Yang X, Mukherjee P, Sulaiman D, Fogelman HR, Grijalva V, Dubinett S, Wasler TC, Paul MK, Salehi-Rad R, Mack JJ, Iruela-Arispe ML, Navab M, Fogelman AM, Reddy ST.

Sci Rep. 2018 Jun 13;8(1):9032. doi: 10.1038/s41598-018-26755-0.


Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer.

Devarajan A, Su F, Grijalva V, Yalamanchi M, Yalamanchi A, Gao F, Trost H, Nwokedi J, Farias-Eisner G, Farias-Eisner R, Fogelman AM, Reddy ST.

Cell Death Dis. 2018 Mar 12;9(3):392. doi: 10.1038/s41419-018-0395-2.


Phospholipid Remodeling and Cholesterol Availability Regulate Intestinal Stemness and Tumorigenesis.

Wang B, Rong X, Palladino END, Wang J, Fogelman AM, Martín MG, Alrefai WA, Ford DA, Tontonoz P.

Cell Stem Cell. 2018 Feb 1;22(2):206-220.e4. doi: 10.1016/j.stem.2017.12.017.


NOTCH1 is a mechanosensor in adult arteries.

Mack JJ, Mosqueiro TS, Archer BJ, Jones WM, Sunshine H, Faas GC, Briot A, Aragón RL, Su T, Romay MC, McDonald AI, Kuo CH, Lizama CO, Lane TF, Zovein AC, Fang Y, Tarling EJ, de Aguiar Vallim TQ, Navab M, Fogelman AM, Bouchard LS, Iruela-Arispe ML.

Nat Commun. 2017 Nov 20;8(1):1620. doi: 10.1038/s41467-017-01741-8.


Making sense of a seemingly odd connection.

Fogelman AM, Reddy ST.

Eur Heart J. 2017 Dec 21;38(48):3588-3589. doi: 10.1093/eurheartj/ehx506. No abstract available.


Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation.

Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Boström KI, Yao Y.

J Cell Biol. 2017 Oct 2;216(10):3369-3385. doi: 10.1083/jcb.201612122. Epub 2017 Aug 24.


Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Index in High-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial.

Dunbar RL, Movva R, Bloedon LT, Duffy D, Norris RB, Navab M, Fogelman AM, Rader DJ.

Clin Transl Sci. 2017 Nov;10(6):455-469. doi: 10.1111/cts.12487. Epub 2017 Aug 9.


Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum.

Mukherjee P, Hough G, Chattopadhyay A, Navab M, Fogelman HR, Meriwether D, Williams K, Bensinger S, Moller T, Faull KF, Lusis AJ, Iruela-Arispe ML, Bostrom KI, Tontonoz P, Reddy ST, Fogelman AM.

J Lipid Res. 2017 Aug;58(8):1636-1647. doi: 10.1194/jlr.M076554. Epub 2017 Jun 7.


Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells.

Jumabay M, Zhumabai J, Mansurov N, Niklason KC, Guihard PJ, Cubberly MR, Fogelman AM, Iruela-Arispe L, Yao Y, Saparov A, Boström KI.

J Cell Physiol. 2018 Mar;233(3):1812-1822. doi: 10.1002/jcp.25983. Epub 2017 Jun 6.


Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites.

Li R, Yang J, Saffari A, Jacobs J, Baek KI, Hough G, Larauche MH, Ma J, Jen N, Moussaoui N, Zhou B, Kang H, Reddy S, Henning SM, Campen MJ, Pisegna J, Li Z, Fogelman AM, Sioutas C, Navab M, Hsiai TK.

Sci Rep. 2017 Feb 17;7:42906. doi: 10.1038/srep42906.


ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.

Cedó L, García-León A, Baila-Rueda L, Santos D, Grijalva V, Martínez-Cignoni MR, Carbó JM, Metso J, López-Vilaró L, Zorzano A, Valledor AF, Cenarro A, Jauhiainen M, Lerma E, Fogelman AM, Reddy ST, Escolà-Gil JC, Blanco-Vaca F.

Sci Rep. 2016 Nov 3;6:36387. doi: 10.1038/srep36387.


Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux.

Meriwether D, Sulaiman D, Wagner A, Grijalva V, Kaji I, Williams KJ, Yu L, Fogelman S, Volpe C, Bensinger SJ, Anantharamaiah GM, Shechter I, Fogelman AM, Reddy ST.

J Lipid Res. 2016 Jul;57(7):1175-93. doi: 10.1194/jlr.M067025. Epub 2016 May 19.


Apolipoprotein E-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function.

Mehta NU, Grijalva V, Hama S, Wagner A, Navab M, Fogelman AM, Reddy ST.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1152-63. doi: 10.1161/ATVBAHA.115.306991. Epub 2016 Apr 14.


Tg6F ameliorates the increase in oxidized phospholipids in the jejunum of mice fed unsaturated LysoPC or WD.

Chattopadhyay A, Navab M, Hough G, Grijalva V, Mukherjee P, Fogelman HR, Hwang LH, Faull KF, Lusis AJ, Reddy ST, Fogelman AM.

J Lipid Res. 2016 May;57(5):832-47. doi: 10.1194/jlr.M064352. Epub 2016 Mar 9.


Outcomes of a Novel Training Program for Physician-Scientists: Integrating Graduate Degree Training With Specialty Fellowship.

Wong MD, Guerrero L, Sallam T, Frank JS, Fogelman AM, Demer LL.

J Grad Med Educ. 2016 Feb;8(1):85-90. doi: 10.4300/JGME-D-15-00135.1.


Proinflammatory high-density lipoprotein results from oxidized lipid mediators in the pathogenesis of both idiopathic and associated types of pulmonary arterial hypertension.

Ross DJ, Hough G, Hama S, Aboulhosn J, Belperio JA, Saggar R, Van Lenten BJ, Ardehali A, Eghbali M, Reddy S, Fogelman AM, Navab M.

Pulm Circ. 2015 Dec;5(4):640-8. doi: 10.1086/683695.


Carboxyl-Terminal Cleavage of Apolipoprotein A-I by Human Mast Cell Chymase Impairs Its Anti-Inflammatory Properties.

Nguyen SD, Maaninka K, Lappalainen J, Nurmi K, Metso J, Öörni K, Navab M, Fogelman AM, Jauhiainen M, Lee-Rueckert M, Kovanen PT.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):274-84. doi: 10.1161/ATVBAHA.115.306827. Epub 2015 Dec 17.


Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis.

Briot A, Civelek M, Seki A, Hoi K, Mack JJ, Lee SD, Kim J, Hong C, Yu J, Fishbein GA, Vakili L, Fogelman AM, Fishbein MC, Lusis AJ, Tontonoz P, Navab M, Berliner JA, Iruela-Arispe ML.

J Exp Med. 2015 Nov 16;212(12):2147-63. doi: 10.1084/jem.20150603. Epub 2015 Nov 9.


Further evidence that high-density lipoprotein is a chameleon-like lipoprotein.

Fogelman AM.

Eur Heart J. 2015 Nov 14;36(43):3017-9. doi: 10.1093/eurheartj/ehv465. Epub 2015 Sep 15. No abstract available.


Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer.

Chattopadhyay A, Grijalva V, Hough G, Su F, Mukherjee P, Farias-Eisner R, Anantharamaiah GM, Faull KF, Hwang LH, Navab M, Fogelman AM, Reddy ST.

Pharmacol Res Perspect. 2015 Aug;3(4):e00154. doi: 10.1002/prp2.154. Epub 2015 Jun 24.


Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation.

Nguyen SD, Javanainen M, Rissanen S, Zhao H, Huusko J, Kivelä AM, Ylä-Herttuala S, Navab M, Fogelman AM, Vattulainen I, Kovanen PT, Öörni K.

J Lipid Res. 2015 Jun;56(6):1206-21. doi: 10.1194/jlr.M059485. Epub 2015 Apr 10.


Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis.

Navab M, Chattopadhyay A, Hough G, Meriwether D, Fogelman SI, Wagner AC, Grijalva V, Su F, Anantharamaiah GM, Hwang LH, Faull KF, Reddy ST, Fogelman AM.

J Lipid Res. 2015 Apr;56(4):871-87. doi: 10.1194/jlr.M056614. Epub 2015 Feb 2.


TMAO is both a biomarker and a renal toxin.

Fogelman AM.

Circ Res. 2015 Jan 30;116(3):396-7. doi: 10.1161/CIRCRESAHA.114.305680. No abstract available.


Apolipoprotein A-I mimetics.

Reddy ST, Navab M, Anantharamaiah GM, Fogelman AM.

Curr Opin Lipidol. 2014 Aug;25(4):304-8. doi: 10.1097/MOL.0000000000000092. Review.


Apolipoprotein A-I mimetic peptide 4F rescues pulmonary hypertension by inducing microRNA-193-3p.

Sharma S, Umar S, Potus F, Iorga A, Wong G, Meriwether D, Breuils-Bonnet S, Mai D, Navab K, Ross D, Navab M, Provencher S, Fogelman AM, Bonnet S, Reddy ST, Eghbali M.

Circulation. 2014 Aug 26;130(9):776-85. doi: 10.1161/CIRCULATIONAHA.114.007405. Epub 2014 Jun 24.


Trying to harness the potential of HDL: wishful thinking or sound strategy?

Fogelman AM.

Eur Heart J. 2014 Dec 7;35(46):3248-9. doi: 10.1093/eurheartj/ehu194. Epub 2014 May 12. No abstract available.


HDL lipid composition is profoundly altered in patients with type 2 diabetes and atherosclerotic vascular disease.

Morgantini C, Meriwether D, Baldi S, Venturi E, Pinnola S, Wagner AC, Fogelman AM, Ferrannini E, Natali A, Reddy ST.

Nutr Metab Cardiovasc Dis. 2014 Jun;24(6):594-9. doi: 10.1016/j.numecd.2013.12.011. Epub 2014 Jan 22.


Searching for a successful HDL-based treatment strategy.

Reddy ST, Navab M, Anantharamaiah GM, Fogelman AM.

Biochim Biophys Acta. 2014 Jan;1841(1):162-7. Review.


High-density lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target.

Lüscher TF, Landmesser U, von Eckardstein A, Fogelman AM.

Circ Res. 2014 Jan 3;114(1):171-82. doi: 10.1161/CIRCRESAHA.114.300935. Review.


Protection against ischemia/reperfusion injury by high-density lipoprotein and its components.

Fogelman AM, Reddy ST, Navab M.

Circ Res. 2013 Dec 6;113(12):1281-2. doi: 10.1161/CIRCRESAHA.113.302943. No abstract available.


Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid.

Navab M, Hough G, Buga GM, Su F, Wagner AC, Meriwether D, Chattopadhyay A, Gao F, Grijalva V, Danciger JS, Van Lenten BJ, Org E, Lusis AJ, Pan C, Anantharamaiah GM, Farias-Eisner R, Smyth SS, Reddy ST, Fogelman AM.

J Lipid Res. 2013 Dec;54(12):3403-18. doi: 10.1194/jlr.M042051. Epub 2013 Oct 1.


Heart failure is associated with impaired anti-inflammatory and antioxidant properties of high-density lipoproteins.

Kim JB, Hama S, Hough G, Navab M, Fogelman AM, Maclellan WR, Horwich TB, Fonarow GC.

Am J Cardiol. 2013 Dec 1;112(11):1770-7. doi: 10.1016/j.amjcard.2013.07.045. Epub 2013 Sep 16.


Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice.

Li R, Navab M, Pakbin P, Ning Z, Navab K, Hough G, Morgan TE, Finch CE, Araujo JA, Fogelman AM, Sioutas C, Hsiai T.

J Lipid Res. 2013 Jun;54(6):1608-15. doi: 10.1194/jlr.M035014. Epub 2013 Apr 6.


Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein.

Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME, Araujo JA.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1153-61. doi: 10.1161/ATVBAHA.112.300552. Epub 2013 Apr 4.


A novel approach to oral apoA-I mimetic therapy.

Chattopadhyay A, Navab M, Hough G, Gao F, Meriwether D, Grijalva V, Springstead JR, Palgnachari MN, Namiri-Kalantari R, Su F, Van Lenten BJ, Wagner AC, Anantharamaiah GM, Farias-Eisner R, Reddy ST, Fogelman AM.

J Lipid Res. 2013 Apr;54(4):995-1010. doi: 10.1194/jlr.M033555. Epub 2013 Feb 2. Erratum in: J Lipid Res. 2013 Nov;54(11):3220. Farias-Eisener, Robin [corrected to Farias-Eisener, Robin].


High-density lipoprotein and 4F peptide reduce systemic inflammation by modulating intestinal oxidized lipid metabolism: novel hypotheses and review of literature.

Navab M, Reddy ST, Van Lenten BJ, Buga GM, Hough G, Wagner AC, Fogelman AM.

Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2553-60. doi: 10.1161/ATVBAHA.112.300282. Review.


Effects of lipid-probe interactions in biochemical fluorometric methods that assess HDL redox activity.

Kelesidis T, Reddy ST, Huynh D, Meriwether D, Fogelman AM, Navab M, Yang OO.

Lipids Health Dis. 2012 Jul 6;11:87. doi: 10.1186/1476-511X-11-87.


Apolipoprotein A-I mimetic peptides inhibit expression and activity of hypoxia-inducible factor-1α in human ovarian cancer cell lines and a mouse ovarian cancer model.

Gao F, Chattopadhyay A, Navab M, Grijalva V, Su F, Fogelman AM, Reddy ST, Farias-Eisner R.

J Pharmacol Exp Ther. 2012 Aug;342(2):255-62. doi: 10.1124/jpet.112.191544. Epub 2012 Apr 25.


LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice.

Hong C, Bradley MN, Rong X, Wang X, Wagner A, Grijalva V, Castellani LW, Salazar J, Realegeno S, Boyadjian R, Fogelman AM, Van Lenten BJ, Reddy ST, Lusis AJ, Tangirala RK, Tontonoz P.

J Lipid Res. 2012 Jun;53(6):1126-33. doi: 10.1194/jlr.M022061. Epub 2012 Mar 26.


HDL mimetics inhibit tumor development in both induced and spontaneous mouse models of colon cancer.

Su F, Grijalva V, Navab K, Ganapathy E, Meriwether D, Imaizumi S, Navab M, Fogelman AM, Reddy ST, Farias-Eisner R.

Mol Cancer Ther. 2012 Jun;11(6):1311-9. doi: 10.1158/1535-7163.MCT-11-0905. Epub 2012 Mar 13.


D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice.

Navab M, Reddy ST, Anantharamaiah GM, Hough G, Buga GM, Danciger J, Fogelman AM.

J Lipid Res. 2012 Mar;53(3):437-45. doi: 10.1194/jlr.M023523. Epub 2011 Dec 13.


A biochemical fluorometric method for assessing the oxidative properties of HDL.

Kelesidis T, Currier JS, Huynh D, Meriwether D, Charles-Schoeman C, Reddy ST, Fogelman AM, Navab M, Yang OO.

J Lipid Res. 2011 Dec;52(12):2341-51. doi: 10.1194/jlr.D018937. Epub 2011 Sep 27.


Anti-inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes.

Morgantini C, Natali A, Boldrini B, Imaizumi S, Navab M, Fogelman AM, Ferrannini E, Reddy ST.

Diabetes. 2011 Oct;60(10):2617-23. doi: 10.2337/db11-0378. Epub 2011 Aug 18.


Salutary effects of hemodialysis on low-density lipoprotein proinflammatory and high-density lipoprotein anti-inflammatory properties in patient with end-stage renal disease.

Vaziri ND, Navab K, Gollapudi P, Moradi H, Pahl MV, Barton CH, Fogelman AM, Navab M.

J Natl Med Assoc. 2011 Jun;103(6):524-33.

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