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Items: 1 to 50 of 186

1.

Ectopic activation of WNT signaling in human embryonal carcinoma cells and its effects in short- and long-term in vitro culture.

Atlasi Y, van Dorsten RT, Sacchetti A, Joosten R, Oosterhuis JW, Looijenga LHJ, Fodde R.

Sci Rep. 2019 Aug 15;9(1):11928. doi: 10.1038/s41598-019-48396-7.

2.

The inflammatory cytokine IL-6 induces FRA1 deacetylation promoting colorectal cancer stem-like properties.

Wang T, Song P, Zhong T, Wang X, Xiang X, Liu Q, Chen H, Xia T, Liu H, Niu Y, Hu Y, Xu L, Shao Y, Zhu L, Qi H, Shen J, Hou T, Fodde R, Shao J.

Oncogene. 2019 Jun;38(25):4932-4947. doi: 10.1038/s41388-019-0763-0. Epub 2019 Feb 25.

PMID:
30804456
3.

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling.

Schmitt M, Schewe M, Sacchetti A, Feijtel D, van de Geer WS, Teeuwssen M, Sleddens HF, Joosten R, van Royen ME, van de Werken HJG, van Es J, Clevers H, Fodde R.

Cell Rep. 2018 Aug 28;24(9):2312-2328.e7. doi: 10.1016/j.celrep.2018.07.085.

4.

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations.

Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA.

Genome Res. 2018 Apr;28(4):432-447. doi: 10.1101/gr.225128.117. Epub 2018 Mar 22.

5.

The Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells.

Schewe M, Sacchetti A, Schmitt M, Fodde R.

J Vis Exp. 2017 Nov 20;(129). doi: 10.3791/56329.

PMID:
29286377
6.

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.

Mohd-Sarip A, Teeuwssen M, Bot AG, De Herdt MJ, Willems SM, Baatenburg de Jong RJ, Looijenga LHJ, Zatreanu D, Bezstarosti K, van Riet J, Oole E, van Ijcken WFJ, van de Werken HJG, Demmers JA, Fodde R, Verrijzer CP.

Cell Rep. 2017 Jul 5;20(1):61-75. doi: 10.1016/j.celrep.2017.06.020.

7.

Modelling western dietary habits in the mouse: easier said than done.

Fodde R, Schmitt M, Schewe M, Augenlicht LH.

Hepatobiliary Surg Nutr. 2017 Apr;6(2):138-140. doi: 10.21037/hbsn.2017.01.20. No abstract available.

8.

Interplay between metabolic identities in the intestinal crypt supports stem cell function.

Rodríguez-Colman MJ, Schewe M, Meerlo M, Stigter E, Gerrits J, Pras-Raves M, Sacchetti A, Hornsveld M, Oost KC, Snippert HJ, Verhoeven-Duif N, Fodde R, Burgering BM.

Nature. 2017 Mar 16;543(7645):424-427. doi: 10.1038/nature21673. Epub 2017 Mar 8.

PMID:
28273069
9.

The role of S100a4 (Mts1) in Apc- and Smad4-driven tumour onset and progression.

Atlasi Y, Noori R, Marolin I, Franken P, Brandao J, Biermann K, Collini P, Grigorian M, Lukanidin E, Ambartsumian N, Fodde R.

Eur J Cancer. 2016 Nov;68:114-124. doi: 10.1016/j.ejca.2016.09.012. Epub 2016 Oct 14.

PMID:
27750112
10.

Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.

Schewe M, Franken PF, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen ME, Jeammet L, Payré C, Scott PM, Webb NR, Gelb M, Cormier RT, Lambeau G, Fodde R.

Cell Stem Cell. 2016 Jul 7;19(1):38-51. doi: 10.1016/j.stem.2016.05.023. Epub 2016 Jun 9.

11.

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells.

Famili F, Brugman MH, Taskesen E, Naber BEA, Fodde R, Staal FJT.

Stem Cell Reports. 2016 May 10;6(5):652-659. doi: 10.1016/j.stemcr.2016.04.009.

12.

CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models.

Cremers N, Neeb A, Uhle T, Dimmler A, Rothley M, Allgayer H, Fodde R, Sleeman JP, Thiele W.

PLoS One. 2016 Mar 15;11(3):e0151468. doi: 10.1371/journal.pone.0151468. eCollection 2016.

13.

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis.

Tricarico R, Cortellino S, Riccio A, Jagmohan-Changur S, Van der Klift H, Wijnen J, Turner D, Ventura A, Rovella V, Percesepe A, Lucci-Cordisco E, Radice P, Bertario L, Pedroni M, Ponz de Leon M, Mancuso P, Devarajan K, Cai KQ, Klein-Szanto AJ, Neri G, Møller P, Viel A, Genuardi M, Fodde R, Bellacosa A.

Oncotarget. 2015 Dec 15;6(40):42892-904. doi: 10.18632/oncotarget.5740.

14.

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden.

van der Zee M, Sacchetti A, Cansoy M, Joosten R, Teeuwssen M, Heijmans-Antonissen C, Ewing-Graham PC, Burger CW, Blok LJ, Fodde R.

Cancer Res. 2015 Sep 1;75(17):3608-22. doi: 10.1158/0008-5472.CAN-14-2498. Epub 2015 Jun 30.

15.

Junk DNA and the long non-coding RNA twist in cancer genetics.

Ling H, Vincent K, Pichler M, Fodde R, Berindan-Neagoe I, Slack FJ, Calin GA.

Oncogene. 2015 Sep 24;34(39):5003-11. doi: 10.1038/onc.2014.456. Epub 2015 Jan 26. Review.

16.

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.

Reimers MS, Bastiaannet E, Langley RE, van Eijk R, van Vlierberghe RL, Lemmens VE, van Herk-Sukel MP, van Wezel T, Fodde R, Kuppen PJ, Morreau H, van de Velde CJ, Liefers GJ.

JAMA Intern Med. 2014 May;174(5):732-9. doi: 10.1001/jamainternmed.2014.511.

PMID:
24687028
17.

Targeted deletion of the C-terminus of the mouse adenomatous polyposis coli tumor suppressor results in neurologic phenotypes related to schizophrenia.

Onouchi T, Kobayashi K, Sakai K, Shimomura A, Smits R, Sumi-Ichinose C, Kurosumi M, Takao K, Nomura R, Iizuka-Kogo A, Suzuki H, Kondo K, Akiyama T, Miyakawa T, Fodde R, Senda T.

Mol Brain. 2014 Mar 29;7:21. doi: 10.1186/1756-6606-7-21.

18.

Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective.

Atlasi Y, Looijenga L, Fodde R.

Curr Top Dev Biol. 2014;107:373-404. doi: 10.1016/B978-0-12-416022-4.00013-5. Review.

PMID:
24439813
19.

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations.

Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, Zhang X, de Weerd V, Shimizu M, Ling H, Buiga R, Pop V, Irimie A, Fodde R, Bedrosian I, Martens JW, Foekens JA, Berindan-Neagoe I, Calin GA.

Oncotarget. 2013 Oct;4(10):1748-62.

20.

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis.

Ghazvini M, Sonneveld P, Kremer A, Franken P, Sacchetti A, Atlasi Y, Roth S, Joosten R, Smits R, Fodde R.

PLoS One. 2013 Sep 17;8(9):e73872. doi: 10.1371/journal.pone.0073872. eCollection 2013.

21.

Cancer stemness in Wnt-driven mammary tumorigenesis.

Monteiro J, Gaspar C, Richer W, Franken PF, Sacchetti A, Joosten R, Idali A, Brandao J, Decraene C, Fodde R.

Carcinogenesis. 2014 Jan;35(1):2-13. doi: 10.1093/carcin/bgt279. Epub 2013 Aug 16.

PMID:
23955540
22.

CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer.

Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Gafà R, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Le Marchand L, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA.

Genome Res. 2013 Sep;23(9):1446-61. doi: 10.1101/gr.152942.112. Epub 2013 Jun 24.

23.

Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.

Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R.

PLoS Genet. 2013 May;9(5):e1003424. doi: 10.1371/journal.pgen.1003424. Epub 2013 May 2.

24.

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression.

van der Zee M, Jia Y, Wang Y, Heijmans-Antonissen C, Ewing PC, Franken P, DeMayo FJ, Lydon JP, Burger CW, Fodde R, Blok LJ.

J Pathol. 2013 May;230(1):48-58. doi: 10.1002/path.4160. Epub 2013 Mar 14.

PMID:
23288720
25.

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.

Mathers JC, Movahedi M, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans G, Maher ER, Bertario L, Bisgaard ML, Dunlop M, Ho JW, Hodgson S, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen H, Gerdes AM, Barker G, Crawford G, Elliott F, Pylvanainen K, Wijnen J, Fodde R, Lynch H, Bishop DT, Burn J; CAPP2 Investigators.

Lancet Oncol. 2012 Dec;13(12):1242-9. doi: 10.1016/S1470-2045(12)70475-8. Epub 2012 Nov 7.

26.

Some fine-structural findings on the thyroid gland in Apc1638T/1638T mice that express a C-terminus lacking truncated Apc.

Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Fodde R, Itoh M, Senda T.

Med Mol Morphol. 2012 Jun;45(3):161-7. Epub 2012 Sep 22.

PMID:
23001298
27.

Identification of quiescent, stem-like cells in the distal female reproductive tract.

Wang Y, Sacchetti A, van Dijk MR, van der Zee M, van der Horst PH, Joosten R, Burger CW, Grootegoed JA, Blok LJ, Fodde R.

PLoS One. 2012;7(7):e40691. doi: 10.1371/journal.pone.0040691. Epub 2012 Jul 24.

28.

Cancer stem cells and metastasis.

Sampieri K, Fodde R.

Semin Cancer Biol. 2012 Jun;22(3):187-93. Review.

PMID:
22774232
29.

Paneth cells in intestinal homeostasis and tissue injury.

Roth S, Franken P, Sacchetti A, Kremer A, Anderson K, Sansom O, Fodde R.

PLoS One. 2012;7(6):e38965. doi: 10.1371/journal.pone.0038965. Epub 2012 Jun 20.

30.

Generation and characterization of an inducible transgenic model for studying mouse esophageal biology.

Roth S, Franken P, Monkhorst K, Kong a San J, Fodde R.

BMC Dev Biol. 2012 Jun 12;12:18. doi: 10.1186/1471-213X-12-18.

31.

Use of aspirin postdiagnosis improves survival for colon cancer patients.

Bastiaannet E, Sampieri K, Dekkers OM, de Craen AJ, van Herk-Sukel MP, Lemmens V, van den Broek CB, Coebergh JW, Herings RM, van de Velde CJ, Fodde R, Liefers GJ.

Br J Cancer. 2012 Apr 24;106(9):1564-70. doi: 10.1038/bjc.2012.101. Epub 2012 Mar 27.

32.

Concepts of metastasis in flux: the stromal progression model.

Sleeman JP, Christofori G, Fodde R, Collard JG, Berx G, Decraene C, Rüegg C.

Semin Cancer Biol. 2012 Jun;22(3):174-86. doi: 10.1016/j.semcancer.2012.02.007. Epub 2012 Feb 21. Review.

33.

Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer.

Fijneman RJ, de Wit M, Pourghiasian M, Piersma SR, Pham TV, Warmoes MO, Lavaei M, Piso C, Smit F, Delis-van Diemen PM, van Turenhout ST, Terhaar sive Droste JS, Mulder CJ, Blankenstein MA, Robanus-Maandag EC, Smits R, Fodde R, van Hinsbergh VW, Meijer GA, Jimenez CR.

Clin Cancer Res. 2012 May 1;18(9):2613-24. doi: 10.1158/1078-0432.CCR-11-1937. Epub 2012 Feb 20.

34.

The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function.

Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T.

Med Mol Morphol. 2011 Dec;44(4):207-12. doi: 10.1007/s00795-010-0529-9. Epub 2011 Dec 17.

PMID:
22179183
35.

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial.

Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, Bisgaard ML, Dunlop MG, Ho JW, Hodgson SV, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen HF, Barker G, Crawford G, Elliott F, Movahedi M, Pylvanainen K, Wijnen JT, Fodde R, Lynch HT, Mathers JC, Bishop DT; CAPP2 Investigators.

Lancet. 2011 Dec 17;378(9809):2081-7. doi: 10.1016/S0140-6736(11)61049-0. Epub 2011 Oct 27.

36.

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

Luis TC, Naber BA, Roozen PP, Brugman MH, de Haas EF, Ghazvini M, Fibbe WE, van Dongen JJ, Fodde R, Staal FJ.

Cell Stem Cell. 2011 Oct 4;9(4):345-56. doi: 10.1016/j.stem.2011.07.017.

37.

Familial adenomatous polyposis-associated desmoids display significantly more genetic changes than sporadic desmoids.

Robanus-Maandag E, Bosch C, Amini-Nik S, Knijnenburg J, Szuhai K, Cervera P, Poon R, Eccles D, Radice P, Giovannini M, Alman BA, Tejpar S, Devilee P, Fodde R.

PLoS One. 2011;6(9):e24354. doi: 10.1371/journal.pone.0024354. Epub 2011 Sep 9.

38.

Quiescent stem cells in intestinal homeostasis and cancer.

Roth S, Fodde R.

Cell Commun Adhes. 2011 Jun;18(3):33-44. doi: 10.3109/15419061.2011.615422. Epub 2011 Sep 14.

PMID:
21913875
39.

Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.

Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U.

Mol Cell Biol. 2011 Aug;31(16):3326-38. doi: 10.1128/MCB.05718-11. Epub 2011 Jun 20.

40.

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice.

Wang Y, Jia Y, Franken P, Smits R, Ewing PC, Lydon JP, DeMayo FJ, Burger CW, Anton Grootegoed J, Fodde R, Blok LJ.

Mol Cell Endocrinol. 2011 Jul 20;341(1-2):48-54. doi: 10.1016/j.mce.2011.05.026. Epub 2011 Jun 1.

PMID:
21664244
41.

The nature of intestinal stem cells' nurture.

Roth S, Fodde R.

EMBO Rep. 2011 Jun;12(6):483-4. doi: 10.1038/embor.2011.97. Epub 2011 May 13. No abstract available.

42.

A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis.

Burn J, Bishop DT, Chapman PD, Elliott F, Bertario L, Dunlop MG, Eccles D, Ellis A, Evans DG, Fodde R, Maher ER, Möslein G, Vasen HF, Coaker J, Phillips RK, Bülow S, Mathers JC; International CAPP consortium.

Cancer Prev Res (Phila). 2011 May;4(5):655-65. doi: 10.1158/1940-6207.CAPR-11-0106.

43.

Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer.

Wang Y, van der Zee M, Fodde R, Blok LJ.

Oncotarget. 2010 Nov;1(7):674-84. Review.

44.

β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis.

van Veelen W, Le NH, Helvensteijn W, Blonden L, Theeuwes M, Bakker ER, Franken PF, van Gurp L, Meijlink F, van der Valk MA, Kuipers EJ, Fodde R, Smits R.

Gut. 2011 Sep;60(9):1204-12. doi: 10.1136/gut.2010.233460. Epub 2011 Feb 9.

45.

Early morbidity encountered in the dietary-related mouse model of Barrett's esophagus: a question of zinc?

Grotenhuis BA, Franken PF, Swinkels WJ, Boonstra A, van der Valk MA, van Lanschot JJ, Fodde R.

Dis Esophagus. 2011 Jul;24(5):371-3. doi: 10.1111/j.1442-2050.2010.01151.x. Epub 2010 Dec 17.

PMID:
21166735
46.

Expression analysis of proline rich 15 (Prr15) in mouse and human gastrointestinal tumors.

Meunier D, Patra K, Smits R, Hägebarth A, Lüttges A, Jaussi R, Wieduwilt MJ, Quintanilla-Fend L, Himmelbauer H, Fodde R, Fundele RH.

Mol Carcinog. 2011 Jan;50(1):8-15. doi: 10.1002/mc.20692.

PMID:
21061267
47.

Leiden Open Variation Database of the MUTYH gene.

Out AA, Tops CM, Nielsen M, Weiss MM, van Minderhout IJ, Fokkema IF, Buisine MP, Claes K, Colas C, Fodde R, Fostira F, Franken PF, Gaustadnes M, Heinimann K, Hodgson SV, Hogervorst FB, Holinski-Feder E, Lagerstedt-Robinson K, Olschwang S, van den Ouweland AM, Redeker EJ, Scott RJ, Vankeirsbilck B, Grønlund RV, Wijnen JT, Wikman FP, Aretz S, Sampson JR, Devilee P, den Dunnen JT, Hes FJ.

Hum Mutat. 2010 Nov;31(11):1205-15. doi: 10.1002/humu.21343.

PMID:
20725929
48.

Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers.

Grotenhuis BA, Dinjens WN, Wijnhoven BP, Sonneveld P, Sacchetti A, Franken PF, van Dekken H, Tilanus HW, van Lanschot JJ, Fodde R.

J Pathol. 2010 Aug;221(4):379-89. doi: 10.1002/path.2733.

PMID:
20549647
49.

Colorectal cancers show distinct mutation spectra in members of the canonical WNT signaling pathway according to their anatomical location and type of genetic instability.

Albuquerque C, Baltazar C, Filipe B, Penha F, Pereira T, Smits R, Cravo M, Lage P, Fidalgo P, Claro I, Rodrigues P, Veiga I, Ramos JS, Fonseca I, Leitão CN, Fodde R.

Genes Chromosomes Cancer. 2010 Aug;49(8):746-59. doi: 10.1002/gcc.20786.

PMID:
20544848
50.

Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma.

Fodde R, Tomlinson I.

J Pathol. 2010 Jul;221(3):239-41. doi: 10.1002/path.2718.

PMID:
20527017

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