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Items: 33


Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.

Klosowiak JL, Park S, Smith KP, French ME, Focia PJ, Freymann DM, Rice SE.

Sci Rep. 2016 Sep 8;6:33019. doi: 10.1038/srep33019.


Structures of KcsA in complex with symmetrical quaternary ammonium compounds reveal a hydrophobic binding site.

Lenaeus MJ, Burdette D, Wagner T, Focia PJ, Gross A.

Biochemistry. 2014 Aug 19;53(32):5365-73. doi: 10.1021/bi500525s. Epub 2014 Aug 8.


Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.

Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE.

EMBO Rep. 2013 Nov;14(11):968-74. doi: 10.1038/embor.2013.151. Epub 2013 Sep 27.


Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge).

Freymann DM, Nakamura Y, Focia PJ, Sakai R, Swanson GT.

Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1163-74. doi: 10.1107/S0907444912022834. Epub 2012 Aug 18.


Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules.

Liu H, Focia PJ, He X.

J Biol Chem. 2011 Jan 7;286(1):797-805. doi: 10.1074/jbc.M110.180281. Epub 2010 Nov 3.


Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.

Liu H, Juo ZS, Shim AH, Focia PJ, Chen X, Garcia KC, He X.

Cell. 2010 Sep 3;142(5):749-61. doi: 10.1016/j.cell.2010.07.040. Epub 2010 Aug 19.


Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

Shim AH, Liu H, Focia PJ, Chen X, Lin PC, He X.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11307-12. doi: 10.1073/pnas.1000806107. Epub 2010 Jun 2.


Electron spin-echo envelope modulation (ESEEM) reveals water and phosphate interactions with the KcsA potassium channel.

Cieslak JA, Focia PJ, Gross A.

Biochemistry. 2010 Feb 23;49(7):1486-94. doi: 10.1021/bi9016523.


Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.

Chen X, Liu H, Focia PJ, Shim AH, He X.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72. doi: 10.1073/pnas.0807762105. Epub 2008 Nov 18.


Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh.

Ramirez UD, Focia PJ, Freymann DM.

Acta Crystallogr D Biol Crystallogr. 2008 Oct;64(Pt 10):1043-53. doi: 10.1107/S090744490802444X. Epub 2008 Sep 19.


Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions.

Chen X, Liu H, Shim AH, Focia PJ, He X.

Nat Struct Mol Biol. 2008 Jan;15(1):50-6. Epub 2007 Dec 16.


Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases.

Liu H, Chen X, Focia PJ, He X.

EMBO J. 2007 Feb 7;26(3):891-901. Epub 2007 Jan 25.


X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases.

Gawronski-Salerno J, Coon JS 5th, Focia PJ, Freymann DM.

Proteins. 2007 Mar 1;66(4):984-95.


Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.

Focia PJ, Gawronski-Salerno J, Coon JS 5th, Freymann DM.

J Mol Biol. 2006 Jul 14;360(3):631-43. Epub 2006 May 26.


Structural basis of TEA blockade in a model potassium channel.

Lenaeus MJ, Vamvouka M, Focia PJ, Gross A.

Nat Struct Mol Biol. 2005 May;12(5):454-9. Epub 2005 Apr 24.


Heterodimeric GTPase core of the SRP targeting complex.

Focia PJ, Shepotinovskaya IV, Seidler JA, Freymann DM.

Science. 2004 Jan 16;303(5656):373-7.


Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.

Canyuk B, Medrano FJ, Wenck MA, Focia PJ, Eakin AE, Craig SP 3rd.

J Mol Biol. 2004 Jan 23;335(4):905-21.


Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh.

Focia PJ, Alam H, Lu T, Ramirez UD, Freymann DM.

Proteins. 2004 Feb 1;54(2):222-30.


An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.

Velentza AV, Wainwright MS, Zasadzki M, Mirzoeva S, Schumacher AM, Haiech J, Focia PJ, Egli M, Watterson DM.

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3465-70.


Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY.

Shepotinovskaya IV, Focia PJ, Freymann DM.

Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1834-7. Epub 2003 Sep 19.


Nanomolar inhibitors of AmpC beta-lactamase.

Morandi F, Caselli E, Morandi S, Focia PJ, Blázquez J, Shoichet BK, Prati F.

J Am Chem Soc. 2003 Jan 22;125(3):685-95.


Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.

Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM.

J Mol Biol. 2002 Jul 19;320(4):783-99.


Structural milestones in the reaction pathway of an amide hydrolase: substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase.

Beadle BM, Trehan I, Focia PJ, Shoichet BK.

Structure. 2002 Mar;10(3):413-24. Erratum in: Structure (Camb) 2002 Jul;10(7):1025.


Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.

Freymann DM, Wenck MA, Engel JC, Feng J, Focia PJ, Eakin AE, Craig SP.

Chem Biol. 2000 Dec;7(12):957-68.


Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.

Balendiran GK, Molina JA, Xu Y, Torres-Martinez J, Stevens R, Focia PJ, Eakin AE, Sacchettini JC, Craig SP 3rd.

Protein Sci. 1999 May;8(5):1023-31.


Approaching the transition state in the crystal structure of a phosphoribosyltransferase.

Focia PJ, Craig SP 3rd, Eakin AE.

Biochemistry. 1998 Dec 8;37(49):17120-7.


Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution.

Nieves-Alicea R, Focia PJ, Craig SP 3rd, Eakin AE.

Biochim Biophys Acta. 1998 Nov 10;1388(2):500-5.


A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.

Focia PJ, Craig SP 3rd, Nieves-Alicea R, Fletterick RJ, Eakin AE.

Biochemistry. 1998 Oct 27;37(43):15066-75.


Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.

Somoza JR, Chin MS, Focia PJ, Wang CC, Fletterick RJ.

Biochemistry. 1996 Jun 4;35(22):7032-40.


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