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Items: 1 to 50 of 156

1.

Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques.

Darrah PA, DiFazio RM, Maiello P, Gideon HP, Myers AJ, Rodgers MA, Hackney JA, Lindenstrom T, Evans T, Scanga CA, Prikhodko V, Andersen P, Lin PL, Laddy D, Roederer M, Seder RA, Flynn JL.

NPJ Vaccines. 2019 May 28;4:21. doi: 10.1038/s41541-019-0113-9. eCollection 2019.

2.

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques.

Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL.

PLoS Pathog. 2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018 Nov.

3.

The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.

Lin PL, Flynn JL.

J Immunol. 2018 Nov 1;201(9):2541-2548. doi: 10.4049/jimmunol.1800993. Review.

PMID:
30348659
4.

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques.

Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL.

PLoS Pathog. 2018 Oct 12;14(10):e1007305. doi: 10.1371/journal.ppat.1007305. eCollection 2018 Oct.

5.

Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure.

Cadena AM, Ma Y, Ding T, Bryant M, Maiello P, Geber A, Lin PL, Flynn JL, Ghedin E.

Microbiome. 2018 Oct 9;6(1):180. doi: 10.1186/s40168-018-0560-y.

6.

Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes.

Joslyn LR, Pienaar E, DiFazio RM, Suliman S, Kagina BM, Flynn JL, Scriba TJ, Linderman JJ, Kirschner DE.

Front Microbiol. 2018 Aug 17;9:1734. doi: 10.3389/fmicb.2018.01734. eCollection 2018.

7.

Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath.

Mellors TR, Nasir M, Franchina FA, Smolinska A, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Wagner J, Hill JE.

J Breath Res. 2018 Oct 30;13(1):016004. doi: 10.1088/1752-7163/aacd18.

PMID:
29910196
8.

Low Levels of T Cell Exhaustion in Tuberculous Lung Granulomas.

Wong EA, Joslyn L, Grant NL, Klein E, Lin PL, Kirschner DE, Flynn JL.

Infect Immun. 2018 Aug 22;86(9). pii: e00426-18. doi: 10.1128/IAI.00426-18. Print 2018 Sep.

9.

Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures.

Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner JA, Aderem A, Flynn JL, Lin PL, Zak DE.

J Infect Dis. 2018 Mar 28;217(8):1318-1322. doi: 10.1093/infdis/jiy006.

10.

Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison.

Maiello P, DiFazio RM, Cadena AM, Rodgers MA, Lin PL, Scanga CA, Flynn JL.

Infect Immun. 2018 Jan 22;86(2). pii: e00505-17. doi: 10.1128/IAI.00505-17. Print 2018 Feb.

11.

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates.

White AG, Maiello P, Coleman MT, Tomko JA, Frye LJ, Scanga CA, Lin PL, Flynn JL.

J Vis Exp. 2017 Sep 5;(127). doi: 10.3791/56375.

12.

Heterogeneity in tuberculosis.

Cadena AM, Fortune SM, Flynn JL.

Nat Rev Immunol. 2017 Nov;17(11):691-702. doi: 10.1038/nri.2017.69. Epub 2017 Jul 24. Review.

13.

Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection.

Warsinske HC, DiFazio RM, Linderman JJ, Flynn JL, Kirschner DE.

J Theor Biol. 2017 Sep 21;429:1-17. doi: 10.1016/j.jtbi.2017.06.017. Epub 2017 Jun 20.

14.

Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells.

Mattila JT, Beaino W, Maiello P, Coleman MT, White AG, Scanga CA, Flynn JL, Anderson CJ.

J Immunol. 2017 Jul 15;199(2):806-815. doi: 10.4049/jimmunol.1700231. Epub 2017 Jun 7.

15.

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes.

Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB.

Front Immunol. 2017 May 12;8:542. doi: 10.3389/fimmu.2017.00542. eCollection 2017.

16.

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis.

Martin CJ, Cadena AM, Leung VW, Lin PL, Maiello P, Hicks N, Chase MR, Flynn JL, Fortune SM.

MBio. 2017 May 9;8(3). pii: e00312-17. doi: 10.1128/mBio.00312-17.

17.

Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques.

Wonderlich ER, Swan ZD, Bissel SJ, Hartman AL, Carney JP, O'Malley KJ, Obadan AO, Santos J, Walker R, Sturgeon TJ, Frye LJ Jr, Maiello P, Scanga CA, Bowling JD, Bouwer AL, Duangkhae PA, Wiley CA, Flynn JL, Wang J, Cole KS, Perez DR, Reed DS, Barratt-Boyes SM.

J Immunol. 2017 Feb 15;198(4):1616-1626. doi: 10.4049/jimmunol.1601770. Epub 2017 Jan 6.

18.

A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting.

Mellors TR, Blanchet L, Flynn JL, Tomko J, O'Malley M, Scanga CA, Lin PL, Hill JE.

J Appl Physiol (1985). 2017 Mar 1;122(3):695-701. doi: 10.1152/japplphysiol.00888.2016. Epub 2017 Jan 5.

19.
20.

Very Low Doses of Mycobacterium tuberculosis Yield Diverse Host Outcomes in Common Marmosets (Callithrix jacchus).

Cadena AM, Klein EC, White AG, Tomko JA, Chedrick CL, Reed DS, Via LE, Lin PL, Flynn JL.

Comp Med. 2016;66(5):412-419.

21.

Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-[18F]fluoro-D-glucose positron emission and computed tomography.

Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry Iii CE, O'Garra A, Wilkinson RJ.

Nat Med. 2016 Oct;22(10):1090-1093. doi: 10.1038/nm.4161. Epub 2016 Sep 5.

22.

PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.

Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, Andersen PL, Fortune SM, Flynn JL.

PLoS Pathog. 2016 Jul 5;12(7):e1005739. doi: 10.1371/journal.ppat.1005739. eCollection 2016 Jul.

23.

Active transforming growth factor-β is associated with phenotypic changes in granulomas after drug treatment in pulmonary tuberculosis.

DiFazio RM, Mattila JT, Klein EC, Cirrincione LR, Howard M, Wong EA, Flynn JL.

Fibrogenesis Tissue Repair. 2016 Apr 27;9:6. doi: 10.1186/s13069-016-0043-3. eCollection 2016.

24.

Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome.

Marino S, Gideon HP, Gong C, Mankad S, McCrone JT, Lin PL, Linderman JJ, Flynn JL, Kirschner DE.

PLoS Comput Biol. 2016 Apr 11;12(4):e1004804. doi: 10.1371/journal.pcbi.1004804. eCollection 2016 Apr.

25.

The Importance of First Impressions: Early Events in Mycobacterium tuberculosis Infection Influence Outcome.

Cadena AM, Flynn JL, Fortune SM.

MBio. 2016 Apr 5;7(2):e00342-16. doi: 10.1128/mBio.00342-16. Review.

26.

A Novel Sample Processing Method for Rapid Detection of Tuberculosis in the Stool of Pediatric Patients Using the Xpert MTB/RIF Assay.

Banada PP, Naidoo U, Deshpande S, Karim F, Flynn JL, O'Malley M, Jones M, Nanassy O, Jeena P, Alland D.

PLoS One. 2016 Mar 23;11(3):e0151980. doi: 10.1371/journal.pone.0151980. eCollection 2016.

27.

Effects of B Cell Depletion on Early Mycobacterium tuberculosis Infection in Cynomolgus Macaques.

Phuah J, Wong EA, Gideon HP, Maiello P, Coleman MT, Hendricks MR, Ruden R, Cirrincione LR, Chan J, Lin PL, Flynn JL.

Infect Immun. 2016 Apr 22;84(5):1301-1311. doi: 10.1128/IAI.00083-16. Print 2016 May.

28.

The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans.

Mothé BR, Lindestam Arlehamn CS, Dow C, Dillon MBC, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, O'Connor DH, Sette A.

Tuberculosis (Edinb). 2015 Dec;95(6):722-735. doi: 10.1016/j.tube.2015.07.005. Epub 2015 Aug 28.

29.

A sterilizing tuberculosis treatment regimen is associated with faster clearance of bacteria in cavitary lesions in marmosets.

Via LE, England K, Weiner DM, Schimel D, Zimmerman MD, Dayao E, Chen RY, Dodd LE, Richardson M, Robbins KK, Cai Y, Hammoud D, Herscovitch P, Dartois V, Flynn JL, Barry CE 3rd.

Antimicrob Agents Chemother. 2015 Jul;59(7):4181-9. doi: 10.1128/AAC.00115-15. Epub 2015 May 4.

30.

CD8 T cells and Mycobacterium tuberculosis infection.

Lin PL, Flynn JL.

Semin Immunopathol. 2015 May;37(3):239-49. doi: 10.1007/s00281-015-0490-8. Epub 2015 Apr 28. Review.

31.

Immunology studies in non-human primate models of tuberculosis.

Flynn JL, Gideon HP, Mattila JT, Lin PL.

Immunol Rev. 2015 Mar;264(1):60-73. doi: 10.1111/imr.12258. Review.

32.

Noninvasive test for tuberculosis detection among primates.

Wolf TM, Mugisha L, Shoyama FM, O'Malley MJ, Flynn JL, Asiimwe B, Travis DA, Singer RS, Sreevatsan S.

Emerg Infect Dis. 2015 Mar;21(3):468-70. doi: 10.3201/eid2103.140052.

33.

Granzyme B-expressing neutrophils correlate with bacterial load in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques.

Mattila JT, Maiello P, Sun T, Via LE, Flynn JL.

Cell Microbiol. 2015 Aug;17(8):1085-97. doi: 10.1111/cmi.12428. Epub 2015 Mar 12.

34.

Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.

Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL.

PLoS Pathog. 2015 Jan 22;11(1):e1004603. doi: 10.1371/journal.ppat.1004603. eCollection 2015 Jan.

35.

Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.

Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ.

J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734. Epub 2014 Dec 15.

36.

A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.

Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ.

J Theor Biol. 2015 Feb 21;367:166-179. doi: 10.1016/j.jtbi.2014.11.021. Epub 2014 Dec 9.

37.

PET/CT imaging reveals a therapeutic response to oxazolidinones in macaques and humans with tuberculosis.

Coleman MT, Chen RY, Lee M, Lin PL, Dodd LE, Maiello P, Via LE, Kim Y, Marriner G, Dartois V, Scanga C, Janssen C, Wang J, Klein E, Cho SN, Barry CE 3rd, Flynn JL.

Sci Transl Med. 2014 Dec 3;6(265):265ra167. doi: 10.1126/scitranslmed.3009500.

38.

Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.

Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE.

Infect Immun. 2015 Jan;83(1):324-38. doi: 10.1128/IAI.02494-14. Epub 2014 Nov 3.

39.

Modeling tuberculosis in nonhuman primates.

Scanga CA, Flynn JL.

Cold Spring Harb Perspect Med. 2014 Sep 11;4(12):a018564. doi: 10.1101/cshperspect.a018564. Review.

40.

Challenges and future in vaccines, drug development, and immunomodulatory therapy.

Kling HM, Nau GJ, Ross TM, Evans TG, Chakraborty K, Empey KM, Flynn JL.

Ann Am Thorac Soc. 2014 Aug;11 Suppl 4:S201-10. doi: 10.1513/AnnalsATS.201401-036PL. Review.

41.

In vivo imaging in an ABSL-3 regional biocontainment laboratory.

Scanga CA, Lopresti BJ, Tomko J, Frye LJ, Coleman TM, Fillmore D, Carney JP, Lin PL, Flynn JL, Gardner CL, Sun C, Klimstra WB, Ryman KD, Reed DS, Fisher DJ, Cole KS.

Pathog Dis. 2014 Jul;71(2):207-12. doi: 10.1111/2049-632X.12186. Epub 2014 Jun 18. Review.

PMID:
24838691
42.

Plasma antibody profiles in non-human primate tuberculosis.

Ravindran R, Krishnan VV, Dhawan R, Wunderlich ML, Lerche NW, Flynn JL, Luciw PA, Khan IH.

J Med Primatol. 2014 Apr;43(2):59-71. doi: 10.1111/jmp.12097. Epub 2014 Jan 22.

PMID:
24446897
43.

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing.

Lin PL, Ford CB, Coleman MT, Myers AJ, Gawande R, Ioerger T, Sacchettini J, Fortune SM, Flynn JL.

Nat Med. 2014 Jan;20(1):75-9. doi: 10.1038/nm.3412. Epub 2013 Dec 15.

44.

B cells regulate neutrophilia during Mycobacterium tuberculosis infection and BCG vaccination by modulating the interleukin-17 response.

Kozakiewicz L, Chen Y, Xu J, Wang Y, Dunussi-Joannopoulos K, Ou Q, Flynn JL, Porcelli SA, Jacobs WR Jr, Chan J.

PLoS Pathog. 2013;9(7):e1003472. doi: 10.1371/journal.ppat.1003472. Epub 2013 Jul 11.

45.

Predicting lymph node output efficiency using systems biology.

Gong C, Mattila JT, Miller M, Flynn JL, Linderman JJ, Kirschner D.

J Theor Biol. 2013 Oct 21;335:169-84. doi: 10.1016/j.jtbi.2013.06.016. Epub 2013 Jun 29.

46.

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens.

Lin PL, Coleman T, Carney JP, Lopresti BJ, Tomko J, Fillmore D, Dartois V, Scanga C, Frye LJ, Janssen C, Klein E, Barry CE 3rd, Flynn JL.

Antimicrob Agents Chemother. 2013 Sep;57(9):4237-4244. doi: 10.1128/AAC.00277-13. Epub 2013 Jun 24.

47.

Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms.

Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE 3rd, Klein E, Kirschner DE, Morris SM Jr, Lin PL, Flynn JL.

J Immunol. 2013 Jul 15;191(2):773-84. doi: 10.4049/jimmunol.1300113. Epub 2013 Jun 7.

48.

Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (Callithrix jacchus).

Via LE, Weiner DM, Schimel D, Lin PL, Dayao E, Tankersley SL, Cai Y, Coleman MT, Tomko J, Paripati P, Orandle M, Kastenmayer RJ, Tartakovsky M, Rosenthal A, Portevin D, Eum SY, Lahouar S, Gagneux S, Young DB, Flynn JL, Barry CE 3rd.

Infect Immun. 2013 Aug;81(8):2909-19. doi: 10.1128/IAI.00632-13. Epub 2013 May 28.

49.

Monocyte-derived IL-5 reduces TNF production by Mycobacterium tuberculosis-specific CD4 T cells during SIV/M. tuberculosis coinfection.

Diedrich CR, Mattila JT, Flynn JL.

J Immunol. 2013 Jun 15;190(12):6320-8. doi: 10.4049/jimmunol.1202043. Epub 2013 May 20.

50.

Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes.

Myers AJ, Marino S, Kirschner DE, Flynn JL.

J Immunol. 2013 May 1;190(9):4707-16. doi: 10.4049/jimmunol.1203465. Epub 2013 Apr 1.

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