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Items: 38

1.

Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins.

Papadopoulou AA, Müller SA, Mentrup T, Shmueli MD, Niemeyer J, Haug-Kröper M, von Blume J, Mayerhofer A, Feederle R, Schröder B, Lichtenthaler SF, Fluhrer R.

EMBO Rep. 2019 Feb 7. pii: e46451. doi: 10.15252/embr.201846451. [Epub ahead of print]

PMID:
30733281
2.

The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.

Niemeyer J, Mentrup T, Heidasch R, Müller SA, Biswas U, Meyer R, Papadopoulou AA, Dederer V, Haug-Kröper M, Adamski V, Lüllmann-Rauch R, Bergmann M, Mayerhofer A, Saftig P, Wennemuth G, Jessberger R, Fluhrer R, Lichtenthaler SF, Lemberg MK, Schröder B.

EMBO Rep. 2019 Feb 7. pii: e46449. doi: 10.15252/embr.201846449. [Epub ahead of print]

PMID:
30733280
3.

Proteolytic ectodomain shedding of membrane proteins in mammals-hardware, concepts, and recent developments.

Lichtenthaler SF, Lemberg MK, Fluhrer R.

EMBO J. 2018 Aug 1;37(15). pii: e99456. doi: 10.15252/embj.201899456. Epub 2018 Jul 5. Review.

PMID:
29976761
4.

Signal peptide peptidase and SPP-like proteases - Possible therapeutic targets?

Mentrup T, Loock AC, Fluhrer R, Schröder B.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2169-2182. doi: 10.1016/j.bbamcr.2017.06.007. Epub 2017 Jun 15. Review.

5.

CLN5 is cleaved by members of the SPP/SPPL family to produce a mature soluble protein.

Jules F, Sauvageau E, Dumaresq-Doiron K, Mazzaferri J, Haug-Kröper M, Fluhrer R, Costantino S, Lefrancois S.

Exp Cell Res. 2017 Aug 1;357(1):40-50. doi: 10.1016/j.yexcr.2017.04.024. Epub 2017 Apr 22.

PMID:
28442266
6.

Latest emerging functions of SPP/SPPL intramembrane proteases.

Mentrup T, Fluhrer R, Schröder B.

Eur J Cell Biol. 2017 Aug;96(5):372-382. doi: 10.1016/j.ejcb.2017.03.002. Epub 2017 Mar 16. Review.

PMID:
28366434
7.

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.

Hüttl S, Helfrich F, Mentrup T, Held S, Fukumori A, Steiner H, Saftig P, Fluhrer R, Schröder B.

Biochem J. 2016 May 15;473(10):1405-22. doi: 10.1042/BCJ20160156. Epub 2016 Mar 17.

PMID:
26987812
8.

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.

J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.

9.

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways.

Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R.

Mol Cell Proteomics. 2015 Jun;14(6):1584-98. doi: 10.1074/mcp.M115.048298. Epub 2015 Mar 31.

10.

A Cell-Based Assay Reveals Nuclear Translocation of Intracellular Domains Released by SPPL Proteases.

Mentrup T, Häsler R, Fluhrer R, Saftig P, Schröder B.

Traffic. 2015 Aug;16(8):871-92. doi: 10.1111/tra.12287. Epub 2015 May 6.

11.

Intramembrane proteolysis of β-amyloid precursor protein by γ-secretase is an unusually slow process.

Kamp F, Winkler E, Trambauer J, Ebke A, Fluhrer R, Steiner H.

Biophys J. 2015 Mar 10;108(5):1229-37. doi: 10.1016/j.bpj.2014.12.045.

12.

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.

Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, Fluhrer R.

EMBO J. 2014 Dec 17;33(24):2890-905. doi: 10.15252/embj.201488375. Epub 2014 Oct 29.

13.

Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells.

Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin CL, Schröder B.

Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53. doi: 10.1016/j.bbrc.2014.07.051. Epub 2014 Jul 15.

14.

Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins.

Fluhrer R.

Cell Cycle. 2014;13(5):695. doi: 10.4161/cc.28089. Epub 2014 Feb 4. No abstract available.

15.

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.

Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B.

Mol Cell Biol. 2014 Apr;34(8):1398-411. doi: 10.1128/MCB.00038-14. Epub 2014 Feb 3.

16.

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases.

Voss M, Schröder B, Fluhrer R.

Biochim Biophys Acta. 2013 Dec;1828(12):2828-39. doi: 10.1016/j.bbamem.2013.03.033. Review.

17.

The intramembrane protease SPPL2A is critical for tooth enamel formation.

Bronckers AL, Gueneli N, Lüllmann-Rauch R, Schneppenheim J, Moraru AP, Himmerkus N, Bervoets TJ, Fluhrer R, Everts V, Saftig P, Schröder B.

J Bone Miner Res. 2013 Jul;28(7):1622-30. doi: 10.1002/jbmr.1895.

18.

The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b.

Zahn C, Kaup M, Fluhrer R, Fuchs H.

FEBS J. 2013 Apr;280(7):1653-63. doi: 10.1111/febs.12176. Epub 2013 Mar 1.

19.

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

Schneppenheim J, Dressel R, Hüttl S, Lüllmann-Rauch R, Engelke M, Dittmann K, Wienands J, Eskelinen EL, Hermans-Borgmeyer I, Fluhrer R, Saftig P, Schröder B.

J Exp Med. 2013 Jan 14;210(1):41-58. doi: 10.1084/jem.20121069. Epub 2012 Dec 24.

20.

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling.

Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F.

Biochim Biophys Acta. 2013 Mar;1833(3):602-12. doi: 10.1016/j.bbamcr.2012.11.009. Epub 2012 Nov 16.

21.

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R.

J Biol Chem. 2012 Dec 21;287(52):43401-9. doi: 10.1074/jbc.M112.371369. Epub 2012 Nov 6.

22.

The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

Fluhrer R, Martin L, Klier B, Haug-Kröper M, Grammer G, Nuscher B, Haass C.

J Biol Chem. 2012 Feb 10;287(7):5156-63. doi: 10.1074/jbc.M111.328104. Epub 2011 Dec 22.

23.

The Nicastrin ectodomain adopts a highly thermostable structure.

Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C.

Biol Chem. 2011 Nov;392(11):995-1001. doi: 10.1515/BC.2011.169.

PMID:
21848507
24.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

25.

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases.

Fluhrer R, Steiner H, Haass C.

J Biol Chem. 2009 May 22;284(21):13975-9. doi: 10.1074/jbc.R800040200. Epub 2009 Feb 3. Review.

26.

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis.

Martin L, Fluhrer R, Haass C.

J Biol Chem. 2009 Feb 27;284(9):5662-70. doi: 10.1074/jbc.M807485200. Epub 2008 Dec 29.

27.

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

J Biol Chem. 2008 Oct 31;283(44):30121-8. doi: 10.1074/jbc.M806092200. Epub 2008 Sep 3.

28.

Intramembrane proteolysis by gamma-secretase.

Steiner H, Fluhrer R, Haass C.

J Biol Chem. 2008 Oct 31;283(44):29627-31. doi: 10.1074/jbc.R800010200. Epub 2008 Jul 23. Review.

29.

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.

Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C.

J Biol Chem. 2008 Jan 18;283(3):1644-52. Epub 2007 Oct 25.

30.

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

Fluhrer R, Haass C.

Neurodegener Dis. 2007;4(2-3):112-6. Review.

PMID:
17596705
31.

A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling.

Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J.

J Biol Chem. 2007 May 11;282(19):14083-93. Epub 2007 Mar 14.

32.

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C.

Nat Cell Biol. 2006 Aug;8(8):894-6. Epub 2006 Jul 9.

33.

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3.

Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C.

J Biol Chem. 2005 Nov 25;280(47):39515-23. Epub 2005 Jul 5.

34.

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis.

Fluhrer R, Friedlein A, Haass C, Walter J.

J Biol Chem. 2004 Jan 16;279(3):1585-93. Epub 2003 Oct 22.

35.

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.

Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C.

J Biol Chem. 2003 Feb 21;278(8):5531-8. Epub 2002 Dec 5.

36.

A non-amyloidogenic function of BACE-2 in the secretory pathway.

Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J.

J Neurochem. 2002 Jun;81(5):1011-20.

37.

Apical sorting of beta-secretase limits amyloid beta-peptide production.

Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C.

J Biol Chem. 2002 Feb 15;277(7):5637-43. Epub 2001 Dec 6.

38.

Phosphorylation regulates intracellular trafficking of beta-secretase.

Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C.

J Biol Chem. 2001 May 4;276(18):14634-41. Epub 2001 Jan 29.

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