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Correcting the R165K substitution in the first voltage-sensor of CaV1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation.

El Ghaleb Y, Campiglio M, Flucher BE.

Channels (Austin). 2019 Dec;13(1):62-71. doi: 10.1080/19336950.2019.1568825.


STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function.

Flucher BE, Campiglio M.

Biochim Biophys Acta Mol Cell Res. 2018 Dec 10. pii: S0167-4889(18)30523-8. doi: 10.1016/j.bbamcr.2018.12.004. [Epub ahead of print] Review.


STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor.

Campiglio M, Kaplan MM, Flucher BE.

J Cell Physiol. 2018 Dec;233(12):9045-9051. doi: 10.1002/jcp.26767. Epub 2018 Aug 2.


Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.

Costé de Bagneaux P, Campiglio M, Benedetti B, Tuluc P, Flucher BE.

Channels (Austin). 2018;12(1):249-261. doi: 10.1080/19336950.2018.1482183.


Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation.

Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE.

Cell Rep. 2018 Jun 26;23(13):3891-3904. doi: 10.1016/j.celrep.2018.05.085.


STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation.

Campiglio M, Costé de Bagneaux P, Ortner NJ, Tuluc P, Van Petegem F, Flucher BE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1376-1381. doi: 10.1073/pnas.1715997115. Epub 2018 Jan 23.


Structural insights into binding of STAC proteins to voltage-gated calcium channels.

Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9520-E9528. doi: 10.1073/pnas.1708852114. Epub 2017 Oct 23.


Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL Jr.

ACS Chem Neurosci. 2017 Jun 21;8(6):1313-1326. doi: 10.1021/acschemneuro.6b00454. Epub 2017 Mar 17.


Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes.

Mastrolia V, Flucher SM, Obermair GJ, Drach M, Hofer H, Renström E, Schwartz A, Striessnig J, Flucher BE, Tuluc P.

Diabetes. 2017 Apr;66(4):897-907. doi: 10.2337/db16-0336. Epub 2017 Jan 23.


STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads.

Campiglio M, Flucher BE.

Sci Rep. 2017 Jan 23;7:41003. doi: 10.1038/srep41003.


How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?

Flucher BE, Tuluc P.

J Physiol. 2017 Mar 1;595(5):1451-1463. doi: 10.1113/JP273423. Review.


Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology.

Stanika R, Campiglio M, Pinggera A, Lee A, Striessnig J, Flucher BE, Obermair GJ.

Sci Rep. 2016 Oct 6;6:34528. doi: 10.1038/srep34528.


Correction: Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation.

Flucher BE.

J Gen Physiol. 2016 Oct;148(4):357. doi: 10.1085/jgp.20161166309142016c. No abstract available.


Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation.

Flucher BE.

J Gen Physiol. 2016 Aug;148(2):91-5. doi: 10.1085/jgp.201611663. No abstract available. Erratum in: J Gen Physiol. 2016 Oct;148(4):357.


Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.

Tuluc P, Benedetti B, Coste de Bagneaux P, Grabner M, Flucher BE.

J Gen Physiol. 2016 Jun;147(6):437-49. doi: 10.1085/jgp.201611568. Epub 2016 May 16.


A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane.

Rzhepetskyy Y, Lazniewska J, Proft J, Campiglio M, Flucher BE, Weiss N.

Channels (Austin). 2016 Sep 2;10(5):346-354. Epub 2016 May 5.


Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice.

Benedetti B, Benedetti A, Flucher BE.

Eur J Neurosci. 2016 Jun;43(11):1486-98. doi: 10.1111/ejn.13241. Epub 2016 Apr 18.


Restricting calcium currents is required for correct fiber type specification in skeletal muscle.

Sultana N, Dienes B, Benedetti A, Tuluc P, Szentesi P, Sztretye M, Rainer J, Hess MW, Schwarzer C, Obermair GJ, Csernoch L, Flucher BE.

Development. 2016 May 1;143(9):1547-59. doi: 10.1242/dev.129676. Epub 2016 Mar 10.


Retrograde Coupling: Muscle's Orphan Signaling Pathway?

Flucher BE.

Biophys J. 2016 Feb 23;110(4):870-1. doi: 10.1016/j.bpj.2015.12.032.


Molecular Interactions in the Voltage Sensor Controlling Gating Properties of CaV Calcium Channels.

Tuluc P, Yarov-Yarovoy V, Benedetti B, Flucher BE.

Structure. 2016 Feb 2;24(2):261-71. doi: 10.1016/j.str.2015.11.011. Epub 2015 Dec 31.


A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function.

Kaur G, Pinggera A, Ortner NJ, Lieb A, Sinnegger-Brauns MJ, Yarov-Yarovoy V, Obermair GJ, Flucher BE, Striessnig J.

J Biol Chem. 2015 Aug 21;290(34):21086-100. doi: 10.1074/jbc.M115.645671. Epub 2015 Jun 22.


Regulation of Postsynaptic Stability by the L-type Calcium Channel CaV1.3 and its Interaction with PDZ Proteins.

Stanika RI, Flucher BE, Obermair GJ.

Curr Mol Pharmacol. 2015;8(1):95-101. Review.


How is SR calcium release in muscle modulated by PIP(4,5)2?

Flucher BE.

J Gen Physiol. 2015 May;145(5):361-4. doi: 10.1085/jgp.201511395. No abstract available.


The role of auxiliary subunits for the functional diversity of voltage-gated calcium channels.

Campiglio M, Flucher BE.

J Cell Physiol. 2015 Sep;230(9):2019-31. doi: 10.1002/jcp.24998. Review.


Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1e.

Benedetti B, Tuluc P, Mastrolia V, Dlaska C, Flucher BE.

Biophys J. 2015 Mar 10;108(5):1072-80. doi: 10.1016/j.bpj.2015.01.026.


Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases.

Gstir R, Schafferer S, Scheideler M, Misslinger M, Griehl M, Daschil N, Humpel C, Obermair GJ, Schmuckermair C, Striessnig J, Flucher BE, Hüttenhofer A.

RNA. 2014 Dec;20(12):1929-43. doi: 10.1261/rna.047225.114. Epub 2014 Oct 24.


Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE.

J Neurosci. 2014 Jan 22;34(4):1446-61. doi: 10.1523/JNEUROSCI.3935-13.2014.


Dominance of P/Q-type calcium channels in depolarization-induced presynaptic FM dye release in cultured hippocampal neurons.

Nimmervoll B, Flucher BE, Obermair GJ.

Neuroscience. 2013 Dec 3;253:330-40. doi: 10.1016/j.neuroscience.2013.08.052. Epub 2013 Sep 5.


CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-β plaques in an Alzheimer's disease mouse model.

Daschil N, Obermair GJ, Flucher BE, Stefanova N, Hutter-Paier B, Windisch M, Humpel C, Marksteiner J.

J Alzheimers Dis. 2013;37(2):439-51. doi: 10.3233/JAD-130560.


Stable incorporation versus dynamic exchange of β subunits in a native Ca2+ channel complex.

Campiglio M, Di Biase V, Tuluc P, Flucher BE.

J Cell Sci. 2013 May 1;126(Pt 9):2092-101. doi: 10.1242/jcs.jcs124537. Epub 2013 Feb 27.


The proximal C-terminus of α(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.

Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M.

Biochem J. 2012 Dec 1;448(2):221-31. doi: 10.1042/BJ20120773.


Divergent biophysical properties, gating mechanisms, and possible functions of the two skeletal muscle Ca(V)1.1 calcium channel splice variants.

Tuluc P, Flucher BE.

J Muscle Res Cell Motil. 2011 Dec;32(4-5):249-56. doi: 10.1007/s10974-011-9270-9. Epub 2011 Nov 5.


A new L-type calcium channel isoform required for normal patterning of the developing neuromuscular junction.

Flucher BE, Tuluc P.

Channels (Austin). 2011 Nov-Dec;5(6):518-24. doi: 10.4161/chan.5.6.17951. Epub 2011 Nov 1. Review.


Surface traffic of dendritic CaV1.2 calcium channels in hippocampal neurons.

Di Biase V, Tuluc P, Campiglio M, Obermair GJ, Heine M, Flucher BE.

J Neurosci. 2011 Sep 21;31(38):13682-94. doi: 10.1523/JNEUROSCI.2300-11.2011.


Identification and functional characterization of malignant hyperthermia mutation T1354S in the outer pore of the Cavalpha1S-subunit.

Pirone A, Schredelseker J, Tuluc P, Gravino E, Fortunato G, Flucher BE, Carsana A, Salvatore F, Grabner M.

Am J Physiol Cell Physiol. 2010 Dec;299(6):C1345-54. doi: 10.1152/ajpcell.00008.2010. Epub 2010 Sep 22.


Rem-induced inhibition of Ca2+ channels--a three-pronged assault.

Flucher BE.

J Physiol. 2010 Jun 1;588(Pt 11):1801-2. doi: 10.1113/jphysiol.2010.191247. No abstract available.


Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

Schlick B, Flucher BE, Obermair GJ.

Neuroscience. 2010 May 19;167(3):786-98. doi: 10.1016/j.neuroscience.2010.02.037. Epub 2010 Feb 24.


Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons.

Obermair GJ, Schlick B, Di Biase V, Subramanyam P, Gebhart M, Baumgartner S, Flucher BE.

J Biol Chem. 2010 Feb 19;285(8):5776-91. doi: 10.1074/jbc.M109.044271. Epub 2009 Dec 8.


Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells.

Subramanyam P, Obermair GJ, Baumgartner S, Gebhart M, Striessnig J, Kaufmann WA, Geley S, Flucher BE.

Channels (Austin). 2009 Sep-Oct;3(5):343-55. Epub 2009 Sep 3.


'Shotgun immunological' approach for analysis of a complex subcellular system.

Mackrill JJ, England K, Flucher BE, McCarthy TV.

Int J Mol Med. 2009 Mar;23(3):399-405.


A CaV1.1 Ca2+ channel splice variant with high conductance and voltage-sensitivity alters EC coupling in developing skeletal muscle.

Tuluc P, Molenda N, Schlick B, Obermair GJ, Flucher BE, Jurkat-Rott K.

Biophys J. 2009 Jan;96(1):35-44. doi: 10.1016/j.bpj.2008.09.027.


Stable membrane expression of postsynaptic CaV1.2 calcium channel clusters is independent of interactions with AKAP79/150 and PDZ proteins.

Di Biase V, Obermair GJ, Szabo Z, Altier C, Sanguesa J, Bourinet E, Flucher BE.

J Neurosci. 2008 Dec 17;28(51):13845-55. doi: 10.1523/JNEUROSCI.3213-08.2008.


Resolving sub-synaptic compartments with double immunofluorescence labeling in hippocampal neurons.

Di Biase V, Flucher BE, Obermair GJ.

J Neurosci Methods. 2009 Jan 30;176(2):78-84. doi: 10.1016/j.jneumeth.2008.08.025. Epub 2008 Aug 30.


Auxiliary Ca(2+) channel subunits: lessons learned from muscle.

Obermair GJ, Tuluc P, Flucher BE.

Curr Opin Pharmacol. 2008 Jun;8(3):311-8. doi: 10.1016/j.coph.2008.01.008. Epub 2008 Mar 7. Review.


SRP-27 is a novel component of the supramolecular signalling complex involved in skeletal muscle excitation-contraction coupling.

Bleunven C, Treves S, Jinyu X, Leo E, Ronjat M, De Waard M, Kern G, Flucher BE, Zorzato F.

Biochem J. 2008 Apr 15;411(2):343-9.


Computer modeling of siRNA knockdown effects indicates an essential role of the Ca2+ channel alpha2delta-1 subunit in cardiac excitation-contraction coupling.

Tuluc P, Kern G, Obermair GJ, Flucher BE.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11091-6. Epub 2007 Jun 11.


Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons.

Szabo Z, Obermair GJ, Cooper CB, Zamponi GW, Flucher BE.

Eur J Neurosci. 2006 Aug;24(3):709-18.


The beta 1a subunit is essential for the assembly of dihydropyridine-receptor arrays in skeletal muscle.

Schredelseker J, Di Biase V, Obermair GJ, Felder ET, Flucher BE, Franzini-Armstrong C, Grabner M.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17219-24. Epub 2005 Nov 14.


The role of auxiliary dihydropyridine receptor subunits in muscle.

Flucher BE, Obermair GJ, Tuluc P, Schredelseker J, Kern G, Grabner M.

J Muscle Res Cell Motil. 2005;26(1):1-6. Epub 2005 Oct 14. Review.


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