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Items: 1 to 50 of 68

1.

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

Arnal JF, Lenfant F, Metivier R, Flouriot G, Henrion D, Adlanmerini M, Fontaine C, Gourdy P, Chambon P, Katzenellenbogen B, Katzenellenbogen J.

Physiol Rev. 2017 Jul 1;97(3):1045-1087. doi: 10.1152/physrev.00024.2016. Review.

2.

The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors.

Chantalat E, Boudou F, Laurell H, Palierne G, Houtman R, Melchers D, Rochaix P, Filleron T, Stella A, Burlet-Schiltz O, Brouchet A, Flouriot G, Métivier R, Arnal JF, Fontaine C, Lenfant F.

Breast Cancer Res. 2016 Dec 7;18(1):123.

3.

A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells.

Jehanno C, Flouriot G, Le Goff P, Michel D.

Biochim Biophys Acta Gene Regul Mech. 2017 Feb;1860(2):184-195. doi: 10.1016/j.bbagrm.2016.11.006. Epub 2016 Nov 20.

PMID:
27876670
4.

Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer.

Jehanno C, Flouriot G, Nicol-Benoît F, Le Page Y, Le Goff P, Michel D.

Breast Dis. 2016 Feb 17;36(1):47-59. doi: 10.3233/BD-150210.

PMID:
27177343
5.

Changes in Gene Expression and Estrogen Receptor Cistrome in Mouse Liver Upon Acute E2 Treatment.

Palierne G, Fabre A, Solinhac R, Le Péron C, Avner S, Lenfant F, Fontaine C, Salbert G, Flouriot G, Arnal JF, Métivier R.

Mol Endocrinol. 2016 Jul;30(7):709-32. doi: 10.1210/me.2015-1311. Epub 2016 May 10.

6.

The Synonymous Ala87 Mutation of Estrogen Receptor Alpha Modifies Transcriptional Activation Through Both ERE and AP1 Sites.

Fernández-Calero T, Flouriot G, Marín M.

Methods Mol Biol. 2016;1366:287-296. doi: 10.1007/978-1-4939-3127-9_22.

PMID:
26585143
7.

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF.

EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112.

8.

Up-regulation of type II collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α.

Maneix L, Servent A, Porée B, Ollitrault D, Branly T, Bigot N, Boujrad N, Flouriot G, Demoor M, Boumediene K, Moslemi S, Galéra P.

J Mol Med (Berl). 2014 Nov;92(11):1179-200. doi: 10.1007/s00109-014-1195-5. Epub 2014 Aug 2.

9.

Differentiation of PC12 cells expressing estrogen receptor alpha: a new bioassay for endocrine-disrupting chemicals evaluation.

Habauzit D, Ferrière F, Botherel N, Flouriot G, Pakdel F, Saligaut C.

Chemosphere. 2014 Oct;112:240-7. doi: 10.1016/j.chemosphere.2014.03.101. Epub 2014 May 14.

10.

COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration.

Boudot A, Kerdivel G, Lecomte S, Flouriot G, Desille M, Godey F, Leveque J, Tas P, Le Dréan Y, Pakdel F.

BMC Cancer. 2014 Jun 6;14:407. doi: 10.1186/1471-2407-14-407.

11.

The actin/MKL1 signalling pathway influences cell growth and gene expression through large-scale chromatin reorganization and histone post-translational modifications.

Flouriot G, Huet G, Demay F, Pakdel F, Boujrad N, Michel D.

Biochem J. 2014 Jul 15;461(2):257-68. doi: 10.1042/BJ20131240.

PMID:
24762104
12.

Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines.

Kerdivel G, Boudot A, Habauzit D, Percevault F, Demay F, Pakdel F, Flouriot G.

Mol Cell Endocrinol. 2014 Jun 5;390(1-2):34-44. doi: 10.1016/j.mce.2014.03.009. Epub 2014 Apr 8.

13.

The transcriptional activities and cellular localization of the human estrogen receptor alpha are affected by the synonymous Ala87 mutation.

Fernández-Calero T, Astrada S, Alberti A, Horjales S, Arnal JF, Rovira C, Bollati-Fogolín M, Flouriot G, Marin M.

J Steroid Biochem Mol Biol. 2014 Sep;143:99-104. doi: 10.1016/j.jsbmb.2014.02.016. Epub 2014 Mar 4.

PMID:
24607813
14.

Unliganded estrogen receptor alpha promotes PC12 survival during serum starvation.

Ferriere F, Habauzit D, Pakdel F, Saligaut C, Flouriot G.

PLoS One. 2013 Jun 25;8(6):e69081. doi: 10.1371/journal.pone.0069081. Print 2013.

15.

Modulation of estrogen receptor alpha activity and expression during breast cancer progression.

Kerdivel G, Flouriot G, Pakdel F.

Vitam Horm. 2013;93:135-60. doi: 10.1016/B978-0-12-416673-8.00004-6. Review.

PMID:
23810005
16.

Tamoxifen elicits atheroprotection through estrogen receptor α AF-1 but does not accelerate reendothelialization.

Fontaine C, Abot A, Billon-Galés A, Flouriot G, Bergès H, Grunenwald E, Vinel A, Valera MC, Gourdy P, Arnal JF.

Am J Pathol. 2013 Jul;183(1):304-12. doi: 10.1016/j.ajpath.2013.03.010. Epub 2013 May 10.

PMID:
23669343
17.

The AF-1 activation function of estrogen receptor α is necessary and sufficient for uterine epithelial cell proliferation in vivo.

Abot A, Fontaine C, Raymond-Letron I, Flouriot G, Adlanmerini M, Buscato M, Otto C, Bergès H, Laurell H, Gourdy P, Lenfant F, Arnal JF.

Endocrinology. 2013 Jun;154(6):2222-33. doi: 10.1210/en.2012-2059. Epub 2013 Apr 11.

PMID:
23580568
18.

Epigenetic memories: structural marks or active circuits?

Nicol-Benoît F, Le-Goff P, Le-Dréan Y, Demay F, Pakdel F, Flouriot G, Michel D.

Cell Mol Life Sci. 2012 Jul;69(13):2189-203. doi: 10.1007/s00018-012-0923-7. Epub 2012 Feb 14. Review.

PMID:
22331281
19.

A dynamic model of transcriptional imprinting derived from the vitellogenesis memory effect.

Nicol-Benoit F, Amon A, Vaillant C, le Goff P, le Dréan Y, Pakdel F, Flouriot G, Valotaire Y, Michel D.

Biophys J. 2011 Oct 5;101(7):1557-68. doi: 10.1016/j.bpj.2011.07.004.

20.

Effects of estrogens and endocrine-disrupting chemicals on cell differentiation-survival-proliferation in brain: contributions of neuronal cell lines.

Habauzit D, Flouriot G, Pakdel F, Saligaut C.

J Toxicol Environ Health B Crit Rev. 2011;14(5-7):300-27. doi: 10.1080/10937404.2011.578554. Review.

PMID:
21790314
21.

Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13311-6. doi: 10.1073/pnas.1105632108. Epub 2011 Jul 25.

22.

Differential estrogen-regulation of CXCL12 chemokine receptors, CXCR4 and CXCR7, contributes to the growth effect of estrogens in breast cancer cells.

Boudot A, Kerdivel G, Habauzit D, Eeckhoute J, Le Dily F, Flouriot G, Samson M, Pakdel F.

PLoS One. 2011;6(6):e20898. doi: 10.1371/journal.pone.0020898. Epub 2011 Jun 10.

23.

From in vivo gene targeting of oestrogen receptors to optimization of their modulation in menopause.

Arnal JF, Lenfant F, Flouriot G, Tremollières F, Laurell H, Fontaine C, Krust A, Chambon P, Gourdy P.

Br J Pharmacol. 2012 Jan;165(1):57-66. doi: 10.1111/j.1476-5381.2011.01538.x. Review.

24.

Development and validation of a test for environmental estrogens: Checking xeno-estrogen activity by CXCL12 secretion in BREAST CANCER CELL LINES (CXCL-test).

Habauzit D, Boudot A, Kerdivel G, Flouriot G, Pakdel F.

Environ Toxicol. 2010 Oct;25(5):495-503. doi: 10.1002/tox.20594.

PMID:
20549624
25.

Comparative effects of R- and S-equol and implication of transactivation functions (AF-1 and AF-2) in estrogen receptor-induced transcriptional activity.

Shinkaruk S, Carreau C, Flouriot G, Bennetau-Pelissero C, Potier M.

Nutrients. 2010 Mar;2(3):340-54. doi: 10.3390/nu2030340. Epub 2010 Mar 15.

26.

Repression of the estrogen receptor-alpha transcriptional activity by the Rho/megakaryoblastic leukemia 1 signaling pathway.

Huet G, Mérot Y, Percevault F, Tiffoche C, Arnal JF, Boujrad N, Pakdel F, Métivier R, Flouriot G.

J Biol Chem. 2009 Dec 4;284(49):33729-39. doi: 10.1074/jbc.M109.045534. Epub 2009 Oct 13.

27.

The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.

Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):2053-8. doi: 10.1073/pnas.0808742106. Epub 2009 Feb 2.

28.
29.

Different outcomes of unliganded and liganded estrogen receptor-alpha on neurite outgrowth in PC12 cells.

Mérot Y, Ferrière F, Gailhouste L, Huet G, Percevault F, Saligaut C, Flouriot G.

Endocrinology. 2009 Jan;150(1):200-11. doi: 10.1210/en.2008-0449. Epub 2008 Sep 4.

PMID:
18772239
30.

Dynamics of estrogen receptor-mediated transcriptional activation of responsive genes in vivo: apprehending transcription in four dimensions.

Métivier R, Huet G, Gallais R, Finot L, Petit F, Tiffoche C, Mérot Y, LePéron C, Reid G, Penot G, Demay F, Gannon F, Flouriot G, Salbert G.

Adv Exp Med Biol. 2008;617:129-38. doi: 10.1007/978-0-387-69080-3_12. Review. No abstract available.

PMID:
18497037
31.

Enterodiol and enterolactone, two major diet-derived polyphenol metabolites have different impact on ERalpha transcriptional activation in human breast cancer cells.

Carreau C, Flouriot G, Bennetau-Pelissero C, Potier M.

J Steroid Biochem Mol Biol. 2008 May;110(1-2):176-85. doi: 10.1016/j.jsbmb.2008.03.032. Epub 2008 Apr 4.

PMID:
18457947
32.

17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors.

Maneix L, Beauchef G, Servent A, Wegrowski Y, Maquart FX, Boujrad N, Flouriot G, Pujol JP, Boumediene K, Galéra P, Moslemi S.

Rheumatology (Oxford). 2008 Mar;47(3):281-8. doi: 10.1093/rheumatology/kem323. Epub 2008 Jan 31.

PMID:
18238796
33.

Loss of E-cadherin-mediated cell contacts reduces estrogen receptor alpha (ER alpha) transcriptional efficiency by affecting the respective contribution exerted by AF1 and AF2 transactivation functions.

Huet G, Mérot Y, Le Dily F, Kern L, Ferrière F, Saligaut C, Boujrad N, Pakdel F, Métivier R, Flouriot G.

Biochem Biophys Res Commun. 2008 Jan 11;365(2):304-9. Epub 2007 Nov 6.

PMID:
17991426
34.

COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells.

Le Dily F, Métivier R, Guéguen MM, Le Péron C, Flouriot G, Tas P, Pakdel F.

Breast Cancer Res Treat. 2008 Jul;110(1):69-83. Epub 2007 Aug 3.

PMID:
17674191
35.

Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: critical role of the A/B domain of the receptor.

Mérot Y, Ferrière F, Debroas E, Flouriot G, Duval D, Saligaut C.

J Mol Endocrinol. 2005 Oct;35(2):257-67.

PMID:
16216907
36.

The human estrogen receptor-alpha isoform hERalpha46 antagonizes the proliferative influence of hERalpha66 in MCF7 breast cancer cells.

Penot G, Le Péron C, Mérot Y, Grimaud-Fanouillère E, Ferrière F, Boujrad N, Kah O, Saligaut C, Ducouret B, Métivier R, Flouriot G.

Endocrinology. 2005 Dec;146(12):5474-84. Epub 2005 Sep 8.

PMID:
16150902
37.

Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis.

Staub C, Rauch M, Ferrière F, Trépos M, Dorval-Coiffec I, Saunders PT, Cobellis G, Flouriot G, Saligaut C, Jégou B.

Biol Reprod. 2005 Oct;73(4):703-12. Epub 2005 Jun 8.

PMID:
15944240
38.

11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor.

Sturm A, Bury N, Dengreville L, Fagart J, Flouriot G, Rafestin-Oblin ME, Prunet P.

Endocrinology. 2005 Jan;146(1):47-55. Epub 2004 Oct 14.

PMID:
15486226
39.

The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell.

Mérot Y, Métivier R, Penot G, Manu D, Saligaut C, Gannon F, Pakdel F, Kah O, Flouriot G.

J Biol Chem. 2004 Jun 18;279(25):26184-91. Epub 2004 Apr 12.

40.

A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains.

Métivier R, Stark A, Flouriot G, Hübner MR, Brand H, Penot G, Manu D, Denger S, Reid G, Kos M, Russell RB, Kah O, Pakdel F, Gannon F.

Mol Cell. 2002 Nov;10(5):1019-32.

41.

A novel promoter is involved in the expression of estrogen receptor alpha in human testis and epididymis.

Brand H, Kos M, Denger S, Flouriot G, Gromoll J, Gannon F, Reid G.

Endocrinology. 2002 Sep;143(9):3397-404.

PMID:
12193552
42.
43.

Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK.

Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F.

EMBO J. 2002 Jul 1;21(13):3443-53.

44.

Natural trans-spliced mRNAs are generated from the human estrogen receptor-alpha (hER alpha) gene.

Flouriot G, Brand H, Seraphin B, Gannon F.

J Biol Chem. 2002 Jul 19;277(29):26244-51. Epub 2002 May 13.

45.

ERalpha gene expression in human primary osteoblasts: evidence for the expression of two receptor proteins.

Denger S, Reid G, Kos M, Flouriot G, Parsch D, Brand H, Korach KS, Sonntag-Buck V, Gannon F.

Mol Endocrinol. 2001 Dec;15(12):2064-77.

PMID:
11731609
47.
48.
49.
50.

The 3'-untranslated region of the human estrogen receptor alpha gene mediates rapid messenger ribonucleic acid turnover.

Kenealy MR, Flouriot G, Sonntag-Buck V, Dandekar T, Brand H, Gannon F.

Endocrinology. 2000 Aug;141(8):2805-13.

PMID:
10919266

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