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Items: 48

1.

TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons.

Vogt MA, Ehsaei Z, Knuckles P, Higginbottom A, Helmbrecht MS, Kunath T, Eggan K, Williams LA, Shaw PJ, Wurst W, Floss T, Huber AB, Taylor V.

Sci Rep. 2018 May 25;8(1):8097. doi: 10.1038/s41598-018-26397-2.

2.

Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer.

Sudarski S, Henzler T, Floss T, Gaa T, Meyer M, Haubenreisser H, Schoenberg SO, Attenberger UI.

Sci Rep. 2018 May 2;8(1):6868. doi: 10.1038/s41598-018-25307-w.

3.

Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.

Vartholomaiou E, Madon-Simon M, Hagmann S, Mühlebach G, Wurst W, Floss T, Picard D.

Oncotarget. 2017 Mar 14;8(11):17428-17442. doi: 10.18632/oncotarget.15659.

4.

The Chromatin-Associated Phf12 Protein Maintains Nucleolar Integrity and Prevents Premature Cellular Senescence.

Graveline R, Marcinkiewicz K, Choi S, Paquet M, Wurst W, Floss T, David G.

Mol Cell Biol. 2017 Feb 15;37(5). pii: e00522-16. doi: 10.1128/MCB.00522-16. Print 2017 Mar 1.

5.

Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.

Zhang D, Wu B, Wang P, Wang Y, Lu P, Nechiporuk T, Floss T, Greally JM, Zheng D, Zhou B.

Nucleic Acids Res. 2017 Apr 7;45(6):3102-3115. doi: 10.1093/nar/gkw1258.

6.

Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice.

Wittmann A, Grimm MO, Scherthan H, Horsch M, Beckers J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Ford SJ, Burton NC, Razansky D, Trümbach D, Aichler M, Walch AK, Calzada-Wack J, Neff F, Wurst W, Hartmann T, Floss T.

PLoS One. 2016 Oct 27;11(10):e0164298. doi: 10.1371/journal.pone.0164298. eCollection 2016.

7.

The REST remodeling complex protects genomic integrity during embryonic neurogenesis.

Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G.

Elife. 2016 Jan 8;5:e09584. doi: 10.7554/eLife.09584.

8.

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.

Mellett M, Atzei P, Bergin R, Horgan A, Floss T, Wurst W, Callanan JJ, Moynagh PN.

Nat Commun. 2015 Mar 26;6:6669. doi: 10.1038/ncomms7669.

PMID:
25808990
9.

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention.

Tischner C, Hofer A, Wulff V, Stepek J, Dumitru I, Becker L, Haack T, Kremer L, Datta AN, Sperl W, Floss T, Wurst W, Chrzanowska-Lightowlers Z, De Angelis MH, Klopstock T, Prokisch H, Wenz T.

Hum Mol Genet. 2015 Apr 15;24(8):2247-66. doi: 10.1093/hmg/ddu743. Epub 2014 Dec 30.

10.

Mga is essential for the survival of pluripotent cells during peri-implantation development.

Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, Papaioannou VE.

Development. 2015 Jan 1;142(1):31-40. doi: 10.1242/dev.111104.

11.

MTO1-deficient mouse model mirrors the human phenotype showing complex I defect and cardiomyopathy.

Becker L, Kling E, Schiller E, Zeh R, Schrewe A, Hölter SM, Mossbrugger I, Calzada-Wack J, Strecker V, Wittig I, Dumitru I, Wenz T, Bender A, Aichler M, Janik D, Neff F, Walch A, Quintanilla-Fend L, Floss T, Bekeredjian R, Gailus-Durner V, Fuchs H, Wurst W, Meitinger T, Prokisch H, de Angelis MH, Klopstock T.

PLoS One. 2014 Dec 15;9(12):e114918. doi: 10.1371/journal.pone.0114918. eCollection 2014.

13.

HIV-1 replication in human immune cells is independent of TAR DNA binding protein 43 (TDP-43) expression.

Nehls J, Koppensteiner H, Brack-Werner R, Floss T, Schindler M.

PLoS One. 2014 Aug 15;9(8):e105478. doi: 10.1371/journal.pone.0105478. eCollection 2014.

14.

HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.

Dykes IM, van Bueren KL, Ashmore RJ, Floss T, Wurst W, Szumska D, Bhattacharya S, Scambler PJ.

Circ Res. 2014 Jun 20;115(1):23-31. doi: 10.1161/CIRCRESAHA.115.303300. Epub 2014 Apr 18.

PMID:
24748541
15.

Mitochondrial dysfunction and decrease in body weight of a transgenic knock-in mouse model for TDP-43.

Stribl C, Samara A, Trümbach D, Peis R, Neumann M, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Rathkolb B, Wolf E, Beckers J, Horsch M, Neff F, Kremmer E, Koob S, Reichert AS, Hans W, Rozman J, Klingenspor M, Aichler M, Walch AK, Becker L, Klopstock T, Glasl L, Hölter SM, Wurst W, Floss T.

J Biol Chem. 2014 Apr 11;289(15):10769-84. doi: 10.1074/jbc.M113.515940. Epub 2014 Feb 10.

16.

Highly efficient targeted mutagenesis in mice using TALENs.

Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R.

Genetics. 2013 Nov;195(3):703-13. doi: 10.1534/genetics.113.156570. Epub 2013 Aug 26.

17.

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.

Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN.

Nat Commun. 2012;3:1119. doi: 10.1038/ncomms2127.

PMID:
23047677
18.

Response to Brosch et al.

Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME.

Cell Metab. 2012 Mar 7;15(3):267-269.

19.

Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.

Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME.

Cell Metab. 2011 Aug 3;14(2):208-18. doi: 10.1016/j.cmet.2011.06.007.

20.

Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.

de Andrés-Aguayo L, Varas F, Kallin EM, Infante JF, Wurst W, Floss T, Graf T.

Blood. 2011 Jul 21;118(3):554-64. doi: 10.1182/blood-2010-12-322081. Epub 2011 May 25.

21.

Resources for proteomics in mouse embryonic stem cells.

Schnütgen F, Ehrmann F, Poser I, Hubner NC, Hansen J, Floss T, deVries I, Wurst W, Hyman A, Mann M, von Melchner H.

Nat Methods. 2011 Feb;8(2):103-4. doi: 10.1038/nmeth0211-103. No abstract available.

PMID:
21278719
22.

Phenotypic annotation of the mouse X chromosome.

Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kühn R, Wurst W, Lickert H, Rossant J.

Genome Res. 2010 Aug;20(8):1154-64. doi: 10.1101/gr.105106.110. Epub 2010 Jun 14.

23.

Efficient conditional and promoter-specific in vivo expression of cDNAs of choice by taking advantage of recombinase-mediated cassette exchange using FlEx gene traps.

Schebelle L, Wolf C, Stribl C, Javaheri T, Schnütgen F, Ettinger A, Ivics Z, Hansen J, Ruiz P, von Melchner H, Wurst W, Floss T.

Nucleic Acids Res. 2010 May;38(9):e106. doi: 10.1093/nar/gkq044. Epub 2010 Feb 5.

24.

DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments.

Pham TT, Giesert F, Röthig A, Floss T, Kallnik M, Weindl K, Hölter SM, Ahting U, Prokisch H, Becker L, Klopstock T, Hrabé de Angelis M, Beyer K, Görner K, Kahle PJ, Vogt Weisenhorn DM, Wurst W.

Genes Brain Behav. 2010 Apr;9(3):305-17. doi: 10.1111/j.1601-183X.2009.00559.x. Epub 2009 Dec 17.

25.

Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development.

Soehn AS, Pham TT, Schaeferhoff K, Floss T, Weisenhorn DM, Wurst W, Bonin M, Riess O.

Genesis. 2009 Oct;47(10):697-707. doi: 10.1002/dvg.20553.

PMID:
19621438
26.

Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import.

Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T.

Biochim Biophys Acta. 2009 May;1787(5):371-6. doi: 10.1016/j.bbabio.2008.12.001. Epub 2008 Dec 9.

27.

Pleiotropic effects in Eya3 knockout mice.

Söker T, Dalke C, Puk O, Floss T, Becker L, Bolle I, Favor J, Hans W, Hölter SM, Horsch M, Kallnik M, Kling E, Moerth C, Schrewe A, Stigloher C, Topp S, Gailus-Durner V, Naton B, Beckers J, Fuchs H, Ivandic B, Klopstock T, Schulz H, Wolf E, Wurst W, Bally-Cuif L, de Angelis MH, Graw J.

BMC Dev Biol. 2008 Dec 22;8:118. doi: 10.1186/1471-213X-8-118.

28.

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice.

Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, Hatfield DL.

Biochem J. 2009 Feb 15;418(1):61-71. doi: 10.1042/BJ20081304.

29.

Sall1, sall2, and sall4 are required for neural tube closure in mice.

Böhm J, Buck A, Borozdin W, Mannan AU, Matysiak-Scholze U, Adham I, Schulz-Schaeffer W, Floss T, Wurst W, Kohlhase J, Barrionuevo F.

Am J Pathol. 2008 Nov;173(5):1455-63. doi: 10.2353/ajpath.2008.071039. Epub 2008 Sep 25.

30.

Enhanced gene trapping in mouse embryonic stem cells.

Schnütgen F, Hansen J, De-Zolt S, Horn C, Lutz M, Floss T, Wurst W, Noppinger PR, von Melchner H.

Nucleic Acids Res. 2008 Nov;36(20):e133. doi: 10.1093/nar/gkn603. Epub 2008 Sep 23.

31.

Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.

Uez N, Lickert H, Kohlhase J, de Angelis MH, Kühn R, Wurst W, Floss T.

Genesis. 2008 Sep;46(9):463-77. doi: 10.1002/dvg.20421.

PMID:
18781635
32.

Conditional gene trapping using the FLEx system.

Floss T, Schnütgen F.

Methods Mol Biol. 2008;435:127-38. doi: 10.1007/978-1-59745-232-8_9.

PMID:
18370072
33.

Reduced body size and decreased intestinal tumor rates in HDAC2-mutant mice.

Zimmermann S, Kiefer F, Prudenziati M, Spiller C, Hansen J, Floss T, Wurst W, Minucci S, Göttlicher M.

Cancer Res. 2007 Oct 1;67(19):9047-54.

34.

Splinkerette PCR for more efficient characterization of gene trap events.

Horn C, Hansen J, Schnütgen F, Seisenberger C, Floss T, Irgang M, De-Zolt S, Wurst W, von Melchner H, Noppinger PR.

Nat Genet. 2007 Aug;39(8):933-4. No abstract available. Erratum in: Nat Genet. 2007 Dec;39(12):1528.

PMID:
17660805
35.

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA.

Nat Med. 2007 Mar;13(3):324-31. Epub 2007 Feb 18.

PMID:
17322895
36.

The Hsp90 cochaperone p23 is essential for perinatal survival.

Grad I, McKee TA, Ludwig SM, Hoyle GW, Ruiz P, Wurst W, Floss T, Miller CA 3rd, Picard D.

Mol Cell Biol. 2006 Dec;26(23):8976-83. Epub 2006 Sep 25.

37.

Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development.

Beekman C, Nichane M, De Clercq S, Maetens M, Floss T, Wurst W, Bellefroid E, Marine JC.

Mol Cell Biol. 2006 Dec;26(24):9291-301. Epub 2006 Sep 25.

38.

High-throughput trapping of secretory pathway genes in mouse embryonic stem cells.

De-Zolt S, Schnütgen F, Seisenberger C, Hansen J, Hollatz M, Floss T, Ruiz P, Wurst W, von Melchner H.

Nucleic Acids Res. 2006 Feb 13;34(3):e25.

39.

Progressive loss of the spongiotrophoblast layer of Birc6/Bruce mutants results in embryonic lethality.

Hitz C, Vogt-Weisenhorn D, Ruiz P, Wurst W, Floss T.

Genesis. 2005 Jun;42(2):91-103. Erratum in: Genesis. 2005 Dec;43(4):216.

PMID:
15887267
40.

Genomewide production of multipurpose alleles for the functional analysis of the mouse genome.

Schnütgen F, De-Zolt S, Van Sloun P, Hollatz M, Floss T, Hansen J, Altschmied J, Seisenberger C, Ghyselinck NB, Ruiz P, Chambon P, Wurst W, von Melchner H.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7221-6. Epub 2005 May 3.

41.

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.

Martinat C, Shendelman S, Jonason A, Leete T, Beal MF, Yang L, Floss T, Abeliovich A.

PLoS Biol. 2004 Nov;2(11):e327. Epub 2004 Oct 5.

42.

Molecular cloning and characterization of an endogenous antisense transcript of Nphs1.

Ihalmo P, Rinta-Valkama J, Mai P, Aström E, Palmén T, Pham TT, Floss T, Holthöfer H.

Genomics. 2004 Jun;83(6):1134-40.

PMID:
15177566
43.

Expression of neurochondrin in the developing and adult mouse brain.

Istvánffy R, Vogt Weisenhorn DM, Floss T, Wurst W.

Dev Genes Evol. 2004 Apr;214(4):206-9. Epub 2004 Mar 9.

PMID:
15007648
44.

A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.

Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22. Epub 2003 Aug 6.

45.

Nephrin TRAP mice lack slit diaphragms and show fibrotic glomeruli and cystic tubular lesions.

Rantanen M, Palmén T, Pätäri A, Ahola H, Lehtonen S, Aström E, Floss T, Vauti F, Wurst W, Ruiz P, Kerjaschki D, Holthöfer H.

J Am Soc Nephrol. 2002 Jun;13(6):1586-94.

46.

Functional genomics by gene-trapping in embryonic stem cells.

Floss T, Wurst W.

Methods Mol Biol. 2002;185:347-79. Review. No abstract available.

PMID:
11769000
47.

A role for FGF-6 in skeletal muscle regeneration.

Floss T, Arnold HH, Braun T.

Genes Dev. 1997 Aug 15;11(16):2040-51.

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