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Mechanistic inferences on metabolic dysfunction in PTSD from an integrated model and multi-omic analysis: Role of glucocorticoid receptor sensitivity.

Somvanshi PR, Mellon SH, Flory JD, Abu-Amara D, Consortium PSB, Wolkowitz OM, Yehuda R, Jett M, Hood L, Marmar C, Doyle FJ.

Am J Physiol Endocrinol Metab. 2019 Jul 19. doi: 10.1152/ajpendo.00065.2019. [Epub ahead of print]


Polygenic risk associated with post-traumatic stress disorder onset and severity.

Misganaw B, Guffanti G, Lori A, Abu-Amara D, Flory JD; SBPBC, Mueller S, Yehuda R, Jett M, Marmar CR, Ressler KJ, Doyle FJ 3rd.

Transl Psychiatry. 2019 Jun 7;9(1):165. doi: 10.1038/s41398-019-0497-3.


Positive impact of IPS supported employment on PTSD-related occupational-psychosocial functional outcomes: Results from a VA randomized-controlled trial.

Mueller L, Wolfe WR, Neylan TC, McCaslin SE, Yehuda R, Flory JD, Kyriakides TC, Toscano R, Davis LL.

Psychiatr Rehabil J. 2019 Apr 1. doi: 10.1037/prj0000345. [Epub ahead of print]


Epigenetic Age in Male Combat-Exposed War Veterans: Associations with Posttraumatic Stress Disorder Status.

Verhoeven JE, Yang R, Wolkowitz OM, Bersani FS, Lindqvist D, Mellon SH, Yehuda R, Flory JD, Lin J, Abu-Amara D, Makotkine I, Marmar C, Jett M, Hammamieh R.

Mol Neuropsychiatry. 2018 Oct;4(2):90-99. doi: 10.1159/000491431. Epub 2018 Sep 5.


Multidimensional assessment of impulsivity-related measures in relation to externalizing behaviors.

Creswell KG, Wright AGC, Flory JD, Skrzynski CJ, Manuck SB.

Psychol Med. 2019 Jul;49(10):1678-1690. doi: 10.1017/S0033291718002295. Epub 2018 Sep 4.


Considering the Genetic and Epigenetic Signature of Early Adversity Within a Biopsychosocial Framework.

Yehuda R, Flory JD.

Am J Psychiatry. 2018 Jun 1;175(6):491-492. doi: 10.1176/appi.ajp.2018.18020156. No abstract available.


Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.

Almli LM, Lori A, Meyers JL, Shin J, Fani N, Maihofer AX, Nievergelt CM, Smith AK, Mercer KB, Kerley K, Leveille JM, Feng H, Abu-Amara D, Flory JD, Yehuda R, Marmar CR, Baker DG, Bradley B, Koenen KC, Conneely KN, Ressler KJ.

Addict Biol. 2018 Sep;23(5):1145-1159. doi: 10.1111/adb.12569. Epub 2017 Oct 30.


Increased circulating blood cell counts in combat-related PTSD: Associations with inflammation and PTSD severity.

Lindqvist D, Mellon SH, Dhabhar FS, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Aschbacher K, Bersani FS, Marmar CR, Wolkowitz OM.

Psychiatry Res. 2017 Dec;258:330-336. doi: 10.1016/j.psychres.2017.08.052. Epub 2017 Aug 24.


Gene expression associated with suicide attempts in US veterans.

Flory JD, Donohue D, Muhie S, Yang R, Miller SA, Hammamieh R, Ryberg K, Yehuda R.

Transl Psychiatry. 2017 Sep 5;7(9):e1226. doi: 10.1038/tp.2017.179.


Posttraumatic stress disorder, symptoms, and white matter abnormalities among combat-exposed veterans.

Aschbacher K, Mellon SH, Wolkowitz OM, Henn-Haase C, Yehuda R, Flory JD, Bierer LM, Abu-Amara D, Marmar CR, Mueller SG.

Brain Imaging Behav. 2018 Aug;12(4):989-999. doi: 10.1007/s11682-017-9759-y.


Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans.

Blessing EM, Reus V, Mellon SH, Wolkowitz OM, Flory JD, Bierer L, Lindqvist D, Dhabhar F, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR.

Psychoneuroendocrinology. 2017 Aug;82:91-97. doi: 10.1016/j.psyneuen.2017.04.016. Epub 2017 May 1.


Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study.

Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM.

Brain Behav Immun. 2017 Jan;59:260-264. doi: 10.1016/j.bbi.2016.09.012. Epub 2016 Sep 13.


Sexual dysfunction and neuroendocrine correlates of posttraumatic stress disorder in combat veterans: Preliminary findings.

Lehrner A, Flory JD, Bierer LM, Makotkine I, Marmar CR, Yehuda R.

Psychoneuroendocrinology. 2016 Jan;63:271-5. doi: 10.1016/j.psyneuen.2015.10.015. Epub 2015 Oct 23.


Personality Correlates of Midlife Cardiometabolic Risk: The Explanatory Role of Higher-Order Factors of the Five-Factor Model.

Dermody SS, Wright AG, Cheong J, Miller KG, Muldoon MF, Flory JD, Gianaros PJ, Marsland AL, Manuck SB.

J Pers. 2016 Dec;84(6):765-776. doi: 10.1111/jopy.12216. Epub 2015 Sep 4.


Glucocorticoid functioning in male combat veterans with posttraumatic stress disorder and mild traumatic brain injury.

Flory JD, Henn-Haase C, Bierer LM, Lehrner A, Makotkine I, Marmar CR, Yehuda R.

Biol Psychiatry. 2015 Aug 1;78(3):e5-6. doi: 10.1016/j.biopsych.2015.02.003. Epub 2015 Feb 11. No abstract available.


Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.

Flory JD, Johnson T, Simmons CR, Lin S, Ghirlanda G, Fromme P.

Artif DNA PNA XNA. 2014;5(3):1-8. doi: 10.4161/1949095X.2014.992181.


Blood pressure interacts with APOE ε4 to predict memory performance in a midlife sample.

Oberlin LE, Manuck SB, Gianaros PJ, Ferrell RE, Muldoon MF, Jennings JR, Flory JD, Erickson KI.

Neuropsychology. 2015 Sep;29(5):693-702. doi: 10.1037/neu0000177. Epub 2015 Mar 2.


WITHDRAWN: Precuneal and amygdala spontaneous activity and functional connectivity in war-zone-related PTSD.

Yan X, Lazar M, Shalev AY, Neylan TC, Wolkowitz OM, Brown AD, Henn-Haase C, Yehuda R, Flory JD, Abu-Amara D, Sodickson DK, Marmar CR.

Psychiatry Res. 2014 Dec 13. pii: S0925-4927(14)00328-X. doi: 10.1016/j.pscychresns.2014.12.001. [Epub ahead of print]


Purification and assembly of thermostable Cy5 labeled γ-PNAs into a 3D DNA nanocage.

Flory JD, Johnson T, Simmons CD, Lin S, Ghirlanda G, Fromme P.

Artif DNA PNA XNA. 2014 Dec 15;5(3):e992181.


OXTR polymorphism predicts social relationships through its effects on social temperament.

Creswell KG, Wright AG, Troxel WM, Ferrell RE, Flory JD, Manuck SB.

Soc Cogn Affect Neurosci. 2015 Jun;10(6):869-76. doi: 10.1093/scan/nsu132. Epub 2014 Oct 16.


Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans.

Yehuda R, Pratchett LC, Elmes MW, Lehrner A, Daskalakis NP, Koch E, Makotkine I, Flory JD, Bierer LM.

Interface Focus. 2014 Oct 6;4(5):20140048. doi: 10.1098/rsfs.2014.0048.


COMT met allele differentially predicts risk versus severity of aberrant eating in a large community sample.

Donofry SD, Roecklein KA, Wildes JE, Miller MA, Flory JD, Manuck SB.

Psychiatry Res. 2014 Dec 15;220(1-2):513-8. doi: 10.1016/j.psychres.2014.08.037. Epub 2014 Aug 27.


Cortisol augmentation of a psychological treatment for warfighters with posttraumatic stress disorder: Randomized trial showing improved treatment retention and outcome.

Yehuda R, Bierer LM, Pratchett LC, Lehrner A, Koch EC, Van Manen JA, Flory JD, Makotkine I, Hildebrandt T.

Psychoneuroendocrinology. 2015 Jan;51:589-97. doi: 10.1016/j.psyneuen.2014.08.004. Epub 2014 Aug 13.


Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress.

Lindqvist D, Wolkowitz OM, Mellon S, Yehuda R, Flory JD, Henn-Haase C, Bierer LM, Abu-Amara D, Coy M, Neylan TC, Makotkine I, Reus VI, Yan X, Taylor NM, Marmar CR, Dhabhar FS.

Brain Behav Immun. 2014 Nov;42:81-8. doi: 10.1016/j.bbi.2014.06.003. Epub 2014 Jun 12.


Low temperature assembly of functional 3D DNA-PNA-protein complexes.

Flory JD, Simmons CR, Lin S, Johnson T, Andreoni A, Zook J, Ghirlanda G, Liu Y, Yan H, Fromme P.

J Am Chem Soc. 2014 Jun 11;136(23):8283-95. doi: 10.1021/ja501228c. Epub 2014 May 28.


Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring.

Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ.

Am J Psychiatry. 2014 Aug;171(8):872-880. doi: 10.1176/appi.ajp.2014.13121571.


The BDNF Val66Met polymorphism does not moderate the effect of self-reported physical activity on depressive symptoms in midlife.

Gujral S, Manuck SB, Ferrell RE, Flory JD, Erickson KI.

Psychiatry Res. 2014 Aug 15;218(1-2):93-7. doi: 10.1016/j.psychres.2014.03.028. Epub 2014 Apr 8.


Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder.

Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ.

Biol Psychiatry. 2015 Feb 15;77(4):356-64. doi: 10.1016/j.biopsych.2014.02.006. Epub 2014 Feb 17.


Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors.

Lehrner A, Bierer LM, Passarelli V, Pratchett LC, Flory JD, Bader HN, Harris IR, Bedi A, Daskalakis NP, Makotkine I, Yehuda R.

Psychoneuroendocrinology. 2014 Feb;40:213-20. doi: 10.1016/j.psyneuen.2013.11.019. Epub 2013 Dec 1.


Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD.

Yehuda R, Daskalakis NP, Desarnaud F, Makotkine I, Lehrner AL, Koch E, Flory JD, Buxbaum JD, Meaney MJ, Bierer LM.

Front Psychiatry. 2013 Sep 27;4:118. doi: 10.3389/fpsyt.2013.00118. eCollection 2013.


The use of biomarkers in the military: from theory to practice.

Yehuda R, Neylan TC, Flory JD, McFarlane AC.

Psychoneuroendocrinology. 2013 Sep;38(9):1912-22. doi: 10.1016/j.psyneuen.2013.06.009. Epub 2013 Aug 6. Review.


The brain-derived neurotrophic factor Val66Met polymorphism moderates an effect of physical activity on working memory performance.

Erickson KI, Banducci SE, Weinstein AM, Macdonald AW 3rd, Ferrell RE, Halder I, Flory JD, Manuck SB.

Psychol Sci. 2013 Sep;24(9):1770-9. doi: 10.1177/0956797613480367. Epub 2013 Aug 1.


Cigarette smoking and measures of impulsivity in a college sample.

Balevich EC, Wein ND, Flory JD.

Subst Abus. 2013;34(3):256-62. doi: 10.1080/08897077.2012.763082.


PNA-peptide assembly in a 3D DNA nanocage at room temperature.

Flory JD, Shinde S, Lin S, Liu Y, Yan H, Ghirlanda G, Fromme P.

J Am Chem Soc. 2013 May 8;135(18):6985-93. doi: 10.1021/ja400762c. Epub 2013 Apr 12.


Hostile mood and social strain during daily life: a test of the transactional model.

Vella EJ, Kamarck TW, Flory JD, Manuck S.

Ann Behav Med. 2012 Dec;44(3):341-52. doi: 10.1007/s12160-012-9400-7.


Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders.

Flory JD, Yehuda R, Passarelli V, Siever LJ.

Depress Res Treat. 2012;2012:350461. doi: 10.1155/2012/350461. Epub 2012 Apr 3.


Using confirmatory factor analysis to measure contemporaneous activation of defined neuronal networks in functional magnetic resonance imaging.

Lahey BB, McNealy K, Knodt A, Zald DH, Sporns O, Manuck SB, Flory JD, Applegate B, Rathouz PJ, Hariri AR.

Neuroimage. 2012 May 1;60(4):1982-91. doi: 10.1016/j.neuroimage.2012.02.002. Epub 2012 Feb 10.


Polymorphic variation in the dopamine D4 receptor predicts delay discounting as a function of childhood socioeconomic status: evidence for differential susceptibility.

Sweitzer MM, Halder I, Flory JD, Craig AE, Gianaros PJ, Ferrell RE, Manuck SB.

Soc Cogn Affect Neurosci. 2013 Jun;8(5):499-508. doi: 10.1093/scan/nss020. Epub 2012 Feb 15.


Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene.

Flory JD, Pytte CL, Hurd Y, Ferrell RE, Manuck SB.

Biol Psychol. 2011 Sep;88(1):51-6. doi: 10.1016/j.biopsycho.2011.06.007. Epub 2011 Jul 5.


Maternal exposure to the holocaust and health complaints in offspring.

Flory JD, Bierer LM, Yehuda R.

Dis Markers. 2011;30(2-3):133-9. doi: 10.3233/DMA-2011-0748.


The role of genes in defining a molecular biology of PTSD.

Yehuda R, Koenen KC, Galea S, Flory JD.

Dis Markers. 2011;30(2-3):67-76. doi: 10.3233/DMA-2011-0794. Review.


Citalopram improves metabolic risk factors among high hostile adults: results of a placebo-controlled intervention.

Kamarck TW, Muldoon MF, Manuck SB, Haskett RF, Cheong J, Flory JD, Vella E.

Psychoneuroendocrinology. 2011 Aug;36(7):1070-9. doi: 10.1016/j.psyneuen.2011.01.005. Epub 2011 Feb 8.


Reported early family environment covaries with menarcheal age as a function of polymorphic variation in estrogen receptor-α.

Manuck SB, Craig AE, Flory JD, Halder I, Ferrell RE.

Dev Psychopathol. 2011 Feb;23(1):69-83. doi: 10.1017/S0954579410000659.


Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD.

Yehuda R, Flory JD, Pratchett LC, Buxbaum J, Ising M, Holsboer F.

Psychopharmacology (Berl). 2010 Oct;212(3):405-17. doi: 10.1007/s00213-010-1969-6. Epub 2010 Aug 13.


Psychometric properties of a short form of the Affective Lability Scale (ALS-18).

Look AE, Flory JD, Harvey PD, Siever LJ.

Pers Individ Dif. 2010 Aug 1;49(3):187-191.


Pergolide treatment of cognitive deficits associated with schizotypal personality disorder: continued evidence of the importance of the dopamine system in the schizophrenia spectrum.

McClure MM, Harvey PD, Goodman M, Triebwasser J, New A, Koenigsberg HW, Sprung LJ, Flory JD, Siever LJ.

Neuropsychopharmacology. 2010 May;35(6):1356-62. doi: 10.1038/npp.2010.5. Epub 2010 Feb 3.


Subjective socioeconomic status and presence of the metabolic syndrome in midlife community volunteers.

Manuck SB, Phillips JE, Gianaros PJ, Flory JD, Muldoon MF.

Psychosom Med. 2010 Jan;72(1):35-45. doi: 10.1097/PSY.0b013e3181c484dc. Epub 2009 Nov 20.


Laboratory induced aggression: a positron emission tomography study of aggressive individuals with borderline personality disorder.

New AS, Hazlett EA, Newmark RE, Zhang J, Triebwasser J, Meyerson D, Lazarus S, Trisdorfer R, Goldstein KE, Goodman M, Koenigsberg HW, Flory JD, Siever LJ, Buchsbaum MS.

Biol Psychiatry. 2009 Dec 15;66(12):1107-14. doi: 10.1016/j.biopsych.2009.07.015. Epub 2009 Sep 12.

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