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Items: 1 to 50 of 274

1.

Biological and Biochemical Basis of the Differential Efficacy of First and Second Generation Somatostatin Receptor Ligands in Neuroendocrine Neoplasms.

Gatto F, Barbieri F, Arvigo M, Thellung S, Amarù J, Albertelli M, Ferone D, Florio T.

Int J Mol Sci. 2019 Aug 13;20(16). pii: E3940. doi: 10.3390/ijms20163940. Review.

2.

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells.

Pastorino O, Gentile MT, Mancini A, Del Gaudio N, Di Costanzo A, Bajetto A, Franco P, Altucci L, Florio T, Stoppelli MP, Colucci-D'Amato L.

Cancers (Basel). 2019 May 29;11(6). pii: E747. doi: 10.3390/cancers11060747.

3.

Repurposed Biguanide Drugs in Glioblastoma Exert Antiproliferative Effects via the Inhibition of Intracellular Chloride Channel 1 Activity.

Barbieri F, Verduci I, Carlini V, Zona G, Pagano A, Mazzanti M, Florio T.

Front Oncol. 2019 Mar 13;9:135. doi: 10.3389/fonc.2019.00135. eCollection 2019. Review.

4.

Proteases Upregulation in Sporadic Alzheimer's Disease Brain.

Medoro A, Bartollino S, Mignogna D, Marziliano N, Porcile C, Nizzari M, Florio T, Pagano A, Raimo G, Intrieri M, Russo C.

J Alzheimers Dis. 2019;68(3):931-938. doi: 10.3233/JAD-181284.

PMID:
30814362
5.

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity.

Thellung S, Corsaro A, Nizzari M, Barbieri F, Florio T.

Int J Mol Sci. 2019 Feb 19;20(4). pii: E901. doi: 10.3390/ijms20040901. Review.

6.

Effects of Substantia Nigra pars compacta lesion on the behavioral sequencing in the 6-OHDA model of Parkinson's disease.

Casarrubea M, Di Giovanni G, Crescimanno G, Rosa I, Aiello S, Di Censo D, Ranieri B, Santangelo A, Busatta D, Cassioli E, Galante A, Alecci M, Florio TM.

Behav Brain Res. 2019 Apr 19;362:28-35. doi: 10.1016/j.bbr.2019.01.004. Epub 2019 Jan 7.

PMID:
30630014
7.

Molecular Architecture of the Inositol Phosphatase Siw14.

Florio TJ, Lokareddy RK, Gillilan RE, Cingolani G.

Biochemistry. 2019 Feb 12;58(6):534-545. doi: 10.1021/acs.biochem.8b01044. Epub 2019 Jan 3.

8.

Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability.

Barbieri F, Würth R, Pattarozzi A, Verduci I, Mazzola C, Cattaneo MG, Tonelli M, Solari A, Bajetto A, Daga A, Vicentini LM, Mazzanti M, Florio T.

Front Pharmacol. 2018 Aug 21;9:899. doi: 10.3389/fphar.2018.00899. eCollection 2018.

9.

Mutual Influence of ROS, pH, and CLIC1 Membrane Protein in the Regulation of G1-S Phase Progression in Human Glioblastoma Stem Cells.

Peretti M, Raciti FM, Carlini V, Verduci I, Sertic S, Barozzi S, Garré M, Pattarozzi A, Daga A, Barbieri F, Costa A, Florio T, Mazzanti M.

Mol Cancer Ther. 2018 Nov;17(11):2451-2461. doi: 10.1158/1535-7163.MCT-17-1223. Epub 2018 Aug 22.

PMID:
30135216
10.

The transcriptional landscape of polyploid wheat.

Ramírez-González RH, Borrill P, Lang D, Harrington SA, Brinton J, Venturini L, Davey M, Jacobs J, van Ex F, Pasha A, Khedikar Y, Robinson SJ, Cory AT, Florio T, Concia L, Juery C, Schoonbeek H, Steuernagel B, Xiang D, Ridout CJ, Chalhoub B, Mayer KFX, Benhamed M, Latrasse D, Bendahmane A; International Wheat Genome Sequencing Consortium, Wulff BBH, Appels R, Tiwari V, Datla R, Choulet F, Pozniak CJ, Provart NJ, Sharpe AG, Paux E, Spannagl M, Bräutigam A, Uauy C.

Science. 2018 Aug 17;361(6403). pii: eaar6089. doi: 10.1126/science.aar6089.

PMID:
30115782
11.

Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity.

Pagano K, Galante D, D'Arrigo C, Corsaro A, Nizzari M, Florio T, Molinari H, Tomaselli S, Ragona L.

Mol Neurobiol. 2019 Mar;56(3):1957-1971. doi: 10.1007/s12035-018-1202-x. Epub 2018 Jul 6.

PMID:
29981054
12.

The Basal Ganglia: More than just a switching device.

Florio TM, Scarnati E, Rosa I, Di Censo D, Ranieri B, Cimini A, Galante A, Alecci M.

CNS Neurosci Ther. 2018 Aug;24(8):677-684. doi: 10.1111/cns.12987. Epub 2018 Jun 7. Review.

13.

Emerging multitarget tyrosine kinase inhibitors in the treatment of neuroendocrine neoplasms.

Grillo F, Florio T, Ferraù F, Kara E, Fanciulli G, Faggiano A, Colao A; NIKE Group.

Endocr Relat Cancer. 2018 Sep;25(9):R453-R466. doi: 10.1530/ERC-17-0531. Epub 2018 May 16.

PMID:
29769293
14.

Sprouty2 enhances the tumorigenic potential of glioblastoma cells.

Park JW, Wollmann G, Urbiola C, Fogli B, Florio T, Geley S, Klimaschewski L.

Neuro Oncol. 2018 Jul 5;20(8):1044-1054. doi: 10.1093/neuonc/noy028. Erratum in: Neuro Oncol. 2018 Jul 5;20(8):1146-1147.

15.

Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects.

Baldassari S, Solari A, Zuccari G, Drava G, Pastorino S, Fucile C, Marini V, Daga A, Pattarozzi A, Ratto A, Ferrari A, Mattioli F, Barbieri F, Caviglioli G, Florio T.

Sci Rep. 2018 Mar 2;8(1):3929. doi: 10.1038/s41598-018-22054-w.

16.

In Silico Identification and Experimental Validation of Novel Anti-Alzheimer's Multitargeted Ligands from a Marine Source Featuring a "2-Aminoimidazole plus Aromatic Group" Scaffold.

Vitale RM, Rispoli V, Desiderio D, Sgammato R, Thellung S, Canale C, Vassalli M, Carbone M, Ciavatta ML, Mollo E, Felicità V, Arcone R, Gavagnin Capoggiani M, Masullo M, Florio T, Amodeo P.

ACS Chem Neurosci. 2018 Jun 20;9(6):1290-1303. doi: 10.1021/acschemneuro.7b00416. Epub 2018 Mar 7.

PMID:
29473731
17.

Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.

Thellung S, Scoti B, Corsaro A, Villa V, Nizzari M, Gagliani MC, Porcile C, Russo C, Pagano A, Tacchetti C, Cortese K, Florio T.

Cell Death Dis. 2018 Feb 7;9(2):166. doi: 10.1038/s41419-017-0252-8.

18.

In vitro and in vivo characterization of stem-like cells from canine osteosarcoma and assessment of drug sensitivity.

Gatti M, Solari A, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Würth R, Corsaro A, Bajetto A, Ratto A, Ferrari A, Daga A, Barbieri F, Florio T.

Exp Cell Res. 2018 Feb 1;363(1):48-64. doi: 10.1016/j.yexcr.2018.01.002. Epub 2018 Jan 4.

PMID:
29305964
19.

Complexity and Selectivity of γ-Secretase Cleavage on Multiple Substrates: Consequences in Alzheimer's Disease and Cancer.

Medoro A, Bartollino S, Mignogna D, Passarella D, Porcile C, Pagano A, Florio T, Nizzari M, Guerra G, Di Marco R, Intrieri M, Raimo G, Russo C.

J Alzheimers Dis. 2018;61(1):1-15. doi: 10.3233/JAD-170628. Review.

PMID:
29103038
20.

Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.

Bajetto A, Pattarozzi A, Corsaro A, Barbieri F, Daga A, Bosio A, Gatti M, Pisaturo V, Sirito R, Florio T.

Front Cell Neurosci. 2017 Oct 13;11:312. doi: 10.3389/fncel.2017.00312. eCollection 2017.

21.

Targeted therapy of human glioblastoma via delivery of a toxin through a peptide directed to cell surface nucleolin.

Dhez AC, Benedetti E, Antonosante A, Panella G, Ranieri B, Florio TM, Cristiano L, Angelucci F, Giansanti F, Di Leandro L, d'Angelo M, Melone M, De Cola A, Federici L, Galzio R, Cascone I, Raineri F, Cimini A, Courty J, Giordano A, Ippoliti R.

J Cell Physiol. 2018 May;233(5):4091-4105. doi: 10.1002/jcp.26205. Epub 2017 Dec 18.

PMID:
28941284
22.

Synergy of two low-affinity NLSs determines the high avidity of influenza A virus nucleoprotein NP for human importin α isoforms.

Wu W, Sankhala RS, Florio TJ, Zhou L, Nguyen NLT, Lokareddy RK, Cingolani G, Panté N.

Sci Rep. 2017 Sep 12;7(1):11381. doi: 10.1038/s41598-017-11018-1.

23.

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells.

Pattarozzi A, Carra E, Favoni RE, Würth R, Marubbi D, Filiberti RA, Mutti L, Florio T, Barbieri F, Daga A.

Stem Cell Res Ther. 2017 May 25;8(1):119. doi: 10.1186/s13287-017-0573-7.

24.

Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.

Thellung S, Gatta E, Pellistri F, Villa V, Corsaro A, Nizzari M, Robello M, Florio T.

Neurotox Res. 2017 Oct;32(3):381-397. doi: 10.1007/s12640-017-9749-2. Epub 2017 May 25.

PMID:
28540665
25.

Anti-proliferative and anti-secretory effects of everolimus on human pancreatic neuroendocrine tumors primary cultures: is there any benefit from combination with somatostatin analogs?

Mohamed A, Romano D, Saveanu A, Roche C, Albertelli M, Barbieri F, Brue T, Niccoli P, Delpero JR, Garcia S, Ferone D, Florio T, Moutardier V, Poizat F, Barlier A, Gerard C.

Oncotarget. 2017 Jun 20;8(25):41044-41063. doi: 10.18632/oncotarget.17008.

26.

Cohort profile: a data linkage cohort to examine health service profiles of people with intellectual disability in New South Wales, Australia.

Reppermund S, Srasuebkul P, Heintze T, Reeve R, Dean K, Emerson E, Coyne D, Snoyman P, Baldry E, Dowse L, Szanto T, Sara G, Florio T, Trollor JN.

BMJ Open. 2017 Apr 12;7(4):e015627. doi: 10.1136/bmjopen-2016-015627.

27.

Does pasireotide directly modulate skeletal muscle metabolism?

Gatto F, Florio T.

Endocrine. 2017 Jul;57(1):6-8. doi: 10.1007/s12020-017-1291-8. Epub 2017 Apr 6. No abstract available.

PMID:
28386722
28.

A novel splice variant of the protein tyrosine phosphatase PTPRJ that encodes for a soluble protein involved in angiogenesis.

Bilotta A, Dattilo V, D'Agostino S, Belviso S, Scalise S, Bilotta M, Gaudio E, Paduano F, Perrotti N, Florio T, Fusco A, Iuliano R, Trapasso F.

Oncotarget. 2017 Feb 7;8(6):10091-10102. doi: 10.18632/oncotarget.14350.

29.

The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells.

Penna I, Gigoni A, Costa D, Vella S, Russo D, Poggi A, Villa F, Brizzolara A, Canale C, Mescola A, Daga A, Russo C, Nizzari M, Florio T, Menichini P, Pagano A.

Oncotarget. 2017 Jan 31;8(5):8189-8205. doi: 10.18632/oncotarget.14138.

30.

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells.

Angeletti F, Fossati G, Pattarozzi A, Würth R, Solari A, Daga A, Masiello I, Barbieri F, Florio T, Comincini S.

Front Mol Neurosci. 2016 Oct 27;9:107. eCollection 2016.

31.

PPAR Gamma in Neuroblastoma: The Translational Perspectives of Hypoglycemic Drugs.

Vella S, Conaldi PG, Florio T, Pagano A.

PPAR Res. 2016;2016:3038164. Epub 2016 Oct 5. Review.

32.

Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.

Corsaro A, Bajetto A, Thellung S, Begani G, Villa V, Nizzari M, Pattarozzi A, Solari A, Gatti M, Pagano A, Würth R, Daga A, Barbieri F, Florio T.

Oncotarget. 2016 Jun 21;7(25):38638-38657. doi: 10.18632/oncotarget.9575.

33.

Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.

Villa V, Thellung S, Bajetto A, Gatta E, Robello M, Novelli F, Tasso B, Tonelli M, Florio T.

Pharmacol Res. 2016 Nov;113(Pt A):500-514. doi: 10.1016/j.phrs.2016.09.010. Epub 2016 Sep 22.

PMID:
27667770
34.

Drug design strategies focusing on the CXCR4/CXCR7/CXCL12 pathway in leukemia and lymphoma.

Barbieri F, Bajetto A, Thellung S, Würth R, Florio T.

Expert Opin Drug Discov. 2016 Nov;11(11):1093-1109. Epub 2016 Sep 20. Review.

PMID:
27598329
35.

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.

Galante D, Ruggeri FS, Dietler G, Pellistri F, Gatta E, Corsaro A, Florio T, Perico A, D'Arrigo C.

Int J Biochem Cell Biol. 2016 Oct;79:261-270. doi: 10.1016/j.biocel.2016.08.037. Epub 2016 Aug 31.

PMID:
27592450
36.

FGFR4 Polymorphism as Molecular Determinant of the Efficacy of mTOR Inhibitors In GH-Secreting Pituitary Adenomas.

Florio T.

Endocrinology. 2016 Sep;157(9):3400-1. doi: 10.1210/en.2016-1454. No abstract available.

PMID:
27580808
37.

Phenotypical and Pharmacological Characterization of Stem-Like Cells in Human Pituitary Adenomas.

Würth R, Barbieri F, Pattarozzi A, Gaudenzi G, Gatto F, Fiaschi P, Ravetti JL, Zona G, Daga A, Persani L, Ferone D, Vitale G, Florio T.

Mol Neurobiol. 2017 Sep;54(7):4879-4895. doi: 10.1007/s12035-016-0025-x. Epub 2016 Aug 11.

PMID:
27514754
38.

Canine osteosarcoma cell lines contain stem-like cancer cells: biological and pharmacological characterization.

Gatti M, Wurth R, Vito G, Pattarozzi A, Campanella C, Thellung S, Maniscalco L, De Maria R, Villa V, Corsaro A, Nizzari M, Bajetto A, Ratto A, Ferrari A, Barbieri F, Florio T.

Jpn J Vet Res. 2016 May;64(2):101-12.

PMID:
27506084
39.

Down-regulation of 21A Alu RNA as a tool to boost proliferation maintaining the tissue regeneration potential of progenitor cells.

Gigoni A, Costa D, Gaetani M, Tasso R, Villa F, Florio T, Pagano A.

Cell Cycle. 2016 Sep 16;15(18):2420-30. doi: 10.1080/15384101.2016.1181242. Epub 2016 Aug 5.

40.

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors.

Gaudenzi G, Albertelli M, Dicitore A, Würth R, Gatto F, Barbieri F, Cotelli F, Florio T, Ferone D, Persani L, Vitale G.

Endocrine. 2017 Aug;57(2):214-219. doi: 10.1007/s12020-016-1048-9. Epub 2016 Aug 2.

PMID:
27481363
41.

The rat tyrosine phosphatase η increases cell adhesion by activating c-Src through dephosphorylation of its inhibitory phosphotyrosine residue.

Le Pera I, Iuliano R, Florio T, Susini C, Trapasso F, Santoro M, Chiariotti L, Schettini G, Viglietto G, Fusco A.

Oncogene. 2016 Oct 13;35(41):5456. doi: 10.1038/onc.2016.138. Epub 2016 Jul 18. No abstract available.

PMID:
27425594
42.

SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells.

Talarico C, Dattilo V, D'Antona L, Barone A, Amodio N, Belviso S, Musumeci F, Abbruzzese C, Bianco C, Trapasso F, Schenone S, Alcaro S, Ortuso F, Florio T, Paggi MG, Perrotti N, Amato R.

Oncotarget. 2016 Mar 29;7(13):15868-84. doi: 10.18632/oncotarget.7520.

43.

Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA.

Vella S, Penna I, Longo L, Pioggia G, Garbati P, Florio T, Rossi F, Pagano A.

Sci Rep. 2015 Dec 17;5:18144. doi: 10.1038/srep18144.

44.

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

Banelli B, Carra E, Barbieri F, Würth R, Parodi F, Pattarozzi A, Carosio R, Forlani A, Allemanni G, Marubbi D, Florio T, Daga A, Romani M.

Cell Cycle. 2015;14(21):3418-29. doi: 10.1080/15384101.2015.1090063.

45.

Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model.

Benedetti E, Antonosante A, d'Angelo M, Cristiano L, Galzio R, Destouches D, Florio TM, Dhez AC, Astarita C, Cinque B, Fidoamore A, Rosati F, Cifone MG, Ippoliti R, Giordano A, Courty J, Cimini A.

Oncotarget. 2015 Dec 8;6(39):42091-104. doi: 10.18632/oncotarget.5990.

46.

Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling.

Brandolini L, Cristiano L, Fidoamore A, De Pizzol M, Di Giacomo E, Florio TM, Confalone G, Galante A, Cinque B, Benedetti E, Ruffini PA, Cifone MG, Giordano A, Alecci M, Allegretti M, Cimini A.

Oncotarget. 2015 Dec 22;6(41):43375-94. doi: 10.18632/oncotarget.6234.

47.

Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds.

Würth R, Thellung S, Bajetto A, Mazzanti M, Florio T, Barbieri F.

Drug Discov Today. 2016 Jan;21(1):190-199. doi: 10.1016/j.drudis.2015.09.017. Epub 2015 Oct 9. Review.

PMID:
26456577
48.

Molecular Pharmacology of Malignant Pleural Mesothelioma: Challenges and Perspectives From Preclinical and Clinical Studies.

Thellung S, Favoni RE, Würth R, Nizzari M, Pattarozzi A, Daga A, Florio T, Barbieri F.

Curr Drug Targets. 2016;17(7):824-49. Review.

PMID:
26240051
49.

Mortality among a Cohort of Persons with an Intellectual Disability in New South Wales, Australia.

Florio T, Trollor J.

J Appl Res Intellect Disabil. 2015 Sep;28(5):383-93. doi: 10.1111/jar.12190. Epub 2015 May 21.

PMID:
25994286
50.

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors.

Barbieri F, Thellung S, Ratto A, Carra E, Marini V, Fucile C, Bajetto A, Pattarozzi A, Würth R, Gatti M, Campanella C, Vito G, Mattioli F, Pagano A, Daga A, Ferrari A, Florio T.

BMC Cancer. 2015 Apr 7;15:228. doi: 10.1186/s12885-015-1235-8.

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