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Anatomy of a viral entry platform differentially functionalized by integrins α3 and α6.

Finke J, Mikuličić S, Loster AL, Gawlitza A, Florin L, Lang T.

Sci Rep. 2020 Mar 24;10(1):5356. doi: 10.1038/s41598-020-62202-9.


Establishment of common reference intervals for hematology parameters in adults, measured in a multicenter study on the Sysmex XN-series analyzer.

Florin L, Oyaert M, Vandevenne M, Van den Bossche J, Vanden Driessche M, Claeys R, Marcelis L, Robbrecht J, Jacobs N, Nijs A, Janssen K, Van Ruymbeke A, de Mûelenaere G, Stove V.

Int J Lab Hematol. 2020 Jan 9. doi: 10.1111/ijlh.13151. [Epub ahead of print] No abstract available.


Evaluation of the primary biliary cholangitis-related serologic profile in a large cohort of Belgian systemic sclerosis patients.

Florin L, Rubben K, Vanhaecke A, Devreese K, De Keyser F, Smith V, Bonroy C.

Clin Chem Lab Med. 2020 Feb 25;58(3):416-423. doi: 10.1515/cclm-2019-0655.


Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2.

Snieder B, Brast S, Grabner A, Buchholz S, Schröter R, Spoden GA, Florin L, Salomon J, Albrecht T, Barz V, Sparreboom A, Ciarimboli G.

SLAS Discov. 2019 Oct;24(9):904-914. doi: 10.1177/2472555219859837. Epub 2019 Jul 18.


ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly.

Mikuličić S, Finke J, Boukhallouk F, Wüstenhagen E, Sons D, Homsi Y, Reiss K, Lang T, Florin L.

Elife. 2019 May 20;8. pii: e44345. doi: 10.7554/eLife.44345.


Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein.

Fink A, Mikuličić S, Blaum F, Reddehase MJ, Florin L, Lemmermann NAW.

Med Microbiol Immunol. 2019 Aug;208(3-4):531-542. doi: 10.1007/s00430-019-00604-x. Epub 2019 Apr 19.


The endocytic trafficking pathway of oncogenic papillomaviruses.

Mikuličić S, Florin L.

Papillomavirus Res. 2019 Jun;7:135-137. doi: 10.1016/j.pvr.2019.03.004. Epub 2019 Apr 1. Review.


Evaluation of an automated algorithm for interpretation of lupus anticoagulant testing.

Florin L, Desloovere M, Devreese KMJ.

Int J Lab Hematol. 2019 Jun;41(3):412-417. doi: 10.1111/ijlh.13001. Epub 2019 Mar 12.


PML nuclear body-residing proteins sequentially associate with HPV genome after infectious nuclear delivery.

Guion L, Bienkowska-Haba M, DiGiuseppe S, Florin L, Sapp M.

PLoS Pathog. 2019 Feb 25;15(2):e1007590. doi: 10.1371/journal.ppat.1007590. eCollection 2019 Feb.


Diagnostic utility of the lymphoid screening tube supplemented with CD34 for Ogata score calculation in patients with peripheral cytopenia.

Muyldermans A, Florin L, Devos H, Cauwelier B, Emmerechts J.

Hematology. 2019 Dec;24(1):166-172. doi: 10.1080/10245332.2018.1535536. Epub 2018 Oct 18.


Inhibition of Tetraspanin Functions Impairs Human Papillomavirus and Cytomegalovirus Infections.

Fast LA, Mikuličić S, Fritzen A, Schwickert J, Boukhallouk F, Hochdorfer D, Sinzger C, Suarez H, Monk PN, Yáñez-Mó M, Lieber D, Florin L.

Int J Mol Sci. 2018 Oct 2;19(10). pii: E3007. doi: 10.3390/ijms19103007.


The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses.

Wüstenhagen E, Boukhallouk F, Negwer I, Rajalingam K, Stubenrauch F, Florin L.

Oncogene. 2018 Nov;37(48):6275-6284. doi: 10.1038/s41388-018-0398-6. Epub 2018 Jul 17.


Performance of the preanalytical check module of the Stago STA R Max2 mechanical endpoint detection analyzer for assessing the impact of hemolysis, lipemia, and icterus on aPTT and PT.

Florin L, Oyaert M, Van Maerken T, Devreese KMJ.

Int J Lab Hematol. 2018 Dec;40(6):e109-e112. doi: 10.1111/ijlh.12871. Epub 2018 Jun 13. No abstract available.


Evaluation of AggreGuide A-100 for monitoring of antiplatelet therapy.

Florin L, Devreese KMJ.

Int J Lab Hematol. 2018 Dec;40(6):e113-e116. doi: 10.1111/ijlh.12872. Epub 2018 Jun 13. No abstract available.


Tetraspanin Assemblies in Virus Infection.

Florin L, Lang T.

Front Immunol. 2018 May 25;9:1140. doi: 10.3389/fimmu.2018.01140. eCollection 2018. Review.


Evaluation of the CellaVision DM96 advanced RBC application for screening and follow-up of malaria infection.

Florin L, Maelegheer K, Muyldermans A, Van Esbroeck M, Nulens E, Emmerechts J.

Diagn Microbiol Infect Dis. 2018 Apr;90(4):253-256. doi: 10.1016/j.diagmicrobio.2017.12.002. Epub 2017 Dec 8.


Surveillance of Endoscopes: Comparison of Different Sampling Techniques.

Cattoir L, Vanzieleghem T, Florin L, Helleputte T, De Vos M, Verhasselt B, Boelens J, Leroux-Roels I.

Infect Control Hosp Epidemiol. 2017 Sep;38(9):1062-1069. doi: 10.1017/ice.2017.115. Epub 2017 Jun 21.


Tetraspanins in infections by human cytomegalo- and papillomaviruses.

Fast LA, Lieber D, Lang T, Florin L.

Biochem Soc Trans. 2017 Apr 15;45(2):489-497. doi: 10.1042/BST20160295. Review.


Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.

Traub S, Stahl H, Rosenbrock H, Simon E, Florin L, Hospach L, Hörer S, Heilker R.

J Pharmacol Exp Ther. 2017 Jun;361(3):355-365. doi: 10.1124/jpet.117.240184. Epub 2017 Mar 28.


Tetraspanin CD63 controls basolateral sorting of organic cation transporter 2 in renal proximal tubules.

Schulze U, Brast S, Grabner A, Albiker C, Snieder B, Holle S, Schlatter E, Schröter R, Pavenstädt H, Herrmann E, Lambert C, Spoden GA, Florin L, Saftig P, Ciarimboli G.

FASEB J. 2017 Apr;31(4):1421-1433. doi: 10.1096/fj.201600901R. Epub 2016 Dec 28.


The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis.

Wüstenhagen E, Hampe L, Boukhallouk F, Schneider MA, Spoden GA, Negwer I, Koynov K, Kast WM, Florin L.

J Virol. 2016 Nov 14;90(23):10629-10641. doi: 10.1128/JVI.01222-16. Print 2016 Dec 1.


The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses.

Gräßel L, Fast LA, Scheffer KD, Boukhallouk F, Spoden GA, Tenzer S, Boller K, Bago R, Rajesh S, Overduin M, Berditchevski F, Florin L.

Sci Rep. 2016 Aug 31;6:32337. doi: 10.1038/srep32337.


Multidrug-resistant cytomegalovirus infection in a pediatric stem cell transplantation patient.

Bauters T, Bordon V, Florin L, Padalko E, Andrei G, Gillemot S, Fiten P, Opdenakker G, Snoeck R, Laureys G.

Antiviral Res. 2016 Aug;132:149-53. doi: 10.1016/j.antiviral.2016.05.020. Epub 2016 Jun 11. No abstract available.


Tetraspanin CD151 Promotes Initial Events in Human Cytomegalovirus Infection.

Hochdorfer D, Florin L, Sinzger C, Lieber D.

J Virol. 2016 Jun 24;90(14):6430-42. doi: 10.1128/JVI.00145-16. Print 2016 Jul 15.


Adenovirus E1A/E1B Transformed Amniotic Fluid Cells Support Human Cytomegalovirus Replication.

Krömmelbein N, Wiebusch L, Schiedner G, Büscher N, Sauer C, Florin L, Sehn E, Wolfrum U, Plachter B.

Viruses. 2016 Feb 2;8(2). pii: E37. doi: 10.3390/v8020037.


Evaluation of the new Methotrexate CMIA assay on the Architect i2000SR.

Florin L, Lemahieu C, Stove V.

Clin Chem Lab Med. 2016 Jan;54(1):e15-7. doi: 10.1515/cclm-2015-0321. No abstract available.


IgM interference in the Abbott iVanco immunoassay: A case report.

Florin L, Vantilborgh A, Pauwels S, Vanwynsberghe T, Vermeersch P, Stove V.

Clin Chim Acta. 2015 Jul 20;447:32-3. doi: 10.1016/j.cca.2015.05.006. Epub 2015 May 14. No abstract available.


Evaluating Source Data Verification as a Quality Control Measure in Clinical Trials.

Sheetz N, Wilson B, Benedict J, Huffman E, Lawton A, Travers M, Nadolny P, Young S, Given K, Florin L.

Ther Innov Regul Sci. 2014 Nov;48(6):671-680. doi: 10.1177/2168479014554400.


The extracellular δ-domain is essential for the formation of CD81 tetraspanin webs.

Homsi Y, Schloetel JG, Scheffer KD, Schmidt TH, Destainville N, Florin L, Lang T.

Biophys J. 2014 Jul 1;107(1):100-13. doi: 10.1016/j.bpj.2014.05.028.


Inhibition by cellular vacuolar ATPase impairs human papillomavirus uncoating and infection.

Müller KH, Spoden GA, Scheffer KD, Brunnhöfer R, De Brabander JK, Maier ME, Florin L, Muller CP.

Antimicrob Agents Chemother. 2014 May;58(5):2905-11. doi: 10.1128/AAC.02284-13. Epub 2014 Mar 10.


The tetraspanin CD151 in papillomavirus infection.

Scheffer KD, Berditchevski F, Florin L.

Viruses. 2014 Feb 18;6(2):893-908. doi: 10.3390/v6020893. Review.


Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus.

Theisen LL, Erdelmeier CA, Spoden GA, Boukhallouk F, Sausy A, Florin L, Muller CP.

PLoS One. 2014 Jan 31;9(1):e88062. doi: 10.1371/journal.pone.0088062. eCollection 2014.


Emergency department CT screening of patients with nontraumatic neurological symptoms referred to the posterior fossa: comparison of thin versus thick slice images.

Kamalian S, Atkinson WL, Florin LA, Pomerantz SR, Lev MH, Romero JM.

Emerg Radiol. 2014 Jun;21(3):251-6. doi: 10.1007/s10140-014-1194-4. Epub 2014 Jan 28.


An L2 SUMO interacting motif is important for PML localization and infection of human papillomavirus type 16.

Bund T, Spoden GA, Koynov K, Hellmann N, Boukhallouk F, Arnold P, Hinderberger D, Florin L.

Cell Microbiol. 2014 Aug;16(8):1179-200. doi: 10.1111/cmi.12271. Epub 2014 Mar 12.


Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells.

Strotbek M, Florin L, Koenitzer J, Tolstrup A, Kaufmann H, Hausser A, Olayioye MA.

Metab Eng. 2013 Nov;20:157-66. doi: 10.1016/j.ymben.2013.10.005. Epub 2013 Oct 18.


Isolation and characterization of pathogen-bearing endosomes enable analysis of endosomal escape and identification of new cellular cofactors of infection.

Scheffer KD, Popa-Wagner R, Florin L.

Methods Mol Biol. 2013;1064:101-13. doi: 10.1007/978-1-62703-601-6_7.


Human papillomavirus types 16, 18, and 31 share similar endocytic requirements for entry.

Spoden G, Kühling L, Cordes N, Frenzel B, Sapp M, Boller K, Florin L, Schelhaas M.

J Virol. 2013 Jul;87(13):7765-73. doi: 10.1128/JVI.00370-13. Epub 2013 Apr 24.


The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.

Schneider MA, Scheffer KD, Bund T, Boukhallouk F, Lambert C, Cotarelo C, Pflugfelder GO, Florin L, Spoden GA.

J Virol. 2013 Apr;87(8):4461-74. doi: 10.1128/JVI.01803-12. Epub 2013 Feb 6.


Tetraspanin CD151 mediates papillomavirus type 16 endocytosis.

Scheffer KD, Gawlitza A, Spoden GA, Zhang XA, Lambert C, Berditchevski F, Florin L.

J Virol. 2013 Mar;87(6):3435-46. doi: 10.1128/JVI.02906-12. Epub 2013 Jan 9.


Host-cell factors involved in papillomavirus entry.

Florin L, Sapp M, Spoden GA.

Med Microbiol Immunol. 2012 Nov;201(4):437-48. doi: 10.1007/s00430-012-0270-1. Epub 2012 Sep 13. Review.


Confocal laser endomicroscopy for diagnosis and histomorphologic imaging of brain tumors in vivo.

Foersch S, Heimann A, Ayyad A, Spoden GA, Florin L, Mpoukouvalas K, Kiesslich R, Kempski O, Goetz M, Charalampaki P.

PLoS One. 2012;7(7):e41760. doi: 10.1371/journal.pone.0041760. Epub 2012 Jul 24.


Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry.

Popa-Wagner R, Porwal M, Kann M, Reuss M, Weimer M, Florin L, Kleinschmidt JA.

J Virol. 2012 Sep;86(17):9163-74. doi: 10.1128/JVI.00282-12. Epub 2012 Jun 13.


Polyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection.

Spoden GA, Besold K, Krauter S, Plachter B, Hanik N, Kilbinger AF, Lambert C, Florin L.

Antimicrob Agents Chemother. 2012 Jan;56(1):75-82. doi: 10.1128/AAC.05147-11. Epub 2011 Oct 3.


Supplementation of serum free media with HT is not sufficient to restore growth properties of DHFR-/- cells in fed-batch processes - Implications for designing novel CHO-based expression platforms.

Florin L, Lipske C, Becker E, Kaufmann H.

J Biotechnol. 2011 Apr 10;152(4):189-93. doi: 10.1016/j.jbiotec.2011.02.002. Epub 2011 Feb 21.


Identification of the dynein light chains required for human papillomavirus infection.

Schneider MA, Spoden GA, Florin L, Lambert C.

Cell Microbiol. 2011 Jan;13(1):32-46. doi: 10.1111/j.1462-5822.2010.01515.x.


Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue.

Treiber N, Maity P, Singh K, Kohn M, Keist AF, Ferchiu F, Sante L, Frese S, Bloch W, Kreppel F, Kochanek S, Sindrilaru A, Iben S, Högel J, Ohnmacht M, Claes LE, Ignatius A, Chung JH, Lee MJ, Kamenisch Y, Berneburg M, Nikolaus T, Braunstein K, Sperfeld AD, Ludolph AC, Briviba K, Wlaschek M, Florin L, Angel P, Scharffetter-Kochanek K.

Aging Cell. 2011 Apr;10(2):239-54. doi: 10.1111/j.1474-9726.2010.00658.x. Epub 2010 Dec 29. Erratum in: Aging Cell. 2011Oct;10(5):912. Florin, Lore [added]; Angel, Peter [added].


Evaluation of a combinatorial cell engineering approach to overcome apoptotic effects in XBP-1(s) expressing cells.

Becker E, Florin L, Pfizenmaier K, Kaufmann H.

J Biotechnol. 2010 Apr 15;146(4):198-206. doi: 10.1016/j.jbiotec.2009.11.018. Epub 2009 Dec 1.


Characterization of mammary epithelial cell line HC11 using the NIA 15k gene array reveals potential regulators of the undifferentiated and differentiated phenotypes.

Perotti C, Wiedl T, Florin L, Reuter H, Moffat S, Silbermann M, Hahn M, Angel P, Shemanko CS.

Differentiation. 2009 Dec;78(5):269-82. doi: 10.1016/j.diff.2009.05.003. Epub 2009 Jun 11.


Heterologous expression of the lipid transfer protein CERT increases therapeutic protein productivity of mammalian cells.

Florin L, Pegel A, Becker E, Hausser A, Olayioye MA, Kaufmann H.

J Biotechnol. 2009 Apr 20;141(1-2):84-90. doi: 10.1016/j.jbiotec.2009.02.014. Epub 2009 Mar 6.


Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).

Spoden G, Freitag K, Husmann M, Boller K, Sapp M, Lambert C, Florin L.

PLoS One. 2008 Oct 2;3(10):e3313. doi: 10.1371/journal.pone.0003313.

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