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Best matches for Florián J[au]:

Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling. Mehrotra N et al. Drug Metab Dispos. (2016)

Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development. Mulugeta Y et al. J Clin Pharmacol. (2016)

Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial. Johannesen L et al. Clin Pharmacol Ther. (2016)

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Items: 1 to 50 of 173


Effects of Repeated, Long-Duration Hyperoxic Water Immersions on Neuromuscular Endurance in Well-Trained Males.

Myers CM, Kim JS, McCully KK, Florian JP.

Front Physiol. 2019 Jul 24;10:858. doi: 10.3389/fphys.2019.00858. eCollection 2019.


Consecutive, Resting, Long-Duration Hyperoxic Exposures Alter Neuromuscular Responses During Maximal Strength Exercises in Trained Men.

Myers CM, Kim JS, Florian JP.

Front Physiol. 2019 Jul 31;10:960. doi: 10.3389/fphys.2019.00960. eCollection 2019.


Divers risk accelerated fatigue and core temperature rise during fully-immersed exercise in warmer water temperature extremes.

Looney DP, Long ET, Potter AW, Xu X, Friedl KE, Hoyt RW, Chalmers CR, Buller MJ, Florian JP.

Temperature (Austin). 2019 Apr 13;6(2):150-157. doi: 10.1080/23328940.2019.1599182. eCollection 2019.


Pulmonary rehabilitation improves survival in patients with idiopathic pulmonary fibrosis undergoing lung transplantation.

Florian J, Watte G, Teixeira PJZ, Altmayer S, Schio SM, Sanchez LB, Nascimento DZ, Camargo SM, Perin FA, Camargo JJ, Felicetti JC, Moreira JDS.

Sci Rep. 2019 Jun 27;9(1):9347. doi: 10.1038/s41598-019-45828-2.


Effect of Body Weight on Risk-Benefit and Dosing Regimen Recommendation of Secukinumab for the Treatment of Moderate to Severe Plaque Psoriasis.

Lee JE, Wang J, Florian J, Wang YM, Kettl D, Marcus K, Woitach A.

Clin Pharmacol Ther. 2019 Jul;106(1):78-80. doi: 10.1002/cpt.1478. Epub 2019 Jun 12. No abstract available.


Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.

Matta MK, Zusterzeel R, Pilli NR, Patel V, Volpe DA, Florian J, Oh L, Bashaw E, Zineh I, Sanabria C, Kemp S, Godfrey A, Adah S, Coelho S, Wang J, Furlong LA, Ganley C, Michele T, Strauss DG.

JAMA. 2019 Jun 4;321(21):2082-2091. doi: 10.1001/jama.2019.5586.


A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β.

Oertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF.

Biochemistry. 2019 Apr 2;58(13):1764-1773. doi: 10.1021/acs.biochem.9b00087. Epub 2019 Mar 14.


Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.

Vicente J, Zusterzeel R, Johannesen L, Ochoa-Jimenez R, Mason JW, Sanabria C, Kemp S, Sager PT, Patel V, Matta MK, Liu J, Florian J, Garnett C, Stockbridge N, Strauss DG.

Clin Pharmacol Ther. 2019 Apr;105(4):943-953. doi: 10.1002/cpt.1303. Epub 2019 Jan 18.


Use of a Systems Pharmacology Model Based Approach Toward Dose Optimization of Parathyroid Hormone Therapy in Hypoparathyroidism.

Khurana M, Zadezensky I, Lowy N, Roman D, Guettier JM, Li L, Florian J, Sahajwalla CG, Sinha V, Mehrotra N.

Clin Pharmacol Ther. 2019 Mar;105(3):710-718. doi: 10.1002/cpt.1200. Epub 2018 Oct 22.


Pulmonary effects of repeated six-hour normoxic and hyperoxic dives.

Shykoff BE, Florian JP.

PLoS One. 2018 Sep 7;13(9):e0202892. doi: 10.1371/journal.pone.0202892. eCollection 2018.


Effects of Resting, Consecutive, Long-Duration Water Immersions on Neuromuscular Endurance in Well-Trained Males.

Myers CM, Kim JS, Musilli M, McCully K, Florian JP.

Front Physiol. 2018 Jul 27;9:977. doi: 10.3389/fphys.2018.00977. eCollection 2018.


Effects of repeated long-duration water immersions on skeletal muscle performance in well-trained male divers.

Myers CM, Kim JS, Florian JP.

Eur J Appl Physiol. 2018 Oct;118(10):2065-2076. doi: 10.1007/s00421-018-3928-6. Epub 2018 Jul 12.


Relationship between International Normalized Ratio and Outcomes in Modern Trials with Warfarin Controls.

McDowell TY, Lawrence J, Florian J, Southworth MR, Grant S, Stockbridge N.

Pharmacotherapy. 2018 Sep;38(9):899-906. doi: 10.1002/phar.2161. Epub 2018 Jul 16.


Time-varying analysis of electrodermal activity during exercise.

Posada-Quintero HF, Reljin N, Mills C, Mills I, Florian JP, VanHeest JL, Chon KH.

PLoS One. 2018 Jun 1;13(6):e0198328. doi: 10.1371/journal.pone.0198328. eCollection 2018.


Changes in Posture Following a Single Session of Long-Duration Water Immersion.

Glass SM, Rhea CK, Wittstein MW, Ross SE, Florian JP, Haran FJ.

J Appl Biomech. 2018 Oct 18:1-7. doi: 10.1123/jab.2017-0181. [Epub ahead of print]


Is there a role for pharmacokinetic/pharmacodynamic-guided dosing for novel oral anticoagulants?

Chan N, Sager PT, Lawrence J, Ortel T, Reilly P, Berkowitz S, Kubitza D, Eikelboom J, Florian J, Stockbridge N, Rose M, Temple R, Seltzer JH.

Am Heart J. 2018 May;199:59-67. doi: 10.1016/j.ahj.2017.10.002. Epub 2017 Oct 10. Review.


Feasibility Testing of Hydrophobic Carbon Electrodes for Acquisition of Underwater Surface Electromyography Data.

Posada-Quintero H, Noh Y, Eaton-Robb C, Florian JP, Chon KH.

Ann Biomed Eng. 2018 Sep;46(9):1397-1405. doi: 10.1007/s10439-018-2042-6. Epub 2018 May 7.


Effect of Shallow and Deep SCUBA Dives on Heart Rate Variability.

Noh Y, Posada-Quintero HF, Bai Y, White J, Florian JP, Brink PR, Chon KH.

Front Physiol. 2018 Feb 27;9:110. doi: 10.3389/fphys.2018.00110. eCollection 2018.


Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase.

Barrozo A, Liao Q, Esguerra M, Marloie G, Florián J, Williams NH, Kamerlin SCL.

Org Biomol Chem. 2018 Mar 28;16(12):2060-2073. doi: 10.1039/c8ob00312b. Epub 2018 Mar 6.


Regulatory Perspectives in Pharmacometric Models of Osteoporosis.

Madrasi K, Li F, Kim MJ, Samant S, Voss S, Kehoe T, Bashaw ED, Ahn HY, Wang Y, Florian J, Schmidt S, Lesko LJ, Li L.

J Clin Pharmacol. 2018 May;58(5):572-585. doi: 10.1002/jcph.1071. Epub 2018 Feb 27. Review.


Pulmonary Rehabilitation in Patients With Advanced Idiopathic Pulmonary Fibrosis Referred for Lung Transplantation.

da Fontoura FF, Berton DC, Watte G, Florian J, Schio SM, Camargo JJP, Teixeira PJZ, Moreira JDS.

J Cardiopulm Rehabil Prev. 2018 Mar;38(2):131-134. doi: 10.1097/HCR.0000000000000315.


Electrodermal Activity Is Sensitive to Cognitive Stress under Water.

Posada-Quintero HF, Florian JP, Orjuela-Cañón AD, Chon KH.

Front Physiol. 2018 Jan 17;8:1128. doi: 10.3389/fphys.2017.01128. eCollection 2017.


Leveraging Big Data in Pediatric Development Programs: Proceedings From the 2016 American College of Clinical Pharmacology Annual Meeting Symposium.

Mulugeta LY, Yao L, Mould D, Jacobs B, Florian J, Smith B, Sinha V, Barrett JS.

Clin Pharmacol Ther. 2018 Jul;104(1):81-87. doi: 10.1002/cpt.975. Epub 2018 Jan 10.


Effects of prolonged and repeated immersions on heart rate variability and complexity in military divers.

Berry NT, Wideman L, Rhea CK, Labban JD, Chon KH, Shykoff BE, Haran FJ, Florian JP.

Undersea Hyperb Med. 2017 Nov-Dec;44(6):589-600.


Public-Private Partnership: Targeting Real-World Data for Hepatitis C Direct-Acting Antivirals.

Mishra P, Florian J, Peter J, Vainorius M, Fried MW, Nelson DR, Birnkrant D.

Gastroenterology. 2017 Sep;153(3):626-631. doi: 10.1053/j.gastro.2017.07.025. Epub 2017 Jul 27. No abstract available.


The impact of repetitive long-duration water immersion on vascular function.

Simmons EE, Bergeron ER, Florian JP.

PLoS One. 2017 Jul 27;12(7):e0181673. doi: 10.1371/journal.pone.0181673. eCollection 2017.


DNA Polymerase λ Active Site Favors a Mutagenic Mispair between the Enol Form of Deoxyguanosine Triphosphate Substrate and the Keto Form of Thymidine Template: A Free Energy Perturbation Study.

Maximoff SN, Kamerlin SCL, Florián J.

J Phys Chem B. 2017 Aug 24;121(33):7813-7822. doi: 10.1021/acs.jpcb.7b04874. Epub 2017 Aug 14.


Breathing 100% oxygen during water immersion improves postimmersion cardiovascular responses to orthostatic stress.

Florian JP, Chon KH, Faes L, Shykoff BE.

Physiol Rep. 2016 Dec;4(23). pii: e13031. doi: 10.14814/phy2.13031. Epub 2016 Dec 15.


Modeling and simulation in dose determination for biodefense products approved under the FDA animal rule.

Bergman KL, Krudys K, Seo SK, Florian J.

J Pharmacokinet Pharmacodyn. 2017 Apr;44(2):153-160. doi: 10.1007/s10928-017-9516-2. Epub 2017 Mar 15.


Metal Ion Complexes of N,N'-Bis(2-Pyridylmethyl)-trans-1,2-Diaminocyclohexane-N,N'-Diacetic Acid, H2bpcd: Lanthanide(III)-bpcd2- Cationic Complexes.

McLauchlan CC, Florián J, Kissel DS, Herlinger AW.

Inorg Chem. 2017 Mar 20;56(6):3556-3567. doi: 10.1021/acs.inorgchem.6b03137. Epub 2017 Mar 7.


Uniform Free-Energy Profiles of the P-O Bond Formation and Cleavage Reactions Catalyzed by DNA Polymerases β and λ.

Klvaňa M, Bren U, Florián J.

J Phys Chem B. 2016 Dec 29;120(51):13017-13030. doi: 10.1021/acs.jpcb.6b08581. Epub 2016 Dec 19.


Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.

Jeřábek P, Florián J, Martínek V.

Phys Chem Chem Phys. 2016 Nov 9;18(44):30344-30356.


Using Photovoice and Asset Mapping to Inform a Community-Based Diabetes Intervention, Boston, Massachusetts, 2015.

Florian J, Roy NM, Quintiliani LM, Truong V, Feng Y, Bloch PP, Russinova ZL, Lasser KE.

Prev Chronic Dis. 2016 Aug 11;13:E107. doi: 10.5888/pcd13.160160.


Highly sensitive index of sympathetic activity based on time-frequency spectral analysis of electrodermal activity.

Posada-Quintero HF, Florian JP, Orjuela-Cañón ÁD, Chon KH.

Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R582-91. doi: 10.1152/ajpregu.00180.2016. Epub 2016 Jul 20.


Role of Quantitative Clinical Pharmacology in Pediatric Approval and Labeling.

Mehrotra N, Bhattaram A, Earp JC, Florian J, Krudys K, Lee JE, Lee JY, Liu J, Mulugeta Y, Yu J, Zhao P, Sinha V.

Drug Metab Dispos. 2016 Jul;44(7):924-33. doi: 10.1124/dmd.116.069559. Epub 2016 Apr 14. Review.


Power Spectral Density Analysis of Electrodermal Activity for Sympathetic Function Assessment.

Posada-Quintero HF, Florian JP, Orjuela-Cañón AD, Aljama-Corrales T, Charleston-Villalobos S, Chon KH.

Ann Biomed Eng. 2016 Oct;44(10):3124-3135. doi: 10.1007/s10439-016-1606-6. Epub 2016 Apr 8.


Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development.

Mulugeta Y, Barrett JS, Nelson R, Eshete AT, Mushtaq A, Yao L, Glasgow N, Mulberg AE, Gonzalez D, Green D, Florian J, Krudys K, Seo S, Kim I, Chilukuri D, Burckart GJ.

J Clin Pharmacol. 2016 Nov;56(11):1326-1334. doi: 10.1002/jcph.744. Review.


Membrane-Anchored Cytochrome P450 1A2-Cytochrome b5 Complex Features an X-Shaped Contact between Antiparallel Transmembrane Helices.

Jeřábek P, Florián J, Martínek V.

Chem Res Toxicol. 2016 Apr 18;29(4):626-36. doi: 10.1021/acs.chemrestox.5b00349. Epub 2016 Mar 16.


Caloric restriction diminishes the pressor response to static exercise.

Florian JP, Baisch FJ, Heer M, Pawelczyk JA.

Extrem Physiol Med. 2016 Jan 20;5:2. doi: 10.1186/s13728-016-0043-3. eCollection 2016.


Novel Conductive Carbon Black and Polydimethlysiloxane ECG Electrode: A Comparison with Commercial Electrodes in Fresh, Chlorinated, and Salt Water.

Noh Y, Bales JR, Reyes BA, Molignano J, Clement AL, Pins GD, Florian JP, Chon KH.

Ann Biomed Eng. 2016 Aug;44(8):2464-79. doi: 10.1007/s10439-015-1528-8. Epub 2016 Jan 14.


Metal Ion Complexes of N,N'-Bis(2-Pyridylmethyl)-trans-1,2-Diaminocyclohexane-N,N'-Diacetic Acid, H2bpcd: Cis/Trans Isomerization Equilibria.

Florián J, McLauchlan CC, Kissel DS, Eichman CC, Herlinger AW.

Inorg Chem. 2015 Nov 2;54(21):10361-70. doi: 10.1021/acs.inorgchem.5b01586. Epub 2015 Oct 19.


Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial.

Johannesen L, Vicente J, Mason JW, Erato C, Sanabria C, Waite-Labott K, Hong M, Lin J, Guo P, Mutlib A, Wang J, Crumb WJ, Blinova K, Chan D, Stohlman J, Florian J, Ugander M, Stockbridge N, Strauss DG.

Clin Pharmacol Ther. 2016 Feb;99(2):214-23. doi: 10.1002/cpt.205. Epub 2015 Nov 28.


Direct-acting antiviral drugs for the treatment of chronic hepatitis C virus infection: Interferon free is now.

Florian J, Mishra P, Arya V, Harrington P, Connelly S, Reynolds KS, Sinha V.

Clin Pharmacol Ther. 2015 Oct;98(4):394-402. doi: 10.1002/cpt.185. Epub 2015 Aug 31. Review.


Thermoneutral water immersion and hyperbaric oxygen do not alter cortisol regulation.

Conaty BJ, Shykoff BE, Florian JP.

Undersea Hyperb Med. 2015 May-Jun;42(3):249-56.


Caloric restriction decreases orthostatic tolerance independently from 6° head-down bedrest.

Florian JP, Baisch FJ, Heer M, Pawelczyk JA.

PLoS One. 2015 Apr 27;10(4):e0118812. doi: 10.1371/journal.pone.0118812. eCollection 2015.


Investigation of potential mechanisms of sex differences in quinidine-induced torsade de pointes risk.

Vicente J, Simlund J, Johannesen L, Sundh F, Florian J, Ugander M, Wagner GS, Woosley RL, Strauss DG.

J Electrocardiol. 2015 Jul-Aug;48(4):533-8. doi: 10.1016/j.jelectrocard.2015.03.011. Epub 2015 Mar 12.


Trial geography, pharmacogenetics, and global drug development.

Schuck RN, Florian J, Charlab R, Pacanowski M.

Clin Pharmacol Ther. 2015 Mar;97(3):218-20. doi: 10.1002/cpt.27. Epub 2014 Dec 15.


FDA perspective on sofosbuvir therapy for patients with chronic hepatitis C virus genotype 1 infection who did not respond to treatment with pegylated interferon and ribavirin.

Mishra P, Florian J, Qi K, Zeng W, Naeger LK, Donaldson E, Connelly S, O'Rear J, Price D, Murray J, Birnkrant D.

Gastroenterology. 2014 Dec;147(6):1196-200. doi: 10.1053/j.gastro.2014.10.027. Epub 2014 Oct 27. No abstract available.


Preventive treatments for breast cancer: recent developments.

Alés-Martínez JE, Ruiz A, Chacón JI, Lluch Hernández A, Ramos M, Córdoba O, Aguirre E, Barnadas A, Jara C, González S, Plazaola A, Florián J, Andrés R, Sánchez Rovira P, Frau A.

Clin Transl Oncol. 2015 Apr;17(4):257-63. doi: 10.1007/s12094-014-1250-2. Epub 2014 Dec 2. Review.


Flexible docking-based molecular dynamics/steered molecular dynamics calculations of protein-protein contacts in a complex of cytochrome P450 1A2 with cytochrome b5.

Jeřábek P, Florián J, Stiborová M, Martínek V.

Biochemistry. 2014 Oct 28;53(42):6695-705. doi: 10.1021/bi500814t. Epub 2014 Oct 14.


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