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Items: 1 to 50 of 73

1.

Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor.

Thysell E, Vidman L, Ylitalo EB, Jernberg E, Crnalic S, Iglesias-Gato D, Flores-Morales A, Stattin P, Egevad L, Widmark A, Rydén P, Bergh A, Wikström P.

Mol Oncol. 2019 Jun 4. doi: 10.1002/1878-0261.12526. [Epub ahead of print]

2.

Correction: Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.

Zhu S, Tian H, Niu X, Wang J, Li X, Jiang N, Wen S, Chen X, Ren S, Xu C, Chang C, Flores-Morales A, Shang Z, Sun Y, Niu Y.

Oncogene. 2019 Jun;38(24):4885. doi: 10.1038/s41388-019-0827-1.

PMID:
31048775
3.

Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome.

Hammarsten P, Josefsson A, Thysell E, Lundholm M, Hägglöf C, Iglesias-Gato D, Flores-Morales A, Stattin P, Egevad L, Granfors T, Wikström P, Bergh A.

Mod Pathol. 2019 Apr 12. doi: 10.1038/s41379-019-0260-6. [Epub ahead of print]

PMID:
30980038
4.

LncRNA PCAT1 activates AKT and NF-κB signaling in castration-resistant prostate cancer by regulating the PHLPP/FKBP51/IKKα complex.

Shang Z, Yu J, Sun L, Tian J, Zhu S, Zhang B, Dong Q, Jiang N, Flores-Morales A, Chang C, Niu Y.

Nucleic Acids Res. 2019 Feb 18. pii: gkz108. doi: 10.1093/nar/gkz108. [Epub ahead of print]

5.

Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.

Zhu S, Tian H, Niu X, Wang J, Li X, Jiang N, Wen S, Chen X, Ren S, Xu C, Chang C, Flores-Morales A, Shang Z, Sun Y, Niu Y.

Oncogene. 2019 Jun;38(24):4875-4884. doi: 10.1038/s41388-019-0750-5. Epub 2019 Feb 15. Erratum in: Oncogene. 2019 May 2;:.

PMID:
30770901
6.

STEMI and NSTEMI: Real-world Study in Mexico (RENASCA).

Borrayo-Sánchez G, Rosas-Peralta M, Ramírez-Arias E, Saturno-Chiu G, Estrada-Gallegos J, Parra-Michel R, Hernandez-García HR, Ayala-López EA, Barraza-Felix R, García-Rincón A, Adalid-Arellano D, Careaga-Reyna G, Lázaro-Castillo JL, Betancourt-Hernández LE, Camacho-Casillas R, Hernández-Gonzalez M, Celis-Quintal G, Villegas-González B, Hernández-Carrillo M, Benitez Arechiga ZM, Flores-Morales A, Sepúlveda-Vildosola AC; RENASCA IMSS group.

Arch Med Res. 2018 Nov;49(8):609-619. doi: 10.1016/j.arcmed.2019.01.005. Epub 2019 Feb 2.

PMID:
30718149
7.

Proteogenomic Characterization of Patient-Derived Xenografts Highlights the Role of REST in Neuroendocrine Differentiation of Castration-Resistant Prostate Cancer.

Flores-Morales A, Bergmann TB, Lavallee C, Batth TS, Lin D, Lerdrup M, Friis S, Bartels A, Kristensen G, Krzyzanowska A, Xue H, Fazli L, Hansen KH, Røder MA, Brasso K, Moreira JM, Bjartell A, Wang Y, Olsen JV, Collins CC, Iglesias-Gato D.

Clin Cancer Res. 2019 Jan 15;25(2):595-608. doi: 10.1158/1078-0432.CCR-18-0729. Epub 2018 Oct 1.

PMID:
30274982
8.

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, Sigurðsson JO, Bartek J, Iglesias-Gato D, Olsen JV, Flores-Morales A.

Nucleic Acids Res. 2018 Oct 12;46(18):9891. doi: 10.1093/nar/gky788. No abstract available.

9.

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability.

Hjorth-Jensen K, Maya-Mendoza A, Dalgaard N, Sigurðsson JO, Bartek J, Iglesias-Gato D, Olsen JV, Flores-Morales A.

Nucleic Acids Res. 2018 Oct 12;46(18):9484-9495. doi: 10.1093/nar/gky719. Erratum in: Nucleic Acids Res. 2018 Oct 12;46(18):9891.

10.

The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications.

Iglesias-Gato D, Thysell E, Tyanova S, Crnalic S, Santos A, Lima TS, Geiger T, Cox J, Widmark A, Bergh A, Mann M, Flores-Morales A, Wikström P.

Clin Cancer Res. 2018 Nov 1;24(21):5433-5444. doi: 10.1158/1078-0432.CCR-18-1229. Epub 2018 Jul 24.

PMID:
30042207
11.

YAP1 regulates prostate cancer stem cell-like characteristics to promote castration resistant growth.

Jiang N, Ke B, Hjort-Jensen K, Iglesias-Gato D, Wang Z, Chang P, Zhao Y, Niu X, Wu T, Peng B, Jiang M, Li X, Shang Z, Wang Q, Chang C, Flores-Morales A, Niu Y.

Oncotarget. 2017 Dec 7;8(70):115054-115067. doi: 10.18632/oncotarget.23014. eCollection 2017 Dec 29.

12.

Quantitative Mass Spectrometry-Based Proteomic Profiling for Precision Medicine in Prostate Cancer.

Flores-Morales A, Iglesias-Gato D.

Front Oncol. 2017 Nov 7;7:267. doi: 10.3389/fonc.2017.00267. eCollection 2017. Review.

13.

Spectroscopic, calorimetric and structural analyses of the effects of hydrothermal treatment of rice beans and the extraction solvent on starch characteristics.

González-Cruz L, Montañez-Soto JL, Conde-Barajas E, Negrete-Rodríguez MLX, Flores-Morales A, Bernardino-Nicanor A.

Int J Biol Macromol. 2018 Feb;107(Pt A):965-972. doi: 10.1016/j.ijbiomac.2017.09.074. Epub 2017 Sep 20.

PMID:
28939522
14.

The ubiquitin ligase Cullin5SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation.

Paul I, Batth TS, Iglesias-Gato D, Al-Araimi A, Al-Haddabi I, Alkharusi A, Norstedt G, Olsen JV, Zadjali F, Flores-Morales A.

Sci Rep. 2017 Feb 20;7:42800. doi: 10.1038/srep42800.

15.

The Proteome of Primary Prostate Cancer.

Iglesias-Gato D, Wikström P, Tyanova S, Lavallee C, Thysell E, Carlsson J, Hägglöf C, Cox J, Andrén O, Stattin P, Egevad L, Widmark A, Bjartell A, Collins CC, Bergh A, Geiger T, Mann M, Flores-Morales A.

Eur Urol. 2016 May;69(5):942-52. doi: 10.1016/j.eururo.2015.10.053. Epub 2015 Dec 2.

PMID:
26651926
16.

Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice.

Alkharusi A, Mirecki-Garrido M, Ma Z, Zadjali F, Flores-Morales A, Nyström T, Castrillo A, Bjorklund A, Norstedt G, Fernandez-Pérez L.

Horm Mol Biol Clin Investig. 2016 Apr 1;26(1):67-76. doi: 10.1515/hmbci-2015-0036.

PMID:
26562042
17.

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.

Iglesias-Gato D, Chuan YC, Jiang N, Svensson C, Bao J, Shang Z, Paul I, Egevad L, Kessler BM, Wikström P, Niu Y, Flores-Morales A.

Mol Cancer. 2015 Apr 18;14:88. doi: 10.1186/s12943-015-0341-1. No abstract available.

18.

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.

Iglesias-Gato D, Chuan YC, Jiang N, Svensson C, Bao J, Paul I, Egevad L, Kessler BM, Wikström P, Niu Y, Flores-Morales A.

Mol Cancer. 2015 Jan 27;14:8. doi: 10.1186/s12943-014-0280-2. Erratum in: Mol Cancer. 2015;14:88.

19.

In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth.

Jiang N, Hjorth-Jensen K, Hekmat O, Iglesias-Gato D, Kruse T, Wang C, Wei W, Ke B, Yan B, Niu Y, Olsen JV, Flores-Morales A.

Oncogene. 2015 May 21;34(21):2764-76. doi: 10.1038/onc.2014.206. Epub 2014 Jul 28.

PMID:
25065596
20.

Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.

Fernández-Pérez L, Santana-Farré R, de Mirecki-Garrido M, García I, Guerra B, Mateo-Díaz C, Iglesias-Gato D, Díaz-Chico JC, Flores-Morales A, Díaz M.

PLoS One. 2014 May 9;9(5):e96305. doi: 10.1371/journal.pone.0096305. eCollection 2014.

21.

SOCS proteins in regulation of receptor tyrosine kinase signaling.

Kazi JU, Kabir NN, Flores-Morales A, Rönnstrand L.

Cell Mol Life Sci. 2014 Sep;71(17):3297-310. doi: 10.1007/s00018-014-1619-y. Epub 2014 Apr 5. Review.

PMID:
24705897
22.

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

Andresen CA, Smedegaard S, Sylvestersen KB, Svensson C, Iglesias-Gato D, Cazzamali G, Nielsen TK, Nielsen ML, Flores-Morales A.

J Biol Chem. 2014 Jan 24;289(4):2043-54. doi: 10.1074/jbc.M113.534602. Epub 2013 Dec 11.

23.

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer.

Svensson C, Ceder J, Iglesias-Gato D, Chuan YC, Pang ST, Bjartell A, Martinez RM, Bott L, Helczynski L, Ulmert D, Wang Y, Niu Y, Collins C, Flores-Morales A.

Nucleic Acids Res. 2014 Jan;42(2):999-1015. doi: 10.1093/nar/gkt921. Epub 2013 Oct 24.

24.

SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer.

Iglesias-Gato D, Chuan YC, Wikström P, Augsten S, Jiang N, Niu Y, Seipel A, Danneman D, Vermeij M, Fernandez-Perez L, Jenster G, Egevad L, Norstedt G, Flores-Morales A.

Carcinogenesis. 2014 Jan;35(1):24-33. doi: 10.1093/carcin/bgt304. Epub 2013 Sep 12.

PMID:
24031028
25.

Estrogens regulate the hepatic effects of growth hormone, a hormonal interplay with multiple fates.

Fernández-Pérez L, Guerra B, Díaz-Chico JC, Flores-Morales A.

Front Endocrinol (Lausanne). 2013 Jun 3;4:66. doi: 10.3389/fendo.2013.00066. eCollection 2013.

26.

Suppressor of cytokine signaling 6 (SOCS6) negatively regulates Flt3 signal transduction through direct binding to phosphorylated tyrosines 591 and 919 of Flt3.

Kazi JU, Sun J, Phung B, Zadjali F, Flores-Morales A, Rönnstrand L.

J Biol Chem. 2012 Oct 19;287(43):36509-17. doi: 10.1074/jbc.M112.376111. Epub 2012 Sep 5.

27.

Common genomic signaling among initial DNA damage and radiation-induced apoptosis in peripheral blood lymphocytes from locally advanced breast cancer patients.

Henríquez-Hernández LA, Pinar B, Carmona-Vigo R, Bordón E, Rodríguez-Gallego C, Flores-Morales A, Lara PC.

Breast. 2013 Feb;22(1):28-33. doi: 10.1016/j.breast.2012.05.005. Epub 2012 Jun 9.

PMID:
22687815
28.

Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood.

Santana-Farré R, Mirecki-Garrido M, Bocos C, Henríquez-Hernández LA, Kahlon N, Herrera E, Norstedt G, Parini P, Flores-Morales A, Fernández-Pérez L.

PLoS One. 2012;7(5):e37386. doi: 10.1371/journal.pone.0037386. Epub 2012 May 16.

29.

SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.

Zadjali F, Santana-Farre R, Vesterlund M, Carow B, Mirecki-Garrido M, Hernandez-Hernandez I, Flodström-Tullberg M, Parini P, Rottenberg M, Norstedt G, Fernandez-Perez L, Flores-Morales A.

FASEB J. 2012 Aug;26(8):3282-91. doi: 10.1096/fj.12-205583. Epub 2012 May 4.

PMID:
22562833
30.

Liver X receptor agonist downregulates growth hormone signaling in the liver.

Zadjali F, Santana-Farre R, Mirecki-Garrido M, Ellis E, Norstedt G, Fernandez-Perez L, Flores-Morales A.

Horm Mol Biol Clin Investig. 2011 Nov 1;8(2):471-8. doi: 10.1515/HMBCI.2011.125.

PMID:
25961345
31.

The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.

Vesterlund M, Zadjali F, Persson T, Nielsen ML, Kessler BM, Norstedt G, Flores-Morales A.

PLoS One. 2011;6(9):e25358. doi: 10.1371/journal.pone.0025358. Epub 2011 Sep 29.

32.

Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase.

Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, Li SS, Rönnstrand L, Knapp S, Bullock AN, Flores-Morales A.

J Biol Chem. 2011 Jan 7;286(1):480-90. doi: 10.1074/jbc.M110.173526. Epub 2010 Oct 28.

33.

Ezrin mediates c-Myc actions in prostate cancer cell invasion.

Chuan YC, Iglesias-Gato D, Fernandez-Perez L, Cedazo-Minguez A, Pang ST, Norstedt G, Pousette A, Flores-Morales A.

Oncogene. 2010 Mar 11;29(10):1531-42. doi: 10.1038/onc.2009.442. Epub 2009 Dec 14.

PMID:
20010876
34.

The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy.

Fernández-Pérez L, Nóvoa J, Ståhlberg N, Santana-Farré R, Boronat M, Marrero D, Henríquez-Hernández L, Norstedt G, Flores-Morales A.

Clin Endocrinol (Oxf). 2010 Jun;72(6):800-6. doi: 10.1111/j.1365-2265.2009.03732.x. Epub 2009 Oct 22.

PMID:
19849699
35.

SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation.

Hu J, Winqvist O, Flores-Morales A, Wikström AC, Norstedt G.

PLoS One. 2009 Sep 25;4(9):e7178. doi: 10.1371/journal.pone.0007178.

36.

Constitutive gene expression profile segregates toxicity in locally advanced breast cancer patients treated with high-dose hyperfractionated radical radiotherapy.

Henríquez Hernández LA, Lara PC, Pinar B, Bordón E, Rodríguez Gallego C, Bilbao C, Fernández Pérez L, Flores Morales A.

Radiat Oncol. 2009 Jun 4;4:17. doi: 10.1186/1748-717X-4-17.

37.

Impaired autoimmune T helper 17 cell responses following DNA vaccination against rat experimental autoimmune encephalomyelitis.

Andersson A, Isaksson M, Wefer J, Norling A, Flores-Morales A, Rorsman F, Kämpe O, Harris RA, Lobell A.

PLoS One. 2008;3(11):e3682. doi: 10.1371/journal.pone.0003682. Epub 2008 Nov 10.

38.

Parkin-mediated ubiquitination regulates phospholipase C-gamma1.

Dehvari N, Sandebring A, Flores-Morales A, Mateos L, Chuan YC, Goldberg MS, Cookson MR, Cowburn RF, Cedazo-Mínguez A.

J Cell Mol Med. 2009 Sep;13(9B):3061-8. doi: 10.1111/j.1582-4934.2008.00443.x. Epub 2008 Jul 30.

39.

Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro.

Mateos L, Akterin S, Gil-Bea FJ, Spulber S, Rahman A, Björkhem I, Schultzberg M, Flores-Morales A, Cedazo-Mínguez A.

Brain Pathol. 2009 Jan;19(1):69-80. doi: 10.1111/j.1750-3639.2008.00174.x. Epub 2008 May 23.

PMID:
18503570
40.

Steroid binding sites in liver membranes: interplay between glucocorticoids, sex steroids, and pituitary hormones.

Fernández-Pérez L, Flores-Morales A, Chirino-Godoy R, Díaz-Chico JC, Díaz-Chico BN.

J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):336-43. doi: 10.1016/j.jsbmb.2008.03.019. Epub 2008 Mar 14. Review.

PMID:
18430567
41.

IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor.

Diaz LE, Chuan YC, Lewitt M, Fernandez-Perez L, Carrasco-Rodríguez S, Sanchez-Gomez M, Flores-Morales A.

Mol Hum Reprod. 2007 Aug;13(8):567-76. Epub 2007 Jun 6.

PMID:
17556377
42.
43.

Role of pituitary hormones on 17alpha-ethinylestradiol-induced cholestasis in rat.

Henríquez-Hernández LA, Flores-Morales A, Santana-Farré R, Axelson M, Nilsson P, Norstedt G, Fernández-Pérez L.

J Pharmacol Exp Ther. 2007 Feb;320(2):695-705. Epub 2006 Nov 15.

PMID:
17108234
44.

Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions.

Rico-Bautista E, Flores-Morales A, Fernández-Pérez L.

Cytokine Growth Factor Rev. 2006 Dec;17(6):431-9. Epub 2006 Oct 27. Review.

PMID:
17070092
45.

In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver.

Vidal OM, Merino R, Rico-Bautista E, Fernandez-Perez L, Chia DJ, Woelfle J, Ono M, Lenhard B, Norstedt G, Rotwein P, Flores-Morales A.

Mol Endocrinol. 2007 Jan;21(1):293-311. Epub 2006 Sep 28.

PMID:
17008382
46.

Androgen induction of prostate cancer cell invasion is mediated by ezrin.

Chuan YC, Pang ST, Cedazo-Minguez A, Norstedt G, Pousette A, Flores-Morales A.

J Biol Chem. 2006 Oct 6;281(40):29938-48. Epub 2006 Jul 26.

47.

Genomic responses in rat cerebral cortex after traumatic brain injury.

von Gertten C, Flores Morales A, Holmin S, Mathiesen T, Nordqvist AC.

BMC Neurosci. 2005 Nov 30;6:69.

48.

High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice.

Rahman A, Akterin S, Flores-Morales A, Crisby M, Kivipelto M, Schultzberg M, Cedazo-Mínguez A.

FEBS Lett. 2005 Nov 21;579(28):6411-6. Epub 2005 Nov 2.

49.

Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer.

Pang ST, Weng WH, Flores-Morales A, Johansson B, Pourian MR, Nilsson P, Pousette A, Larsson C, Norstedt G.

Prostate. 2006 Feb 1;66(2):157-72.

PMID:
16173030
50.

Negative regulation of growth hormone receptor signaling.

Flores-Morales A, Greenhalgh CJ, Norstedt G, Rico-Bautista E.

Mol Endocrinol. 2006 Feb;20(2):241-53. Epub 2005 Jul 21. Review.

PMID:
16037128

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