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Items: 35


Biological models in multiple sclerosis.

Sanabria-Castro A, Flores-Díaz M, Alape-Girón A.

J Neurosci Res. 2019 Oct 1. doi: 10.1002/jnr.24528. [Epub ahead of print] Review.


Deficient Skeletal Muscle Regeneration after Injury Induced by a Clostridium perfringens Strain Associated with Gas Gangrene.

Zúñiga-Pereira AM, Santamaría C, Gutierrez JM, Alape-Girón A, Flores-Díaz M.

Infect Immun. 2019 Jul 23;87(8). pii: e00200-19. doi: 10.1128/IAI.00200-19. Print 2019 Aug.


Identification of B cell recognized linear epitopes in a snake venom serine proteinase from the central American bushmaster Lachesis stenophrys.

Madrigal M, Alape-Girón A, Barboza-Arguedas E, Aguilar-Ulloa W, Flores-Díaz M.

Toxicon. 2017 Dec 15;140:72-82. doi: 10.1016/j.toxicon.2017.10.022. Epub 2017 Oct 27.


Cross-reactivity, antivenomics, and neutralization of toxic activities of Lachesis venoms by polyspecific and monospecific antivenoms.

Madrigal M, Pla D, Sanz L, Barboza E, Arroyo-Portilla C, Corrêa-Netto C, Gutiérrez JM, Alape-Girón A, Flores-Díaz M, Calvete JJ.

PLoS Negl Trop Dis. 2017 Aug 7;11(8):e0005793. doi: 10.1371/journal.pntd.0005793. eCollection 2017 Aug.


Bacterial Sphingomyelinases and Phospholipases as Virulence Factors.

Flores-Díaz M, Monturiol-Gross L, Naylor C, Alape-Girón A, Flieger A.

Microbiol Mol Biol Rev. 2016 Jun 15;80(3):597-628. doi: 10.1128/MMBR.00082-15. Print 2016 Sep. Review.


Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NFκB activation.

Monturiol-Gross L, Flores-Díaz M, Pineda-Padilla MJ, Castro-Castro AC, Alape-Giron A.

PLoS One. 2014 Jan 23;9(1):e86475. doi: 10.1371/journal.pone.0086475. eCollection 2014.


Internalization of Clostridium perfringens α-toxin leads to ERK activation and is involved on its cytotoxic effect.

Monturiol-Gross L, Flores-Díaz M, Campos-Rodríguez D, Mora R, Rodríguez-Vega M, Marks DL, Alape-Girón A.

Cell Microbiol. 2014 Apr;16(4):535-47. doi: 10.1111/cmi.12237. Epub 2013 Dec 13.


Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis.

Pla D, Sanz L, Molina-Sánchez P, Zorita V, Madrigal M, Flores-Díaz M, Alape-Girón A, Núñez V, Andrés V, Gutiérrez JM, Calvete JJ.

J Proteomics. 2013 Aug 26;89:112-23. doi: 10.1016/j.jprot.2013.05.028. Epub 2013 Jun 4.


Snake venomics across genus Lachesis. Ontogenetic changes in the venom composition of Lachesis stenophrys and comparative proteomics of the venoms of adult Lachesis melanocephala and Lachesis acrochorda.

Madrigal M, Sanz L, Flores-Díaz M, Sasa M, Núñez V, Alape-Girón A, Calvete JJ.

J Proteomics. 2012 Dec 21;77:280-97. doi: 10.1016/j.jprot.2012.09.003. Epub 2012 Sep 12.


Reactive oxygen species and the MEK/ERK pathway are involved in the toxicity of clostridium perfringens α-toxin, a prototype bacterial phospholipase C.

Monturiol-Gross L, Flores-Díaz M, Araya-Castillo C, Pineda-Padilla MJ, Clark GC, Titball RW, Alape-Girón A.

J Infect Dis. 2012 Oct;206(8):1218-26. Epub 2012 Aug 16.


Unexpected wide substrate specificity of C. perfringens α-toxin phospholipase C.

Urbina P, Collado MI, Alonso A, Goñi FM, Flores-Díaz M, Alape-Girón A, Ruysschaert JM, Lensink MF.

Biochim Biophys Acta. 2011 Oct;1808(10):2618-27. doi: 10.1016/j.bbamem.2011.06.008. Epub 2011 Jun 24.


Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing.

Durban J, Juárez P, Angulo Y, Lomonte B, Flores-Diaz M, Alape-Girón A, Sasa M, Sanz L, Gutiérrez JM, Dopazo J, Conesa A, Calvete JJ.

BMC Genomics. 2011 May 23;12:259. doi: 10.1186/1471-2164-12-259.


Comparison of a nontoxic variant of Clostridium perfringens α-toxin with the toxic wild-type strain.

Vachieri SG, Clark GC, Alape-Girón A, Flores-Díaz M, Justin N, Naylor CE, Titball RW, Basak AK.

Acta Crystallogr D Biol Crystallogr. 2010 Oct;66(Pt 10):1067-74. doi: 10.1107/S090744491003369X. Epub 2010 Sep 18.


Effects of bilayer composition and physical properties on the phospholipase C and sphingomyelinase activities of Clostridium perfringens α-toxin.

Urbina P, Flores-Díaz M, Alape-Girón A, Alonso A, Goñi FM.

Biochim Biophys Acta. 2011 Jan;1808(1):279-86. doi: 10.1016/j.bbamem.2010.08.011. Epub 2010 Aug 17.


Impact of regional variation in Bothrops asper snake venom on the design of antivenoms: integrating antivenomics and neutralization approaches.

Gutiérrez JM, Sanz L, Flores-Díaz M, Figueroa L, Madrigal M, Herrera M, Villalta M, León G, Estrada R, Borges A, Alape-Girón A, Calvete JJ.

J Proteome Res. 2010 Jan;9(1):564-77. doi: 10.1021/pr9009518.


Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.

Calvete JJ, Sanz L, Cid P, de la Torre P, Flores-Díaz M, Dos Santos MC, Borges A, Bremo A, Angulo Y, Lomonte B, Alape-Girón A, Gutiérrez JM.

J Proteome Res. 2010 Jan;9(1):528-44. doi: 10.1021/pr9008749.


The NanI and NanJ sialidases of Clostridium perfringens are not essential for virulence.

Chiarezza M, Lyras D, Pidot SJ, Flores-Díaz M, Awad MM, Kennedy CL, Cordner LM, Phumoonna T, Poon R, Hughes ML, Emmins JJ, Alape-Girón A, Rood JI.

Infect Immun. 2009 Oct;77(10):4421-8. doi: 10.1128/IAI.00548-09. Epub 2009 Aug 3.


Studies on the venom proteome of Bothrops asper: perspectives and applications.

Alape-Girón A, Flores-Díaz M, Sanz L, Madrigal M, Escolano J, Sasa M, Calvete JJ.

Toxicon. 2009 Dec 1;54(7):938-48. doi: 10.1016/j.toxicon.2009.06.011. Epub 2009 Jun 17.


Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing to its taxonomy and snakebite management.

Calvete JJ, Borges A, Segura A, Flores-Díaz M, Alape-Girón A, Gutiérrez JM, Diez N, De Sousa L, Kiriakos D, Sánchez E, Faks JG, Escolano J, Sanz L.

J Proteomics. 2009 Mar 6;72(2):227-40. doi: 10.1016/j.jprot.2009.01.005. Epub 2009 Jan 16.


Phospholipase C and sphingomyelinase activities of the Clostridium perfringens alpha-toxin.

Urbina P, Flores-Díaz M, Alape-Girón A, Alonso A, Goni FM.

Chem Phys Lipids. 2009 May;159(1):51-7. doi: 10.1016/j.chemphyslip.2009.02.007. Epub 2009 Feb 28.


Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.

Gutiérrez JM, Lomonte B, León G, Alape-Girón A, Flores-Díaz M, Sanz L, Angulo Y, Calvete JJ.

J Proteomics. 2009 Mar 6;72(2):165-82. doi: 10.1016/j.jprot.2009.01.008. Epub 2009 Jan 21. Review.


Neutralization of venom-induced hemorrhage by equine antibodies raised by immunization with a plasmid encoding a novel P-II metalloproteinase from the lancehead pitviper Bothrops asper.

Arce-Estrada V, Azofeifa-Cordero G, Estrada R, Alape-Girón A, Flores-Díaz M.

Vaccine. 2009 Jan 14;27(3):460-6. doi: 10.1016/j.vaccine.2008.10.066. Epub 2008 Nov 12.


Immunization with cDNA of a novel P-III type metalloproteinase from the rattlesnake Crotalus durissus durissus elicits antibodies which neutralize 69% of the hemorrhage induced by the whole venom.

Azofeifa-Cordero G, Arce-Estrada V, Flores-Díaz M, Alape-Girón A.

Toxicon. 2008 Aug 1;52(2):302-8. doi: 10.1016/j.toxicon.2008.05.023. Epub 2008 Jun 13.


Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations.

Alape-Girón A, Sanz L, Escolano J, Flores-Díaz M, Madrigal M, Sasa M, Calvete JJ.

J Proteome Res. 2008 Aug;7(8):3556-71. doi: 10.1021/pr800332p. Epub 2008 Jun 17.


Effects of Clostridium perfringens phospholipase C in mammalian cells.

Flores-Díaz M, Thelestam M, Clark GC, Titball RW, Alape-Girón A.

Anaerobe. 2004 Apr;10(2):115-23.


A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.

Flores-Díaz M, Alape-Girón A, Clark G, Catimel B, Hirabayashi Y, Nice E, Gutiérrez JM, Titball R, Thelestam M.

J Biol Chem. 2005 Jul 22;280(29):26680-9. Epub 2005 May 26.


A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements.

Flores-Diaz M, Higuita JC, Florin I, Okada T, Pollesello P, Bergman T, Thelestam M, Mori K, Alape-Giron A.

J Biol Chem. 2004 May 21;279(21):21724-31. Epub 2004 Mar 12.


Role of Clostridium perfringens phospholipase C in the pathogenesis of gas gangrene.

Flores-Díaz M, Alape-Girón A.

Toxicon. 2003 Dec 15;42(8):979-86. Review.


Ocatin. A novel tuber storage protein from the andean tuber crop oca with antibacterial and antifungal activities.

Flores T, Alape-Girón A, Flores-Díaz M, Flores HE.

Plant Physiol. 2002 Apr;128(4):1291-302.


Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity.

Jepson M, Bullifent HL, Crane D, Flores-Diaz M, Alape-Giron A, Jayasekeera P, Lingard B, Moss D, Titball RW.

FEBS Lett. 2001 Apr 27;495(3):172-7.


Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.

Walker N, Holley J, Naylor CE, Flores-Díaz M, Alape-Girón A, Carter G, Carr FJ, Thelestam M, Keyte M, Moss DS, Basak AK, Miller J, Titball RW.

Arch Biochem Biophys. 2000 Dec 1;384(1):24-30.


Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.

Alape-Girón A, Flores-Díaz M, Guillouard I, Naylor CE, Titball RW, Rucavado A, Lomonte B, Basak AK, Gutiérrez JM, Cole ST, Thelestam M.

Eur J Biochem. 2000 Aug;267(16):5191-7.


Elapid venom toxins: multiple recruitments of ancient scaffolds.

Alape-Girón A, Persson B, Cederlund E, Flores-Díaz M, Gutiérrez JM, Thelestam M, Bergman T, Jörnvall H.

Eur J Biochem. 1999 Jan;259(1-2):225-34.


UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C.

Flores-Díaz M, Alape-Girón A, Titball RW, Moos M, Guillouard I, Cole S, Howells AM, von Eichel-Streiber C, Florin I, Thelestam M.

J Biol Chem. 1998 Sep 18;273(38):24433-8.


Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene.

Flores-Díaz M, Alape-Girón A, Persson B, Pollesello P, Moos M, von Eichel-Streiber C, Thelestam M, Florin I.

J Biol Chem. 1997 Sep 19;272(38):23784-91.

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