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Items: 13

1.

SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

Kuduk SD, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2405-2409. doi: 10.1016/j.bmcl.2019.05.029. Epub 2019 May 16.

PMID:
31227344
2.

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.

Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01734-18. doi: 10.1128/AAC.01734-18. Print 2019 Jan.

3.

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Klumpp K, Shimada T, Allweiss L, Volz T, LĆ¼tgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M.

Gastroenterology. 2018 Feb;154(3):652-662.e8. doi: 10.1053/j.gastro.2017.10.017. Epub 2017 Oct 24.

PMID:
29079518
4.

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.

Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00680-17. doi: 10.1128/AAC.00680-17. Print 2017 Aug.

5.

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.

6.

Eplerenone decreases inflammatory foci in spontaneously hypertensive rat hearts with minimal effects on blood pressure.

Brandish PE, Forest TW, Chen H, Gatto NT, Molon-Noblot S, Zwierzynski I, Szczerba P, Adamson GE, Ma BK, Flores OA, Hershey JC.

J Cardiovasc Pharmacol. 2009 Jan;53(1):44-51. doi: 10.1097/FJC.0b013e3181953e65.

PMID:
19129737
7.

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.

Ludmerer SW, Graham DJ, Boots E, Murray EM, Simcoe A, Markel EJ, Grobler JA, Flores OA, Olsen DB, Hazuda DJ, LaFemina RL.

Antimicrob Agents Chemother. 2005 May;49(5):2059-69.

8.

A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication.

Zuck P, Murray EM, Stec E, Grobler JA, Simon AJ, Strulovici B, Inglese J, Flores OA, Ferrer M.

Anal Biochem. 2004 Nov 15;334(2):344-55.

PMID:
15494142
9.

Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.

Eldrup AB, Prhavc M, Brooks J, Bhat B, Prakash TP, Song Q, Bera S, Bhat N, Dande P, Cook PD, Bennett CF, Carroll SS, Ball RG, Bosserman M, Burlein C, Colwell LF, Fay JF, Flores OA, Getty K, LaFemina RL, Leone J, MacCoss M, McMasters DR, Tomassini JE, Von Langen D, Wolanski B, Olsen DB.

J Med Chem. 2004 Oct 7;47(21):5284-97.

PMID:
15456273
10.

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.

Olsen DB, Eldrup AB, Bartholomew L, Bhat B, Bosserman MR, Ceccacci A, Colwell LF, Fay JF, Flores OA, Getty KL, Grobler JA, LaFemina RL, Markel EJ, Migliaccio G, Prhavc M, Stahlhut MW, Tomassini JE, MacCoss M, Hazuda DJ, Carroll SS.

Antimicrob Agents Chemother. 2004 Oct;48(10):3944-53.

11.

Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro.

Migliaccio G, Tomassini JE, Carroll SS, Tomei L, Altamura S, Bhat B, Bartholomew L, Bosserman MR, Ceccacci A, Colwell LF, Cortese R, De Francesco R, Eldrup AB, Getty KL, Hou XS, LaFemina RL, Ludmerer SW, MacCoss M, McMasters DR, Stahlhut MW, Olsen DB, Hazuda DJ, Flores OA.

J Biol Chem. 2003 Dec 5;278(49):49164-70. Epub 2003 Sep 8.

12.

Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.

Grobler JA, Markel EJ, Fay JF, Graham DJ, Simcoe AL, Ludmerer SW, Murray EM, Migliaccio G, Flores OA.

J Biol Chem. 2003 May 9;278(19):16741-6. Epub 2003 Feb 28.

13.

Persistent replication of hepatitis C virus replicons expressing the beta-lactamase reporter in subpopulations of highly permissive Huh7 cells.

Murray EM, Grobler JA, Markel EJ, Pagnoni MF, Paonessa G, Simon AJ, Flores OA.

J Virol. 2003 Mar;77(5):2928-35.

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