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Nucleosome Dynamics: a new tool for the dynamic analysis of nucleosome positioning.

Buitrago D, Codó L, Illa R, de Jorge P, Battistini F, Flores O, Bayarri G, Royo R, Del Pino M, Heath S, Hospital A, Gelpí JL, Heath IB, Orozco M.

Nucleic Acids Res. 2019 Oct 10;47(18):9511-9523. doi: 10.1093/nar/gkz759.


Epitope Mapping by NMR of a Novel Anti-Aβ Antibody (STAB-MAb).

Posado-Fernández A, Afonso CF, Dória G, Flores O, Cabrita EJ.

Sci Rep. 2019 Aug 22;9(1):12241. doi: 10.1038/s41598-019-47626-2.


SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators.

Kuduk SD, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2405-2409. doi: 10.1016/j.bmcl.2019.05.029. Epub 2019 May 16.


Rapid Synthesis and Antiproliferative Properties of Polyazamacrocycle-Based Bi- and Tetra-Gold(I) Phosphine Dithiocarbamate Complexes.

Florès O, Velic D, Mabrouk N, Bettaïeb A, Tomasoni C, Robert JM, Paul C, Goze C, Roussakis C, Bodio E.

Chembiochem. 2019 Sep 2;20(17):2255-2261. doi: 10.1002/cbic.201900227. Epub 2019 Jul 19.


A multifactorial approach of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables affecting the scholastic achievement in Chilean students: An eight- year follow-up study.

Ivanovic DM, Almagià AF, Arancibia VC, Ibaceta CV, Arias VF, Rojas TR, Flores OC, Villagrán FS, Tapia LU, Acevedo JA, Morales GI, Martínez VC, Larraín CG, Silva CFA, Valenzuela RB, Barrera CR, Billeke PB, Zamorano FM, Orellana YZ.

PLoS One. 2019 Feb 20;14(2):e0212279. doi: 10.1371/journal.pone.0212279. eCollection 2019.


Great Genetic Diversity but High Selfing Rates and Short-Distance Gene Flow Characterize Populations of a Tree (Foetidia; Lecythidaceae) in the Fragmented Tropical Dry Forest of the Mascarene Islands.

Cuénin N, Flores O, Rivière E, Lebreton G, Reynaud B, Martos F.

J Hered. 2019 May 7;110(3):287-299. doi: 10.1093/jhered/esy069.


Early postnatal environmental enrichment restores neurochemical and functional plasticities of the cerebral cortex and improves learning performance in hidden-prenatally-malnourished young-adult rats.

Burgos H, Hernández A, Constandil L, Ríos M, Flores O, Puentes G, Hernández K, Morgan C, Valladares L, Castillo A, Cofre C, Milla LA, Sáez-Briones P, Barra R.

Behav Brain Res. 2019 May 2;363:182-190. doi: 10.1016/j.bbr.2019.02.001. Epub 2019 Feb 2.


Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

Yuen MF, Gane EJ, Kim DJ, Weilert F, Yuen Chan HL, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N.

Gastroenterology. 2019 Apr;156(5):1392-1403.e7. doi: 10.1053/j.gastro.2018.12.023. Epub 2019 Jan 6.


Randomized Controlled Trial of a Leucine-Metformin-Sildenafil Combination (NS-0200) on Weight and Metabolic Parameters.

Zemel MB, Kolterman O, Rinella M, Vuppalanchi R, Flores O, Barritt AS 4th, Siddiqui M, Chalasani N.

Obesity (Silver Spring). 2019 Jan;27(1):59-67. doi: 10.1002/oby.22346.


Spatial patterns of species richness and nestedness in ant assemblages along an elevational gradient in a Mediterranean mountain range.

Flores O, Seoane J, Hevia V, Azcárate FM.

PLoS One. 2018 Dec 19;13(12):e0204787. doi: 10.1371/journal.pone.0204787. eCollection 2018.


Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice.

Gabbouj S, Natunen T, Koivisto H, Jokivarsi K, Takalo M, Marttinen M, Wittrahm R, Kemppainen S, Naderi R, Posado-Fernández A, Ryhänen S, Mäkinen P, Paldanius KMA, Doria G, Poutiainen P, Flores O, Haapasalo A, Tanila H, Hiltunen M.

Neurobiol Aging. 2019 Mar;75:98-108. doi: 10.1016/j.neurobiolaging.2018.11.008. Epub 2018 Nov 17.


Macroalgae as a tool for assessing the ecological status of coral reefs under the Water Framework Directive: A case study on the reef flats of La Réunion (Indian Ocean).

Zubia M, Depetris M, Flores O, Turquet J, Cuet P.

Mar Pollut Bull. 2018 Dec;137:339-351. doi: 10.1016/j.marpolbul.2018.10.029. Epub 2018 Oct 20.


Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.

Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01734-18. doi: 10.1128/AAC.01734-18. Print 2019 Jan.


Overnutrition and Scholastic Achievement: Is There a Relationship? An 8-Year Follow-Up Study.

Flores OC, Orellana YZ, Leyton BD, Valenzuela RB, Barrera CR, Almagià AF, Martínez VC, Ivanovic D.

Obes Facts. 2018;11(5):344-359. doi: 10.1159/000492004. Epub 2018 Oct 12.


Genetic and Phenotypic Characterization of Indole-Producing Isolates of Pseudomonas syringae pv. actinidiae Obtained From Chilean Kiwifruit Orchards.

Flores O, Prince C, Nuñez M, Vallejos A, Mardones C, Yañez C, Besoain X, Bastías R.

Front Microbiol. 2018 Aug 22;9:1907. doi: 10.3389/fmicb.2018.01907. eCollection 2018.


Formation of a protein corona influences the biological identity of nanomaterials.

Nierenberg D, Khaled AR, Flores O.

Rep Pract Oncol Radiother. 2018 Jul-Aug;23(4):300-308. doi: 10.1016/j.rpor.2018.05.005. Epub 2018 May 28.


Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis.

Wildman-Tobriner B, Middleton MM, Moylan CA, Rossi S, Flores O, Chang ZA, Abdelmalek MF, Sirlin CB, Bashir MR.

Gastroenterology. 2018 Nov;155(5):1428-1435.e2. doi: 10.1053/j.gastro.2018.07.018. Epub 2018 Jul 19.


Randomised clinical trial: a leucine-metformin-sildenafil combination (NS-0200) vs placebo in patients with non-alcoholic fatty liver disease.

Chalasani N, Vuppalanchi R, Rinella M, Middleton MS, Siddiqui MS, Barritt AS 4th, Kolterman O, Flores O, Alonso C, Iruarrizaga-Lejarreta M, Gil-Redondo R, Sirlin CB, Zemel MB.

Aliment Pharmacol Ther. 2018 Jun;47(12):1639-1651. doi: 10.1111/apt.14674. Epub 2018 Apr 25.


Kinematics and dynamics of the auto-rotation of a model winged seed.

Arranz G, Moriche M, Uhlmann M, Flores O, García-Villalba M.

Bioinspir Biomim. 2018 Apr 18;13(3):036011. doi: 10.1088/1748-3190/aab144.


Exercise training for improving outcomes post-burns: a systematic review and meta-analysis.

Flores O, Tyack Z, Stockton K, Ware R, Paratz JD.

Clin Rehabil. 2018 Jun;32(6):734-746. doi: 10.1177/0269215517751586. Epub 2018 Jan 10.


Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer.

Carr AC, Khaled AS, Bassiouni R, Flores O, Nierenberg D, Bhatti H, Vishnubhotla P, Manuel JP, Santra S, Khaled AR.

Oncotarget. 2017 Nov 25;8(66):110273-110288. doi: 10.18632/oncotarget.22681. eCollection 2017 Dec 15.


Antibody-functionalized polymer nanoparticle leading to memory recovery in Alzheimer's disease-like transgenic mouse model.

Carradori D, Balducci C, Re F, Brambilla D, Le Droumaguet B, Flores O, Gaudin A, Mura S, Forloni G, Ordoñez-Gutierrez L, Wandosell F, Masserini M, Couvreur P, Nicolas J, Andrieux K.

Nanomedicine. 2018 Feb;14(2):609-618. doi: 10.1016/j.nano.2017.12.006. Epub 2017 Dec 15.


Allele specific LAMP- gold nanoparticle for characterization of single nucleotide polymorphisms.

Carlos FF, Veigas B, Matias AS, Doria G, Flores O, Baptista PV.

Biotechnol Rep (Amst). 2017 Oct 27;16:21-25. doi: 10.1016/j.btre.2017.10.003. eCollection 2017 Dec.


Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M.

Gastroenterology. 2018 Feb;154(3):652-662.e8. doi: 10.1053/j.gastro.2017.10.017. Epub 2017 Oct 24.


PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer.

Flores O, Santra S, Kaittanis C, Bassiouni R, Khaled AS, Khaled AR, Grimm J, Perez JM.

Theranostics. 2017 Jun 24;7(9):2477-2494. doi: 10.7150/thno.18879. eCollection 2017.


In vitro and in vivo trackable titanocene-based complexes using optical imaging or SPECT.

Florès O, Trommenschlager A, Amor S, Marques F, Silva F, Gano L, Denat F, Cabral Campello MP, Goze C, Bodio E, Le Gendre P.

Dalton Trans. 2017 Oct 31;46(42):14548-14555. doi: 10.1039/c7dt01981e.


Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.

Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00680-17. doi: 10.1128/AAC.00680-17. Print 2017 Aug.


ImmunoPEGliposome-mediated reduction of blood and brain amyloid levels in a mouse model of Alzheimer's disease is restricted to aged animals.

Ordóñez-Gutiérrez L, Posado-Fernández A, Ahmadvand D, Lettiero B, Wu L, Antón M, Flores O, Moghimi SM, Wandosell F.

Biomaterials. 2017 Jan;112:141-152. doi: 10.1016/j.biomaterials.2016.07.027. Epub 2016 Aug 2.


Development and evaluation of an enhanced diabetes prevention program with psychosocial support for urban American Indians and Alaska natives: A randomized controlled trial.

Rosas LG, Vasquez JJ, Naderi R, Jeffery N, Hedlin H, Qin F, LaFromboise T, Megginson N, Pasqua C, Flores O, McClinton-Brown R, Evans J, Stafford RS.

Contemp Clin Trials. 2016 Sep;50:28-36. doi: 10.1016/j.cct.2016.06.015. Epub 2016 Jul 2.


A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice.

Chisamore MJ, Gentile MA, Dillon GM, Baran M, Gambone C, Riley S, Schmidt A, Flores O, Wilkinson H, Alves SE.

J Steroid Biochem Mol Biol. 2016 Oct;163:88-97. doi: 10.1016/j.jsbmb.2016.04.007. Epub 2016 Apr 19.


An eco-epidemiological study of Morbilli-related paramyxovirus infection in Madagascar bats reveals host-switching as the dominant macro-evolutionary mechanism.

Mélade J, Wieseke N, Ramasindrazana B, Flores O, Lagadec E, Gomard Y, Goodman SM, Dellagi K, Pascalis H.

Sci Rep. 2016 Apr 12;6:23752. doi: 10.1038/srep23752.


Chaperonin Containing TCP-1 Protein Level in Breast Cancer Cells Predicts Therapeutic Application of a Cytotoxic Peptide.

Bassiouni R, Nemec KN, Iketani A, Flores O, Showalter A, Khaled AS, Vishnubhotla P, Sprung RW Jr, Kaittanis C, Perez JM, Khaled AR.

Clin Cancer Res. 2016 Sep 1;22(17):4366-79. doi: 10.1158/1078-0432.CCR-15-2502. Epub 2016 Mar 24.


Nucleosome architecture throughout the cell cycle.

Deniz Ö, Flores O, Aldea M, Soler-López M, Orozco M.

Sci Rep. 2016 Jan 28;6:19729. doi: 10.1038/srep19729.


[Therapeutic attitude of tutors and fourth year residents of Family and Community Medicine from Girona towards peri-articular infiltration].

Flores O, Seminario SS, Contreras E, Pérez P.

Aten Primaria. 2016 Jun-Jul;48(6):421-2. doi: 10.1016/j.aprim.2015.09.007. Epub 2016 Jan 23. Spanish. No abstract available.


High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.


The efficacy and safety of adrenergic blockade after burn injury: A systematic review and meta-analysis.

Flores O, Stockton K, Roberts JA, Muller MJ, Paratz JD.

J Trauma Acute Care Surg. 2016 Jan;80(1):146-55. doi: 10.1097/TA.0000000000000887. Review.


Calpain-like: A Ca(2+) dependent cystein protease in Entamoeba histolytica cell death.

Monroy VS, Flores OM, García CG, Maya YC, Fernández TD, Pérez Ishiwara DG.

Exp Parasitol. 2015 Dec;159:245-51. doi: 10.1016/j.exppara.2015.10.005. Epub 2015 Oct 22.


Comparison of Various Types of Ligand Decorated Nanoliposomes for their Ability to Inhibit Amyloid Aggregation and to Reverse Amyloid Cytotoxicity.

Markoutsa E, Mourtas S, Bereczki E, Zona C, La Ferla B, Nicotra F, Flores O, Pei JJ, Antimisiaris SG.

Curr Top Med Chem. 2015;15(22):2267-76.


Glycinamide prevents MK-801-induced hyperactivity and deficits in object recognition memory in an animal model of positive and cognitive symptoms of schizophrenia.

Basurto E, Flores OG, Hoffman KL.

Schizophr Res. 2015 Aug;166(1-3):349-50. doi: 10.1016/j.schres.2015.02.024. Epub 2015 Mar 29. No abstract available.


A functional characterisation of a wide range of cover crop species: growth and nitrogen acquisition rates, leaf traits and ecological strategies.

Tribouillois H, Fort F, Cruz P, Charles R, Flores O, Garnier E, Justes E.

PLoS One. 2015 Mar 19;10(3):e0122156. doi: 10.1371/journal.pone.0122156. eCollection 2015.


Wolbachia-based population control strategy targeting Culex quinquefasciatus mosquitoes proves efficient under semi-field conditions.

Atyame CM, Cattel J, Lebon C, Flores O, Dehecq JS, Weill M, Gouagna LC, Tortosa P.

PLoS One. 2015 Mar 13;10(3):e0119288. doi: 10.1371/journal.pone.0119288. eCollection 2015.


Characterization of virus-like particles and identification of capsid proteins in Xanthophyllomyces dendrorhous.

Flores O, Alcaíno J, Fernandez-Lobato M, Cifuentes V, Baeza M.

Virus Genes. 2015 Apr;50(2):253-9. doi: 10.1007/s11262-015-1171-3. Epub 2015 Feb 8.


Functional traits help predict post-disturbance demography of tropical trees.

Flores O, Hérault B, Delcamp M, Garnier É, Gourlet-Fleury S.

PLoS One. 2014 Sep 16;9(9):e105022. doi: 10.1371/journal.pone.0105022. eCollection 2014.


An evolutionary perspective on leaf economics: phylogenetics of leaf mass per area in vascular plants.

Flores O, Garnier E, Wright IJ, Reich PB, Pierce S, Dìaz S, Pakeman RJ, Rusch GM, Bernard-Verdier M, Testi B, Bakker JP, Bekker RM, Cerabolini BE, Ceriani RM, Cornu G, Cruz P, Delcamp M, Dolezal J, Eriksson O, Fayolle A, Freitas H, Golodets C, Gourlet-Fleury S, Hodgson JG, Brusa G, Kleyer M, Kunzmann D, Lavorel S, Papanastasis VP, Pérez-Harguindeguy N, Vendramini F, Weiher E.

Ecol Evol. 2014 Jul;4(14):2799-811. doi: 10.1002/ece3.1087. Epub 2014 Jul 1.


Localized surface plasmon resonance (LSPR) biosensing using gold nanotriangles: detection of DNA hybridization events at room temperature.

Soares L, Csáki A, Jatschka J, Fritzsche W, Flores O, Franco R, Pereira E.

Analyst. 2014 Oct 7;139(19):4964-73. doi: 10.1039/c4an00810c.


Characterization of genomic single nucleotide polymorphism via colorimetric detection using a single gold nanoprobe.

Carlos FF, Flores O, Doria G, Baptista PV.

Anal Biochem. 2014 Nov 15;465:1-5. doi: 10.1016/j.ab.2014.07.019. Epub 2014 Jul 29.


Genome sequence of the model sulfate reducer Desulfovibrio gigas: a comparative analysis within the Desulfovibrio genus.

Morais-Silva FO, Rezende AM, Pimentel C, Santos CI, Clemente C, Varela-Raposo A, Resende DM, da Silva SM, de Oliveira LM, Matos M, Costa DA, Flores O, Ruiz JC, Rodrigues-Pousada C.

Microbiologyopen. 2014 Aug;3(4):513-30. doi: 10.1002/mbo3.184. Epub 2014 Jul 23.


Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs.

Bogerd HP, Skalsky RL, Kennedy EM, Furuse Y, Whisnant AW, Flores O, Schultz KL, Putnam N, Barrows NJ, Sherry B, Scholle F, Garcia-Blanco MA, Griffin DE, Cullen BR.

J Virol. 2014 Jul;88(14):8065-76. doi: 10.1128/JVI.00985-14. Epub 2014 May 7.


Wood production response to climate change will depend critically on forest composition and structure.

Coomes DA, Flores O, Holdaway R, Jucker T, Lines ER, Vanderwel MC.

Glob Chang Biol. 2014 Dec;20(12):3632-45. doi: 10.1111/gcb.12622. Epub 2014 Jun 4.


Derivation and characterization of Dicer- and microRNA-deficient human cells.

Bogerd HP, Whisnant AW, Kennedy EM, Flores O, Cullen BR.

RNA. 2014 Jun;20(6):923-37. doi: 10.1261/rna.044545.114. Epub 2014 Apr 22.

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