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Items: 1 to 50 of 75

1.

Beware of thy neighbor: Senescent cancer cells feast on adjacent cells to persist.

Napoli M, Flores ER.

J Cell Biol. 2019 Oct 18. pii: jcb.201910040. doi: 10.1083/jcb.201910040. [Epub ahead of print]

PMID:
31628158
2.

AMPK Alpha-1 Intrinsically Regulates the Function and Differentiation of Tumor Myeloid-Derived Suppressor Cells.

Trillo-Tinoco J, Sierra RA, Mohamed E, Cao Y, de Mingo-Pulido Á, Gilvary DL, Anadon CM, Costich TL, Wei S, Flores ER, Ruffell B, Conejo-Garcia JR, Rodriguez PC.

Cancer Res. 2019 Oct 1;79(19):5034-5047. doi: 10.1158/0008-5472.CAN-19-0880. Epub 2019 Aug 13.

PMID:
31409640
3.

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

Gunaratne PH, Pan Y, Rao AK, Lin C, Hernandez-Herrera A, Liang K, Rait AS, Venkatanarayan A, Benham AL, Rubab F, Kim SS, Rajapakshe K, Chan CK, Mangala LS, Lopez-Berestein G, Sood AK, Rowat AC, Coarfa C, Pirollo KF, Flores ER, Chang EH.

Cancer. 2019 Jul 15;125(14):2409-2422. doi: 10.1002/cncr.32053. Epub 2019 Apr 23.

4.

Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.

Jinesh GG, Flores ER, Brohl AS.

PLoS One. 2018 Oct 18;13(10):e0206008. doi: 10.1371/journal.pone.0206008. eCollection 2018.

5.

miR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential During Mammary Reconstitution.

Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JM.

Stem Cells. 2018 Dec;36(12):1875-1889. doi: 10.1002/stem.2914. Epub 2018 Oct 31.

6.

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.

Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG.

Mol Cell. 2018 Jun 7;70(5):825-841.e6. doi: 10.1016/j.molcel.2018.04.028. Epub 2018 May 31.

7.

HP1γ Promotes Lung Adenocarcinoma by Downregulating the Transcription-Repressive Regulators NCOR2 and ZBTB7A.

Alam H, Li N, Dhar SS, Wu SJ, Lv J, Chen K, Flores ER, Baseler L, Lee MG.

Cancer Res. 2018 Jul 15;78(14):3834-3848. doi: 10.1158/0008-5472.CAN-17-3571. Epub 2018 May 15.

8.

p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells.

Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK.

J Thorac Cardiovasc Surg. 2018 Aug;156(2):556-565.e1. doi: 10.1016/j.jtcvs.2018.03.162. Epub 2018 Apr 13.

9.

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis.

Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A Jr, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y.

Nat Commun. 2018 Apr 18;9(1):1544. doi: 10.1038/s41467-018-03796-7.

10.

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, Gevaert O, Prunello M, Shen H, Anur P, Chen J, Cheng H, Hayes DN, Bullman S, Pedamallu CS, Ojesina AI, Sadeghi S, Mungall KL, Robertson AG, Benz C, Schultz A, Kanchi RS, Gay CM, Hegde A, Diao L, Wang J, Ma W, Sumazin P, Chiu HS, Chen TW, Gunaratne P, Donehower L, Rader JS, Zuna R, Al-Ahmadie H, Lazar AJ, Flores ER, Tsai KY, Zhou JH, Rustgi AK, Drill E, Shen R, Wong CK; Cancer Genome Atlas Research Network, Stuart JM, Laird PW, Hoadley KA, Weinstein JN, Peto M, Pickering CR, Chen Z, Van Waes C.

Cell Rep. 2018 Apr 3;23(1):194-212.e6. doi: 10.1016/j.celrep.2018.03.063.

11.

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.

Abbas HA, Bui NHB, Rajapakshe K, Wong J, Gunaratne P, Tsai KY, Coarfa C, Flores ER.

Cancer Res. 2018 Jan 15;78(2):451-462. doi: 10.1158/0008-5472.CAN-17-1803. Epub 2017 Nov 27.

12.

A chemical compound based on methylxanthine-polyphenols lowers nitric oxide levels and increases post-thaw human sperm viability.

Werner C, Cadoná FC, da Cruz IBM, Flôres ERDS, Machado AK, Fantinel MR, Weis GCC, Assmann CE, Alves AO, Bonadiman BDSR, Ribeiro EE, Montano MAE.

Zygote. 2017 Dec;25(6):719-730. doi: 10.1017/S0967199417000600. Epub 2017 Nov 28.

PMID:
29179786
13.

JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.

Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C.

J Clin Invest. 2017 Dec 1;127(12):4498-4515. doi: 10.1172/JCI91553. Epub 2017 Nov 13.

14.

Another case for diet restriction: TAp73-expressing medulloblastomas are stunted by glutamine withdrawal.

Napoli M, Flores ER.

Genes Dev. 2017 Sep 1;31(17):1715-1716. doi: 10.1101/gad.306837.117.

15.

p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming.

Martin-Lopez M, Maeso-Alonso L, Fuertes-Alvarez S, Balboa D, Rodríguez-Cortez V, Weltner J, Diez-Prieto I, Davis A, Wu Y, Otonkoski T, Flores ER, Menéndez P, Marques MM, Marin MC.

Cell Death Dis. 2017 Sep 7;8(9):e3034. doi: 10.1038/cddis.2017.432.

16.

Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism.

Liao W, Liu H, Zhang Y, Jung JH, Chen J, Su X, Kim YC, Flores ER, Wang SM, Czarny-Ratajczak M, Li W, Zeng SX, Lu H.

Sci Rep. 2017 Aug 21;7(1):9020. doi: 10.1038/s41598-017-09228-8.

17.

N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration.

Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Gafà R, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Melo SA, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA.

Genome Biol. 2017 May 24;18(1):98. doi: 10.1186/s13059-017-1224-0.

18.

Pastoralism in the drylands of Latin America: Argentina, Chile, Mexico and Peru.

Grünwaldt JM, Castellaro G, Flores ER, Morales-Nieto CR, Valdez-Cepeda RD, Guevera JC, Grünwaldt EG.

Rev Sci Tech. 2016 Nov;35(2):543-560. doi: 10.20506/rst.35.2.2526. Review. English, Spanish.

PMID:
27917972
19.

Commentary on "Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents".

Flores ER.

Cancer Res. 2016 Dec 1;76(23):6763-6764. No abstract available.

20.

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy.

Napoli M, Flores ER.

Br J Cancer. 2017 Jan 17;116(2):149-155. doi: 10.1038/bjc.2016.384. Epub 2016 Nov 24. Review.

21.

TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway.

Su X, Napoli M, Abbas HA, Venkatanarayan A, Bui NHB, Coarfa C, Gi YJ, Kittrell F, Gunaratne PH, Medina D, Rosen JM, Behbod F, Flores ER.

Oncogene. 2017 Apr 27;36(17):2377-2393. doi: 10.1038/onc.2016.388. Epub 2016 Nov 21.

22.

Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.

Matre P, Velez J, Jacamo R, Qi Y, Su X, Cai T, Chan SM, Lodi A, Sweeney SR, Ma H, Davis RE, Baran N, Haferlach T, Su X, Flores ER, Gonzalez D, Konoplev S, Samudio I, DiNardo C, Majeti R, Schimmer AD, Li W, Wang T, Tiziani S, Konopleva M.

Oncotarget. 2016 Nov 29;7(48):79722-79735. doi: 10.18632/oncotarget.12944.

23.

Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates.

Chitsazzadeh V, Coarfa C, Drummond JA, Nguyen T, Joseph A, Chilukuri S, Charpiot E, Adelmann CH, Ching G, Nguyen TN, Nicholas C, Thomas VD, Migden M, MacFarlane D, Thompson E, Shen J, Takata Y, McNiece K, Polansky MA, Abbas HA, Rajapakshe K, Gower A, Spira A, Covington KR, Xiao W, Gunaratne P, Pickering C, Frederick M, Myers JN, Shen L, Yao H, Su X, Rapini RP, Wheeler DA, Hawk ET, Flores ER, Tsai KY.

Nat Commun. 2016 Aug 30;7:12601. doi: 10.1038/ncomms12601.

24.

ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer.

Napoli M, Venkatanarayan A, Raulji P, Meyers BA, Norton W, Mangala LS, Sood AK, Rodriguez-Aguayo C, Lopez-Berestein G, Vin H, Duvic M, Tetzlaff MB, Curry JL, Rook AH, Abbas HA, Coarfa C, Gunaratne PH, Tsai KY, Flores ER.

Cancer Cell. 2016 Jun 13;29(6):874-888. doi: 10.1016/j.ccell.2016.04.016.

25.

Unifying the p73 knockout phenotypes: TAp73 orchestrates multiciliogenesis.

Napoli M, Flores ER.

Genes Dev. 2016 Jun 1;30(11):1253-4. doi: 10.1101/gad.283663.116.

26.

MEK Is a Therapeutic and Chemopreventative Target in Squamous Cell Carcinoma.

Adelmann CH, Truong KA, Liang RJ, Bansal V, Gandee L, Saporito RC, Lee W, Du L, Nicholas C, Napoli M, Mino B, South AP, Proby CM, Leigh IM, Coarfa C, Flores ER, Tsai KY.

J Invest Dermatol. 2016 Sep;136(9):1920-1924. doi: 10.1016/j.jid.2016.05.110. Epub 2016 Jun 9. No abstract available.

27.

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation.

Wang Y, Wang X, Flores ER, Yu J, Chang S.

Aging Cell. 2016 Aug;15(4):646-60. doi: 10.1111/acel.12476. Epub 2016 Apr 26.

28.

Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.

Venkatanarayan A, Raulji P, Norton W, Flores ER.

Cell Cycle. 2016;15(2):164-71. doi: 10.1080/15384101.2015.1121333.

29.

Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila.

Wu Y, Lindblad JL, Garnett J, Kamber Kaya HE, Xu D, Zhao Y, Flores ER, Hardy J, Bergmann A.

Cell Death Differ. 2016 Apr;23(4):723-32. doi: 10.1038/cdd.2015.144. Epub 2015 Nov 6.

30.

Persistent Nociception Triggered by Nerve Growth Factor (NGF) Is Mediated by TRPV1 and Oxidative Mechanisms.

Eskander MA, Ruparel S, Green DP, Chen PB, Por ED, Jeske NA, Gao X, Flores ER, Hargreaves KM.

J Neurosci. 2015 Jun 3;35(22):8593-603. doi: 10.1523/JNEUROSCI.3993-14.2015.

31.

Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.

Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J.

Neuro Oncol. 2015 Nov;17(11):1463-73. doi: 10.1093/neuonc/nov041. Epub 2015 Mar 19.

32.

Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Børresen-Dale AL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB.

Cancer Cell. 2014 Dec 8;26(6):863-879. doi: 10.1016/j.ccell.2014.10.010.

33.

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.

Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, Sandur SK, Ramirez MS, Lee J, Kingsley CV, Sananikone EF, Rajapakshe K, Naff K, Parker-Thornburg J, Bankson JA, Tsai KY, Gunaratne PH, Flores ER.

Nature. 2015 Jan 29;517(7536):626-30. doi: 10.1038/nature13910. Epub 2014 Nov 17.

34.

Impact of cell arrangement of pleural effusion in survival of patients with breast cancer.

Camillo ND, Dos Santos GT, Prolla JC, Flôres ER, Introíni GO, Brackmann RL, da Cruz IB, Bica CG.

Acta Cytol. 2014;58(5):446-52. doi: 10.1159/000367919. Epub 2014 Nov 5.

PMID:
25377597
35.

p53/p63/p73 in the epidermis in health and disease.

Botchkarev VA, Flores ER.

Cold Spring Harb Perspect Med. 2014 Aug 1;4(8). pii: a015248. doi: 10.1101/cshperspect.a015248. Review.

36.

Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.

Chakravarti D, Su X, Cho MS, Bui NH, Coarfa C, Venkatanarayan A, Benham AL, Flores González RE, Alana J, Xiao W, Leung ML, Vin H, Chan IL, Aquino A, Müller N, Wang H, Cooney AJ, Parker-Thornburg J, Tsai KY, Gunaratne PH, Flores ER.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E572-81. doi: 10.1073/pnas.1319743111. Epub 2014 Jan 21.

37.

BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.

Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY.

Elife. 2013 Nov 5;2:e00969. doi: 10.7554/eLife.00969.

38.

p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.

Cancino GI, Yiu AP, Fatt MP, Dugani CB, Flores ER, Frankland PW, Josselyn SA, Miller FD, Kaplan DR.

J Neurosci. 2013 Jul 31;33(31):12569-85. doi: 10.1523/JNEUROSCI.1251-13.2013.

39.

Functions of TAp63 and p53 in restraining the development of metastatic cancer.

Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, Muller PA.

Oncogene. 2014 Jun 19;33(25):3325-33. doi: 10.1038/onc.2013.287. Epub 2013 Jul 22.

40.

Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress.

Eno CO, Zhao G, Venkatanarayan A, Wang B, Flores ER, Li C.

Free Radic Biol Med. 2013 Dec;65:26-37. doi: 10.1016/j.freeradbiomed.2013.05.051. Epub 2013 Jun 14.

41.

Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis.

Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ.

Cell Death Differ. 2013 Aug;20(8):1080-8. doi: 10.1038/cdd.2013.41. Epub 2013 May 17.

42.

The family that eats together stays together: new p53 family transcriptional targets in autophagy.

Napoli M, Flores ER.

Genes Dev. 2013 May 1;27(9):971-4. doi: 10.1101/gad.219147.113.

43.

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness.

Terrinoni A, Serra V, Bruno E, Strasser A, Valente E, Flores ER, van Bokhoven H, Lu X, Knight RA, Melino G.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7300-5. doi: 10.1073/pnas.1214498110. Epub 2013 Apr 15. Erratum in: Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2854.

44.

IκB kinase β (IKKβ) inhibits p63 isoform γ (TAp63γ) transcriptional activity.

Liao JM, Zhang Y, Liao W, Zeng SX, Su X, Flores ER, Lu H.

J Biol Chem. 2013 Jun 21;288(25):18184-93. doi: 10.1074/jbc.M113.466540. Epub 2013 Apr 15.

45.

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.

Su X, Chakravarti D, Flores ER.

Nat Rev Cancer. 2013 Feb;13(2):136-43. doi: 10.1038/nrc3446. Review.

46.

The p63 protein isoform ΔNp63α inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205.

Tran MN, Choi W, Wszolek MF, Navai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker-Radtke A, Czerniak B, Dinney C, Barton M, McConkey DJ.

J Biol Chem. 2013 Feb 1;288(5):3275-88. doi: 10.1074/jbc.M112.408104. Epub 2012 Dec 13.

47.

TAp63 is a master transcriptional regulator of lipid and glucose metabolism.

Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER.

Cell Metab. 2012 Oct 3;16(4):511-25. doi: 10.1016/j.cmet.2012.09.006.

48.

The p53 family grows old.

Flores ER, Lozano G.

Genes Dev. 2012 Sep 15;26(18):1997-2000. doi: 10.1101/gad.202648.112.

49.

Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.

Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR.

Cell Stem Cell. 2012 Aug 3;11(2):179-94. doi: 10.1016/j.stem.2012.05.020.

50.

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.

Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM.

J Clin Invest. 2012 Sep;122(9):3170-83. doi: 10.1172/JCI63608. Epub 2012 Aug 1.

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