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Items: 36

1.

Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain.

Ferré G, Louet M, Saurel O, Delort B, Czaplicki G, M'Kadmi C, Damian M, Renault P, Cantel S, Gavara L, Demange P, Marie J, Fehrentz JA, Floquet N, Milon A, Banères JL.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17525-17530. doi: 10.1073/pnas.1905105116. Epub 2019 Aug 15.

PMID:
31416915
2.

Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2A Receptor by a Mini-G Protein.

Renault P, Louet M, Marie J, Labesse G, Floquet N.

Sci Rep. 2019 Apr 2;9(1):5495. doi: 10.1038/s41598-019-41980-x.

3.

GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation.

Damian M, Pons V, Renault P, M'Kadmi C, Delort B, Hartmann L, Kaya AI, Louet M, Gagne D, Ben Haj Salah K, Denoyelle S, Ferry G, Boutin JA, Wagner R, Fehrentz JA, Martinez J, Marie J, Floquet N, Galès C, Mary S, Hamm HE, Banères JL.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4501-4506. doi: 10.1073/pnas.1712725115. Epub 2018 Apr 9.

4.

Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues.

Fanelli R, Floquet N, Besserer-Offroy É, Delort B, Vivancos M, Longpré JM, Renault P, Martinez J, Sarret P, Cavelier F.

J Med Chem. 2017 Apr 27;60(8):3303-3313. doi: 10.1021/acs.jmedchem.6b01848. Epub 2017 Apr 10.

PMID:
28368584
5.

Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors.

Delort B, Renault P, Charlier L, Raussin F, Martinez J, Floquet N.

J Chem Inf Model. 2017 Mar 27;57(3):562-571. doi: 10.1021/acs.jcim.6b00503. Epub 2017 Mar 7.

PMID:
28230370
6.

Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein.

Mercredi PY, Bucca N, Loeliger B, Gaines CR, Mehta M, Bhargava P, Tedbury PR, Charlier L, Floquet N, Muriaux D, Favard C, Sanders CR, Freed EO, Marchant J, Summers MF.

J Mol Biol. 2016 Apr 24;428(8):1637-55. doi: 10.1016/j.jmb.2016.03.005. Epub 2016 Mar 16.

7.

Conformational Equilibrium of CDK/Cyclin Complexes by Molecular Dynamics with Excited Normal Modes.

Floquet N, Costa MG, Batista PR, Renault P, Bisch PM, Raussin F, Martinez J, Morris MC, Perahia D.

Biophys J. 2015 Sep 15;109(6):1179-89. doi: 10.1016/j.bpj.2015.07.003. Epub 2015 Aug 6.

8.

Identification of TAX2 peptide as a new unpredicted anti-cancer agent.

Jeanne A, Sick E, Devy J, Floquet N, Belloy N, Theret L, Boulagnon-Rombi C, Diebold MD, Dauchez M, Martiny L, Schneider C, Dedieu S.

Oncotarget. 2015 Jul 20;6(20):17981-8000.

9.

Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.

Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20.

10.

Coarse-grained simulations of the HIV-1 matrix protein anchoring: revisiting its assembly on membrane domains.

Charlier L, Louet M, Chaloin L, Fuchs P, Martinez J, Muriaux D, Favard C, Floquet N.

Biophys J. 2014 Feb 4;106(3):577-85. doi: 10.1016/j.bpj.2013.12.019.

11.

Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: a putative activation mode of GPCRs?

Louet M, Karakas E, Perret A, Perahia D, Martinez J, Floquet N.

FEBS Lett. 2013 Aug 19;587(16):2656-61. doi: 10.1016/j.febslet.2013.06.052. Epub 2013 Jul 10.

12.

Interaction between the elastin peptide VGVAPG and human elastin binding protein.

Blanchevoye C, Floquet N, Scandolera A, Baud S, Maurice P, Bocquet O, Blaise S, Ghoneim C, Cantarelli B, Delacoux F, Dauchez M, Efremov RG, Martiny L, Duca L, Debelle L.

J Biol Chem. 2013 Jan 11;288(2):1317-28. doi: 10.1074/jbc.M112.419929. Epub 2012 Nov 19.

13.

Dissociation of membrane-anchored heterotrimeric G-protein induced by G(α) subunit binding to GTP.

Louet M, Charlier L, Martinez J, Floquet N.

J Chem Inf Model. 2012 Nov 26;52(11):3022-7. doi: 10.1021/ci3003717. Epub 2012 Nov 7.

PMID:
23094679
14.

GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins.

Louet M, Martinez J, Floquet N.

PLoS Comput Biol. 2012;8(7):e1002595. doi: 10.1371/journal.pcbi.1002595. Epub 2012 Jul 19.

15.

Ligands and signaling proteins govern the conformational landscape explored by a G protein-coupled receptor.

Mary S, Damian M, Louet M, Floquet N, Fehrentz JA, Marie J, Martinez J, Banères JL.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8304-9. doi: 10.1073/pnas.1119881109. Epub 2012 May 9.

16.

Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting.

Malcor JD, Payrot N, David M, Faucon A, Abouzid K, Jacquot G, Floquet N, Debarbieux F, Rougon G, Martinez J, Khrestchatisky M, Vlieghe P, Lisowski V.

J Med Chem. 2012 Mar 8;55(5):2227-41. doi: 10.1021/jm2014919. Epub 2012 Feb 14.

PMID:
22257077
17.

A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins.

Louet M, Perahia D, Martinez J, Floquet N.

J Mol Biol. 2011 Aug 5;411(1):298-312. doi: 10.1016/j.jmb.2011.05.034. Epub 2011 May 30.

PMID:
21663745
18.

L-arginine binding to human inducible nitric oxide synthase: an antisymmetric funnel route toward isoform-specific inhibitors?

Floquet N, Hernandez JF, Boucher JL, Martinez J.

J Chem Inf Model. 2011 Jun 27;51(6):1325-35. doi: 10.1021/ci100422v. Epub 2011 May 16.

PMID:
21574590
19.

Involvement of tryptophan W276 and of two surrounding amino acid residues in the high constitutive activity of the ghrelin receptor GHS-R1a.

Gozé C, Bergé G, M'Kadmi C, Floquet N, Gagne D, Galleyrand JC, Fehrentz JA, Martinez J.

Eur J Pharmacol. 2010 Sep 25;643(2-3):153-61. doi: 10.1016/j.ejphar.2010.06.018. Epub 2010 Jun 30.

PMID:
20599926
20.

The spirocyclopropyl moiety as a methyl surrogate in the structure of l-fucosidase and l-rhamnosidase inhibitors.

Pearson MS, Floquet N, Bello C, Vogel P, Plantier-Royon R, Szymoniak J, Bertus P, Behr JB.

Bioorg Med Chem. 2009 Dec 1;17(23):8020-6. doi: 10.1016/j.bmc.2009.10.010. Epub 2009 Oct 12.

PMID:
19875298
21.

Expanding the borononucleotide family: synthesis of borono-analogues of dCMP, dGMP and dAMP.

Martin AR, Mohanan K, Luvino D, Floquet N, Baraguey C, Smietana M, Vasseur JJ.

Org Biomol Chem. 2009 Nov 7;7(21):4369-77. doi: 10.1039/b912616c. Epub 2009 Aug 27.

PMID:
19830285
22.

Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G-protein coupled receptor (GPCR).

Floquet N, M'Kadmi C, Perahia D, Gagne D, Bergé G, Marie J, Banères JL, Galleyrand JC, Fehrentz JA, Martinez J.

J Mol Biol. 2010 Jan 29;395(4):769-84. doi: 10.1016/j.jmb.2009.09.051. Epub 2009 Sep 25.

PMID:
19782690
23.

The YSNSG cyclopeptide derived from tumstatin inhibits tumor angiogenesis by down-regulating endothelial cell migration.

Thevenard J, Ramont L, Devy J, Brassart B, Dupont-Deshorgue A, Floquet N, Schneider L, Ouchani F, Terryn C, Maquart FX, Monboisse JC, Brassart-Pasco S.

Int J Cancer. 2010 Mar 1;126(5):1055-66. doi: 10.1002/ijc.24688.

24.

Collective motions in glucosamine-6-phosphate synthase: influence of ligand binding and role in ammonia channelling and opening of the fructose-6-phosphate binding site.

Floquet N, Durand P, Maigret B, Badet B, Badet-Denisot MA, Perahia D.

J Mol Biol. 2009 Jan 16;385(2):653-64. doi: 10.1016/j.jmb.2008.10.032. Epub 2008 Oct 19.

PMID:
18976669
25.

Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study.

Floquet N, Dedieu S, Martiny L, Dauchez M, Perahia D.

Arch Biochem Biophys. 2008 Oct 1;478(1):103-9. doi: 10.1016/j.abb.2008.07.015. Epub 2008 Jul 23.

PMID:
18675774
26.

Ammonia channeling in bacterial glucosamine-6-phosphate synthase (Glms): molecular dynamics simulations and kinetic studies of protein mutants.

Floquet N, Mouilleron S, Daher R, Maigret B, Badet B, Badet-Denisot MA.

FEBS Lett. 2007 Jun 26;581(16):2981-7. Epub 2007 Jun 4.

27.

Expression and purification of active human internal His(6)-tagged L-glutamine: D-Fructose-6P amidotransferase I.

Richez C, Boetzel J, Floquet N, Koteshwar K, Stevens J, Badet B, Badet-Denisot MA.

Protein Expr Purif. 2007 Jul;54(1):45-53. Epub 2007 Feb 9.

PMID:
17379537
28.

Discovering new inhibitors of bacterial glucosamine-6P synthase (GlmS) by docking simulations.

Floquet N, Richez C, Durand P, Maigret B, Badet B, Badet-Denisot MA.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1966-70. Epub 2007 Jan 25.

PMID:
17291748
29.

Structural and antitumor properties of the YSNSG cyclopeptide derived from tumstatin.

Thevenard J, Floquet N, Ramont L, Prost E, Nuzillard JM, Dauchez M, Yezid H, Alix AJ, Maquart FX, Monboisse JC, Brassart-Pasco S.

Chem Biol. 2006 Dec;13(12):1307-15.

30.

Normal mode analysis as a prerequisite for drug design: application to matrix metalloproteinases inhibitors.

Floquet N, Marechal JD, Badet-Denisot MA, Robert CH, Dauchez M, Perahia D.

FEBS Lett. 2006 Oct 2;580(22):5130-6. Epub 2006 Sep 1.

31.

Structure and modeling studies of the carboxy-terminus region of human tropoelastin.

Floquet N, Pepe A, Dauchez M, Bochicchio B, Tamburro AM, Alix AJ.

Matrix Biol. 2005 Jun;24(4):271-82.

PMID:
15961300
32.

Dissection of human tropoelastin: solution structure, dynamics and self-assembly of the exon 5 peptide.

Bochicchio B, Floquet N, Pepe A, Alix AJ, Tamburro AM.

Chemistry. 2004 Jul 5;10(13):3166-76.

PMID:
15224325
33.

Structural characterization of VGVAPG, an elastin-derived peptide.

Floquet N, Héry-Huynh S, Dauchez M, Derreumaux P, Tamburro AM, Alix AJ.

Biopolymers. 2004;76(3):266-80. Review.

PMID:
15148686
34.

Elastin as a matrikine.

Duca L, Floquet N, Alix AJ, Haye B, Debelle L.

Crit Rev Oncol Hematol. 2004 Mar;49(3):235-44. Review.

PMID:
15036263
35.

Molecular mobility of confined phases in model mesoporous (MCM-41) and microporous (AlPO(4)-5 zeolite) host materials.

Coulomb JP, Floquet N, Martin C, Kahn R.

Eur Phys J E Soft Matter. 2003 Nov;12 Suppl 1:S25-9. Epub 2003 Nov 5.

PMID:
15011009
36.

The antitumor properties of the alpha3(IV)-(185-203) peptide from the NC1 domain of type IV collagen (tumstatin) are conformation-dependent.

Floquet N, Pasco S, Ramont L, Derreumaux P, Laronze JY, Nuzillard JM, Maquart FX, Alix AJ, Monboisse JC.

J Biol Chem. 2004 Jan 16;279(3):2091-100. Epub 2003 Oct 28.

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