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Items: 28


CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway.

Richardson CD, Kazane KR, Feng SJ, Zelin E, Bray NL, Schäfer AJ, Floor SN, Corn JE.

Nat Genet. 2018 Aug;50(8):1132-1139. doi: 10.1038/s41588-018-0174-0. Epub 2018 Jul 27.


The Traffic Jam: Polyamine Prevalence Pauses Protein Production.

Venkataramanan S, Floor SN.

Mol Cell. 2018 Apr 19;70(2):191-192. doi: 10.1016/j.molcel.2018.04.005.


Thyroid follicular adenomas and carcinomas: molecular profiling provides evidence for a continuous evolution.

Dom G, Frank S, Floor S, Kehagias P, Libert F, Hoang C, Andry G, Spinette A, Craciun L, de Saint Aubin N, Tresallet C, Tissier F, Savagner F, Majjaj S, Gutierrez-Roelens I, Marbaix E, Dumont JE, Maenhaut C.

Oncotarget. 2017 Dec 8;9(12):10343-10359. doi: 10.18632/oncotarget.23130. eCollection 2018 Feb 13.


Widespread Translational Remodeling during Human Neuronal Differentiation.

Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN.

Cell Rep. 2017 Nov 14;21(7):2005-2016. doi: 10.1016/j.celrep.2017.10.095.


Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes.

Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA.

Nat Biotechnol. 2017 May;35(5):431-434. doi: 10.1038/nbt.3806. Epub 2017 Feb 13.


Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Iwasaki S, Floor SN, Ingolia NT.

Nature. 2016 Jun 23;534(7608):558-61. doi: 10.1038/nature17978. Epub 2016 Jun 15.


Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.

Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna JA, Pfister SM, Taylor MD, Chang HY, Cho YJ.

Oncotarget. 2016 May 10;7(19):28169-82. doi: 10.18632/oncotarget.8612.


Tunable protein synthesis by transcript isoforms in human cells.

Floor SN, Doudna JA.

Elife. 2016 Jan 6;5. pii: e10921. doi: 10.7554/eLife.10921.


Analog sensitive chemical inhibition of the DEAD-box protein DDX3.

Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA.

Protein Sci. 2016 Mar;25(3):638-49. doi: 10.1002/pro.2857. Epub 2015 Dec 26.


Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome.

Floor SN, Doudna JA.

Mol Cell. 2015 Dec 3;60(5):712-714. doi: 10.1016/j.molcel.2015.11.014.


Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3.

Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA.

J Biol Chem. 2016 Jan 29;291(5):2412-21. doi: 10.1074/jbc.M115.700625. Epub 2015 Nov 23.


microRNA expression in autonomous thyroid adenomas: Correlation with mRNA regulation.

Floor SL, Trésallet C, Hébrant A, Desbuleux A, Libert F, Hoang C, Capello M, Andry G, van Staveren WC, Maenhaut C.

Mol Cell Endocrinol. 2015 Aug 15;411:1-10. doi: 10.1016/j.mce.2015.04.001. Epub 2015 Apr 23.


MiRNA expression may account for chronic but not for acute regulation of mRNA expression in human thyroid tumor models.

Floor SL, Hebrant A, Pita JM, Saiselet M, Trésallet C, Libert F, Andry G, Dumont JE, van Staveren WC, Maenhaut C.

PLoS One. 2014 Nov 6;9(11):e111581. doi: 10.1371/journal.pone.0111581. eCollection 2014.


miRNA expression in anaplastic thyroid carcinomas.

Hébrant A, Floor S, Saiselet M, Antoniou A, Desbuleux A, Snyers B, La C, de Saint Aubain N, Leteurtre E, Andry G, Maenhaut C.

PLoS One. 2014 Aug 25;9(8):e103871. doi: 10.1371/journal.pone.0103871. eCollection 2014.


Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2.

Aglietti RA, Floor SN, McClendon CL, Jacobson MP, Gross JD.

Structure. 2013 Sep 3;21(9):1571-80. doi: 10.1016/j.str.2013.06.021. Epub 2013 Aug 1.


Thyroid cancer cell lines: an overview.

Saiselet M, Floor S, Tarabichi M, Dom G, Hébrant A, van Staveren WC, Maenhaut C.

Front Endocrinol (Lausanne). 2012 Nov 16;3:133. doi: 10.3389/fendo.2012.00133. eCollection 2012.


Hallmarks of cancer: of all cancer cells, all the time?

Floor SL, Dumont JE, Maenhaut C, Raspe E.

Trends Mol Med. 2012 Sep;18(9):509-15. doi: 10.1016/j.molmed.2012.06.005. Epub 2012 Jul 13.


Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.

Floor SN, Borja MS, Gross JD.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2872-7. doi: 10.1073/pnas.1113620109. Epub 2012 Feb 9.


Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: distinct, overlapping or same populations.

Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C.

Oncogene. 2011 Nov 17;30(46):4609-21. doi: 10.1038/onc.2011.184. Epub 2011 Jun 6. Review.


A split active site couples cap recognition by Dcp2 to activation.

Floor SN, Jones BN, Hernandez GA, Gross JD.

Nat Struct Mol Biol. 2010 Sep;17(9):1096-101. doi: 10.1038/nsmb.1879. Epub 2010 Aug 15.


Two patients with a complete proximal rupture of the hamstring.

Floor S, van der Veen AH, Devilee RJ.

Arch Orthop Trauma Surg. 2010 Apr;130(4):523-6. doi: 10.1007/s00402-009-0950-5. Epub 2009 Aug 18.


SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction.

Neher SB, Bradshaw N, Floor SN, Gross JD, Walter P.

Nat Struct Mol Biol. 2008 Sep;15(9):916-23.


Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine.

Lampe JN, Floor SN, Gross JD, Nishida CR, Jiang Y, Trnka MJ, Ortiz de Montellano PR.

J Am Chem Soc. 2008 Dec 3;130(48):16168-9. doi: 10.1021/ja8071463.


Control of mRNA decapping by Dcp2: An open and shut case?

Floor SN, Jones BN, Gross JD.

RNA Biol. 2008 Oct-Dec;5(4):189-92. Epub 2008 Oct 26.


mRNA decapping is promoted by an RNA-binding channel in Dcp2.

Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD.

Mol Cell. 2008 Feb 15;29(3):324-36. doi: 10.1016/j.molcel.2007.11.027.


Daily ambulatory exhaled nitric oxide measurements in asthma.

Pijnenburg MW, Floor SE, Hop WC, De Jongste JC.

Pediatr Allergy Immunol. 2006 May;17(3):189-93.


Empirical investigation of extreme single-particle behavior of nuclear quadrupole moments in highly collective A approximately 150 superdeformed bands.

Clark ST, Hackman G, Janssens RV, Clark RM, Fallon P, Floor SN, Lane GJ, Macchiavelli AO, Norris J, Sanders SJ, Svensson CE.

Phys Rev Lett. 2001 Oct 22;87(17):172503. Epub 2001 Oct 9.


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