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Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine.

Hankaniemi MM, Stone VM, Andrejeff T, Heinimäki S, Sioofy-Khojine AB, Marjomäki V, Hyöty H, Blazevic V, Flodström-Tullberg M, Hytönen VP, Laitinen OH.

Antiviral Res. 2019 Sep 3;171:104595. doi: 10.1016/j.antiviral.2019.104595. [Epub ahead of print]


A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine.

Hankaniemi MM, Stone VM, Sioofy-Khojine AB, Heinimäki S, Marjomäki V, Hyöty H, Blazevic V, Laitinen OH, Flodström-Tullberg M, Hytönen VP.

Vaccine. 2019 Sep 20;37(40):5962-5971. doi: 10.1016/j.vaccine.2019.08.037. Epub 2019 Aug 27.


Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells.

Lietzén N, Hirvonen K, Honkimaa A, Buchacher T, Laiho JE, Oikarinen S, Mazur MA, Flodström-Tullberg M, Dufour E, Sioofy-Khojine AB, Hyöty H, Lahesmaa R.

iScience. 2019 Sep 27;19:340-357. doi: 10.1016/j.isci.2019.07.040. Epub 2019 Jul 29.


Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?

Blanter M, Sork H, Tuomela S, Flodström-Tullberg M.

Curr Diab Rep. 2019 Aug 10;19(9):82. doi: 10.1007/s11892-019-1192-8. Review.


Short-term CFTR inhibition reduces islet area in C57BL/6 mice.

Khan D, Kelsey R, Maheshwari RR, Stone VM, Hasib A, Manderson Koivula FN, Watson A, Harkin S, Irwin N, Shaw JA, McClenaghan NH, Venglovecz V, Ébert A, Flodström-Tullberg M, White MG, Kelly C.

Sci Rep. 2019 Aug 2;9(1):11244. doi: 10.1038/s41598-019-47745-w.


Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter].

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 Jun;62(6):1100-1103. doi: 10.1007/s00125-019-4873-6. Epub 2019 Apr 23. No abstract available.


Defective exocytosis and processing of insulin in a cystic fibrosis mouse model.

Edlund A, Barghouth M, Huhn M, Abels M, Esguerra J, Mollet I, Svedin E, Wendt A, Renstrom E, Zhang E, Wierup N, Scholte BJ, Flodström-Tullberg M, Eliasson L.

J Endocrinol. 2019 Feb 1. pii: JOE-18-0570.R1. doi: 10.1530/JOE-18-0570. [Epub ahead of print]


Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A.

Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23.


Severely Impaired Control of Bacterial Infections in a Patient With Cystic Fibrosis Defective in Mucosal-Associated Invariant T Cells.

Pincikova T, Paquin-Proulx D, Moll M, Flodström-Tullberg M, Hjelte L, Sandberg JK.

Chest. 2018 May;153(5):e93-e96. doi: 10.1016/j.chest.2018.01.020.


New Coxsackievirus 2Apro and 3Cpro protease antibodies for virus detection and discovery of pathogenic mechanisms.

Laitinen OH, Svedin E, Kapell S, Hankaniemi MM, Larsson PG, Domsgen E, Stone VM, Määttä JAE, Hyöty H, Hytönen VP, Flodström-Tullberg M.

J Virol Methods. 2018 May;255:29-37. doi: 10.1016/j.jviromet.2018.02.001. Epub 2018 Feb 6.


A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses.

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH.

Sci Rep. 2018 Jan 8;8(1):33. doi: 10.1038/s41598-017-18495-4.


A Coxsackievirus B vaccine protects against virus-induced diabetes in an experimental mouse model of type 1 diabetes.

Stone VM, Hankaniemi MM, Svedin E, Sioofy-Khojine A, Oikarinen S, Hyöty H, Laitinen OH, Hytönen VP, Flodström-Tullberg M.

Diabetologia. 2018 Feb;61(2):476-481. doi: 10.1007/s00125-017-4492-z. Epub 2017 Nov 18.


A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.

Svedin E, Utorova R, Hühn MH, Larsson PG, Stone VM, Garimella M, Lind K, Hägglöf T, Pincikova T, Laitinen OH, McInerney GM, Scholte B, Hjelte L, Karlsson MCI, Flodström-Tullberg M.

J Infect Dis. 2017 Dec 5;216(10):1308-1317. doi: 10.1093/infdis/jix474.


Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, Nagasawa M, Erjefält JS, Mori M, Flodström-Tullberg M, Bergquist A, Ljunggren HG, Westgren M, Lindforss U, Friberg D, Jorns C, Ellis E, Björkström NK, Mjösberg J.

Eur J Immunol. 2017 Aug;47(8):1280-1294. doi: 10.1002/eji.201646890. Epub 2017 Jul 11.


Optimized production and purification of Coxsackievirus B1 vaccine and its preclinical evaluation in a mouse model.

Hankaniemi MM, Laitinen OH, Stone VM, Sioofy-Khojine A, Määttä JAE, Larsson PG, Marjomäki V, Hyöty H, Flodström-Tullberg M, Hytönen VP.

Vaccine. 2017 Jun 27;35(30):3718-3725. doi: 10.1016/j.vaccine.2017.05.057. Epub 2017 Jun 1.


Vitamin D treatment modulates immune activation in cystic fibrosis.

Pincikova T, Paquin-Proulx D, Sandberg JK, Flodström-Tullberg M, Hjelte L.

Clin Exp Immunol. 2017 Sep;189(3):359-371. doi: 10.1111/cei.12984. Epub 2017 May 24.


CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.

Edlund A, Pedersen MG, Lindqvist A, Wierup N, Flodström-Tullberg M, Eliasson L.

Sci Rep. 2017 Mar 7;7(1):90. doi: 10.1038/s41598-017-00098-8.


An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets.

Domsgen E, Lind K, Kong L, Hühn MH, Rasool O, van Kuppeveld F, Korsgren O, Lahesmaa R, Flodström-Tullberg M.

Sci Rep. 2016 Dec 21;6:39378. doi: 10.1038/srep39378.


Clinical impact of vitamin D treatment in cystic fibrosis: a pilot randomized, controlled trial.

Pincikova T, Paquin-Proulx D, Sandberg JK, Flodström-Tullberg M, Hjelte L.

Eur J Clin Nutr. 2017 Feb;71(2):203-205. doi: 10.1038/ejcn.2016.259. Epub 2016 Dec 14.


Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.

Schulte BM, Gielen PR, Kers-Rebel ED, Prosser AC, Lind K, Flodström-Tullberg M, Tack CJ, Elving LD, Adema GJ.

Viral Immunol. 2016 Sep;29(7):389-97. doi: 10.1089/vim.2015.0140. Epub 2016 Aug 2.


Enteroviral proteases: structure, host interactions and pathogenicity.

Laitinen OH, Svedin E, Kapell S, Nurminen A, Hytönen VP, Flodström-Tullberg M.

Rev Med Virol. 2016 Jul;26(4):251-67. doi: 10.1002/rmv.1883. Epub 2016 May 4. Review.


Coxsackievirus counters the host innate immune response by blocking type III interferon expression.

Lind K, Svedin E, Domsgen E, Kapell S, Laitinen OH, Moll M, Flodström-Tullberg M.

J Gen Virol. 2016 Jun;97(6):1368-1380. doi: 10.1099/jgv.0.000443. Epub 2016 Mar 2.


Cystic fibrosis bronchial epithelial cells have impaired ability to activate vitamin D.

Pincikova T, Svedin E, Domsgen E, Flodström-Tullberg M, Hjelte L.

Acta Paediatr. 2016 Jul;105(7):851-3. doi: 10.1111/apa.13361. Epub 2016 Mar 28. No abstract available.


Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice.

Brauner H, Hall HT, Flodström-Tullberg M, Kärre K, Höglund P, Johansson S.

Immunol Cell Biol. 2016 Feb;94(2):177-84. doi: 10.1038/icb.2015.78. Epub 2015 Aug 5.


Application of bioinformatics in probe design enables detection of enteroviruses on different taxonomic levels by advanced in situ hybridization technology.

Laiho JE, Oikarinen S, Oikarinen M, Larsson PG, Stone VM, Hober D, Oberste S, Flodström-Tullberg M, Isola J, Hyöty H.

J Clin Virol. 2015 Aug;69:165-71. doi: 10.1016/j.jcv.2015.06.085. Epub 2015 Jun 23.


A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.

Larsson PG, Lakshmikanth T, Laitinen OH, Utorova R, Jacobson S, Oikarinen M, Domsgen E, Koivunen MR, Chaux P, Devard N, Lecouturier V, Almond J, Knip M, Hyöty H, Flodström-Tullberg M.

Diabetologia. 2015 Feb;58(2):346-54. doi: 10.1007/s00125-014-3436-0. Epub 2014 Nov 5.


Novel role for matricellular proteins in the regulation of islet β cell survival: the effect of SPARC on survival, proliferation, and signaling.

Ryall CL, Viloria K, Lhaf F, Walker AJ, King A, Jones P, Mackintosh D, McNeice R, Kocher H, Flodstrom-Tullberg M, Edling C, Hill NJ.

J Biol Chem. 2014 Oct 31;289(44):30614-24. doi: 10.1074/jbc.M114.573980. Epub 2014 Sep 9.


CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.

Edlund A, Esguerra JL, Wendt A, Flodström-Tullberg M, Eliasson L.

BMC Med. 2014 May 28;12:87. doi: 10.1186/1741-7015-12-87.


Type III interferons are expressed by Coxsackievirus-infected human primary hepatocytes and regulate hepatocyte permissiveness to infection.

Lind K, Svedin E, Utorova R, Stone VM, Flodström-Tullberg M.

Clin Exp Immunol. 2014 Sep;177(3):687-95. doi: 10.1111/cei.12368.


Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter].

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ, Foulis AK, Frisk G, Flodström-Tullberg M, Hober D, Hyoty H, Pugliese A, Morgan NG.

Diabetologia. 2014 Mar;57(3):647-9. doi: 10.1007/s00125-014-3167-2. Epub 2014 Jan 16. No abstract available.


Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas.

Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, Bone AJ; nPOD-V Consortium, Foulis AK, Frisk G, Flodstrom-Tullberg M, Hober D, Hyoty H, Morgan NG.

Diabetologia. 2014 Feb;57(2):392-401. doi: 10.1007/s00125-013-3094-7. Epub 2013 Nov 5.


Protection against type 1 diabetes upon Coxsackievirus B4 infection and iNKT-cell stimulation: role of suppressive macrophages.

Ghazarian L, Diana J, Beaudoin L, Larsson PG, Puri RK, van Rooijen N, Flodström-Tullberg M, Lehuen A.

Diabetes. 2013 Nov;62(11):3785-96. doi: 10.2337/db12-0958. Epub 2013 Jul 26.


Induction of an antiviral state and attenuated coxsackievirus replication in type III interferon-treated primary human pancreatic islets.

Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M.

J Virol. 2013 Jul;87(13):7646-54. doi: 10.1128/JVI.03431-12. Epub 2013 May 1.


Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.

Larsson PG, Lakshmikanth T, Svedin E, King C, Flodström-Tullberg M.

Diabetologia. 2013 Apr;56(4):867-74. doi: 10.1007/s00125-013-2834-z. Epub 2013 Jan 24.


The TheraCyte™ device protects against islet allograft rejection in immunized hosts.

Kumagai-Braesch M, Jacobson S, Mori H, Jia X, Takahashi T, Wernerson A, Flodström-Tullberg M, Tibell A.

Cell Transplant. 2013;22(7):1137-46. doi: 10.3727/096368912X657486. Epub 2012 Oct 3.


SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice.

Zadjali F, Santana-Farre R, Vesterlund M, Carow B, Mirecki-Garrido M, Hernandez-Hernandez I, Flodström-Tullberg M, Parini P, Rottenberg M, Norstedt G, Fernandez-Perez L, Flores-Morales A.

FASEB J. 2012 Aug;26(8):3282-91. doi: 10.1096/fj.12-205583. Epub 2012 May 4.


Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.

Lind K, Hühn MH, Flodström-Tullberg M.

Clin Exp Immunol. 2012 Apr;168(1):30-8. doi: 10.1111/j.1365-2249.2011.04557.x. Review.


Beta-cell specific expression of suppressor of cytokine signaling-1 (SOCS-1) delays islet allograft rejection by down-regulating Interferon Regulatory Factor-1 (IRF-1) signaling.

Solomon M, Flodström-Tullberg M, Sarvetnick N.

Transpl Immunol. 2011 Apr 15;24(3):181-8. doi: 10.1016/j.trim.2010.11.007. Epub 2010 Dec 1.


Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.

Björkström NK, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson MA, Björklund AT, Flodström-Tullberg M, Michaëlsson J, Rottenberg ME, Guzmán CA, Ljunggren HG, Malmberg KJ.

Blood. 2010 Nov 11;116(19):3853-64. doi: 10.1182/blood-2010-04-281675. Epub 2010 Aug 9.


Alloreactivity but failure to reject human islet transplants by humanized Balb/c/Rag2gc mice.

Jacobson S, Heuts F, Juarez J, Hultcrantz M, Korsgren O, Svensson M, Rottenberg M, Flodström-Tullberg M.

Scand J Immunol. 2010 Feb;71(2):83-90. doi: 10.1111/j.1365-3083.2009.02356.x.


Melanoma differentiation-associated protein-5 (MDA-5) limits early viral replication but is not essential for the induction of type 1 interferons after Coxsackievirus infection.

Hühn MH, McCartney SA, Lind K, Svedin E, Colonna M, Flodström-Tullberg M.

Virology. 2010 May 25;401(1):42-8. doi: 10.1016/j.virol.2010.02.010. Epub 2010 Mar 5.


Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice.

Brauner H, Elemans M, Lemos S, Broberger C, Holmberg D, Flodström-Tullberg M, Kärre K, Höglund P.

J Immunol. 2010 Mar 1;184(5):2272-80. doi: 10.4049/jimmunol.0804358. Epub 2010 Feb 3.


Natural killer cells in human autoimmunity.

Flodström-Tullberg M, Bryceson YT, Shi FD, Höglund P, Ljunggren HG.

Curr Opin Immunol. 2009 Dec;21(6):634-40. doi: 10.1016/j.coi.2009.09.012. Epub 2009 Nov 4. Review.


Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.

McGuire HM, Vogelzang A, Hill N, Flodström-Tullberg M, Sprent J, King C.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19438-43. doi: 10.1073/pnas.0903561106. Epub 2009 Oct 30.


Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death.

Zaitseva II, Hultcrantz M, Sharoyko V, Flodström-Tullberg M, Zaitsev SV, Berggren PO.

Cell Mol Life Sci. 2009 Dec;66(23):3787-95. doi: 10.1007/s00018-009-0151-y.


Co-transplantation of stromal cells interferes with the rejection of allogeneic islet grafts.

Jacobson S, Kumagai-Braesch M, Tibell A, Svensson M, Flodström-Tullberg M.

Ann N Y Acad Sci. 2008 Dec;1150:213-6. doi: 10.1196/annals.1447.042.


The target cell response to cytokines governs the autoreactive T cell repertoire in the pancreas of NOD mice.

Hultcrantz M, Jacobson S, Hill NJ, Santamaria P, Flodström-Tullberg M.

Diabetologia. 2009 Feb;52(2):299-305. doi: 10.1007/s00125-008-1193-7. Epub 2008 Nov 25.


Expression of intestinal and lung alkaline sphingomyelinase and neutral ceramidase in cystic fibrosis f508del transgenic mice.

Ohlsson L, Hjelte L, Hühn M, Scholte BJ, Wilke M, Flodström-Tullberg M, Nilsson A.

J Pediatr Gastroenterol Nutr. 2008 Nov;47(5):547-54. doi: 10.1097/MPG.0b013e3181826daf.


Recent acquisitions on the genetic basis of autoimmune disease.

Hill NJ, King C, Flodstrom-Tullberg M.

Front Biosci. 2008 May 1;13:4838-51. Review.


IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection.

Hühn MH, Hultcrantz M, Lind K, Ljunggren HG, Malmberg KJ, Flodström-Tullberg M.

Cell Microbiol. 2008 Feb;10(2):426-36. Epub 2007 Oct 24.


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