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Items: 41


Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.

Borok Z, Horie M, Flodby P, Wang H, Liu Y, Ganesh S, Firth AL, Minoo P, Li C, Beers MF, Lee AS, Zhou B.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):198-211. doi: 10.1164/rccm.201902-0451OC.


Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1.

Little DR, Gerner-Mauro KN, Flodby P, Crandall ED, Borok Z, Akiyama H, Kimura S, Ostrin EJ, Chen J.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20545-20555. doi: 10.1073/pnas.1906663116. Epub 2019 Sep 23.


Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.

Kage H, Flodby P, Zhou B, Borok Z.

Cell Mol Life Sci. 2019 Dec;76(23):4663-4672. doi: 10.1007/s00018-019-03238-7. Epub 2019 Jul 23. Review.


CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro.

Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z.

Int J Cancer. 2018 Dec 15;143(12):3169-3180. doi: 10.1002/ijc.31734. Epub 2018 Oct 16.


Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis.

Sipos A, Kim KJ, Chow RH, Flodby P, Borok Z, Crandall ED.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L286-L300. doi: 10.1152/ajplung.00108.2018. Epub 2018 May 3.


Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.

J Clin Invest. 2018 Mar 1;128(3):970-984. doi: 10.1172/JCI90429. Epub 2018 Feb 5.


Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1016-L1029. doi: 10.1152/ajplung.00023.2017. Epub 2017 Aug 24.


Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.

Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR.

J Clin Invest. 2017 Aug 1;127(8):3136-3151. doi: 10.1172/JCI91301. Epub 2017 Jul 24.


Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation.

Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B.

Sci Rep. 2017 Jun 14;7(1):3473. doi: 10.1038/s41598-017-03152-7.


Region-specific role for Pten in maintenance of epithelial phenotype and integrity.

Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L131-L142. doi: 10.1152/ajplung.00005.2015. Epub 2016 Nov 18.


IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A.

Eur J Immunol. 2016 Nov;46(11):2531-2541. doi: 10.1002/eji.201646366. Epub 2016 Sep 22.


Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.

Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321. doi: 10.1165/rcmb.2016-0071OC.


Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.

Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406. doi: 10.1165/rcmb.2016-0005OC.


The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development.

Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49. doi: 10.1165/rcmb.2015-0327OC.


Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung.

Liebler JM, Marconett CN, Juul N, Wang H, Liu Y, Flodby P, Laird-Offringa IA, Minoo P, Zhou B.

Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L114-20. doi: 10.1152/ajplung.00337.2015. Epub 2015 Nov 6.


A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.

Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2263-8. doi: 10.1073/pnas.1415739112. Epub 2015 Feb 2.


Dynamic involvement of ATG5 in cellular stress responses.

Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.

Cell Death Dis. 2014 Oct 23;5:e1478. doi: 10.1038/cddis.2014.428.


Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.

Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L524-36. doi: 10.1152/ajplung.00077.2014. Epub 2014 Aug 8.


TRIM72 is required for effective repair of alveolar epithelial cell wounding.

Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X.

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15;307(6):L449-59. doi: 10.1152/ajplung.00172.2014. Epub 2014 Aug 8.


Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.

Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22. doi: 10.1165/rcmb.2013-0353OC.


Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.

Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH.

J Dent Res. 2013 Oct;92(10):911-7. doi: 10.1177/0022034513499350. Epub 2013 Jul 24.


Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z.

J Biol Chem. 2012 Mar 2;287(10):7026-38. doi: 10.1074/jbc.M111.276311. Epub 2012 Jan 12.


Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.

MacFarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ.

J Biol Chem. 2011 Dec 23;286(51):44015-22. doi: 10.1074/jbc.M111.307629. Epub 2011 Nov 4.


Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition.

DeMaio L, Buckley ST, Krishnaveni MS, Flodby P, Dubourd M, Banfalvi A, Xing Y, Ehrhardt C, Minoo P, Zhou B, Crandall ED, Borok Z.

J Pathol. 2012 Mar;226(4):633-44. doi: 10.1002/path.3016. Epub 2011 Dec 9.


Directed expression of Cre in alveolar epithelial type 1 cells.

Flodby P, Borok Z, Banfalvi A, Zhou B, Gao D, Minoo P, Ann DK, Morrisey EE, Crandall ED.

Am J Respir Cell Mol Biol. 2010 Aug;43(2):173-8. doi: 10.1165/rcmb.2009-0226OC. Epub 2009 Sep 18.


Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice.

MacFarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ.

J Biol Chem. 2008 Sep 19;283(38):25846-53. doi: 10.1074/jbc.M802671200. Epub 2008 Jul 21.


Rat aquaporin-5 4.3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo.

Zhou B, Ann DK, Flodby P, Minoo P, Liebler JM, Crandall ED, Borok Z.

Am J Physiol Cell Physiol. 2008 Jul;295(1):C111-20. doi: 10.1152/ajpcell.90620.2007. Epub 2008 Apr 30.


Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers.

Flodby P, Zhou B, Ann DK, Kim KJ, Minoo P, Crandall ED, Borok Z.

Biochem Biophys Res Commun. 2007 Apr 27;356(1):26-31. Epub 2007 Feb 23.


Role for ELOVL3 and fatty acid chain length in development of hair and skin function.

Westerberg R, Tvrdik P, Undén AB, Månsson JE, Norlén L, Jakobsson A, Holleran WH, Elias PM, Asadi A, Flodby P, Toftgård R, Capecchi MR, Jacobsson A.

J Biol Chem. 2004 Feb 13;279(7):5621-9. Epub 2003 Oct 27.


Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction.

Antonson P, Schuster GU, Wang L, Rozell B, Holter E, Flodby P, Treuter E, Holmgren L, Gustafsson JA.

Mol Cell Biol. 2003 Feb;23(4):1260-8.


Knockout mice and steroid receptor research.

Flodby P, Teglund S, Gustafsson JA.

Methods Mol Biol. 2001;176:201-26. Review. No abstract available.


Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.

Gaufo GO, Flodby P, Capecchi MR.

Development. 2000 Dec;127(24):5343-54.


Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.

Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, Xanthopoulos KG.

J Biol Chem. 1996 Oct 4;271(40):24753-60.


Analysis of antibody specificity against the third variable region of the envelope glycoprotein gp120 of HIV-1 in plasma from HIV-1-positive individuals residing in Brazil.

Bongertz V, Jansson M, Flodby P, Morgado MG, Galvão-Castro B, Wigzell H.

Braz J Med Biol Res. 1994 May;27(5):1225-36.


Differential patterns of expression of three C/EBP isoforms, HNF-1, and HNF-4 after partial hepatectomy in rats.

Flodby P, Antonson P, Barlow C, Blanck A, Porsch-Hällström I, Xanthopoulos KG.

Exp Cell Res. 1993 Sep;208(1):248-56.


Effects of mutations in glycosylation sites and disulphide bonds on processing, CD4-binding and fusion activity of human immunodeficiency virus envelope glycoproteins.

Bolmstedt A, Hemming A, Flodby P, Berntsson P, Travis B, Lin JP, Ledbetter J, Tsu T, Wigzell H, Hu SL, et al.

J Gen Virol. 1991 Jun;72 ( Pt 6):1269-77.


Production and characterization of a fragment containing the HIV-gp120 binding region of CD4 using a bovine papilloma virus (BPV) vector.

Gidlund M, Sydow M, Stenbeck A, Flodby P, Fossum H, Matsuda S, Lundin K, Wigzell H, Lind P.

Arch Virol. 1990;113(3-4):209-19.


Cystein 402 of HIV gp 120 is essential for CD4-binding and resistance of gp 120 to intracellular degradation.

Hemming A, Bolmstedt A, Flodby P, Lundberg L, Gidlund M, Wigzell H, Olofsson S.

Arch Virol. 1989;109(3-4):269-76.


Coexpression of human immunodeficiency virus envelope proteins and tat from a single simian virus 40 late replacement vector.

Rekosh D, Nygren A, Flodby P, Hammarskjöld ML, Wigzell H.

Proc Natl Acad Sci U S A. 1988 Jan;85(2):334-8.

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