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Items: 1 to 50 of 198

1.

Early auto-immune targeting of photoreceptor ribbon synapses in mouse models of multiple sclerosis.

Dembla M, Kesharwani A, Natarajan S, Fecher-Trost C, Fairless R, Williams SK, Flockerzi V, Diem R, Schwarz K, Schmitz F.

EMBO Mol Med. 2018 Sep 28. pii: e8926. doi: 10.15252/emmm.201808926. [Epub ahead of print]

2.

Aberrant Deactivation-Induced Gain of Function in TRPM4 Mutant Is Associated with Human Cardiac Conduction Block.

Xian W, Hui X, Tian Q, Wang H, Moretti A, Laugwitz KL, Flockerzi V, Ruppenthal S, Lipp P.

Cell Rep. 2018 Jul 17;24(3):724-731. doi: 10.1016/j.celrep.2018.06.034.

3.

Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels.

Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E, Chen XZ.

Nat Commun. 2018 Jun 13;9(1):2302. doi: 10.1038/s41467-018-04586-x.

4.

Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2.

Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ.

Cell Rep. 2018 Feb 6;22(6):1560-1573. doi: 10.1016/j.celrep.2018.01.042.

5.

IP3 Receptor-Dependent Cytoplasmic Ca2+ Signals Are Tightly Controlled by Cavβ3.

Belkacemi A, Hui X, Wardas B, Laschke MW, Wissenbach U, Menger MD, Lipp P, Beck A, Flockerzi V.

Cell Rep. 2018 Jan 30;22(5):1339-1349. doi: 10.1016/j.celrep.2018.01.010.

6.

Cytotoxic granule endocytosis depends on the Flower protein.

Chang HF, Mannebach S, Beck A, Ravichandran K, Krause E, Frohnweiler K, Fecher-Trost C, Schirra C, Pattu V, Flockerzi V, Rettig J.

J Cell Biol. 2018 Feb 5;217(2):667-683. doi: 10.1083/jcb.201706053. Epub 2017 Dec 29.

7.

Cell calcium special issue: Preface.

Gudermann T, Flockerzi V.

Cell Calcium. 2017 Nov;67:21. doi: 10.1016/j.ceca.2017.08.001. Epub 2017 Aug 2. No abstract available.

PMID:
29029786
8.

Identification and characterization of hydrophobic gate residues in TRP channels.

Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J, Light P, Flockerzi V, Cao Y, Chen XZ.

FASEB J. 2018 Feb;32(2):639-653. doi: 10.1096/fj.201700599RR. Epub 2018 Jan 4.

PMID:
28970257
9.

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.

EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8.

10.

TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.

Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A.

Glia. 2017 Sep;65(9):1535-1549. doi: 10.1002/glia.23180. Epub 2017 Jun 21.

11.

Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells.

Wei WC, Huang WC, Lin YP, Becker EBE, Ansorge O, Flockerzi V, Conti D, Cenacchi G, Glitsch MD.

J Physiol. 2017 Aug 15;595(16):5525-5544. doi: 10.1113/JP274659. Epub 2017 Jul 20.

12.

Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples.

Richter LHJ, Flockerzi V, Maurer HH, Meyer MR.

J Pharm Biomed Anal. 2017 Sep 5;143:32-42. doi: 10.1016/j.jpba.2017.05.028. Epub 2017 May 18.

PMID:
28601767
13.

Genetic strategies to analyze primary TRP channel-expressing cells in mice.

Wyatt A, Wartenberg P, Candlish M, Krasteva-Christ G, Flockerzi V, Boehm U.

Cell Calcium. 2017 Nov;67:91-104. doi: 10.1016/j.ceca.2017.05.009. Epub 2017 May 17. Review.

PMID:
28571899
14.

The stoichiometry of the TMEM16A ion channel determined in intact plasma membranes of COS-7 cells using liquid-phase electron microscopy.

Peckys DB, Stoerger C, Latta L, Wissenbach U, Flockerzi V, de Jonge N.

J Struct Biol. 2017 Aug;199(2):102-113. doi: 10.1016/j.jsb.2017.05.009. Epub 2017 May 27.

PMID:
28559167
15.

The S4---S5 linker - gearbox of TRP channel gating.

Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V.

Cell Calcium. 2017 Nov;67:156-165. doi: 10.1016/j.ceca.2017.04.002. Epub 2017 Apr 4. Review.

PMID:
28416203
16.

Antihypertensive medications and the risk of kidney stones in older adults: a retrospective cohort study.

Alexander RT, McArthur E, Jandoc R, Welk B, Hayward JS, Jain AK, Braam B, Flockerzi V, Garg AX, Quinn RR.

Hypertens Res. 2017 Sep;40(9):837-842. doi: 10.1038/hr.2017.42. Epub 2017 Mar 23.

PMID:
28331214
17.

Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes.

Beck A, Götz V, Qiao S, Weissgerber P, Flockerzi V, Freichel M, Boehm U.

Endocrinology. 2017 Apr 1;158(4):887-902. doi: 10.1210/en.2016-1810.

PMID:
28324107
18.

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.

Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, Kaufmann U, Karoly Jani P, Lacruz RS, Flockerzi V, Kacskovics I, Prakriya M, Feske S.

Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714.

19.

Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.

Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, Dascal N.

J Physiol. 2017 May 15;595(10):3181-3202. doi: 10.1113/JP274015. Epub 2017 Mar 23.

20.

Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.

Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):318-328. doi: 10.1167/iovs.16-20419.

PMID:
28114593
21.

A conserved gating element in TRPV6 channels.

Hofmann L, Wang H, Beck A, Wissenbach U, Flockerzi V.

Cell Calcium. 2017 May;63:24-28. doi: 10.1016/j.ceca.2016.10.003. Epub 2016 Oct 28.

PMID:
28029385
22.

Identification of Sidt2 as a lysosomal cation-conducting protein.

Beck A, Fecher-Trost C, Wolske K, Philipp SE, Flockerzi V, Wissenbach U.

FEBS Lett. 2017 Jan;591(1):76-87. doi: 10.1002/1873-3468.12528. Epub 2017 Jan 2.

23.

Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.

Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AÖ, Gudermann T, Königshoff M, Dietrich A.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):560-568. doi: 10.1016/j.bbadis.2016.12.002. Epub 2016 Dec 6.

24.

Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.

Chrétien C, Fenech C, Liénard F, Grall S, Chevalier C, Chaudy S, Brenachot X, Berges R, Louche K, Stark R, Nédélec E, Laderrière A, Andrews ZB, Benani A, Flockerzi V, Gascuel J, Hartmann J, Moro C, Birnbaumer L, Leloup C, Pénicaud L, Fioramonti X.

Diabetes. 2017 Feb;66(2):314-324. doi: 10.2337/db16-1114. Epub 2016 Nov 29.

25.

α2δ2 Controls the Function and Trans-Synaptic Coupling of Cav1.3 Channels in Mouse Inner Hair Cells and Is Essential for Normal Hearing.

Fell B, Eckrich S, Blum K, Eckrich T, Hecker D, Obermair GJ, Münkner S, Flockerzi V, Schick B, Engel J.

J Neurosci. 2016 Oct 26;36(43):11024-11036.

26.

Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation.

Zheng W, Yang J, Beauchamp E, Cai R, Hussein S, Hofmann L, Li Q, Flockerzi V, Berthiaume LG, Tang J, Chen XZ.

J Biol Chem. 2016 Dec 2;291(49):25678-25691. Epub 2016 Oct 17.

27.

Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.

Thakur DP, Tian JB, Jeon J, Xiong J, Huang Y, Flockerzi V, Zhu MX.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1092-7. doi: 10.1073/pnas.1522294113. Epub 2016 Jan 11.

28.

Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis.

Jha A, Singh AK, Weissgerber P, Freichel M, Flockerzi V, Flavell RA, Jha MK.

Sci Signal. 2015 Oct 20;8(399):ra103. doi: 10.1126/scisignal.aac7538.

PMID:
26486172
29.

A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.

Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M, Lipp P.

Eur Heart J. 2015 Sep 1;36(33):2257-66. doi: 10.1093/eurheartj/ehv250. Epub 2015 Jun 11.

30.

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.

Kecskés M, Jacobs G, Kerselaers S, Syam N, Menigoz A, Vangheluwe P, Freichel M, Flockerzi V, Voets T, Vennekens R.

Basic Res Cardiol. 2015;110(4):43. doi: 10.1007/s00395-015-0501-x. Epub 2015 Jun 5.

31.

Emerging Alternative Functions for the Auxiliary Subunits of the Voltage-Gated Calcium Channels.

Hofmann F, Belkacemi A, Flockerzi V.

Curr Mol Pharmacol. 2015;8(2):162-8. Review.

PMID:
25966689
32.

A Binary Genetic Approach to Characterize TRPM5 Cells in Mice.

Kusumakshi S, Voigt A, Hübner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dörr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U.

Chem Senses. 2015 Jul;40(6):413-25. doi: 10.1093/chemse/bjv023. Epub 2015 May 4.

PMID:
25940069
33.

Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses.

Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2312-24. doi: 10.1167/iovs.15-16654.

PMID:
25766584
34.

Protonophore properties of hyperforin are essential for its pharmacological activity.

Sell TS, Belkacemi T, Flockerzi V, Beck A.

Sci Rep. 2014 Dec 16;4:7500. doi: 10.1038/srep07500.

35.

The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins.

Stoerger C, Flockerzi V.

Biochem Cell Biol. 2014 Dec;92(6):441-8. doi: 10.1139/bcb-2014-0063. Epub 2014 Aug 26. Review.

PMID:
25372600
36.

Mammalian transient receptor potential (TRP) cation channels. Preface.

Nilius B, Flockerzi V.

Handb Exp Pharmacol. 2014;223:v - vi. No abstract available.

PMID:
25296415
37.

What do we really know and what do we need to know: some controversies, perspectives, and surprises.

Nilius B, Flockerzi V.

Handb Exp Pharmacol. 2014;223:1239-80. doi: 10.1007/978-3-319-05161-1_20. Review.

PMID:
24961986
38.

TRPs: truly remarkable proteins.

Flockerzi V, Nilius B.

Handb Exp Pharmacol. 2014;222:1-12. doi: 10.1007/978-3-642-54215-2_1.

PMID:
24756700
39.

Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein.

Zimmermann J, Latta L, Beck A, Leidinger P, Fecher-Trost C, Schlenstedt G, Meese E, Wissenbach U, Flockerzi V.

J Biol Chem. 2014 Apr 4;289(14):9766-80. doi: 10.1074/jbc.M114.557066. Epub 2014 Feb 21.

40.

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

Etemad S, Obermair GJ, Bindreither D, Benedetti A, Stanika R, Di Biase V, Burtscher V, Koschak A, Kofler R, Geley S, Wille A, Lusser A, Flockerzi V, Flucher BE.

J Neurosci. 2014 Jan 22;34(4):1446-61. doi: 10.1523/JNEUROSCI.3935-13.2014.

41.

L-type CaV1.2 calcium channels: from in vitro findings to in vivo function.

Hofmann F, Flockerzi V, Kahl S, Wegener JW.

Physiol Rev. 2014 Jan;94(1):303-26. doi: 10.1152/physrev.00016.2013. Review.

42.

Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ahlbrecht K, Fecher-Trost C, Flockerzi V, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Dietrich A, Weissmann N.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9. doi: 10.1164/rccm.201307-1252OC.

PMID:
24251695
43.

Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice.

Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londoño JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R.

Circ Res. 2014 Jan 17;114(2):283-94. doi: 10.1161/CIRCRESAHA.114.302835. Epub 2013 Nov 13.

PMID:
24226423
44.

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels.

Tian J, Thakur DP, Lu Y, Zhu Y, Freichel M, Flockerzi V, Zhu MX.

Pflugers Arch. 2014 Jul;466(7):1301-16.

45.

The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone.

Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, Hofmann F, Wegener JW.

Cardiovasc Res. 2013 Nov 1;100(2):280-7. doi: 10.1093/cvr/cvt176. Epub 2013 Jul 4.

46.

Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.

PMID:
23800468
47.

Conserved gating elements in TRPC4 and TRPC5 channels.

Beck A, Speicher T, Stoerger C, Sell T, Dettmer V, Jusoh SA, Abdulmughni A, Cavalié A, Philipp SE, Zhu MX, Helms V, Wissenbach U, Flockerzi V.

J Biol Chem. 2013 Jul 5;288(27):19471-83. doi: 10.1074/jbc.M113.478305. Epub 2013 May 15.

48.

The in vivo TRPV6 protein starts at a non-AUG triplet, decoded as methionine, upstream of canonical initiation at AUG.

Fecher-Trost C, Wissenbach U, Beck A, Schalkowsky P, Stoerger C, Doerr J, Dembek A, Simon-Thomas M, Weber A, Wollenberg P, Ruppert T, Middendorff R, Maurer HH, Flockerzi V.

J Biol Chem. 2013 Jun 7;288(23):16629-44. doi: 10.1074/jbc.M113.469726. Epub 2013 Apr 23.

49.

Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.

Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F.

Mol Pharmacol. 2013 Feb;83(2):429-38. doi: 10.1124/mol.112.082271. Epub 2012 Nov 27.

50.

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.

Nat Med. 2012 Dec;18(12):1805-11. doi: 10.1038/nm.3015. Epub 2012 Nov 18.

PMID:
23160238

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