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Items: 42

1.

Functional analysis of altered reduced folate carrier sequence changes identified in osteosarcomas.

Flintoff WF, Sadlish H, Gorlick R, Yang R, Williams FM.

Biochim Biophys Acta. 2004 Oct 14;1690(2):110-7.

2.

The region between transmembrane domains 1 and 2 of the reduced folate carrier forms part of the substrate-binding pocket.

Flintoff WF, Williams FM, Sadlish H.

J Biol Chem. 2003 Oct 17;278(42):40867-76. Epub 2003 Aug 8. Erratum in: J Biol Chem. 2004 Jan 16;279(3):2332.

3.

A single point mutation in Drosophila dihydrofolate reductase confers methotrexate resistance to a transgenic CHO cell line.

Neumann K, Al-Batayneh KM, Kuiper MJ, Parsons-Sheldrake J, Tyshenko MG, Flintoff WF, Cole SP, Walker VK.

Genome. 2003 Aug;46(4):707-15.

PMID:
12897877
4.

Functional role of arginine 373 in substrate translocation by the reduced folate carrier.

Sadlish H, Williams FM, Flintoff WF.

J Biol Chem. 2002 Nov 1;277(44):42105-12. Epub 2002 Aug 22.

5.

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function.

Sadlish H, Williams FM, Flintoff WF.

Biochem J. 2002 Jun 15;364(Pt 3):777-86.

6.

Mutations in the reduced-folate carrier affect protein localization and stability.

Sadlish H, Murray RC, Williams FM, Flintoff WF.

Biochem J. 2000 Mar 1;346 Pt 2:509-18.

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Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression.

Gorlick R, Goker E, Trippett T, Steinherz P, Elisseyeff Y, Mazumdar M, Flintoff WF, Bertino JR.

Blood. 1997 Feb 1;89(3):1013-8.

PMID:
9028333
10.

Structural organization of the reduced folate carrier gene in Chinese hamster ovary cells.

Murray RC, Williams FM, Flintoff WF.

J Biol Chem. 1996 Aug 9;271(32):19174-9.

11.
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Chromosomal localization of the reduced folate transporter gene (SLC19A1) in Chinese hamster ovary cells.

Chan FP, Williams FM, Rogers KA, Flintoff WF.

Cytogenet Cell Genet. 1995;71(2):148-50. No abstract available.

PMID:
7656585
13.

Isolation of a hamster cDNA clone coding for a function involved in methotrexate uptake.

Williams FM, Murray RC, Underhill TM, Flintoff WF.

J Biol Chem. 1994 Feb 25;269(8):5810-6.

14.

No evidence for linkage to the type 1 or type 2 neurofibromatosis loci in Noonan syndrome families.

Flintoff WF, Bahuau M, Lyonnet S, Gilgenkrantz S, Lacombe D, Marçon F, Levilliers J, Kachaner J, Munnich A, Le Merrer M.

Am J Med Genet. 1993 Jul 1;46(6):700-5.

PMID:
8362913
15.

Molecular cloning of a gene involved in methotrexate uptake by DNA-mediated gene transfer.

Underhill TM, Williams FM, Murray RC, Flintoff WF.

Somat Cell Mol Genet. 1992 Jul;18(4):337-49.

PMID:
1440056
16.

DXS165 detects a translocation breakpoint in a woman with choroideremia and a de novo X; 13 translocation.

Merry DE, Lesko JG, Siu V, Flintoff WF, Collins F, Lewis RA, Nussbaum RL.

Genomics. 1990 Apr;6(4):609-15.

17.

Choroideremia associated with an X-autosomal translocation.

Siu VM, Gonder JR, Jung JH, Sergovich FR, Flintoff WF.

Hum Genet. 1990 Apr;84(5):459-64.

PMID:
2323779
18.

Chromosomal jumping from the DXS165 locus allows molecular characterization of four microdeletions and a de novo chromosome X/13 translocation associated with choroideremia.

Cremers FP, van de Pol DJ, Wieringa B, Collins FS, Sankila EM, Siu VM, Flintoff WF, Brunsmann F, Blonden LA, Ropers HH.

Proc Natl Acad Sci U S A. 1989 Oct;86(19):7510-4.

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24.

Rat glial C6 cells are defective in murine coronavirus internalization.

Van Dinter S, Flintoff WF.

J Gen Virol. 1987 Jun;68 ( Pt 6):1677-85.

PMID:
3035065
25.

A cell line defective in murine coronavirus internalization.

Flintoff WF, Van Dinter S.

Adv Exp Med Biol. 1987;218:271-2. No abstract available.

PMID:
2829538
28.

Characterization and chromosomal location of endogenous mouse mammary tumor virus loci in GR, NFS, and DBA mice.

MacInnes JI, Morris VL, Flintoff WF, Kozak CA.

Virology. 1984 Jan 15;132(1):12-25.

PMID:
6320529
31.
32.

Overproduction of dihydrofolate reductase and gene amplification in methotrexate-resistant Chinese hamster ovary cells.

Flintoff WF, Weber MK, Nagainis CR, Essani AK, Robertson D, Salser W.

Mol Cell Biol. 1982 Mar;2(3):275-85.

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In vivo and in vitro models of demyelinating diseases. IV. Isolation of Hallé measles virus-specific RNA from BGMK cells and preparation of complementary DNA.

Coulter-Mackie MB, Bradbury WC, Dales S, Flintoff WF, Morris VL.

Virology. 1980 Apr 30;102(2):327-38. No abstract available.

PMID:
6768187
36.

Isolation of mutant mammalian cells altered in polyamine transport.

Mandel JL, Flintoff WF.

J Cell Physiol. 1978 Dec;97(3 Pt 1):335-43.

PMID:
730773
37.
38.

Genetic characterization of methotrexate-resistant chinese hamster ovary cells.

Flintoff WF, Spindler SM, Siminovitch L.

In Vitro. 1976 Nov;12(11):749-57.

PMID:
1035580
39.

Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells.

Flintoff WF, Davidson SV, Siminovitch L.

Somatic Cell Genet. 1976 May;2(3):245-61.

PMID:
1028172
40.
41.

Enzymatic synthesis of deoxyribonucleic acids with repeating sequences. A new repeating trinucleotide deoxyribonucleic acid, d(T-C-C)n-d(G-G-A)n.

Morgan AR, Coulter MB, Flintoff WF, Paetkau VH.

Biochemistry. 1974 Apr 9;13(8):1596-603. No abstract available.

PMID:
4364707
42.

Thymine-guanine base pairing during transcription of polydeoxypyrimidines in vitro.

Paetkau V, Coulter MB, Flintoff WF, Morgan AR.

J Mol Biol. 1972 Nov 14;71(2):293-306. No abstract available.

PMID:
4564482

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