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Items: 34


PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.

Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, Alawa J, López-Giráldez F, Gaule P, Lee SW, Zhang JP, Nie X, Nassar A, Boto A, Flies DB, Zheng L, Kim TK, Moeckel GW, McNiff JM, Chen L.

Sci Transl Med. 2019 Dec 11;11(522). pii: eaax1159. doi: 10.1126/scitranslmed.aax1159.


Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy.

Wang J, Sun J, Liu LN, Flies DB, Nie X, Toki M, Zhang J, Song C, Zarr M, Zhou X, Han X, Archer KA, O'Neill T, Herbst RS, Boto AN, Sanmamed MF, Langermann S, Rimm DL, Chen L.

Nat Med. 2019 Apr;25(4):656-666. doi: 10.1038/s41591-019-0374-x. Epub 2019 Mar 4.


Programmed death one homolog maintains the pool size of regulatory T cells by promoting their differentiation and stability.

Wang Q, He J, Flies DB, Luo L, Chen L.

Sci Rep. 2017 Jul 20;7(1):6086. doi: 10.1038/s41598-017-06410-w.


Immune checkpoint blockade reveals the stimulatory capacity of tumor-associated CD103(+) dendritic cells in late-stage ovarian cancer.

Flies DB, Higuchi T, Harris JC, Jha V, Gimotty PA, Adams SF.

Oncoimmunology. 2016 May 13;5(8):e1185583. doi: 10.1080/2162402X.2016.1185583. eCollection 2016 Aug.


CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.

Higuchi T, Flies DB, Marjon NA, Mantia-Smaldone G, Ronner L, Gimotty PA, Adams SF.

Cancer Immunol Res. 2015 Nov;3(11):1257-68. doi: 10.1158/2326-6066.CIR-15-0044. Epub 2015 Jul 2.


Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.

Flies DB, Higuchi T, Chen L.

J Immunol. 2015 Jun 1;194(11):5294-304. doi: 10.4049/jimmunol.1402648. Epub 2015 Apr 27.


Coinhibitory receptor PD-1H preferentially suppresses CD4⁺ T cell-mediated immunity.

Flies DB, Han X, Higuchi T, Zheng L, Sun J, Ye JJ, Chen L.

J Clin Invest. 2014 May;124(5):1966-75. doi: 10.1172/JCI74589. Epub 2014 Apr 17.


Molecular mechanisms of T cell co-stimulation and co-inhibition.

Chen L, Flies DB.

Nat Rev Immunol. 2013 Apr;13(4):227-42. doi: 10.1038/nri3405. Epub 2013 Mar 8. Review. Erratum in: Nat Rev Immunol. 2013 Jul;13(7):542.


Strain-specific induction of experimental autoimmune prostatitis (EAP) in mice.

Jackson CM, Flies DB, Mosse CA, Parwani A, Hipkiss EL, Drake CG.

Prostate. 2013 May;73(6):651-6. doi: 10.1002/pros.22606. Epub 2012 Nov 5.


Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.

Flies DB, Sandler BJ, Sznol M, Chen L.

Yale J Biol Med. 2011 Dec;84(4):409-21. Review.


Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.

Flies DB, Wang S, Xu H, Chen L.

J Immunol. 2011 Aug 15;187(4):1537-41. doi: 10.4049/jimmunol.1100660. Epub 2011 Jul 18.


Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

Nguyen LT, Ciric B, Van Keulen VP, Rodriguez M, Pease LR, Tamada K, Flies DB, Chen L.

Cancer Res. 2010 Nov 15;70(22):9528. doi: 10.1158/0008-5472.CAN-10-3461. Epub 2010 Nov 2. No abstract available.


The new B7s: playing a pivotal role in tumor immunity.

Flies DB, Chen L.

J Immunother. 2007 Apr;30(3):251-60. Review.


Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.

Xu Y, Flies AS, Flies DB, Zhu G, Anand S, Flies SJ, Xu H, Anders RA, Hancock WW, Chen L, Tamada K.

Blood. 2007 May 1;109(9):4097-104. Epub 2006 Dec 19.


Modulation of immune response by B7 family molecules in tumor microenvironments.

Flies DB, Chen L.

Immunol Invest. 2006;35(3-4):395-418. Review.


Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.

Anand S, Wang P, Yoshimura K, Choi IH, Hilliard A, Chen YH, Wang CR, Schulick R, Flies AS, Flies DB, Zhu G, Xu Y, Pardoll DM, Chen L, Tamada K.

J Clin Invest. 2006 Apr;116(4):1045-51. Epub 2006 Mar 23.


Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen.

Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, Hipkiss EL, Flies DB, Kennedy EP, Long M, McGary PW, Coryell L, Nelson WG, Pardoll DM, Adler AJ.

Cancer Cell. 2005 Mar;7(3):239-49.


Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.

Hirano F, Kaneko K, Tamura H, Dong H, Wang S, Ichikawa M, Rietz C, Flies DB, Lau JS, Zhu G, Tamada K, Chen L.

Cancer Res. 2005 Feb 1;65(3):1089-96.


B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.

Luo L, Chapoval AI, Flies DB, Zhu G, Hirano F, Wang S, Lau JS, Dong H, Tamada K, Flies AS, Liu Y, Chen L.

J Immunol. 2004 Nov 1;173(9):5445-50.


B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.

Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L.

Immunity. 2004 Mar;20(3):327-36.


Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.

Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L.

J Immunol. 2003 Nov 1;171(9):4650-4.


B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L.

Cancer Res. 2003 Oct 1;63(19):6501-5.


Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.

Wilcox RA, Tamada K, Flies DB, Zhu G, Chapoval AI, Blazar BR, Kast WM, Chen L.

Blood. 2004 Jan 1;103(1):177-84. Epub 2003 Sep 11.


B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.

Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L.

Immunity. 2003 Jun;18(6):849-61.


A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.

Flies DB, Chen L.

J Immunol Methods. 2003 May 1;276(1-2):239-42.


Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.

Wang S, Bajorath J, Flies DB, Dong H, Honjo T, Chen L.

J Exp Med. 2003 May 5;197(9):1083-91. Epub 2003 Apr 28.


Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.

Dong H, Strome SE, Matteson EL, Moder KG, Flies DB, Zhu G, Tamura H, Driscoll CL, Chen L.

J Clin Invest. 2003 Feb;111(3):363-70.


Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.

Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L.

Nat Med. 2002 Aug;8(8):793-800. Epub 2002 Jun 24. Erratum in: Nat Med 2002 Sep;8(9):1039.


Cutting edge: Expression of functional CD137 receptor by dendritic cells.

Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L.

J Immunol. 2002 May 1;168(9):4262-7.


Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.

Wilcox RA, Flies DB, Zhu G, Johnson AJ, Tamada K, Chapoval AI, Strome SE, Pease LR, Chen L.

J Clin Invest. 2002 Mar;109(5):651-9.


Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.

Zhu G, Flies DB, Tamada K, Sun Y, Rodriguez M, Fu YX, Chen L.

J Immunol. 2001 Sep 1;167(5):2671-6.


B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.

Tamura H, Dong H, Zhu G, Sica GL, Flies DB, Tamada K, Chen L.

Blood. 2001 Mar 15;97(6):1809-16.


B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.

Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, Dong H, Sica GL, Zhu G, Tamada K, Chen L.

Nat Immunol. 2001 Mar;2(3):269-74.


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