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C. Ronald Kahn: The Louisville Slugger of metabolic science.

Flier JS.

J Clin Invest. 2019 Dec 2;129(12):5066-5070. doi: 10.1172/JCI133156. No abstract available.


Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis.

Watanabe M, Singhal G, Fisher FM, Beck TC, Morgan DA, Socciarelli F, Mather ML, Risi R, Bourke J, Rahmouni K, McGuinness OP, Flier JS, Maratos-Flier E.

Endocrine. 2020 Jan;67(1):95-108. doi: 10.1007/s12020-019-02124-3. Epub 2019 Nov 14.


Credit and Priority in Scientific Discovery: A Scientist's Perspective.

Flier JS.

Perspect Biol Med. 2019;62(2):189-215. doi: 10.1353/pbm.2019.0010.


Academia and industry: allocating credit for discovery and development of new therapies.

Flier JS.

J Clin Invest. 2019 May 20;129(6):2172-2174. doi: 10.1172/JCI129122. eCollection 2019 May 20. No abstract available.


Starvation in the Midst of Plenty: Reflections on the History and Biology of Insulin and Leptin.

Flier JS.

Endocr Rev. 2019 Feb 1;40(1):1-16. doi: 10.1210/er.2018-00179. Review.


Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet.

Singhal G, Kumar G, Chan S, Fisher FM, Ma Y, Vardeh HG, Nasser IA, Flier JS, Maratos-Flier E.

Mol Metab. 2018 Jul;13:56-66. doi: 10.1016/j.molmet.2018.03.002. Epub 2018 Mar 8.


Dealing with Consequences of Irreproducibility and Modifying the Published Literature: Retractions versus Revisions.

Glass DJ, Flier JS.

Cell Metab. 2017 Nov 7;26(5):695-696. doi: 10.1016/j.cmet.2017.10.010.


Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.

Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E.

Mol Metab. 2017 Nov;6(11):1395-1406. doi: 10.1016/j.molmet.2017.08.004. Epub 2017 Aug 19.


Categorizing biomedical research: the basics of translation.

Flier JS, Loscalzo J.

FASEB J. 2017 Aug;31(8):3210-3215. doi: 10.1096/fj.201700303R. Review.


Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice.

Douris N, Desai BN, Fisher FM, Cisu T, Fowler AJ, Zarebidaki E, Nguyen NLT, Morgan DA, Bartness TJ, Rahmouni K, Flier JS, Maratos-Flier E.

Mol Metab. 2017 Jun 6;6(8):854-862. doi: 10.1016/j.molmet.2017.05.017. eCollection 2017 Aug.


Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?

Flier JS, Maratos-Flier E.

Cell Metab. 2017 Jul 5;26(1):24-26. doi: 10.1016/j.cmet.2017.05.013. Epub 2017 Jun 22.


Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach.

Flier JS.

JAMA. 2017 May 2;317(17):1731-1732. doi: 10.1001/jama.2017.1751. No abstract available.


Irreproducibility of published bioscience research: Diagnosis, pathogenesis and therapy.

Flier JS.

Mol Metab. 2016 Nov 21;6(1):2-9. doi: 10.1016/j.molmet.2016.11.006. eCollection 2017 Jan. No abstract available.


Fibroblast growth factor 21 has no direct role in regulating fertility in female mice.

Singhal G, Douris N, Fish AJ, Zhang X, Adams AC, Flier JS, Pissios P, Maratos-Flier E.

Mol Metab. 2016 May 18;5(8):690-698. doi: 10.1016/j.molmet.2016.05.010. eCollection 2016 Aug.


Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas.

Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E.

PLoS One. 2016 Feb 12;11(2):e0148252. doi: 10.1371/journal.pone.0148252. eCollection 2016.


Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet.

Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E.

Biochim Biophys Acta. 2015 Oct;1852(10 Pt A):2056-65. doi: 10.1016/j.bbadis.2015.07.009. Epub 2015 Jul 11.


Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice.

Douris N, Stevanovic DM, Fisher FM, Cisu TI, Chee MJ, Nguyen NL, Zarebidaki E, Adams AC, Kharitonenkov A, Flier JS, Bartness TJ, Maratos-Flier E.

Endocrinology. 2015 Jul;156(7):2470-81. doi: 10.1210/en.2014-2001. Epub 2015 Apr 29.


Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets.

Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E.

Gastroenterology. 2014 Nov;147(5):1073-83.e6. doi: 10.1053/j.gastro.2014.07.044. Epub 2014 Jul 30.


Adipsin is an adipokine that improves β cell function in diabetes.

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM.

Cell. 2014 Jul 3;158(1):41-53. doi: 10.1016/j.cell.2014.06.005.


Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo.

Domouzoglou EM, Fisher FM, Astapova I, Fox EC, Kharitonenkov A, Flier JS, Hollenberg AN, Maratos-Flier E.

Endocrinology. 2014 May;155(5):2031-40. doi: 10.1210/en.2013-1902. Epub 2014 Feb 24.


α-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors.

Robins SC, Stewart I, McNay DE, Taylor V, Giachino C, Goetz M, Ninkovic J, Briancon N, Maratos-Flier E, Flier JS, Kokoeva MV, Placzek M.

Nat Commun. 2013;4:2049. doi: 10.1038/ncomms3049.


Creating a Nobel culture.

Flier JS.

Science. 2013 Jan 11;339(6116):140-1. doi: 10.1126/science.339.6116.140. No abstract available.


Hormone resistance in diabetes and obesity: insulin, leptin, and FGF21.

Flier JS.

Yale J Biol Med. 2012 Sep;85(3):405-14. Epub 2012 Sep 25.


FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis.

Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM.

Genes Dev. 2012 Feb 1;26(3):271-81. doi: 10.1101/gad.177857.111.


Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice.

McNay DE, Briançon N, Kokoeva MV, Maratos-Flier E, Flier JS.

J Clin Invest. 2012 Jan;122(1):142-52. doi: 10.1172/JCI43134. Epub 2011 Dec 27.


Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice.

Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD.

Science. 2011 Nov 25;334(6059):1133-7. doi: 10.1126/science.1209870.


Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.

Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E.

Endocrinology. 2011 Aug;152(8):2996-3004. doi: 10.1210/en.2011-0281. Epub 2011 Jun 28.


Polymerase I and transcript release factor regulates lipolysis via a phosphorylation-dependent mechanism.

Aboulaich N, Chui PC, Asara JM, Flier JS, Maratos-Flier E.

Diabetes. 2011 Mar;60(3):757-65. doi: 10.2337/db10-0744. Epub 2011 Jan 31.


Lasker lauds leptin.

Flier JS, Maratos-Flier E.

Cell Metab. 2010 Oct 6;12(4):317-320. doi: 10.1016/j.cmet.2010.09.008.


Lasker lauds leptin.

Flier JS, Maratos-Flier E.

Cell. 2010 Oct 1;143(1):9-12. doi: 10.1016/j.cell.2010.09.021.


Obesity is a fibroblast growth factor 21 (FGF21)-resistant state.

Fisher FM, Chui PC, Antonellis PJ, Bina HA, Kharitonenkov A, Flier JS, Maratos-Flier E.

Diabetes. 2010 Nov;59(11):2781-9. doi: 10.2337/db10-0193. Epub 2010 Aug 3.


Gut check: testing a role for the intestinal microbiome in human obesity.

Flier JS, Mekalanos JJ.

Sci Transl Med. 2009 Nov 11;1(6):6ps7. doi: 10.1126/scitranslmed.3000483.


Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner.

Adams AC, Astapova I, Fisher FM, Badman MK, Kurgansky KE, Flier JS, Hollenberg AN, Maratos-Flier E.

J Biol Chem. 2010 May 7;285(19):14078-82. doi: 10.1074/jbc.C110.107375. Epub 2010 Mar 17.


Health care reform: without a correct diagnosis, there is no cure.

Flier JS.

J Clin Invest. 2009 Oct;119(10):2850-2. No abstract available.


Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine.

Nesse RM, Bergstrom CT, Ellison PT, Flier JS, Gluckman P, Govindaraju DR, Niethammer D, Omenn GS, Perlman RL, Schwartz MD, Thomas MG, Stearns SC, Valle D.

Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1800-7. doi: 10.1073/pnas.0906224106. Epub 2009 Nov 16.


Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis.

Badman MK, Koester A, Flier JS, Kharitonenkov A, Maratos-Flier E.

Endocrinology. 2009 Nov;150(11):4931-40. doi: 10.1210/en.2009-0532. Epub 2009 Oct 9.


Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.

Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE.

J Biol Chem. 2009 Oct 30;284(44):30218-29. doi: 10.1074/jbc.M109.047787. Epub 2009 Aug 31.


Reduced adiposity and high-fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B.

Zhang R, Maratos-Flier E, Flier JS.

Endocrinology. 2009 Jul;150(7):3076-82. doi: 10.1210/en.2009-0108. Epub 2009 Apr 9.


Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice.

Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H Jr, Flier JS, Strom TB.

Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16242-7. doi: 10.1073/pnas.0808031105. Epub 2008 Oct 13.


Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. doi: 10.1210/en.2008-0805. Epub 2008 Jul 31.


Evidence for constitutive neural cell proliferation in the adult murine hypothalamus.

Kokoeva MV, Yin H, Flier JS.

J Comp Neurol. 2007 Nov 10;505(2):209-20.


PPARgamma regulates adipose triglyceride lipase in adipocytes in vitro and in vivo.

Kershaw EE, Schupp M, Guan HP, Gardner NP, Lazar MA, Flier JS.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1736-45. Epub 2007 Sep 11.


What fuels fat.

Flier JS, Maratos-Flier E.

Sci Am. 2007 Sep;297(3):72-81. No abstract available.


Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.

Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H Jr, Zheng XX, Strom TB.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13074-9. Epub 2007 Aug 1.


Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.

Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E.

Cell Metab. 2007 Jun;5(6):426-37.


The adipocyte as an active participant in energy balance and metabolism.

Badman MK, Flier JS.

Gastroenterology. 2007 May;132(6):2103-15. Review.


Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS.

Diabetes. 2007 Sep;56(9):2242-50. Epub 2007 May 1.


Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity.

Cheung KJ, Tzameli I, Pissios P, Rovira I, Gavrilova O, Ohtsubo T, Chen Z, Finkel T, Flier JS, Friedman JM.

Cell Metab. 2007 Feb;5(2):115-28.


TLR4 links innate immunity and fatty acid-induced insulin resistance.

Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS.

J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.

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