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Items: 31


P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP.

Johnsen B, Kaschubowski KE, Nader S, Schneider E, Nicola JA, Fliegert R, Wolf IMA, Guse AH, Nikolaev VO, Koch-Nolte F, Haag F.

Purinergic Signal. 2019 Jun;15(2):155-166. doi: 10.1007/s11302-019-09654-5. Epub 2019 Apr 23.


Synthesis of Terminal Ribose Analogues of Adenosine 5'-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2.

Baszczyňski O, Watt JM, Rozewitz MD, Guse AH, Fliegert R, Potter BVL.

J Org Chem. 2019 May 17;84(10):6143-6157. doi: 10.1021/acs.joc.9b00338. Epub 2019 May 7.


Adenine nucleotides as paracrine mediators and intracellular second messengers in immunity and inflammation.

Fliegert R, Heeren J, Koch-Nolte F, Nikolaev VO, Lohr C, Meier C, Guse AH.

Biochem Soc Trans. 2019 Feb 28;47(1):329-337. doi: 10.1042/BST20180419. Epub 2019 Jan 23. Review.


Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2.

Gattkowski E, Johnsen A, Bauche A, Möckl F, Kulow F, Garcia Alai M, Rutherford TJ, Fliegert R, Tidow H.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1162-1170. doi: 10.1016/j.bbamcr.2018.12.010. Epub 2018 Dec 22.


NAD binding by human CD38 analyzed by Trp189 fluorescence.

Wolters V, Rosche A, Bauche A, Kulow F, Harneit A, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1189-1196. doi: 10.1016/j.bbamcr.2018.11.011. Epub 2018 Nov 22.


TRPM2 activation: Paradigm shifted?

Fliegert R, Hölzer HT, Guse AH.

Cell Calcium. 2018 Dec;76:132-134. doi: 10.1016/j.ceca.2018.11.001. Epub 2018 Nov 3.


Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.

Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F.

Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6.


2'-Deoxyadenosine 5'-diphosphoribose is an endogenous TRPM2 superagonist.

Fliegert R, Bauche A, Wolf Pérez AM, Watt JM, Rozewitz MD, Winzer R, Janus M, Gu F, Rosche A, Harneit A, Flato M, Moreau C, Kirchberger T, Wolters V, Potter BVL, Guse AH.

Nat Chem Biol. 2017 Sep;13(9):1036-1044. doi: 10.1038/nchembio.2415. Epub 2017 Jun 26.


Ligand-induced activation of human TRPM2 requires the terminal ribose of ADPR and involves Arg1433 and Tyr1349.

Fliegert R, Watt JM, Schöbel A, Rozewitz MD, Moreau C, Kirchberger T, Thomas MP, Sick W, Araujo AC, Harneit A, Potter BVL, Guse AH.

Biochem J. 2017 Jun 16;474(13):2159-2175. doi: 10.1042/BCJ20170091.


Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations.

Diercks BP, Fliegert R, Guse AH.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):977-986. doi: 10.1016/j.bbamcr.2016.11.026. Epub 2016 Nov 30.


Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor.

Wolf IM, Diercks BP, Gattkowski E, Czarniak F, Kempski J, Werner R, Schetelig D, Mittrücker HW, Schumacher V, von Osten M, Lodygin D, Flügel A, Fliegert R, Guse AH.

Sci Signal. 2015 Oct 13;8(398):ra102. doi: 10.1126/scisignal.aab0863.


NAD derived second messengers: Role in spontaneous diastolic Ca(2+) transients in murine cardiac myocytes.

Warszta D, Nebel M, Fliegert R, Guse AH.

DNA Repair (Amst). 2014 Nov;23:69-78. doi: 10.1016/j.dnarep.2014.05.007. Epub 2014 Jul 2.


Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists.

Moreau C, Kirchberger T, Swarbrick JM, Bartlett SJ, Fliegert R, Yorgan T, Bauche A, Harneit A, Guse AH, Potter BV.

J Med Chem. 2013 Dec 27;56(24):10079-102. doi: 10.1021/jm401497a. Epub 2013 Dec 13.


NAADP signaling revisited.

Guse AH, Ernst IM, Fliegert R.

Curr Top Med Chem. 2013;13(23):2978-90. Review.


A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties.

Schmeitz C, Hernandez-Vargas EA, Fliegert R, Guse AH, Meyer-Hermann M.

Front Immunol. 2013 Sep 18;4:277. doi: 10.3389/fimmu.2013.00277. eCollection 2013.


Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling.

Ernst IM, Fliegert R, Guse AH.

Front Immunol. 2013 Aug 29;4:259. doi: 10.3389/fimmu.2013.00259. eCollection 2013. Review.


Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

Nebel M, Schwoerer AP, Warszta D, Siebrands CC, Limbrock AC, Swarbrick JM, Fliegert R, Weber K, Bruhn S, Hohenegger M, Geisler A, Herich L, Schlegel S, Carrier L, Eschenhagen T, Potter BV, Ehmke H, Guse AH.

J Biol Chem. 2013 May 31;288(22):16017-30. doi: 10.1074/jbc.M112.441246. Epub 2013 Apr 5.


Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase.

Schmid F, Fliegert R, Westphal T, Bauche A, Guse AH.

J Biol Chem. 2012 Sep 21;287(39):32525-34. Epub 2012 Jul 31.


Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

Schwarz N, Drouot L, Nicke A, Fliegert R, Boyer O, Guse AH, Haag F, Adriouch S, Koch-Nolte F.

PLoS One. 2012;7(7):e41269. doi: 10.1371/journal.pone.0041269. Epub 2012 Jul 27.


Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope.

Nalaskowski MM, Fliegert R, Ernst O, Brehm MA, Fanick W, Windhorst S, Lin H, Giehler S, Hein J, Lin YN, Mayr GW.

J Biol Chem. 2011 Feb 11;286(6):4500-10. doi: 10.1074/jbc.M110.173062. Epub 2010 Dec 9.


Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities.

Windhorst S, Fliegert R, Blechner C, Möllmann K, Hosseini Z, Günther T, Eiben M, Chang L, Lin HY, Fanick W, Schumacher U, Brandt B, Mayr GW.

J Biol Chem. 2010 Feb 19;285(8):5541-54. doi: 10.1074/jbc.M109.047050. Epub 2009 Dec 17.


8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.

Kirchberger T, Moreau C, Wagner GK, Fliegert R, Siebrands CC, Nebel M, Schmid F, Harneit A, Odoardi F, Flügel A, Potter BV, Guse AH.

Biochem J. 2009 Jul 29;422(1):139-49. doi: 10.1042/BJ20082308.


Activation of the P2X7 ion channel by soluble and covalently bound ligands.

Schwarz N, Fliegert R, Adriouch S, Seman M, Guse AH, Haag F, Koch-Nolte F.

Purinergic Signal. 2009 Jun;5(2):139-49. doi: 10.1007/s11302-009-9135-5. Epub 2009 Mar 3.


Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by adp-ribose, the major product generated by the CD38 enzyme reaction.

Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE.

J Immunol. 2007 Dec 1;179(11):7827-39.


ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.

Adriouch S, Bannas P, Schwarz N, Fliegert R, Guse AH, Seman M, Haag F, Koch-Nolte F.

FASEB J. 2008 Mar;22(3):861-9. Epub 2007 Oct 10.


Modulation of Ca2+ entry and plasma membrane potential by human TRPM4b.

Fliegert R, Glassmeier G, Schmid F, Cornils K, Genisyuerek S, Harneit A, Schwarz JR, Guse AH.

FEBS J. 2007 Feb;274(3):704-13.


Regulation of calcium signalling by adenine-based second messengers.

Fliegert R, Gasser A, Guse AH.

Biochem Soc Trans. 2007 Feb;35(Pt 1):109-14. Review.


Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives.

Kirchberger T, Wagner G, Xu J, Cordiglieri C, Wang P, Gasser A, Fliegert R, Bruhn S, Flügel A, Lund FE, Zhang LH, Potter BV, Guse AH.

Br J Pharmacol. 2006 Oct;149(4):337-44. Epub 2006 Sep 11.


Activation of T cell calcium influx by the second messenger ADP-ribose.

Gasser A, Glassmeier G, Fliegert R, Langhorst MF, Meinke S, Hein D, Krüger S, Weber K, Heiner I, Oppenheimer N, Schwarz JR, Guse AH.

J Biol Chem. 2006 Feb 3;281(5):2489-96. Epub 2005 Nov 29.


TSST-1 induces Th1 or Th2 differentiation in naïve CD4+ T cells in a dose- and APC-dependent manner.

Brandt K, van der Bosch J, Fliegert R, Gehring S.

Scand J Immunol. 2002 Dec;56(6):572-9.

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