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Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of (R)-1,3-butanediol.

Kim T, Stogios PJ, Khusnutdinova AN, Nemr K, Skarina T, Flick R, Joo JC, Mahadevan R, Savchenko A, Yakunin AF.

J Biol Chem. 2019 Dec 5. pii: jbc.RA119.011363. doi: 10.1074/jbc.RA119.011363. [Epub ahead of print]


Sixteen years of bathymetry and waves at San Diego beaches.

Ludka BC, Guza RT, O'Reilly WC, Merrifield MA, Flick RE, Bak AS, Hesser T, Bucciarelli R, Olfe C, Woodward B, Boyd W, Smith K, Okihiro M, Grenzeback R, Parry L, Boyd G.

Sci Data. 2019 Aug 29;6(1):161. doi: 10.1038/s41597-019-0167-6.


Accumulation of soluble menaquinones MK-7 in honey coincides with death of Bacillus spp. present in honey.

Brudzynski K, Flick R.

Food Chem X. 2019 Feb 20;1:100008. doi: 10.1016/j.fochx.2019.100008. eCollection 2019 Mar 30.


Mechanisms of pharmaceutical and personal care product removal in algae-based wastewater treatment systems.

Larsen C, Yu ZH, Flick R, Passeport E.

Sci Total Environ. 2019 Dec 10;695:133772. doi: 10.1016/j.scitotenv.2019.133772. Epub 2019 Aug 5.


VITAL Start: Video-Based Intervention to Inspire Treatment Adherence for Life-Pilot of a Novel Video-Based Approach to HIV Counseling for Pregnant Women Living with HIV.

Kim MH, Ahmed S, Tembo T, Sabelli R, Flick R, Yu X, Mazenga A, Le Blond H, Simon K, Hartig M, Wetzel E, Nyirenda R, Kazembe PN, Mphande M, Mkandawire A, Chitani MJ, Abrams EJ.

AIDS Behav. 2019 Nov;23(11):3140-3151. doi: 10.1007/s10461-019-02634-1.


Site-directed mutagenesis and stability of the carboxylic acid reductase MAB4714 from Mycobacterium abscessus.

Fedorchuk TP, Khusnutdinova AN, Flick R, Yakunin AF.

J Biotechnol. 2019 Sep 10;303:72-79. doi: 10.1016/j.jbiotec.2019.07.009. Epub 2019 Aug 2.


Multigene Biomarkers of Pyrethroid Exposure: Exploratory Experiments.

Kostich MS, Bencic DC, Batt AL, See MJ, Flick RW, Gordon DA, Lazorchak JM, Biales AD.

Environ Toxicol Chem. 2019 Nov;38(11):2436-2446. doi: 10.1002/etc.4552. Epub 2019 Oct 3.


Alliance, Trust, and Loss: Experiences of Patients Cared for by Students in a Longitudinal Integrated Clerkship.

Flick RJ, Felder-Heim C, Gong J, Corral J, Kalata K, Marin A, Adams JE.

Acad Med. 2019 Nov;94(11):1806-1813. doi: 10.1097/ACM.0000000000002812.


Routine laboratory measures of heparin anticoagulation for children on extracorporeal membrane oxygenation: Systematic review and meta-analysis.

Padhya DP, Prutsky GJ, Nemergut ME, Schears GS, Flick RP, Farah W, Wang Z, Prokop LJ, Murad MH, Alsawas M.

Thromb Res. 2019 Jul;179:132-139. doi: 10.1016/j.thromres.2019.05.006. Epub 2019 May 7. Review.


Prenylated FMN: Biosynthesis, purification, and Fdc1 activation.

Khusnutdinova AN, Xiao J, Wang PH, Batyrova KA, Flick R, Edwards EA, Yakunin AF.

Methods Enzymol. 2019;620:469-488. doi: 10.1016/bs.mie.2019.03.021. Epub 2019 Apr 11.


The HIV diagnostic assistant: early findings from a novel HIV testing cadre in Malawi.

Flick RJ, Simon KR, Nyirenda R, Namachapa K, Hosseinipour MC, Schooley A, Kavuta E, Theu J, Kazembe PN, Ahmed S, Kim MH.

AIDS. 2019 Jun 1;33(7):1215-1224. doi: 10.1097/QAD.0000000000002159.


Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress.

Molinaro R, Mukherjee T, Flick R, Philpott DJ, Girardin SE.

J Biol Chem. 2019 May 31;294(22):9007-9015. doi: 10.1074/jbc.RA119.007997. Epub 2019 Apr 17.


Patterns of neuropsychological changes after general anaesthesia in young children: secondary analysis of the Mayo Anesthesia Safety in Kids study.

Zaccariello MJ, Frank RD, Lee M, Kirsch AC, Schroeder DR, Hanson AC, Schulte PJ, Wilder RT, Sprung J, Katusic SK, Flick RP, Warner DO.

Br J Anaesth. 2019 May;122(5):671-681. doi: 10.1016/j.bja.2019.01.022.


Performance on the Operant Test Battery in young children exposed to procedures requiring general anaesthesia: the MASK study.

Warner DO, Chelonis JJ, Paule MG, Frank RD, Lee M, Zaccariello MJ, Katusic SK, Schroeder DR, Hanson AC, Schulte PJ, Wilder RT, Sprung J, Flick RP.

Br J Anaesth. 2019 Apr;122(4):470-479. doi: 10.1016/j.bja.2018.12.020. Epub 2019 Feb 4.


Characterization of the Fundulus heteroclitus embryo transcriptional response and development of a gene expression-based fingerprint of exposure for the alternative flame retardant, TBPH (bis (2-ethylhexyl)-tetrabromophthalate).

Huang W, Bencic DC, Flick RL, Nacci DE, Clark BW, Burkhard L, Lahren T, Biales AD.

Environ Pollut. 2019 Apr;247:696-705. doi: 10.1016/j.envpol.2019.01.010. Epub 2019 Jan 10.


An interspecies malate-pyruvate shuttle reconciles redox imbalance in an anaerobic microbial community.

Wang PH, Correia K, Ho HC, Venayak N, Nemr K, Flick R, Mahadevan R, Edwards EA.

ISME J. 2019 Apr;13(4):1042-1055. doi: 10.1038/s41396-018-0333-4. Epub 2019 Jan 3.


Bisphosphonic acids and related compounds as inhibitors of nucleotide- and polyphosphate-processing enzymes: A PPK1 and PPK2 case study.

Burda-Grabowska M, Macegoniuk K, Flick R, Nocek BP, Joachimiak A, Yakunin AF, Mucha A, Berlicki Ł.

Chem Biol Drug Des. 2019 Jun;93(6):1197-1206. doi: 10.1111/cbdd.13439. Epub 2018 Nov 28.


Cumulative Anesthesia Exposure in Patients Treated for Early-Onset Scoliosis.

Baky FJ, Milbrandt TA, Flick R, Larson AN.

Spine Deform. 2018 Nov - Dec;6(6):781-786. doi: 10.1016/j.jspd.2018.05.001.


Screening and Characterization of Novel Polyesterases from Environmental Metagenomes with High Hydrolytic Activity against Synthetic Polyesters.

Hajighasemi M, Tchigvintsev A, Nocek B, Flick R, Popovic A, Hai T, Khusnutdinova AN, Brown G, Xu X, Cui H, Anstett J, Chernikova TN, Brüls T, Le Paslier D, Yakimov MM, Joachimiak A, Golyshina OV, Savchenko A, Golyshin PN, Edwards EA, Yakunin AF.

Environ Sci Technol. 2018 Nov 6;52(21):12388-12401. doi: 10.1021/acs.est.8b04252. Epub 2018 Oct 15.


Family Testing: An Index Case Finding Strategy to Close the Gaps in Pediatric HIV Diagnosis.

Simon KR, Flick RJ, Kim MH, Sabelli RA, Tembo T, Phelps BR, Rosenberg NE, Ahmed S.

J Acquir Immune Defic Syndr. 2018 Aug 15;78 Suppl 2:S88-S97. doi: 10.1097/QAI.0000000000001731. Review.


Neuropsychological and Behavioral Outcomes after Exposure of Young Children to Procedures Requiring General Anesthesia: The Mayo Anesthesia Safety in Kids (MASK) Study.

Warner DO, Zaccariello MJ, Katusic SK, Schroeder DR, Hanson AC, Schulte PJ, Buenvenida SL, Gleich SJ, Wilder RT, Sprung J, Hu D, Voigt RG, Paule MG, Chelonis JJ, Flick RP.

Anesthesiology. 2018 Jul;129(1):89-105. doi: 10.1097/ALN.0000000000002232.


Biosynthesis and Activity of Prenylated FMN Cofactors.

Wang PH, Khusnutdinova AN, Luo F, Xiao J, Nemr K, Flick R, Brown G, Mahadevan R, Edwards EA, Yakunin AF.

Cell Chem Biol. 2018 May 17;25(5):560-570.e6. doi: 10.1016/j.chembiol.2018.02.007. Epub 2018 Mar 15.


Anesthesia and Neurodevelopment in Children: Perhaps the End of the Beginning.

Warner DO, Shi Y, Flick RP.

Anesthesiology. 2018 Apr;128(4):700-703. doi: 10.1097/ALN.0000000000002121. No abstract available.


Epidemiology of general anesthesia prior to age 3 in a population-based birth cohort.

Shi Y, Hu D, Rodgers EL, Katusic SK, Gleich SJ, Hanson AC, Schroeder DR, Flick RP, Warner DO.

Paediatr Anaesth. 2018 Jun;28(6):513-519. doi: 10.1111/pan.13359. Epub 2018 Mar 13.


Anemia in people on second line antiretroviral treatment in Lilongwe, Malawi: a cross-sectional study.

Ngongondo M, Rosenberg NE, Stanley CC, Lim R, Ongubo D, Broadhurst R, Speight C, Flick R, Tembo P, Hosseinpour MC.

BMC Infect Dis. 2018 Jan 15;18(1):39. doi: 10.1186/s12879-018-2952-9.


Direct analysis by time-of-flight secondary ion mass spectrometry reveals action of bacterial laccase-mediator systems on both hardwood and softwood samples.

Goacher RE, Braham EJ, Michienzi CL, Flick RM, Yakunin AF, Master ER.

Physiol Plant. 2018 Sep;164(1):5-16. doi: 10.1111/ppl.12688. Epub 2018 Mar 13.


American College of Surgeons Children's Surgery Verification Quality Improvement Program: What Anesthesiologists Need to Know Now.

Brooks Peterson M, Houck CS, Deshpande JK, Flick RP.

Anesth Analg. 2018 May;126(5):1624-1632. doi: 10.1213/ANE.0000000000002672. Review.


Assessing infection control practices to protect health care workers and patients in Malawi from nosocomial transmission of Mycobacterium tuberculosis.

Flick RJ, Munthali A, Simon K, Hosseinipour M, Kim MH, Mlauzi L, Kazembe PN, Ahmed S.

PLoS One. 2017 Dec 6;12(12):e0189140. doi: 10.1371/journal.pone.0189140. eCollection 2017.


Exploring Bacterial Carboxylate Reductases for the Reduction of Bifunctional Carboxylic Acids.

Khusnutdinova AN, Flick R, Popovic A, Brown G, Tchigvintsev A, Nocek B, Correia K, Joo JC, Mahadevan R, Yakunin AF.

Biotechnol J. 2017 Nov;12(11). doi: 10.1002/biot.201600751. Epub 2017 Sep 5.


Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid.

Joo JC, Khusnutdinova AN, Flick R, Kim T, Bornscheuer UT, Yakunin AF, Mahadevan R.

Chem Sci. 2017 Feb 1;8(2):1406-1413. doi: 10.1039/c6sc02842j. Epub 2016 Oct 11.


Association between Exposure of Young Children to Procedures Requiring General Anesthesia and Learning and Behavioral Outcomes in a Population-based Birth Cohort.

Hu D, Flick RP, Zaccariello MJ, Colligan RC, Katusic SK, Schroeder DR, Hanson AC, Buenvenida SL, Gleich SJ, Wilder RT, Sprung J, Warner DO.

Anesthesiology. 2017 Aug;127(2):227-240. doi: 10.1097/ALN.0000000000001735.


Corrigendum: SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788a. No abstract available.


Anesthetic-Related Neurotoxicity and Neuroimaging in Children: A Call for Conversation.

Bjur KA, Payne ET, Nemergut ME, Hu D, Flick RP.

J Child Neurol. 2017 May;32(6):594-602. doi: 10.1177/0883073817691696. Epub 2017 Feb 13.


How consistent are we? Interlaboratory comparison study in fathead minnows using the model estrogen 17α-ethinylestradiol to develop recommendations for environmental transcriptomics.

Feswick A, Isaacs M, Biales A, Flick RW, Bencic DC, Wang RL, Vulpe C, Brown-Augustine M, Loguinov A, Falciani F, Antczak P, Herbert J, Brown L, Denslow ND, Kroll KJ, Lavelle C, Dang V, Escalon L, Garcia-Reyero N, Martyniuk CJ, Munkittrick KR.

Environ Toxicol Chem. 2017 Oct;36(10):2614-2623. doi: 10.1002/etc.3799. Epub 2017 Apr 19.


The American College of Surgeons Children's Surgery Verification and Quality Improvement Program: implications for anesthesiologists.

Houck CS, Deshpande JK, Flick RP.

Curr Opin Anaesthesiol. 2017 Jun;30(3):376-382. doi: 10.1097/ACO.0000000000000467. Review.


Comment on Growth in an Anesthesiologist and Nurse Anesthetist-Supervised Sedation Nurse Program Using Propofol and Dexmedetomidine.

Cravero JP, Flick RP, Malviya SV.

A A Case Rep. 2017 Jun 15;8(12):337. doi: 10.1213/XAA.0000000000000504. No abstract available.


Activity screening of environmental metagenomic libraries reveals novel carboxylesterase families.

Popovic A, Hai T, Tchigvintsev A, Hajighasemi M, Nocek B, Khusnutdinova AN, Brown G, Glinos J, Flick R, Skarina T, Chernikova TN, Yim V, Brüls T, Paslier DL, Yakimov MM, Joachimiak A, Ferrer M, Golyshina OV, Savchenko A, Golyshin PN, Yakunin AF.

Sci Rep. 2017 Mar 8;7:44103. doi: 10.1038/srep44103.


Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies.

Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, Joo JC, Minasov GA, Anderson WF, Mahadevan R, Savchenko A, Yakunin AF.

Appl Environ Microbiol. 2017 Mar 17;83(7). pii: e03172-16. doi: 10.1128/AEM.03172-16. Print 2017 Apr 1.


An Analysis of the Last Clinical Encounter before Outpatient Mortality among Children with HIV Infection and Exposure in Lilongwe, Malawi.

Rees CA, Flick RJ, Sullivan D, Bvumbwe M, Mhango J, Hosseinipour MC, Kazembe PN.

PLoS One. 2017 Jan 18;12(1):e0169057. doi: 10.1371/journal.pone.0169057. eCollection 2017.


Anesthetic Outcomes of Children With Arthrogryposis Syndromes: No Evidence of Hyperthermia.

Gleich SJ, Tien M, Schroeder DR, Hanson AC, Flick R, Nemergut ME.

Anesth Analg. 2017 Mar;124(3):908-914. doi: 10.1213/ANE.0000000000001822.


Aquatic concentrations of chemical analytes compared to ecotoxicity estimates.

Kostich MS, Flick RW, Batt AL, Mash HE, Boone JS, Furlong ET, Kolpin DW, Glassmeyer ST.

Sci Total Environ. 2017 Feb 1;579:1649-1657. doi: 10.1016/j.scitotenv.2016.06.234.


SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.

Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr.

Nat Med. 2017 Feb;23(2):250-255. doi: 10.1038/nm.4255. Epub 2016 Dec 19. Erratum in: Nat Med. 2017 Jun 6;23 (6):788.


Refined experimental annotation reveals conserved corrinoid autotrophy in chloroform-respiring Dehalobacter isolates.

Wang PH, Tang S, Nemr K, Flick R, Yan J, Mahadevan R, Yakunin AF, Löffler FE, Edwards EA.

ISME J. 2017 Mar;11(3):626-640. doi: 10.1038/ismej.2016.158. Epub 2016 Nov 29.


PMTCT Option B+ Does Not Increase Preterm Birth Risk and May Prevent Extreme Prematurity: A Retrospective Cohort Study in Malawi.

Chagomerana MB, Miller WC, Pence BW, Hosseinipour MC, Hoffman IF, Flick RJ, Tweya H, Mumba S, Chimbwandira F, Powers KA.

J Acquir Immune Defic Syndr. 2017 Apr 1;74(4):367-374. doi: 10.1097/QAI.0000000000001253.


Summary of the Update Session on Clinical Neurotoxicity Studies.

Pinyavat T, Warner DO, Flick RP, McCann ME, Andropoulos DB, Hu D, Sall JW, Spann MN, Ing C.

J Neurosurg Anesthesiol. 2016 Oct;28(4):356-360. Review.


Pediatric bicycle-related head injuries: a population-based study in a county without a helmet law.

Kaushik R, Krisch IM, Schroeder DR, Flick R, Nemergut ME.

Inj Epidemiol. 2015 Dec;2(1):16. Epub 2015 Jul 7.


Initial development of a multigene 'omics-based exposure biomarker for pyrethroid pesticides.

Biales AD, Kostich MS, Batt AL, See MJ, Flick RW, Gordon DA, Lazorchak JM, Bencic DC.

Aquat Toxicol. 2016 Oct;179:27-35. doi: 10.1016/j.aquatox.2016.08.004. Epub 2016 Aug 12.


Burden of disease and risk factors for death among children treated for tuberculosis in Malawi.

Flick RJ, Kim MH, Simon K, Munthali A, Hosseinipour MC, Rosenberg NE, Kazembe PN, Mpunga J, Ahmed S.

Int J Tuberc Lung Dis. 2016 Aug;20(8):1046-54. doi: 10.5588/ijtld.15.0928.


An automated real-time method for the detection of patients at risk for malignant hyperthermia.

Gleich SJ, Strupp K, Wilder RT, Kor DJ, Flick R.

Paediatr Anaesth. 2016 Sep;26(9):876-82. doi: 10.1111/pan.12954. Epub 2016 Jun 27.


A family of metal-dependent phosphatases implicated in metabolite damage-control.

Huang L, Khusnutdinova A, Nocek B, Brown G, Xu X, Cui H, Petit P, Flick R, Zallot R, Balmant K, Ziemak MJ, Shanklin J, de Crécy-Lagard V, Fiehn O, Gregory JF 3rd, Joachimiak A, Savchenko A, Yakunin AF, Hanson AD.

Nat Chem Biol. 2016 Aug;12(8):621-7. doi: 10.1038/nchembio.2108. Epub 2016 Jun 20.


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