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Items: 1 to 50 of 66

1.

Proteolytic and Nonproteolytic Activation Mechanisms Result in Conformationally and Functionally Different Forms of Coagulation Factor XIII A.

Anokhin BA, Dean WL, Smith KA, Flick MJ, Ariëns RAS, Philippou H, Maurer MC.

FEBS J. 2019 Aug 13. doi: 10.1111/febs.15040. [Epub ahead of print]

PMID:
31407850
2.

Cancer-Associated Thrombosis: A Two-Way Street.

Sharma BK, Flick MJ, Palumbo JS.

Semin Thromb Hemost. 2019 Aug 5. doi: 10.1055/s-0039-1693472. [Epub ahead of print]

PMID:
31382306
3.

Does fibrinogen serve the host or the microbe in Staphylococcus infection?

Negrón O, Flick MJ.

Curr Opin Hematol. 2019 Sep;26(5):343-348. doi: 10.1097/MOH.0000000000000527.

PMID:
31348048
4.

Plasmin-mediated fibrinolysis enables macrophage migration in a murine model of inflammation.

Silva LM, Lum AG, Tran C, Shaw MW, Gao Z, Flick MJ, Moutsopoulos NM, Bugge TH, Mullins ES.

Blood. 2019 Jul 18;134(3):291-303. doi: 10.1182/blood.2018874859. Epub 2019 May 17.

PMID:
31101623
5.

Thrombin Signaling Promotes Pancreatic Adenocarcinoma through PAR-1-Dependent Immune Evasion.

Yang Y, Stang A, Schweickert PG, Lanman NA, Paul EN, Monia BP, Revenko AS, Palumbo JS, Mullins ES, Elzey BD, Janssen EM, Konieczny SF, Flick MJ.

Cancer Res. 2019 Jul 1;79(13):3417-3430. doi: 10.1158/0008-5472.CAN-18-3206. Epub 2019 May 2.

PMID:
31048498
6.

The FOXM1 Inhibitor RCM-1 Decreases Carcinogenesis and Nuclear β-Catenin.

Shukla S, Milewski D, Pradhan A, Rama N, Rice K, Le T, Flick MJ, Vaz S, Zhao X, Setchell KD, Logarinho E, Kalinichenko VV, Kalin TV.

Mol Cancer Ther. 2019 Jul;18(7):1217-1229. doi: 10.1158/1535-7163.MCT-18-0709. Epub 2019 Apr 30.

PMID:
31040162
7.

Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b.

Landers CT, Tung HY, Knight JM, Madison MC, Wu Y, Zeng Z, Porter PC, Rodriguez A, Flick MJ, Kheradmand F, Corry DB.

J Biol Chem. 2019 May 31;294(22):8834-8847. doi: 10.1074/jbc.RA118.006724. Epub 2019 Apr 16.

PMID:
30992366
8.

The multifaceted role of fibrinogen in tissue injury and inflammation.

Luyendyk JP, Schoenecker JG, Flick MJ.

Blood. 2019 Feb 7;133(6):511-520. doi: 10.1182/blood-2018-07-818211. Epub 2018 Dec 6. Review.

PMID:
30523120
9.

Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice.

Stagaard R, Ley CD, Almholt K, Olsen LH, Knudsen T, Flick MJ.

Blood Adv. 2018 Nov 27;2(22):3126-3136. doi: 10.1182/bloodadvances.2018024851.

10.

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.

Poole LG, Pant A, Baker KS, Kopec AK, Cline-Fedewa HM, Iismaa SE, Flick MJ, Luyendyk JP.

J Thromb Haemost. 2019 Jan;17(1):113-125. doi: 10.1111/jth.14330. Epub 2018 Dec 10.

PMID:
30415489
11.

Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice.

Adams GN, Sharma BK, Rosenfeldt L, Frederick M, Flick MJ, Witte DP, Mosnier LO, Harmel-Laws E, Steinbrecher KA, Palumbo JS.

J Thromb Haemost. 2018 Nov;16(11):2258-2269. doi: 10.1111/jth.14277. Epub 2018 Sep 27.

PMID:
30152921
12.

Abrogating fibrinolysis does not improve bleeding or rFVIIa/rFVIII treatment in a non-mucosal venous injury model in haemophilic rodents.

Stagaard R, Flick MJ, Bojko B, Goryński K, Goryńska PZ, Ley CD, Olsen LH, Knudsen T.

J Thromb Haemost. 2018 Jul;16(7):1369-1382. doi: 10.1111/jth.14148. Epub 2018 Jun 21.

PMID:
29758126
13.

Platelets couple inflammation to tumorigenesis, a bridge too far.

Flick MJ, Palumbo JS.

J Thromb Haemost. 2018 Apr;16(4):759-761. doi: 10.1111/jth.13967. Epub 2018 Mar 2. No abstract available.

PMID:
29418061
14.

Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.

15.

Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice.

Kattula S, Byrnes JR, Martin SM, Holle LA, Cooley BC, Flick MJ, Wolberg AS.

Blood Adv. 2018 Jan 3;2(1):25-35. doi: 10.1182/bloodadvances.2017011890. eCollection 2018 Jan 9.

16.

Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells.

Thornton S, Raghu H, Cruz C, Frederick MD, Palumbo JS, Mullins ES, Almholt K, Usher PA, Flick MJ.

Blood Adv. 2017 Mar 21;1(9):545-556. doi: 10.1182/bloodadvances.2016004002. eCollection 2017 Mar 28.

17.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.

Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ.

J Clin Invest. 2017 Aug 1;127(8):3152-3166. doi: 10.1172/JCI92744. Epub 2017 Jul 24.

18.

Plasminogen Deficiency Delays the Onset and Protects from Demyelination and Paralysis in Autoimmune Neuroinflammatory Disease.

Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Ryu JK, Akassoglou K, Mullins ES.

J Neurosci. 2017 Apr 5;37(14):3776-3788. doi: 10.1523/JNEUROSCI.2932-15.2017. Epub 2017 Mar 8.

19.

Fibrin(ogen) drives repair after acetaminophen-induced liver injury via leukocyte αMβ2 integrin-dependent upregulation of Mmp12.

Kopec AK, Joshi N, Cline-Fedewa H, Wojcicki AV, Ray JL, Sullivan BP, Froehlich JE, Johnson BF, Flick MJ, Luyendyk JP.

J Hepatol. 2017 Apr;66(4):787-797. doi: 10.1016/j.jhep.2016.12.004. Epub 2016 Dec 10.

20.

Plasminogen-receptor KT : plasminogen activation and beyond.

Flick MJ, Bugge TH.

J Thromb Haemost. 2017 Jan;15(1):150-154. doi: 10.1111/jth.13541. Epub 2016 Nov 25. No abstract available.

21.

The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.

Byrnes JR, Wilson C, Boutelle AM, Brandner CB, Flick MJ, Philippou H, Wolberg AS.

Blood. 2016 Oct 13;128(15):1969-1978. Epub 2016 Aug 25.

22.

Plasmin Prevents Dystrophic Calcification After Muscle Injury.

Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AR, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, Flick MJ, Cates JM, Schoenecker JG.

J Bone Miner Res. 2017 Feb;32(2):294-308. doi: 10.1002/jbmr.2973. Epub 2016 Dec 5.

23.

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice.

Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES.

Blood. 2016 Aug 4;128(5):721-31. doi: 10.1182/blood-2015-11-680280. Epub 2016 Jun 1.

24.

Fibrinogen Is at the Interface of Host Defense and Pathogen Virulence in Staphylococcus aureus Infection.

Ko YP, Flick MJ.

Semin Thromb Hemost. 2016 Jun;42(4):408-21. doi: 10.1055/s-0036-1579635. Epub 2016 Apr 7. Review.

25.

Fibrin deposition following bile duct injury limits fibrosis through an αMβ2-dependent mechanism.

Joshi N, Kopec AK, Ray JL, Cline-Fedewa H, Nawabi A, Schmitt T, Nault R, Zacharewski TR, Rockwell CE, Flick MJ, Luyendyk JP.

Blood. 2016 Jun 2;127(22):2751-62. doi: 10.1182/blood-2015-09-670703. Epub 2016 Feb 26.

26.

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

Motley MP, Madsen DH, Jürgensen HJ, Spencer DE, Szabo R, Holmbeck K, Flick MJ, Lawrence DA, Castellino FJ, Weigert R, Bugge TH.

Blood. 2016 Mar 3;127(9):1085-96. doi: 10.1182/blood-2015-05-644260. Epub 2015 Dec 8.

27.

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, Schoenecker JG.

J Clin Invest. 2015 Sep;125(9):3723. doi: 10.1172/JCI84059. Epub 2015 Sep 1. No abstract available.

28.

Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen.

Adams GN, Rosenfeldt L, Frederick M, Miller W, Waltz D, Kombrinck K, McElhinney KE, Flick MJ, Monia BP, Revenko AS, Palumbo JS.

Cancer Res. 2015 Oct 1;75(19):4235-43. doi: 10.1158/0008-5472.CAN-15-0964. Epub 2015 Aug 3.

29.

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.

Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ.

Blood. 2015 Oct 22;126(17):2047-58. doi: 10.1182/blood-2015-04-639849. Epub 2015 Jul 30.

30.

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, Schoenecker JG.

J Clin Invest. 2015 Aug 3;125(8):3117-31. doi: 10.1172/JCI80313. Epub 2015 Jul 27. Erratum in: J Clin Invest. 2015 Sep;125(9):3723.

31.

Coagulation-driven platelet activation reduces cholestatic liver injury and fibrosis in mice.

Joshi N, Kopec AK, O'Brien KM, Towery KL, Cline-Fedewa H, Williams KJ, Copple BL, Flick MJ, Luyendyk JP.

J Thromb Haemost. 2015 Jan;13(1):57-71. doi: 10.1111/jth.12770. Epub 2014 Dec 11.

32.

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion.

Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ.

Blood. 2015 Jan 15;125(3):427-37. doi: 10.1182/blood-2014-08-594754. Epub 2014 Oct 21.

33.

Thrombin inhibition with dabigatran protects against high-fat diet-induced fatty liver disease in mice.

Kopec AK, Joshi N, Towery KL, Kassel KM, Sullivan BP, Flick MJ, Luyendyk JP.

J Pharmacol Exp Ther. 2014 Nov;351(2):288-97. doi: 10.1124/jpet.114.218545. Epub 2014 Aug 19.

34.

Factor XIII activity mediates red blood cell retention in venous thrombi.

Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Di Paola J, Mackman N, Degen JL, Flick MJ, Wolberg AS.

J Clin Invest. 2014 Aug;124(8):3590-600. doi: 10.1172/JCI75386. Epub 2014 Jul 1.

35.

Thrombin drives tumorigenesis in colitis-associated colon cancer.

Turpin B, Miller W, Rosenfeldt L, Kombrinck K, Flick MJ, Steinbrecher KA, Harmel-Laws E, Mullins ES, Shaw M, Witte DP, Revenko A, Monia B, Palumbo JS.

Cancer Res. 2014 Jun 1;74(11):3020-3030. doi: 10.1158/0008-5472.CAN-13-3276. Epub 2014 Apr 7.

36.

Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice.

Cole HA, Ohba T, Nyman JS, Hirotaka H, Cates JM, Flick MJ, Degen JL, Schoenecker JG.

Arthritis Rheumatol. 2014 Aug;66(8):2222-33. doi: 10.1002/art.38639.

37.

Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.

Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Thornton S, Degen JL, Flick MJ.

Arthritis Rheumatol. 2014 Jun;66(6):1504-16. doi: 10.1002/art.38402.

38.

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Höök M, Degen JL.

Blood. 2013 Mar 7;121(10):1783-94. doi: 10.1182/blood-2012-09-453894. Epub 2013 Jan 8.

39.

Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury.

Sullivan BP, Kassel KM, Jone A, Flick MJ, Luyendyk JP.

Am J Pathol. 2012 Jun;180(6):2321-9. doi: 10.1016/j.ajpath.2012.02.011. Epub 2012 Apr 13.

40.

Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity.

Qi X, Flick MJ, Frederick M, Chu Z, Mason R, DeLay M, Thornton S.

PLoS One. 2012;7(3):e33966. doi: 10.1371/journal.pone.0033966. Epub 2012 Mar 28.

41.

Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor.

Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P.

Hum Mol Genet. 2012 May 1;21(9):1989-2004. doi: 10.1093/hmg/dds012. Epub 2012 Mar 1.

42.

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS.

Blood. 2011 Sep 8;118(10):2889-95. doi: 10.1182/blood-2011-03-341222. Epub 2011 Jul 25.

43.

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL.

Blood. 2011 Jun 9;117(23):6326-37. doi: 10.1182/blood-2010-08-304915. Epub 2011 Mar 24.

44.

Targeting the coagulation factor fibrinogen for arthritis therapy.

Raghu H, Flick MJ.

Curr Pharm Biotechnol. 2011 Sep;12(9):1497-506. Review.

PMID:
21401516
45.

Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.

Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS.

Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465. Epub 2010 Mar 16.

46.

Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo.

Lykens JE, Terrell CE, Zoller EE, Divanovic S, Trompette A, Karp CL, Aliberti J, Flick MJ, Jordan MB.

J Immunol. 2010 Jan 15;184(2):877-85. doi: 10.4049/jimmunol.0902346. Epub 2009 Dec 14.

47.

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

Yang H, Lang S, Zhai Z, Li L, Kahr WH, Chen P, Brkić J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H.

Blood. 2009 Jul 9;114(2):425-36. doi: 10.1182/blood-2008-03-145821. Epub 2009 Mar 30.

48.

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL.

Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16.

49.

Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function.

Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL.

J Thromb Haemost. 2008 May;6(5):812-9. doi: 10.1111/j.1538-7836.2008.02938.x. Epub 2008 Feb 25.

50.

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL.

J Clin Invest. 2007 Nov;117(11):3224-35.

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