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A Receptor Tyrosine Kinase Plays Separate Roles in Sensory Integration and Associative Learning in C. elegans.

Wolfe GS, Tong VW, Povse E, Merritt DM, Stegeman GW, Flibotte S, van der Kooy D.

eNeuro. 2019 Aug 13;6(4). pii: ENEURO.0244-18.2019. doi: 10.1523/ENEURO.0244-18.2019. Print 2019 Jul/Aug.


Heparanase protects the heart against chemical or ischemia/reperfusion injury.

Wang F, Pulinilkunnil T, Flibotte S, Nislow C, Vlodavsky I, Hussein B, Rodrigues B.

J Mol Cell Cardiol. 2019 Jun;131:29-40. doi: 10.1016/j.yjmcc.2019.04.008. Epub 2019 Apr 17.


The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing.

Billmyre KK, Doebley AL, Spichal M, Heestand B, Belicard T, Sato-Carlton A, Flibotte S, Simon M, Gnazzo M, Skop A, Moerman D, Carlton PM, Sarkies P, Ahmed S.

PLoS Genet. 2019 Mar 28;15(3):e1008004. doi: 10.1371/journal.pgen.1008004. eCollection 2019 Mar.


MicroRNA Biomarkers in Cerebrospinal Fluid and Serum Reflect Injury Severity in Human Acute Traumatic Spinal Cord Injury.

Tigchelaar S, Gupta R, Shannon CP, Streijger F, Sinha S, Flibotte S, Rizzuto MA, Street J, Paquette S, Ailon T, Charest-Morin R, Dea N, Fisher C, Dvorak MF, Dhall S, Mac-Thiong JM, Parent S, Bailey C, Christie S, Van Keuren-Jensen K, Nislow C, Kwon BK.

J Neurotrauma. 2019 Aug 1;36(15):2358-2371. doi: 10.1089/neu.2018.6256. Epub 2019 May 14.


Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element.

Vuilleumier R, Lian T, Flibotte S, Khan ZN, Fuchs A, Pyrowolakis G, Allan DW.

Nucleic Acids Res. 2019 Jan 25;47(2):679-699. doi: 10.1093/nar/gky1135.


CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans.

Au V, Li-Leger E, Raymant G, Flibotte S, Chen G, Martin K, Fernando L, Doell C, Rosell FI, Wang S, Edgley ML, Rougvie AE, Hutter H, Moerman DG.

G3 (Bethesda). 2019 Jan 9;9(1):135-144. doi: 10.1534/g3.118.200778.


DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons.

Noblett N, Wu Z, Ding ZH, Park S, Roenspies T, Flibotte S, Chisholm AD, Jin Y, Colavita A.

J Cell Biol. 2019 Jan 7;218(1):125-133. doi: 10.1083/jcb.201804207. Epub 2018 Nov 5.


Mutational and transcriptional landscape of spontaneous gene duplications and deletions in Caenorhabditis elegans.

Konrad A, Flibotte S, Taylor J, Waterston RH, Moerman DG, Bergthorsson U, Katju V.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7386-7391. doi: 10.1073/pnas.1801930115. Epub 2018 Jun 25.


A Strategy To Isolate Modifiers of Caenorhabditis elegans Lethal Mutations: Investigating the Endoderm Specifying Ability of the Intestinal Differentiation GATA Factor ELT-2.

Wiesenfahrt T, Duanmu J, Snider F, Moerman D, Au V, Li-Leger E, Flibotte S, Parker DM, Marshall CJ, Nishimura EO, Mains PE, McGhee JD.

G3 (Bethesda). 2018 May 4;8(5):1425-1437. doi: 10.1534/g3.118.200079.


The Molecular Chaperone HSP90 Promotes Notch Signaling in the Germline of Caenorhabditis elegans.

Lissemore JL, Connors E, Liu Y, Qiao L, Yang B, Edgley ML, Flibotte S, Taylor J, Au V, Moerman DG, Maine EM.

G3 (Bethesda). 2018 May 4;8(5):1535-1544. doi: 10.1534/g3.118.300551.


Ribosomal Protein S12e Has a Distinct Function in Cell Competition.

Kale A, Ji Z, Kiparaki M, Blanco J, Rimesso G, Flibotte S, Baker NE.

Dev Cell. 2018 Jan 8;44(1):42-55.e4. doi: 10.1016/j.devcel.2017.12.007. Epub 2018 Jan 8.


Reducing insulin via conditional partial gene ablation in adults reverses diet-induced weight gain.

Page MM, Skovsø S, Cen H, Chiu AP, Dionne DA, Hutchinson DF, Lim GE, Szabat M, Flibotte S, Sinha S, Nislow C, Rodrigues B, Johnson JD.

FASEB J. 2018 Mar;32(3):1196-1206. doi: 10.1096/fj.201700518R. Epub 2018 Jan 3.


Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan.

Templeman NM, Flibotte S, Chik JHL, Sinha S, Lim GE, Foster LJ, Nislow C, Johnson JD.

Cell Rep. 2017 Jul 11;20(2):451-463. doi: 10.1016/j.celrep.2017.06.048.


Comparative functional genomic screens of three yeast deletion collections reveal unexpected effects of genotype in response to diverse stress.

Acton E, Lee AH, Zhao PJ, Flibotte S, Neira M, Sinha S, Chiang J, Flaherty P, Nislow C, Giaever G.

Open Biol. 2017 Jun;7(6). pii: 160330. doi: 10.1098/rsob.160330.


Insight into the Recent Genome Duplication of the Halophilic Yeast Hortaea werneckii: Combining an Improved Genome with Gene Expression and Chromatin Structure.

Sinha S, Flibotte S, Neira M, Formby S, Plemenitaš A, Cimerman NG, Lenassi M, Gostinčar C, Stajich JE, Nislow C.

G3 (Bethesda). 2017 Jul 5;7(7):2015-2022. doi: 10.1534/g3.117.040691.


Serum MicroRNAs Reflect Injury Severity in a Large Animal Model of Thoracic Spinal Cord Injury.

Tigchelaar S, Streijger F, Sinha S, Flibotte S, Manouchehri N, So K, Shortt K, Okon E, Rizzuto MA, Malenica I, Courtright-Lim A, Eisen A, Keuren-Jensen KV, Nislow C, Kwon BK.

Sci Rep. 2017 May 3;7(1):1376. doi: 10.1038/s41598-017-01299-x.


Phenotypic diversity and genotypic flexibility of Burkholderia cenocepacia during long-term chronic infection of cystic fibrosis lungs.

Lee AH, Flibotte S, Sinha S, Paiero A, Ehrlich RL, Balashov S, Ehrlich GD, Zlosnik JE, Mell JC, Nislow C.

Genome Res. 2017 Apr;27(4):650-662. doi: 10.1101/gr.213363.116. Epub 2017 Mar 21.


Genome-Wide Screen Reveals sec21 Mutants of Saccharomyces cerevisiae Are Methotrexate-Resistant.

Wong LH, Flibotte S, Sinha S, Chiang J, Giaever G, Nislow C.

G3 (Bethesda). 2017 Apr 3;7(4):1251-1257. doi: 10.1534/g3.116.038117.


Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes.

Zhang D, Wang F, Lal N, Chiu AP, Wan A, Jia J, Bierende D, Flibotte S, Sinha S, Asadi A, Hu X, Taghizadeh F, Pulinilkunnil T, Nislow C, Vlodavsky I, Johnson JD, Kieffer TJ, Hussein B, Rodrigues B.

Diabetes. 2017 Jan;66(1):45-57. doi: 10.2337/db16-0761. Epub 2016 Oct 7.


Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.

Mathew MD, Mathew ND, Miller A, Simpson M, Au V, Garland S, Gestin M, Edgley ML, Flibotte S, Balgi A, Chiang J, Giaever G, Dean P, Tung A, Roberge M, Roskelley C, Forge T, Nislow C, Moerman D.

PLoS Negl Trop Dis. 2016 Oct 18;10(10):e0005058. doi: 10.1371/journal.pntd.0005058. eCollection 2016 Oct.


Accelerating Gene Discovery by Phenotyping Whole-Genome Sequenced Multi-mutation Strains and Using the Sequence Kernel Association Test (SKAT).

Timbers TA, Garland SJ, Mohan S, Flibotte S, Edgley M, Muncaster Q, Au V, Li-Leger E, Rosell FI, Cai J, Rademakers S, Jansen G, Moerman DG, Leroux MR.

PLoS Genet. 2016 Aug 10;12(8):e1006235. doi: 10.1371/journal.pgen.1006235. eCollection 2016 Aug.


Novel small molecules potentiate premature termination codon readthrough by aminoglycosides.

Baradaran-Heravi A, Balgi AD, Zimmerman C, Choi K, Shidmoossavee FS, Tan JS, Bergeaud C, Krause A, Flibotte S, Shimizu Y, Anderson HJ, Mouly V, Jan E, Pfeifer T, Jaquith JB, Roberge M.

Nucleic Acids Res. 2016 Aug 19;44(14):6583-98. doi: 10.1093/nar/gkw638. Epub 2016 Jul 12.


The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans.

Flibotte S, Kim BR, Van de Laar E, Brown L, Moghal N.

Dev Biol. 2016 Jul 1;415(1):46-63. doi: 10.1016/j.ydbio.2016.05.009. Epub 2016 May 17.


UBR-5, a Conserved HECT-Type E3 Ubiquitin Ligase, Negatively Regulates Notch-Type Signaling in Caenorhabditis elegans.

Safdar K, Gu A, Xu X, Au V, Taylor J, Flibotte S, Moerman DG, Maine EM.

G3 (Bethesda). 2016 Jul 7;6(7):2125-34. doi: 10.1534/g3.116.027805.


N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3' Splice Site Function in Vivo.

Itani OA, Flibotte S, Dumas KJ, Guo C, Blumenthal T, Hu PJ.

G3 (Bethesda). 2016 Jun 1;6(6):1751-6. doi: 10.1534/g3.116.028662.


Rapid Increase in frequency of gene copy-number variants during experimental evolution in Caenorhabditis elegans.

Farslow JC, Lipinski KJ, Packard LB, Edgley ML, Taylor J, Flibotte S, Moerman DG, Katju V, Bergthorsson U.

BMC Genomics. 2015 Dec 9;16:1044. doi: 10.1186/s12864-015-2253-2.


Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans.

Itani OA, Flibotte S, Dumas KJ, Moerman DG, Hu PJ.

G3 (Bethesda). 2015 Dec 1;6(2):351-6. doi: 10.1534/g3.115.024257.


Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation.

Tarailo-Graovac M, Wong T, Qin Z, Flibotte S, Taylor J, Moerman DG, Rose AM, Chen N.

BMC Genomics. 2015 Mar 18;16:210. doi: 10.1186/s12864-015-1402-y.


Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.

Tarailo-Graovac M, Wong T, Qin Z, Flibotte S, Taylor J, Moerman DG, Rose AM, Chen N.

Cell Cycle. 2014;13(19):3089-199. doi: 10.4161/15384101.2014.949491.


Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon.

Frøkjær-Jensen C, Davis MW, Sarov M, Taylor J, Flibotte S, LaBella M, Pozniakovsky A, Moerman DG, Jorgensen EM.

Nat Methods. 2014 May;11(5):529-34. doi: 10.1038/nmeth.2889. Epub 2014 Mar 16.


A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.

Gysi S, Rhiner C, Flibotte S, Moerman DG, Hengartner MO.

PLoS One. 2013 Sep 16;8(9):e74908. doi: 10.1371/journal.pone.0074908. eCollection 2013.


The million mutation project: a new approach to genetics in Caenorhabditis elegans.

Thompson O, Edgley M, Strasbourger P, Flibotte S, Ewing B, Adair R, Au V, Chaudhry I, Fernando L, Hutter H, Kieffer A, Lau J, Lee N, Miller A, Raymant G, Shen B, Shendure J, Taylor J, Turner EH, Hillier LW, Moerman DG, Waterston RH.

Genome Res. 2013 Oct;23(10):1749-62. doi: 10.1101/gr.157651.113. Epub 2013 Jun 25.


Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans.

Dumas KJ, Delaney CE, Flibotte S, Moerman DG, Csankovszki G, Hu PJ.

Genetics. 2013 Jul;194(3):619-29. doi: 10.1534/genetics.113.149948. Epub 2013 Jun 3.


Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.

Labrador L, Barroso C, Lightfoot J, Müller-Reichert T, Flibotte S, Taylor J, Moerman DG, Villeneuve AM, Martinez-Perez E.

PLoS Genet. 2013 May;9(5):e1003497. doi: 10.1371/journal.pgen.1003497. Epub 2013 May 9.


Genetic control of vulval development in Caenorhabditis briggsae.

Sharanya D, Thillainathan B, Marri S, Bojanala N, Taylor J, Flibotte S, Moerman DG, Waterston RH, Gupta BP.

G3 (Bethesda). 2012 Dec;2(12):1625-41. doi: 10.1534/g3.112.004598. Epub 2012 Dec 1.


DNA synthesis generates terminal duplications that seal end-to-end chromosome fusions.

Lowden MR, Flibotte S, Moerman DG, Ahmed S.

Science. 2011 Apr 22;332(6028):468-71. doi: 10.1126/science.1199022.


C. elegans ADAMTS ADT-2 regulates body size by modulating TGFβ signaling and cuticle collagen organization.

Fernando T, Flibotte S, Xiong S, Yin J, Yzeiraj E, Moerman DG, Meléndez A, Savage-Dunn C.

Dev Biol. 2011 Apr 1;352(1):92-103. doi: 10.1016/j.ydbio.2011.01.016. Epub 2011 Jan 21.


Whole-genome profiling of mutagenesis in Caenorhabditis elegans.

Flibotte S, Edgley ML, Chaudhry I, Taylor J, Neil SE, Rogula A, Zapf R, Hirst M, Butterfield Y, Jones SJ, Marra MA, Barstead RJ, Moerman DG.

Genetics. 2010 Jun;185(2):431-41. doi: 10.1534/genetics.110.116616. Epub 2010 May 3.


Genomic sequence of a mutant strain of Caenorhabditis elegans with an altered recombination pattern.

Rose AM, O'Neil NJ, Bilenky M, Butterfield YS, Malhis N, Flibotte S, Jones MR, Marra M, Baillie DL, Jones SJ.

BMC Genomics. 2010 Feb 23;11:131. doi: 10.1186/1471-2164-11-131.


Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans.

Maydan JS, Lorch A, Edgley ML, Flibotte S, Moerman DG.

BMC Genomics. 2010 Jan 25;11:62. doi: 10.1186/1471-2164-11-62.


New tools for investigating the comparative biology of Caenorhabditis briggsae and C. elegans.

Zhao Z, Flibotte S, Murray JI, Blick D, Boyle TJ, Gupta B, Moerman DG, Waterston RH.

Genetics. 2010 Mar;184(3):853-63. doi: 10.1534/genetics.109.110270. Epub 2009 Dec 14.


Detection of pathogenic copy number variants in children with idiopathic intellectual disability using 500 K SNP array genomic hybridization.

Friedman J, Adam S, Arbour L, Armstrong L, Baross A, Birch P, Boerkoel C, Chan S, Chai D, Delaney AD, Flibotte S, Gibson WT, Langlois S, Lemyre E, Li HI, MacLeod P, Mathers J, Michaud JL, McGillivray BC, Patel MS, Qian H, Rouleau GA, Van Allen MI, Yong SL, Zahir FR, Eydoux P, Marra MA.

BMC Genomics. 2009 Nov 16;10:526. doi: 10.1186/1471-2164-10-526.


Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development.

O'Meara MM, Bigelow H, Flibotte S, Etchberger JF, Moerman DG, Hobert O.

Genetics. 2009 Apr;181(4):1679-86. doi: 10.1534/genetics.108.097832. Epub 2009 Feb 2.


De Novo identification of single nucleotide mutations in Caenorhabditis elegans using array comparative genomic hybridization.

Maydan JS, Okada HM, Flibotte S, Edgley ML, Moerman DG.

Genetics. 2009 Apr;181(4):1673-7. doi: 10.1534/genetics.108.100065. Epub 2009 Feb 2.


Rapid high resolution single nucleotide polymorphism-comparative genome hybridization mapping in Caenorhabditis elegans.

Flibotte S, Edgley ML, Maydan J, Taylor J, Zapf R, Waterston R, Moerman DG.

Genetics. 2009 Jan;181(1):33-7. doi: 10.1534/genetics.108.096487. Epub 2008 Oct 28.


Transcription of foreign DNA in Escherichia coli.

Warren RL, Freeman JD, Levesque RC, Smailus DE, Flibotte S, Holt RA.

Genome Res. 2008 Nov;18(11):1798-805. doi: 10.1101/gr.080358.108. Epub 2008 Aug 13.


Impact of whole genome amplification on analysis of copy number variants.

Pugh TJ, Delaney AD, Farnoud N, Flibotte S, Griffith M, Li HI, Qian H, Farinha P, Gascoyne RD, Marra MA.

Nucleic Acids Res. 2008 Aug;36(13):e80. doi: 10.1093/nar/gkn378. Epub 2008 Jun 17.

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