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Independent validation of the prognostic significance of invasion patterns in endocervical adenocarcinoma: Pattern A predicts excellent survival.

Spaans VM, Scheunhage DA, Barzaghi B, de Kroon CD, Fleuren GJ, Bosse T, Jordanova ES.

Gynecol Oncol. 2018 Nov;151(2):196-201. doi: 10.1016/j.ygyno.2018.09.013. Epub 2018 Sep 24.


The landscape of somatic mutations in Indonesian cervical cancer is predominated by the PI3K pathway.

Spaans VM, Nyoman Bayu Mahendra I, Purwoto G, Trietsch MD, Osse M, Ter Haar N, Peters AAW, Fleuren GJ, Jordanova ES.

Gynecol Oncol. 2018 Jan;148(1):189-196. doi: 10.1016/j.ygyno.2017.10.009. Epub 2017 Nov 4.


Autocrine expression of the epidermal growth factor receptor ligand heparin-binding EGF-like growth factor in cervical cancer.

Schrevel M, Osse EM, Prins FA, Trimbos JBMZ, Fleuren GJ, Gorter A, Jordanova ES.

Int J Oncol. 2017 Jun;50(6):1947-1954. doi: 10.3892/ijo.2017.3980. Epub 2017 May 3.


Human Leukocyte Antigen-DR Expression is Significantly Related to an Increased Disease-Free and Disease-Specific Survival in Patients With Cervical Adenocarcinoma.

Samuels S, Spaans VM, Osse M, Peters LA, Kenter GG, Fleuren GJ, Jordanova ES.

Int J Gynecol Cancer. 2016 Oct;26(8):1503-1509.


Somatic mutation profiles in primary colorectal cancers and matching ovarian metastases: Identification of driver and passenger mutations.

Crobach S, Ruano D, van Eijk R, Schrumpf M; PALGA group, Fleuren G, van Wezel T, Morreau H.

J Pathol Clin Res. 2016 Apr 15;2(3):166-74. doi: 10.1002/cjp2.45. eCollection 2016 Jul.


Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response.

van Poelgeest MI, Welters MJ, Vermeij R, Stynenbosch LF, Loof NM, Berends-van der Meer DM, Löwik MJ, Hamming IL, van Esch EM, Hellebrekers BW, van Beurden M, Schreuder HW, Kagie MJ, Trimbos JB, Fathers LM, Daemen T, Hollema H, Valentijn AR, Oostendorp J, Oude Elberink JH, Fleuren GJ, Bosse T, Kenter GG, Stijnen T, Nijman HW, Melief CJ, van der Burg SH.

Clin Cancer Res. 2016 May 15;22(10):2342-50. doi: 10.1158/1078-0432.CCR-15-2594. Epub 2016 Jan 26.


Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome.

Spaans VM, Trietsch MD, Peters AA, Osse M, Ter Haar N, Fleuren GJ, Jordanova ES.

PLoS One. 2015 Jul 21;10(7):e0133670. doi: 10.1371/journal.pone.0133670. eCollection 2015.


Molecular backgrounds of ERAP1 downregulation in cervical carcinoma.

Mehta AM, Osse M, Kolkman-Uljee S, Fleuren GJ, Jordanova ES.

Anal Cell Pathol (Amst). 2015;2015:367837. doi: 10.1155/2015/367837. Epub 2015 Jun 4.


The correlations between IL-17 vs. Th17 cells and cancer patient survival: a systematic review.

Punt S, Langenhoff JM, Putter H, Fleuren GJ, Gorter A, Jordanova ES.

Oncoimmunology. 2015 Mar 6;4(2):e984547. eCollection 2015 Feb. Review.


Angels and demons: Th17 cells represent a beneficial response, while neutrophil IL-17 is associated with poor prognosis in squamous cervical cancer.

Punt S, Fleuren GJ, Kritikou E, Lubberts E, Trimbos JB, Jordanova ES, Gorter A.

Oncoimmunology. 2015 Feb 3;4(1):e984539. eCollection 2015 Jan.


Correlations between immune response and vascularization qRT-PCR gene expression clusters in squamous cervical cancer.

Punt S, Houwing-Duistermaat JJ, Schulkens IA, Thijssen VL, Osse EM, de Kroon CD, Griffioen AW, Fleuren GJ, Gorter A, Jordanova ES.

Mol Cancer. 2015 Mar 31;14:71. doi: 10.1186/s12943-015-0350-0.


Differences in genetic variation in antigen-processing machinery components and association with cervical carcinoma risk in two Indonesian populations.

Mehta AM, Spaans VM, Mahendra NB, Osse EM, Vet JN, Purwoto G, Surya IG, Cornian S, Peters AA, Fleuren GJ, Jordanova ES.

Immunogenetics. 2015 Jun;67(5-6):267-75. doi: 10.1007/s00251-015-0834-5. Epub 2015 Mar 22.


FoxP3(+) and IL-17(+) cells are correlated with improved prognosis in cervical adenocarcinoma.

Punt S, van Vliet ME, Spaans VM, de Kroon CD, Fleuren GJ, Gorter A, Jordanova ES.

Cancer Immunol Immunother. 2015 Jun;64(6):745-53. doi: 10.1007/s00262-015-1678-4. Epub 2015 Mar 21.


Target-enriched next-generation sequencing reveals differences between primary and secondary ovarian tumors in formalin-fixed, paraffin-embedded tissue.

Crobach S, Ruano D, van Eijk R, Fleuren GJ, Minderhout I, Snowdowne R, Tops C, van Wezel T, Morreau H.

J Mol Diagn. 2015 Mar;17(2):193-200. doi: 10.1016/j.jmoldx.2014.10.006. Epub 2014 Dec 26.


Searching for metastases in ovarian tissue before autotransplantation: a tailor-made approach.

Hoekman EJ, Smit VT, Fleming TP, Louwe LA, Fleuren GJ, Hilders CG.

Fertil Steril. 2015 Feb;103(2):469-77. doi: 10.1016/j.fertnstert.2014.11.001. Epub 2014 Dec 10.


Expression of coinhibitory receptors on T cells in the microenvironment of usual vulvar intraepithelial neoplasia is related to proinflammatory effector T cells and an increased recurrence-free survival.

van Esch EM, van Poelgeest MI, Kouwenberg S, Osse EM, Trimbos JB, Fleuren GJ, Jordanova ES, van der Burg SH.

Int J Cancer. 2015 Feb 15;136(4):E95-106. doi: 10.1002/ijc.29174. Epub 2014 Sep 15.


Intraepithelial macrophage infiltration is related to a high number of regulatory T cells and promotes a progressive course of HPV-induced vulvar neoplasia.

van Esch EM, van Poelgeest MI, Trimbos JB, Fleuren GJ, Jordanova ES, van der Burg SH.

Int J Cancer. 2015 Feb 15;136(4):E85-94. doi: 10.1002/ijc.29173. Epub 2014 Sep 15.


CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma.

Trietsch MD, Spaans VM, ter Haar NT, Osse EM, Peters AA, Gaarenstroom KN, Fleuren GJ.

Gynecol Oncol. 2014 Oct;135(1):149-55. doi: 10.1016/j.ygyno.2014.07.094. Epub 2014 Jul 27.


Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers.

Spaans VM, Trietsch MD, Crobach S, Stelloo E, Kremer D, Osse EM, Haar NT, van Eijk R, Muller S, van Wezel T, Trimbos JB, Bosse T, Smit VT, Fleuren GJ.

PLoS One. 2014 Mar 26;9(3):e93451. doi: 10.1371/journal.pone.0093451. eCollection 2014.


Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV-induced usual vulvar intraepithelial neoplasia and implications for immunotherapy.

van Esch EM, Tummers B, Baartmans V, Osse EM, Ter Haar N, Trietsch MD, Hellebrekers BW, Holleboom CA, Nagel HT, Tan LT, Fleuren GJ, van Poelgeest MI, van der Burg SH, Jordanova ES.

Int J Cancer. 2014 Aug 15;135(4):830-42. doi: 10.1002/ijc.28713. Epub 2014 Jan 28.


Clinical characteristics associated with development of recurrence and progression in usual-type vulvar intraepithelial neoplasia.

van Esch EM, Dam MC, Osse ME, Putter H, Trimbos BJ, Fleuren G, van der Burg SH, van Poelgeest MI.

Int J Gynecol Cancer. 2013 Oct;23(8):1476-83. doi: 10.1097/IGC.0b013e3182a57fd6.


The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study.

de Vos van Steenwijk PJ, van Poelgeest MI, Ramwadhdoebe TH, Löwik MJ, Berends-van der Meer DM, van der Minne CE, Loof NM, Stynenbosch LF, Fathers LM, Valentijn AR, Oostendorp J, Osse EM, Fleuren GJ, Nooij L, Kagie MJ, Hellebrekers BW, Melief CJ, Welters MJ, van der Burg SH, Kenter GG.

Cancer Immunol Immunother. 2014 Feb;63(2):147-60. Epub 2013 Nov 15.


Spindle cell morphology is related to poor prognosis in vulvar squamous cell carcinoma.

Trietsch MD, Peters AA, Gaarenstroom KN, van Koningsbrugge SH, ter Haar NT, Osse EM, Halbesma N, Fleuren GJ.

Br J Cancer. 2013 Oct 15;109(8):2259-65. doi: 10.1038/bjc.2013.563. Epub 2013 Sep 24.


Loss of heterozygosity and copy number alterations in flow-sorted bulky cervical cancer.

van den Tillaart SA, Corver WE, Ruano Neto D, ter Haar NT, Goeman JJ, Trimbos JB, Fleuren GJ, Oosting J.

PLoS One. 2013 Jul 9;8(7):e67414. doi: 10.1371/journal.pone.0067414. Print 2013.


HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial.

van Poelgeest MI, Welters MJ, van Esch EM, Stynenbosch LF, Kerpershoek G, van Persijn van Meerten EL, van den Hende M, Löwik MJ, Berends-van der Meer DM, Fathers LM, Valentijn AR, Oostendorp J, Fleuren GJ, Melief CJ, Kenter GG, van der Burg SH.

J Transl Med. 2013 Apr 4;11:88. doi: 10.1186/1479-5876-11-88.


Role of IL-12p40 in cervical carcinoma.

Zijlmans HJ, Punt S, Fleuren GJ, Trimbos JB, Kenter GG, Gorter A.

Br J Cancer. 2012 Dec 4;107(12):1956-62. doi: 10.1038/bjc.2012.488. Epub 2012 Oct 25.


HLA-E expression in cervical adenocarcinomas: association with improved long-term survival.

Spaans VM, Peters AA, Fleuren GJ, Jordanova ES.

J Transl Med. 2012 Sep 4;10:184. doi: 10.1186/1479-5876-10-184.


Single-visit approach of cervical cancer screening: see and treat in Indonesia.

Vet JN, Kooijman JL, Henderson FC, Aziz FM, Purwoto G, Susanto H, Surya IG, Budiningsih S, Cornain S, Fleuren GJ, Trimbos JB, Peters AA.

Br J Cancer. 2012 Aug 21;107(5):772-7. doi: 10.1038/bjc.2012.334. Epub 2012 Jul 31.


A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions.

de Vos van Steenwijk PJ, Ramwadhdoebe TH, Löwik MJ, van der Minne CE, Berends-van der Meer DM, Fathers LM, Valentijn AR, Oostendorp J, Fleuren GJ, Hellebrekers BW, Welters MJ, van Poelgeest MI, Melief CJ, Kenter GG, van der Burg SH.

Cancer Immunol Immunother. 2012 Sep;61(9):1485-92. doi: 10.1007/s00262-012-1292-7. Epub 2012 Jun 9.


CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients.

Schrevel M, Karim R, ter Haar NT, van der Burg SH, Trimbos JB, Fleuren GJ, Gorter A, Jordanova ES.

Br J Cancer. 2012 Apr 24;106(9):1520-5. doi: 10.1038/bjc.2012.110.


Cytomorphological analysis of uterine cervical pap smears in relation to human papillomavirus infection in Indonesian women.

Rachmadi L, Jordanova ES, Kolkman-Uljee S, van der Linden-Narain I, Purwoto G, Siregar B, Fleuren GJ, Cornain S, Veselic M.

Acta Cytol. 2012;56(2):171-6. doi: 10.1159/000335562. Epub 2012 Feb 17.


Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations.

Corver WE, Ter Haar NT, Fleuren GJ, Oosting J.

Cell Oncol (Dordr). 2011 Dec;34(6):553-63. doi: 10.1007/s13402-011-0061-5. Epub 2011 Nov 1.


Decidual infiltration of FoxP3⁺ regulatory T cells, CD3⁺ T cells, CD56⁺ decidual natural killer cells and Ki-67 trophoblast cells in hydatidiform mole compared to normal and ectopic pregnancies.

Sundara YT, Jordanova ES, Hernowo BS, Gandamihardja S, Fleuren GJ.

Mol Med Rep. 2012 Jan;5(1):275-81. doi: 10.3892/mmr.2011.633. Epub 2011 Oct 14.


Patterns of parametrial involvement in radical hysterectomy specimens of cervical cancer patients.

van den Tillaart SA, Trimbos JB, Dreef EJ, Jordanova ES, Fleuren GJ.

Int J Gynecol Pathol. 2011 Mar;30(2):185-92. doi: 10.1097/PGP.0b013e3181fa5a7e.


Molecular mechanisms of epidermal growth factor receptor overexpression in patients with cervical cancer.

Schrevel M, Gorter A, Kolkman-Uljee SM, Trimbos JB, Fleuren GJ, Jordanova ES.

Mod Pathol. 2011 May;24(5):720-8. doi: 10.1038/modpathol.2010.239. Epub 2011 Jan 21.


Versican expression is associated with tumor-infiltrating CD8-positive T cells and infiltration depth in cervical cancer.

Gorter A, Zijlmans HJ, van Gent H, Trimbos JB, Fleuren GJ, Jordanova ES.

Mod Pathol. 2010 Dec;23(12):1605-15. doi: 10.1038/modpathol.2010.154. Epub 2010 Aug 20.


Abdominal scar recurrences of cervical cancer: incidence and characteristics: a case-control study.

van den Tillaart SA, Schoneveld A, Peters IT, Trimbos JB, Van Hylckama Vlieg A, Fleuren GJ, Peters AA.

Int J Gynecol Cancer. 2010 Aug;20(6):1031-40. doi: 10.1111/IGC.0b013e3181db5153.


Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses.

Welters MJ, Kenter GG, de Vos van Steenwijk PJ, Löwik MJ, Berends-van der Meer DM, Essahsah F, Stynenbosch LF, Vloon AP, Ramwadhdoebe TH, Piersma SJ, van der Hulst JM, Valentijn AR, Fathers LM, Drijfhout JW, Franken KL, Oostendorp J, Fleuren GJ, Melief CJ, van der Burg SH.

Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11895-9. doi: 10.1073/pnas.1006500107. Epub 2010 Jun 14.


The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors.

Heusinkveld M, Welters MJ, van Poelgeest MI, van der Hulst JM, Melief CJ, Fleuren GJ, Kenter GG, van der Burg SH.

Int J Cancer. 2011 Jan 15;128(2):379-89. doi: 10.1002/ijc.25361. Epub 2010 Apr 5.


Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia.

Kenter GG, Welters MJ, Valentijn AR, Lowik MJ, Berends-van der Meer DM, Vloon AP, Essahsah F, Fathers LM, Offringa R, Drijfhout JW, Wafelman AR, Oostendorp J, Fleuren GJ, van der Burg SH, Melief CJ.

N Engl J Med. 2009 Nov 5;361(19):1838-47. doi: 10.1056/NEJMoa0810097.


Expression of endoglin (CD105) in cervical cancer.

Zijlmans HJ, Fleuren GJ, Hazelbag S, Sier CF, Dreef EJ, Kenter GG, Gorter A.

Br J Cancer. 2009 May 19;100(10):1617-26. doi: 10.1038/sj.bjc.6605009. Epub 2009 Apr 7.


Nerve-sparing radical hysterectomy: local recurrence rate, feasibility, and safety in cervical cancer patients stage IA to IIA.

van den Tillaart SA, Kenter GG, Peters AA, Dekker FW, Gaarenstroom KN, Fleuren GJ, Trimbos JB.

Int J Gynecol Cancer. 2009 Jan;19(1):39-45. doi: 10.1111/IGC.0b013e318197f675.


Genome-wide allelic state analysis on flow-sorted tumor fractions provides an accurate measure of chromosomal aberrations.

Corver WE, Middeldorp A, ter Haar NT, Jordanova ES, van Puijenbroek M, van Eijk R, Cornelisse CJ, Fleuren GJ, Morreau H, Oosting J, van Wezel T.

Cancer Res. 2008 Dec 15;68(24):10333-40. doi: 10.1158/0008-5472.CAN-08-2665.


Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response.

de Vos van Steenwijk PJ, Piersma SJ, Welters MJ, van der Hulst JM, Fleuren G, Hellebrekers BW, Kenter GG, van der Burg SH.

Clin Cancer Res. 2008 Nov 15;14(22):7188-95. doi: 10.1158/1078-0432.CCR-08-0994.


Prevalence of human papillomavirus in Indonesia: a population-based study in three regions.

Vet JN, de Boer MA, van den Akker BE, Siregar B, Lisnawati, Budiningsih S, Tyasmorowati D, Moestikaningsih, Cornain S, Peters AA, Fleuren GJ.

Br J Cancer. 2008 Jul 8;99(1):214-8.


Elevated expression of SerpinA1 and SerpinA3 in HLA-positive cervical carcinoma.

Kloth JN, Gorter A, Fleuren GJ, Oosting J, Uljee S, ter Haar N, Dreef EJ, Kenter GG, Jordanova ES.

J Pathol. 2008 Jul;215(3):222-30. doi: 10.1002/path.2347.


Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival.

Kloth JN, Kenter GG, Spijker HS, Uljee S, Corver WE, Jordanova ES, Fleuren GJ, Gorter A.

Mod Pathol. 2008 Jul;21(7):866-75. doi: 10.1038/modpathol.2008.62. Epub 2008 Apr 18.


Frequent mutations in the 3'-untranslated region of IFNGR1 lack functional impairment in microsatellite-unstable colorectal tumours.

Dierssen JW, van Puijenbroek M, Dezentjé DA, Fleuren GJ, Cornelisse CJ, van Wezel T, Offringa R, Morreau H.

Eur J Hum Genet. 2008 Oct;16(10):1235-9. doi: 10.1038/ejhg.2008.81. Epub 2008 Apr 16.


Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia.

van den Hende M, van Poelgeest MI, van der Hulst JM, de Jong J, Drijfhout JW, Fleuren GJ, Valentijn AR, Wafelman AR, Slappendel GM, Melief CJ, Offringa R, van der Burg SH, Kenter GG.

Int J Cancer. 2008 Jul 1;123(1):146-52. doi: 10.1002/ijc.23502.


Human leukocyte antigen class I, MHC class I chain-related molecule A, and CD8+/regulatory T-cell ratio: which variable determines survival of cervical cancer patients?

Jordanova ES, Gorter A, Ayachi O, Prins F, Durrant LG, Kenter GG, van der Burg SH, Fleuren GJ.

Clin Cancer Res. 2008 Apr 1;14(7):2028-35. doi: 10.1158/1078-0432.CCR-07-4554.

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