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Items: 36


Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface.

Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM.

Cancer Res. 2019 Sep 9. pii: canres.1112.2019. doi: 10.1158/0008-5472.CAN-19-1112. [Epub ahead of print]


MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells.

Gana CC, Hanssen KM, Yu DMT, Flemming CL, Wheatley MS, Conseil G, Cole SPC, Norris MD, Haber M, Fletcher JI.

Biochem Pharmacol. 2019 Oct;168:237-248. doi: 10.1016/j.bcp.2019.07.009. Epub 2019 Jul 11.


Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.

Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.


Too many targets, not enough patients: rethinking neuroblastoma clinical trials.

Fletcher JI, Ziegler DS, Trahair TN, Marshall GM, Haber M, Norris MD.

Nat Rev Cancer. 2018 Jun;18(6):389-400. doi: 10.1038/s41568-018-0003-x. Review.


Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

Murray J, Valli E, Yu DMT, Truong AM, Gifford AJ, Eden GL, Gamble LD, Hanssen KM, Flemming CL, Tan A, Tivnan A, Allan S, Saletta F, Cheung L, Ruhle M, Schuetz JD, Henderson MJ, Byrne JA, Norris MD, Haber M, Fletcher JI.

Eur J Cancer. 2017 Sep;83:132-141. doi: 10.1016/j.ejca.2017.06.024. Epub 2017 Jul 20.


Remodelling of lace plant leaves: antioxidants and ROS are key regulators of programmed cell death.

Dauphinee AN, Fletcher JI, Denbigh GL, Lacroix CR, Gunawardena AHLAN.

Planta. 2017 Jul;246(1):133-147. doi: 10.1007/s00425-017-2683-y. Epub 2017 Apr 7.


A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

Jung M, Russell AJ, Liu B, George J, Liu PY, Liu T, DeFazio A, Bowtell DD, Oberthuer A, London WB, Fletcher JI, Haber M, Norris MD, Henderson MJ.

Cancer Res. 2017 Feb 15;77(4):971-981. doi: 10.1158/0008-5472.CAN-15-2906. Epub 2016 Dec 6.


MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL.

Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13.


ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

Fletcher JI, Williams RT, Henderson MJ, Norris MD, Haber M.

Drug Resist Updat. 2016 May;26:1-9. doi: 10.1016/j.drup.2016.03.001. Epub 2016 Mar 17. Review.


The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression.

Tee AE, Liu B, Song R, Li J, Pasquier E, Cheung BB, Jiang C, Marshall GM, Haber M, Norris MD, Fletcher JI, Dinger ME, Liu T.

Oncotarget. 2016 Feb 23;7(8):8663-75. doi: 10.18632/oncotarget.6675.


MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma.

Lau DT, Flemming CL, Gherardi S, Perini G, Oberthuer A, Fischer M, Juraeva D, Brors B, Xue C, Norris MD, Marshall GM, Haber M, Fletcher JI, Ashton LJ.

Oncotarget. 2015 Jun 20;6(17):15510-23.


Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen.

Cheung L, Yu DM, Neiron Z, Failes TW, Arndt GM, Fletcher JI.

Biochem Pharmacol. 2015 Feb 1;93(3):380-8. doi: 10.1016/j.bcp.2014.11.006. Epub 2014 Nov 22.


High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, Fletcher JI, Haber M, Norris MD.

Biochem Pharmacol. 2014 Sep 1;91(1):97-108. doi: 10.1016/j.bcp.2014.05.023. Epub 2014 Jun 25.


RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model.

Byrne FL, Yang L, Phillips PA, Hansford LM, Fletcher JI, Ormandy CJ, McCarroll JA, Kavallaris M.

Oncogene. 2014 Feb 13;33(7):882-90. doi: 10.1038/onc.2013.11. Epub 2013 Feb 11.


N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

Fletcher JI, Gherardi S, Murray J, Burkhart CA, Russell A, Valli E, Smith J, Oberthuer A, Ashton LJ, London WB, Marshall GM, Norris MD, Perini G, Haber M.

Cancer Res. 2012 Feb 15;72(4):845-53. doi: 10.1158/0008-5472.CAN-11-1885. Epub 2011 Dec 27.


ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

Henderson MJ, Haber M, Porro A, Munoz MA, Iraci N, Xue C, Murray J, Flemming CL, Smith J, Fletcher JI, Gherardi S, Kwek CK, Russell AJ, Valli E, London WB, Buxton AB, Ashton LJ, Sartorelli AC, Cohn SL, Schwab M, Marshall GM, Perini G, Norris MD.

J Natl Cancer Inst. 2011 Aug 17;103(16):1236-51. doi: 10.1093/jnci/djr256. Epub 2011 Jul 28.


Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.

Kvansakul M, Wei AH, Fletcher JI, Willis SN, Chen L, Roberts AW, Huang DC, Colman PM.

PLoS Pathog. 2010 Dec 23;6(12):e1001236. doi: 10.1371/journal.ppat.1001236.


ABC transporters in cancer: more than just drug efflux pumps.

Fletcher JI, Haber M, Henderson MJ, Norris MD.

Nat Rev Cancer. 2010 Feb;10(2):147-56. doi: 10.1038/nrc2789. Epub 2010 Jan 15.


Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening.

Branson KM, Mertens HD, Swarbrick JD, Fletcher JI, Kedzierski L, Gayler KR, Gooley PR, Smith BJ.

Biochemistry. 2009 Aug 18;48(32):7614-20. doi: 10.1021/bi900813x.


Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18081-7. doi: 10.1073/pnas.0808691105. Epub 2008 Nov 3. Erratum in: Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1678.


Controlling the cell death mediators Bax and Bak: puzzles and conundrums.

Fletcher JI, Huang DC.

Cell Cycle. 2008 Jan 1;7(1):39-44. Epub 2007 Oct 16. Review.


Programmed anuclear cell death delimits platelet life span.

Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S, Kelly PN, Ekert PG, Metcalf D, Roberts AW, Huang DC, Kile BT.

Cell. 2007 Mar 23;128(6):1173-86.


Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.


Subversion of the Bcl-2 life/death switch in cancer development and therapy.

Adams JM, Huang DC, Strasser A, Willis S, Chen L, Wei A, van Delft M, Fletcher JI, Puthalakath H, Kuroda J, Michalak EM, Kelly PN, Bouillet P, Villunger A, O'Reilly L, Bath ML, Smith DP, Egle A, Harris AW, Hinds M, Colman P, Cory S.

Cold Spring Harb Symp Quant Biol. 2005;70:469-77.


BH3-only proteins: orchestrating cell death.

Fletcher JI, Huang DC.

Cell Death Differ. 2006 Aug;13(8):1268-71. Epub 2006 Jun 9. No abstract available.


Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC.

Genes Dev. 2005 Jun 1;19(11):1294-305. Epub 2005 May 18.


1H, 13C, and 15N resonance assignments of the 17 kDa Ap4A hydrolase from Homo sapiens in the presence and absence of ATP.

Swarbrick JD, Buyya S, Gunawardana D, Fletcher JI, Branson K, Smith B, Pepe S, McLennan AG, Gayler KR, Gooley PR.

J Biomol NMR. 2005 Feb;31(2):181-2. No abstract available.


Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC.

Mol Cell. 2005 Feb 4;17(3):393-403.


The alphaM1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment.

de Planque MR, Rijkers DT, Fletcher JI, Liskamp RM, Separovic F.

Biochim Biophys Acta. 2004 Oct 11;1665(1-2):40-7.


The structure of Ap(4)A hydrolase complexed with ATP-MgF(x) reveals the basis of substrate binding.

Fletcher JI, Swarbrick JD, Maksel D, Gayler KR, Gooley PR.

Structure. 2002 Feb;10(2):205-13.


Functional significance of the beta hairpin in the insecticidal neurotoxin omega-atracotoxin-Hv1a.

Tedford HW, Fletcher JI, King GF.

J Biol Chem. 2001 Jul 13;276(28):26568-76. Epub 2001 Apr 19.


High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide.

Fletcher JI, Dingley AJ, Smith R, Connor M, Christie MJ, King GF.

Eur J Biochem. 1999 Sep;264(2):525-33.


Structure-function studies of omega-atracotoxin, a potent antagonist of insect voltage-gated calcium channels.

Wang X, Smith R, Fletcher JI, Wilson H, Wood CJ, Howden ME, King GF.

Eur J Biochem. 1999 Sep;264(2):488-94.


Solution structure of a defensin-like peptide from platypus venom.

Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW.

Biochem J. 1999 Aug 1;341 ( Pt 3):785-94.


The structure of a novel insecticidal neurotoxin, omega-atracotoxin-HV1, from the venom of an Australian funnel web spider.

Fletcher JI, Smith R, O'Donoghue SI, Nilges M, Connor M, Howden ME, Christie MJ, King GF.

Nat Struct Biol. 1997 Jul;4(7):559-66.


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