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Pak1 Kinase Maintains Apical Membrane Identity in Epithelia.

Aguilar-Aragon M, Elbediwy A, Foglizzo V, Fletcher GC, Li VSW, Thompson BJ.

Cell Rep. 2018 Feb 13;22(7):1639-1646. doi: 10.1016/j.celrep.2018.01.060.


Mechanical strain regulates the Hippo pathway in Drosophila.

Fletcher GC, Diaz-de-la-Loza MD, Borreguero-Muñoz N, Holder M, Aguilar-Aragon M, Thompson BJ.

Development. 2018 Mar 8;145(5). pii: dev159467. doi: 10.1242/dev.159467.


Inhibition of foodborne bacteria by antibacterial coatings printed onto food packaging films.

Widsten P, Mesic BB, Cruz CD, Fletcher GC, Chycka MA.

J Food Sci Technol. 2017 Jul;54(8):2379-2386. doi: 10.1007/s13197-017-2678-5. Epub 2017 May 29.


Correction: Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.

Khanal I, Elbediwy A, Diaz de la Loza MDC, Fletcher GC, Thompson BJ.

J Cell Sci. 2017 Jul 1;130(13):2221. doi: 10.1242/jcs.206912. No abstract available.


Persistent Listeria monocytogenes strains isolated from mussel production facilities form more biofilm but are not linked to specific genetic markers.

Nowak J, Cruz CD, Tempelaars M, Abee T, van Vliet AHM, Fletcher GC, Hedderley D, Palmer J, Flint S.

Int J Food Microbiol. 2017 Sep 1;256:45-53. doi: 10.1016/j.ijfoodmicro.2017.05.024. Epub 2017 Jun 1.


Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer.

Mason JM, Wei X, Fletcher GC, Kiarash R, Brokx R, Hodgson R, Beletskaya I, Bray MR, Mak TW.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3127-3132. doi: 10.1073/pnas.1700234114. Epub 2017 Mar 7.


Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Liu Y, Laufer R, Patel NK, Ng G, Sampson PB, Li SW, Lang Y, Feher M, Brokx R, Beletskaya I, Hodgson R, Plotnikova O, Awrey DE, Qiu W, Chirgadze NY, Mason JM, Wei X, Lin DC, Che Y, Kiarash R, Fletcher GC, Mak TW, Bray MR, Pauls HW.

ACS Med Chem Lett. 2016 May 6;7(7):671-5. doi: 10.1021/acsmedchemlett.5b00485. eCollection 2016 Jul 14.


Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.

Laufer R, Li SW, Liu Y, Ng G, Lang Y, Feher M, Brokx R, Beletskaya I, Hodgson R, Mao G, Plotnikova O, Awrey DE, Mason JM, Wei X, Lin DC, Che Y, Kiarash R, Madeira B, Fletcher GC, Mak TW, Bray MR, Pauls HW.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6. doi: 10.1016/j.bmcl.2016.06.021. Epub 2016 Jun 9.


Shot and Patronin polarise microtubules to direct membrane traffic and biogenesis of microvilli in epithelia.

Khanal I, Elbediwy A, Diaz de la Loza Mdel C, Fletcher GC, Thompson BJ.

J Cell Sci. 2016 Jul 1;129(13):2651-9. doi: 10.1242/jcs.189076. Epub 2016 May 26. Erratum in: J Cell Sci. 2017 Jul 1;130(13):2221.


Prevalence, characteristics and ecology of Vibrio vulnificus found in New Zealand shellfish.

Cruz CD, Chycka M, Hedderley D, Fletcher GC.

J Appl Microbiol. 2016 Apr;120(4):1100-7. doi: 10.1111/jam.13064. Epub 2016 Mar 7.


Biofilm formation of the L. monocytogenes strain 15G01 is influenced by changes in environmental conditions.

Nowak J, Cruz CD, Palmer J, Fletcher GC, Flint S.

J Microbiol Methods. 2015 Dec;119:189-95. doi: 10.1016/j.mimet.2015.10.022. Epub 2015 Oct 31.


The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.

Liu Y, Lang Y, Patel NK, Ng G, Laufer R, Li SW, Edwards L, Forrest B, Sampson PB, Feher M, Ban F, Awrey DE, Beletskaya I, Mao G, Hodgson R, Plotnikova O, Qiu W, Chirgadze NY, Mason JM, Wei X, Lin DC, Che Y, Kiarash R, Madeira B, Fletcher GC, Mak TW, Bray MR, Pauls HW.

J Med Chem. 2015 Apr 23;58(8):3366-92. doi: 10.1021/jm501740a. Epub 2015 Apr 3.


Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove.

Ivanova ME, Fletcher GC, O'Reilly N, Purkiss AG, Thompson BJ, McDonald NQ.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):555-64. doi: 10.1107/S139900471402776X. Epub 2015 Feb 26.


The Spectrin cytoskeleton regulates the Hippo signalling pathway.

Fletcher GC, Elbediwy A, Khanal I, Ribeiro PS, Tapon N, Thompson BJ.

EMBO J. 2015 Apr 1;34(7):940-54. doi: 10.15252/embj.201489642. Epub 2015 Feb 23.


Long-term study of Vibrio parahaemolyticus prevalence and distribution in New Zealand shellfish.

Cruz CD, Hedderley D, Fletcher GC.

Appl Environ Microbiol. 2015 Apr;81(7):2320-7. doi: 10.1128/AEM.04020-14. Epub 2015 Jan 23.


Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia.

Bell GP, Fletcher GC, Brain R, Thompson BJ.

Curr Biol. 2015 Jan 5;25(1):61-8. doi: 10.1016/j.cub.2014.10.052. Epub 2014 Dec 4.


Color change of the snapper (Pagrus auratus) and Gurnard (Chelidonichthys kumu) skin and eyes during storage: effect of light polarization and contact with ice.

Balaban MO, Stewart K, Fletcher GC, Alçiçek Z.

J Food Sci. 2014 Dec;79(12):E2456-62. doi: 10.1111/1750-3841.12693. Epub 2014 Nov 10.


Tannins and extracts of fruit byproducts: antibacterial activity against foodborne bacteria and antioxidant capacity.

Widsten P, Cruz CD, Fletcher GC, Pajak MA, McGhie TK.

J Agric Food Chem. 2014 Nov 19;62(46):11146-56. doi: 10.1021/jf503819t. Epub 2014 Nov 4.


Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent.

Mason JM, Lin DC, Wei X, Che Y, Yao Y, Kiarash R, Cescon DW, Fletcher GC, Awrey DE, Bray MR, Pan G, Mak TW.

Cancer Cell. 2014 Aug 11;26(2):163-76. doi: 10.1016/j.ccr.2014.05.006. Epub 2014 Jul 17.


Listeria monocytogenes associated with New Zealand seafood production and clinical cases: unique sequence types, truncated InlA, and attenuated invasiveness.

Cruz CD, Pitman AR, Harrow SA, Fletcher GC.

Appl Environ Microbiol. 2014 Feb;80(4):1489-97. doi: 10.1128/AEM.03305-13. Epub 2013 Dec 20.


An improved method for quantification of Vibrio vulnificus in oysters.

Cruz CD, Win JK, Fletcher GC.

J Microbiol Methods. 2013 Dec;95(3):397-9. doi: 10.1016/j.mimet.2013.07.024. Epub 2013 Aug 7.


The Hippo pathway polarizes the actin cytoskeleton during collective migration of Drosophila border cells.

Lucas EP, Khanal I, Gaspar P, Fletcher GC, Polesello C, Tapon N, Thompson BJ.

J Cell Biol. 2013 Jun 10;201(6):875-85. doi: 10.1083/jcb.201210073. Epub 2013 Jun 3.


An extension of the Coconut Cream Agar method to screen Penicillium citrinum isolates for citrinin production.

Mohamed S, Flint S, Palmer J, Fletcher GC, Pitt JI.

Lett Appl Microbiol. 2013 Sep;57(3):214-9. doi: 10.1111/lam.12102. Epub 2013 Jun 24.


Effect of water activity and temperature on the germination and growth of Aspergillus tamarii isolated from "Maldive fish".

Mohamed S, Mo L, Flint S, Palmer J, Fletcher GC.

Int J Food Microbiol. 2012 Nov 15;160(2):119-23. doi: 10.1016/j.ijfoodmicro.2012.09.022. Epub 2012 Oct 3.


Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.

Diamond JR, Eckhardt SG, Tan AC, Newton TP, Selby HM, Brunkow KL, Kachaeva MI, Varella-Garcia M, Pitts TM, Bray MR, Fletcher GC, Tentler JJ.

Clin Cancer Res. 2013 Jan 1;19(1):291-303. doi: 10.1158/1078-0432.CCR-12-1611. Epub 2012 Nov 7.


Prediction of the amount and rate of histamine degradation by diamine oxidase (DAO).

Naila A, Flint S, Fletcher GC, Bremer PJ, Meerdink G, Morton RH.

Food Chem. 2012 Dec 15;135(4):2650-60. doi: 10.1016/j.foodchem.2012.07.022. Epub 2012 Jul 17.


Histamine stability in Rihaakuru at -80, 4 and 30°C.

Naila A, Flint S, Fletcher GC, Bremer PJ, Meerdink G.

Food Chem. 2012 Dec 1;135(3):1226-9. doi: 10.1016/j.foodchem.2012.05.066. Epub 2012 May 24.


Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium.

Fletcher GC, Lucas EP, Brain R, Tournier A, Thompson BJ.

Curr Biol. 2012 Jun 19;22(12):1116-22. doi: 10.1016/j.cub.2012.04.020. Epub 2012 May 31.


Comparing rapid methods for detecting Listeria in seafood and environmental samples using the most probably number (MPN) technique.

Cruz CD, Win JK, Chantarachoti J, Mutukumira AN, Fletcher GC.

Int J Food Microbiol. 2012 Feb 15;153(3):483-7. doi: 10.1016/j.ijfoodmicro.2011.12.009. Epub 2011 Dec 14.


Biogenic amines and potential histamine - Forming bacteria in Rihaakuru (a cooked fish paste).

Naila A, Flint S, Fletcher GC, Bremer PJ, Meerdink G.

Food Chem. 2011 Sep 15;128(2):479-84. doi: 10.1016/j.foodchem.2011.03.057. Epub 2011 Mar 15.


Prevalence and biofilm-forming ability of Listeria monocytogenes in New Zealand mussel (Perna canaliculus) processing plants.

Cruz CD, Fletcher GC.

Food Microbiol. 2011 Oct;28(7):1387-93. doi: 10.1016/ Epub 2011 Jun 30.


ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action.

Fletcher GC, Brokx RD, Denny TA, Hembrough TA, Plum SM, Fogler WE, Sidor CF, Bray MR.

Mol Cancer Ther. 2011 Jan;10(1):126-37. doi: 10.1158/1535-7163.MCT-10-0574. Epub 2010 Dec 21.


Phase I safety, pharmacokinetic, and pharmacodynamic study of ENMD-2076, a novel angiogenic and Aurora kinase inhibitor, in patients with advanced solid tumors.

Diamond JR, Bastos BR, Hansen RJ, Gustafson DL, Eckhardt SG, Kwak EL, Pandya SS, Fletcher GC, Pitts TM, Kulikowski GN, Morrow M, Arnott J, Bray MR, Sidor C, Messersmith W, Shapiro GI.

Clin Cancer Res. 2011 Feb 15;17(4):849-60. doi: 10.1158/1078-0432.CCR-10-2144. Epub 2010 Dec 3.


Chemistry and microbiology of traditional Rihaakuru (fish paste) from the Maldives.

Naila A, Flint S, Fletcher GC, Bremer PJ, Meerdink G.

Int J Food Sci Nutr. 2011 Mar;62(2):139-47. doi: 10.3109/09637486.2010.515566. Epub 2010 Oct 1.


Assessment of the in vivo antitumor effects of ENMD-2076, a novel multitargeted kinase inhibitor, against primary and cell line-derived human colorectal cancer xenograft models.

Tentler JJ, Bradshaw-Pierce EL, Serkova NJ, Hasebroock KM, Pitts TM, Diamond JR, Fletcher GC, Bray MR, Eckhardt SG.

Clin Cancer Res. 2010 Jun 1;16(11):2989-2998. doi: 10.1158/1078-0432.CCR-10-0325. Epub 2010 Apr 20.


CD70 (TNFSF7) is expressed at high prevalence in renal cell carcinomas and is rapidly internalised on antibody binding.

Adam PJ, Terrett JA, Steers G, Stockwin L, Loader JA, Fletcher GC, Lu LS, Leach BI, Mason S, Stamps AC, Boyd RS, Pezzella F, Gatter KC, Harris AL.

Br J Cancer. 2006 Aug 7;95(3):298-306.


DJ-1, a novel regulator of the tumor suppressor PTEN.

Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian AS, Bray MR, Liu FF, Tsao MS, Mak TW.

Cancer Cell. 2005 Mar;7(3):263-73.


Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B.

Boyd RS, Adam PJ, Patel S, Loader JA, Berry J, Redpath NT, Poyser HR, Fletcher GC, Burgess NA, Stamps AC, Hudson L, Smith P, Griffiths M, Willis TG, Karran EL, Oscier DG, Catovsky D, Terrett JA, Dyer MJ.

Leukemia. 2003 Aug;17(8):1605-12.


hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.

Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA.

Br J Cancer. 2003 Feb 24;88(4):579-85.


Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer.

Adam PJ, Boyd R, Tyson KL, Fletcher GC, Stamps A, Hudson L, Poyser HR, Redpath N, Griffiths M, Steers G, Harris AL, Patel S, Berry J, Loader JA, Townsend RR, Daviet L, Legrain P, Parekh R, Terrett JA.

J Biol Chem. 2003 Feb 21;278(8):6482-9. Epub 2002 Dec 10.


Haemoglobin level in Scottish intensive care patients--a national one day survey.

Garrioch MA, Fletcher GC, Holmes AP.

Scott Med J. 2002 Jun;47(3):54-6.


Mitochondrial disappearance from cells: a clue to the role of autophagy in programmed cell death and disease?

Tolkovsky AM, Xue L, Fletcher GC, Borutaite V.

Biochimie. 2002 Feb-Mar;84(2-3):233-40. Review.


The role of non-technical skills in anaesthesia: a review of current literature.

Fletcher GC, McGeorge P, Flin RH, Glavin RJ, Maran NJ.

Br J Anaesth. 2002 Mar;88(3):418-29. Review. No abstract available.


Death commitment point is advanced by axotomy in sympathetic neurons.

Fletcher GC, Xue L, Passingham SK, Tolkovsky AM.

J Cell Biol. 2000 Aug 21;150(4):741-54.


The effect of 100% CO2 on the growth of nonproteolytic Clostridium botulinum at chill temperatures.

Gibson AM, Ellis-Brownlee RC, Cahill ME, Szabo EA, Fletcher GC, Bremer PJ.

Int J Food Microbiol. 2000 Mar 10;54(1-2):39-48.


Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution.

Xue L, Fletcher GC, Tolkovsky AM.

Mol Cell Neurosci. 1999 Sep;14(3):180-98.


Levels of histamine and histamine-producing bacteria in smoked fish from New Zealand markets.

Fletcher GC, Summers G, van Veghel PW.

J Food Prot. 1998 Aug;61(8):1064-70.


Thermal death times of Hafnia alvei cells in a model suspension and in artificially contaminated hot-smoked kahawai (Arripis trutta).

Bremer PJ, Osborne CM, Kemp RA, van Veghel P, Fletcher GC.

J Food Prot. 1998 Aug;61(8):1047-51.


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