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Opioid prescribing is rising in many countries.

Smith BH, Fletcher EH, Colvin LA.

BMJ. 2019 Oct 17;367:l5823. doi: 10.1136/bmj.l5823. No abstract available.


Translating evidence into practice: recommendations by a UK expert panel on the use of aflibercept in diabetic macular oedema.

Pearce I, Bailey C, Fletcher E, Ghanchi F, Rennie C, Santiago C, Napier J, Yang Y.

Eye (Lond). 2019 Oct 16. doi: 10.1038/s41433-019-0615-8. [Epub ahead of print]


Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways.

Horgusluoglu-Moloch E, Risacher SL, Crane PK, Hibar D, Thompson PM, Saykin AJ, Nho K; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Sci Rep. 2019 Oct 10;9(1):14498. doi: 10.1038/s41598-019-50507-3.


Dynamic change of cognitive reserve: associations with changes in brain, cognition, and diagnosis.

Bettcher BM, Gross AL, Gavett BE, Widaman KF, Fletcher E, Dowling NM, Buckley RF, Arenaza-Urquijo EM, Zahodne LB, Hohman TJ, Vonk JMJ, Rentz DM, Mungas D.

Neurobiol Aging. 2019 Aug 21;83:95-104. doi: 10.1016/j.neurobiolaging.2019.08.016. [Epub ahead of print]


Update on Therapeutic Protein-Drug Interaction: Information in Labeling.

Jing X, Ji P, Schrieber SJ, Fletcher EP, Sahajwalla C.

Clin Pharmacokinet. 2019 Oct 3. doi: 10.1007/s40262-019-00810-z. [Epub ahead of print] Review.


Laparoscopic cholecystectomy in the Acute Care Surgery model: risk factors for complications.

Fletcher E, Seabold E, Herzing K, Markert R, Gans A, Ekeh AP.

Trauma Surg Acute Care Open. 2019 Sep 13;4(1):e000312. doi: 10.1136/tsaco-2019-000312. eCollection 2019.


Multimodal Hippocampal Subfield Grading For Alzheimer's Disease Classification.

Hett K, Ta VT, Catheline G, Tourdias T, Manjón JV, Coupé P; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2019 Sep 25;9(1):13845. doi: 10.1038/s41598-019-49970-9.


New Perspective for Non-invasive Brain Stimulation Site Selection in Mild Cognitive Impairment: Based on Meta- and Functional Connectivity Analyses.

Liu J, Zhang B, Wilson G, Kong J; Alzheimer’s Disease Neuroimaging Initiative.

Front Aging Neurosci. 2019 Aug 27;11:228. doi: 10.3389/fnagi.2019.00228. eCollection 2019.


The role of education in a vascular pathway to episodic memory: brain maintenance or cognitive reserve?

Zahodne LB, Mayeda ER, Hohman TJ, Fletcher E, Racine AM, Gavett B, Manly JJ, Schupf N, Mayeux R, Brickman AM, Mungas D.

Neurobiol Aging. 2019 Aug 14;84:109-118. doi: 10.1016/j.neurobiolaging.2019.08.009. [Epub ahead of print]


Reversibility of Retinal Ganglion Cell Dysfunction From Chronic IOP Elevation.

Zhao D, Wong VHY, Nguyen CTO, Jobling AI, Fletcher EL, Vingrys AJ, Bui BV.

Invest Ophthalmol Vis Sci. 2019 Sep 3;60(12):3878-3886. doi: 10.1167/iovs.19-27113.


Identifying policies and strategies for general practitioner retention in direct patient care in the United Kingdom: a RAND/UCLA appropriateness method panel study.

Chilvers R, Richards SH, Fletcher E, Aylward A, Dean S, Salisbury C, Campbell J.

BMC Fam Pract. 2019 Sep 12;20(1):130. doi: 10.1186/s12875-019-1020-x.


Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group.

JAMA Ophthalmol. 2019 Aug 29. doi: 10.1001/jamaophthalmol.2019.3305. [Epub ahead of print]


The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory.

Li Y, Yao Z, Yu Y, Fu Y, Zou Y, Hu B; Alzheimer’s Disease Neuroimaging Initiative.

Front Aging Neurosci. 2019 Aug 8;11:208. doi: 10.3389/fnagi.2019.00208. eCollection 2019.


The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease.

Phipps JA, Dixon MA, Jobling AI, Wang AY, Greferath U, Vessey KA, Fletcher EL.

Exp Eye Res. 2019 Oct;187:107753. doi: 10.1016/j.exer.2019.107753. Epub 2019 Aug 10. Review.


The impact of worldwide, national and sub-national severity distributions in Burden of Disease studies: A case study of cancers in Scotland.

Wyper GMA, Grant I, Fletcher E, McCartney G, Stockton DL.

PLoS One. 2019 Aug 9;14(8):e0221026. doi: 10.1371/journal.pone.0221026. eCollection 2019.


Epigenetic reprogramming of immune cells in women with PCOS impact genes controlling reproductive function.

Hiam D, Simar D, Laker R, Altıntaş A, Gibson-Helm M, Fletcher E, Moreno-Asso A, Trewin AJ, Barres R, Stepto NK.

J Clin Endocrinol Metab. 2019 Aug 7. pii: jc.2019-01015. doi: 10.1210/jc.2019-01015. [Epub ahead of print]


Overseas GP recruitment: comparing international GP training with the UK and ensuring that registration standards and patient safety are maintained.

Fletcher E, Sansom A, Pitchforth E, Curnow G, Freeman A, Hawthorne K, Campbell J.

BJGP Open. 2019 Jul 23;3(2). pii: bjgpopen18X101640. doi: 10.3399/bjgpopen18X101640. Print 2019 Jul.


Non-coding variability at the APOE locus contributes to the Alzheimer's risk.

Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY.

Nat Commun. 2019 Jul 25;10(1):3310. doi: 10.1038/s41467-019-10945-z.


Performing Sparse Regularization and Dimension Reduction Simultaneously in Multimodal Data Fusion.

Yang Z, Zhuang X, Bird C, Sreenivasan K, Mishra V, Banks S, Cordes D; Alzheimer's Disease Neuroimaging Initiative.

Front Neurosci. 2019 Jul 3;13:642. doi: 10.3389/fnins.2019.00642. eCollection 2019.


Multifunctional elastin-like polypeptide renders β-glucosidase enzyme phase transition and high stability.

Zhou Y, Li X, Yan D, Addai Peprah F, Ji X, Fletcher EE, Wang Y, Wang Y, Gu J, Lin F, Shi H.

Biotechnol Biofuels. 2019 Jun 24;12:157. doi: 10.1186/s13068-019-1497-5. eCollection 2019.


Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats.

Fletcher EJR, Jamieson AD, Williams G, Doherty P, Duty S.

Sci Rep. 2019 Jun 6;9(1):8336. doi: 10.1038/s41598-019-44803-1.


White Matter Hyperintensities and Hippocampal Atrophy in Relation to Cognition: The 90+ Study.

Legdeur N, Visser PJ, Woodworth DC, Muller M, Fletcher E, Maillard P, Scheltens P, DeCarli C, Kawas CH, Corrada MM.

J Am Geriatr Soc. 2019 Sep;67(9):1827-1834. doi: 10.1111/jgs.15990. Epub 2019 Jun 6.


Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients.

Zhao Q, Liu M, Ha L, Zhou Y; Alzheimer's Disease Neuroimaging Initiative.

Front Neurol. 2019 May 15;10:486. doi: 10.3389/fneur.2019.00486. eCollection 2019.


Impact of Hepatitis C treatment on behavioural change in relation to drug use in people who inject drugs: A systematic review.

Caven M, Malaguti A, Robinson E, Fletcher E, Dillon JF.

Int J Drug Policy. 2019 Oct;72:169-176. doi: 10.1016/j.drugpo.2019.05.011. Epub 2019 May 18.


Density functional orbitals in quantum Monte Carlo: The importance of accurate densities.

Per MC, Fletcher EK, Cleland DM.

J Chem Phys. 2019 May 14;150(18):184101. doi: 10.1063/1.5095158.


Blood Pressure Circadian Variation, Cognition and Brain Imaging in 90+ Year-Olds.

Paganini-Hill A, Bryant N, Corrada MM, Greenia DE, Fletcher E, Singh B, Floriolli D, Kawas CH, Fisher MJ.

Front Aging Neurosci. 2019 Apr 17;11:54. doi: 10.3389/fnagi.2019.00054. eCollection 2019.


Topographic Rod Recovery Profiles after a Prolonged Dark Adaptation in Subjects with Reticular Pseudodrusen.

Luu CD, Tan R, Caruso E, Fletcher EL, Lamb TD, Guymer RH.

Ophthalmol Retina. 2018 Dec;2(12):1206-1217. doi: 10.1016/j.oret.2018.06.016. Epub 2018 Aug 18.


The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.

Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae HJ, Caballero MÁA, Chappell FM, Chen CPLH, Dichgans M, Duering M, Georgakis MK, van der Giessen RS, Gyanwali B, Hamilton OKL, Hilal S, Vom Hofe EM, de Kort PLM, Koudstaal PJ, Lam BYK, Lim JS, Makin SDJ, Mok VCT, Shi L, Valdés Hernández MC, Venketasubramanian N, Wardlaw JM, Wollenweber FA, Wong A, Xin X; Meta VCI Map consortium, Biessels GJ.

Alzheimers Dement (Amst). 2019 Apr 12;11:310-326. doi: 10.1016/j.dadm.2019.02.007. eCollection 2019 Dec.


The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory.

Franzmeier N, Rubinski A, Neitzel J, Ewers M; Alzheimer’s Disease Neuroimaging Initiative (ADNI).

Nat Commun. 2019 Apr 16;10(1):1766. doi: 10.1038/s41467-019-09564-5.


Policies and strategies to retain and support the return of experienced GPs in direct patient care: the ReGROUP mixed-methods study.

Campbell JL, Fletcher E, Abel G, Anderson R, Chilvers R, Dean SG, Richards SH, Sansom A, Terry R, Aylward A, Fitzner G, Gomez-Cano M, Long L, Mustafee N, Robinson S, Smart PA, Warren FC, Welsman J, Salisbury C.

Southampton (UK): NIHR Journals Library; 2019 Apr.


Targeting P2X7 receptors as a means for treating retinal disease.

Fletcher EL, Wang AY, Jobling AI, Rutar MV, Greferath U, Gu B, Vessey KA.

Drug Discov Today. 2019 Aug;24(8):1598-1605. doi: 10.1016/j.drudis.2019.03.029. Epub 2019 Apr 4. Review.


Cerebral white matter free water: A sensitive biomarker of cognition and function.

Maillard P, Fletcher E, Singh B, Martinez O, Johnson DK, Olichney JM, Farias ST, DeCarli C.

Neurology. 2019 May 7;92(19):e2221-e2231. doi: 10.1212/WNL.0000000000007449. Epub 2019 Apr 5.


Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study.

Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK, Mahmoud TG, Frits ML, Lu B, Rosas IO, Dellaripa PF, Weinblatt ME, Karlson EW, Shadick NA, Doyle TJ.

Arthritis Rheumatol. 2019 Sep;71(9):1472-1482. doi: 10.1002/art.40904. Epub 2019 Aug 4.


Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.

Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ.

Cell Rep. 2019 Mar 26;26(13):3522-3536.e5. doi: 10.1016/j.celrep.2019.02.097.


A blood-based signature of cerebrospinal fluid Aβ1-42 status.

Goudey B, Fung BJ, Schieber C, Faux NG; Alzheimer’s Disease Metabolomics Consortium; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2019 Mar 11;9(1):4163. doi: 10.1038/s41598-018-37149-7.


Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

Pérez-Fernández V, Milosavljevic N, Allen AE, Vessey KA, Jobling AI, Fletcher EL, Breen PP, Morley JW, Cameron MA.

Curr Biol. 2019 Mar 4;29(5):763-774.e5. doi: 10.1016/j.cub.2019.01.042. Epub 2019 Feb 21.


Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics.

Varatharajah Y, Ramanan VK, Iyer R, Vemuri P; Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2019 Feb 19;9(1):2235. doi: 10.1038/s41598-019-38793-3.


Vascular Burden Score Impacts Cognition Independent of Amyloid PET and MRI Measures of Alzheimer's Disease and Vascular Brain Injury.

DeCarli C, Villeneuve S, Maillard P, Harvey D, Singh B, Carmichael O, Fletcher E, Olichney J, Farias S, Jagust W, Reed B, Mungas D.

J Alzheimers Dis. 2019;68(1):187-196. doi: 10.3233/JAD-180965.


Predicting Alzheimer's disease progression using multi-modal deep learning approach.

Lee G, Nho K, Kang B, Sohn KA, Kim D; for Alzheimer’s Disease Neuroimaging Initiative.

Sci Rep. 2019 Feb 13;9(1):1952. doi: 10.1038/s41598-018-37769-z.


A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women

Steiger H, Booij L, Kahan `, McGregor K, Thaler L, Fletcher E, Labbe A, Joober R, Israël M, Szyf M, Agellon LB, Gauvin L, St-Hilaire A, Rossi E.

J Psychiatry Neurosci. 2019 May 1;44(3):205-213.


Cardiomyocyte transcription is controlled by combined MR and circadian clock signalling.

Fletcher EK, Kanki M, Morgan J, Ray DW, Delbridge L, Fuller PJ, Clyne CD, Young MJ.

J Endocrinol. 2019 Jan 1. pii: JOE-18-0584.R3. doi: 10.1530/JOE-18-0584. [Epub ahead of print]


Type 2 diabetes mellitus, brain atrophy, and cognitive decline.

Moran C, Beare R, Wang W, Callisaya M, Srikanth V; Alzheimer's Disease Neuroimaging Initiative (ADNI).

Neurology. 2019 Feb 19;92(8):e823-e830. doi: 10.1212/WNL.0000000000006955. Epub 2019 Jan 23.


A comparison of automated segmentation and manual tracing in estimating hippocampal volume in ischemic stroke and healthy control participants.

Khlif MS, Egorova N, Werden E, Redolfi A, Boccardi M, DeCarli CS, Fletcher E, Singh B, Li Q, Bird L, Brodtmann A.

Neuroimage Clin. 2019;21:101581. doi: 10.1016/j.nicl.2018.10.019. Epub 2018 Oct 22.


Glucocorticoid response to both predictable and unpredictable challenges detected as corticosterone metabolites in collared flycatcher droppings.

Fletcher K, Xiong Y, Fletcher E, Gustafsson L.

PLoS One. 2018 Dec 20;13(12):e0209289. doi: 10.1371/journal.pone.0209289. eCollection 2018.


Preschool children's physical activity and cardiovascular disease risk: A systematic review.

Bell LA, Fletcher EA, Timperio A, Vuillermin P, Hesketh K.

J Sci Med Sport. 2019 May;22(5):568-573. doi: 10.1016/j.jsams.2018.11.021. Epub 2018 Nov 28.


"Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders.

Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH.

Front Aging Neurosci. 2018 Nov 9;10:343. doi: 10.3389/fnagi.2018.00343. eCollection 2018.


Antiemetic doses of dexamethasone and their effects on immune cell populations and plasma mediators of inflammation resolution in healthy volunteers.

Barden A, Phillips M, Hill LM, Fletcher EM, Mas E, Loh PS, French MA, Ho KM, Mori TA, Corcoran TB.

Prostaglandins Leukot Essent Fatty Acids. 2018 Dec;139:31-39. doi: 10.1016/j.plefa.2018.11.004. Epub 2018 Nov 8.


Psychometric properties of the "Autonomous and Controlled Motivation for Treatment Questionnaire" in women with eating disorders.

Sansfaçon J, Fletcher É, Zuroff DC, Schmitz N, Miller A, Israel M, Steiger H.

Eur Eat Disord Rev. 2019 May;27(3):306-314. doi: 10.1002/erv.2656. Epub 2018 Nov 12.


Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer's Dementia.

Schilling LP, Pascoal TA, Zimmer ER, Mathotaarachchi S, Shin M, de Mello Rieder CR, Gauthier S, Palmini A, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative.

Mol Neurobiol. 2019 Jul;56(7):4916-4924. doi: 10.1007/s12035-018-1405-1. Epub 2018 Nov 9.


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