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Items: 1 to 50 of 160

1.

In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis.

Jenkins WS, Vesey AT, Vickers A, Neale A, Moles C, Connell M, Joshi NV, Lucatelli C, Fletcher AM, Spratt JC, Mirsadraee S, van Beek EJ, Rudd JH, Newby DE, Dweck MR.

Heart. 2019 Aug 17. pii: heartjnl-2019-315103. doi: 10.1136/heartjnl-2019-315103. [Epub ahead of print]

2.

Partial Reconstruction of the Nigrostriatal Circuit along a Preformed Molecular Guidance Pathway.

Ghosh B, Zhang C, Ziemba KS, Fletcher AM, Yurek DM, Smith GM.

Mol Ther Methods Clin Dev. 2019 Jul 11;14:217-227. doi: 10.1016/j.omtm.2019.06.008. eCollection 2019 Sep 13.

3.

SuperQuat chiral auxiliaries: design, synthesis, and utility.

Davies SG, Fletcher AM, Roberts PM, Thomson JE.

Org Biomol Chem. 2019 Feb 6;17(6):1322-1335. doi: 10.1039/c8ob02819b. Review.

PMID:
30633283
4.

The Hancock Alkaloids (-)-Cuspareine, (-)-Galipinine, (-)-Galipeine, and (-)-Angustureine: Asymmetric Syntheses and Corrected 1H and 13C NMR Data.

Davies SG, Fletcher AM, Houlsby ITT, Roberts PM, Thomson JE, Zimmer D.

J Nat Prod. 2018 Dec 28;81(12):2731-2742. doi: 10.1021/acs.jnatprod.8b00672. Epub 2018 Nov 20.

PMID:
30457859
5.

Patterns and predictors of personal protection compliance and workplace hygiene behaviors among workers with elevated blood lead levels in New York State.

Nwudu V, Fletcher AM, Bauer M.

J Occup Environ Hyg. 2018 Sep;15(9):654-663. doi: 10.1080/15459624.2018.1487066.

PMID:
30081768
6.

Diastereoselective Ammonium-Directed Epoxidation in the Asymmetric Syntheses of Dihydroconduramines (+)-C-2, (-)-C-2, (+)-D-2, (+)-E-2, (+)-F-2, and (-)-F-2.

Da Silva Pinto S, Davies SG, Fletcher AM, Roberts PM, Thomson JE.

J Org Chem. 2018 Sep 7;83(17):9939-9957. doi: 10.1021/acs.joc.8b01359. Epub 2018 Aug 7.

PMID:
30037221
7.

Asymmetric Syntheses of (2 R,3 S)-3-Hydroxyproline and (2 S,3 S)-3-Hydroxyproline.

Davies SG, Fletcher AM, Linsdall SM, Roberts PM, Thomson JE.

Org Lett. 2018 Jul 6;20(13):4135-4139. doi: 10.1021/acs.orglett.8b01736. Epub 2018 Jun 26.

PMID:
29943568
8.

Substantial Metabolic Activity of Human Brown Adipose Tissue during Warm Conditions and Cold-Induced Lipolysis of Local Triglycerides.

Weir G, Ramage LE, Akyol M, Rhodes JK, Kyle CJ, Fletcher AM, Craven TH, Wakelin SJ, Drake AJ, Gregoriades ML, Ashton C, Weir N, van Beek EJR, Karpe F, Walker BR, Stimson RH.

Cell Metab. 2018 Jun 5;27(6):1348-1355.e4. doi: 10.1016/j.cmet.2018.04.020. Epub 2018 May 24.

9.

Asymmetric Syntheses of 3-Deoxy-3-aminosphingoid Bases: Approaches Based on Parallel Kinetic Resolution and Double Asymmetric Induction.

Csatayová K, Davies SG, Fletcher AM, Fowler TR, Kennedy MS, Roberts PM, Thomson JE.

J Org Chem. 2017 Dec 1;82(23):12447-12466. doi: 10.1021/acs.joc.7b02233. Epub 2017 Nov 1.

PMID:
29022337
10.

Probing Competitive and Co-operative Hydroxyl and Ammonium Hydrogen-Bonding Directed Epoxidations.

Brambilla M, Brennan MB, Csatayová K, Davies SG, Fletcher AM, Kennett AMR, Lee JA, Roberts PM, Russell AJ, Thomson JE.

J Org Chem. 2017 Oct 6;82(19):10297-10309. doi: 10.1021/acs.joc.7b01774. Epub 2017 Sep 19.

PMID:
28858526
11.

Structural Revision of the Hancock Alkaloid (-)-Galipeine.

Davies SG, Fletcher AM, Houlsby ITT, Roberts PM, Thomson JE.

J Org Chem. 2017 Oct 6;82(19):10673-10679. doi: 10.1021/acs.joc.7b01720. Epub 2017 Sep 8.

PMID:
28809120
12.

Asymmetric Synthesis of the Tetraponerine Alkaloids.

Davies SG, Fletcher AM, Houlsby ITT, Roberts PM, Thomson JE.

J Org Chem. 2017 Jul 7;82(13):6689-6702. doi: 10.1021/acs.joc.7b00837. Epub 2017 Jun 13.

PMID:
28537078
13.

(-)-Pseudodistomin E: First Asymmetric Synthesis and Absolute Configuration Assignment.

Davies SG, Fletcher AM, Roberts PM, Thomson JE, Zimmer D.

Org Lett. 2017 Apr 7;19(7):1638-1641. doi: 10.1021/acs.orglett.7b00434. Epub 2017 Mar 17.

PMID:
28306263
14.

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation.

Ramage LE, Akyol M, Fletcher AM, Forsythe J, Nixon M, Carter RN, van Beek EJ, Morton NM, Walker BR, Stimson RH.

Cell Metab. 2016 Jul 12;24(1):130-41. doi: 10.1016/j.cmet.2016.06.011.

15.

Asymmetric Syntheses of (+)-Preussin B, the C(2)-Epimer of (-)-Preussin B, and 3-Deoxy-(+)-preussin B.

Buchman M, Csatayová K, Davies SG, Fletcher AM, Houlsby IT, Roberts PM, Rowe SM, Thomson JE.

J Org Chem. 2016 Jun 17;81(12):4907-22. doi: 10.1021/acs.joc.6b00362. Epub 2016 May 13.

PMID:
27077325
16.

Positron Emission Tomography and Magnetic Resonance Imaging of Cellular Inflammation in Patients with Abdominal Aortic Aneurysms.

McBride OM, Joshi NV, Robson JM, MacGillivray TJ, Gray CD, Fletcher AM, Dweck MR, van Beek EJ, Rudd JH, Newby DE, Semple SI.

Eur J Vasc Endovasc Surg. 2016 Apr;51(4):518-26. doi: 10.1016/j.ejvs.2015.12.018. Epub 2016 Feb 23.

17.

Benzonatate inhibition of voltage-gated sodium currents.

Evans MS, Maglinger GB, Fletcher AM, Johnson SR.

Neuropharmacology. 2016 Feb;101:179-87. doi: 10.1016/j.neuropharm.2015.09.020. Epub 2015 Sep 16.

PMID:
26386152
18.

Systemic Atherosclerotic Inflammation Following Acute Myocardial Infarction: Myocardial Infarction Begets Myocardial Infarction.

Joshi NV, Toor I, Shah AS, Carruthers K, Vesey AT, Alam SR, Sills A, Hoo TY, Melville AJ, Langlands SP, Jenkins WS, Uren NG, Mills NL, Fletcher AM, van Beek EJ, Rudd JH, Fox KA, Dweck MR, Newby DE.

J Am Heart Assoc. 2015 Aug 27;4(9):e001956. doi: 10.1161/JAHA.115.001956.

19.

Syntheses of Dihydroconduramines (±)-B-1, (±)-E-1, and (±)-F-1 via Diastereoselective Epoxidation of N-Protected 4-Aminocyclohex-2-en-1-ols.

Brennan MB, Csatayová K, Davies SG, Fletcher AM, Green WD, Lee JA, Roberts PM, Russell AJ, Thomson JE.

J Org Chem. 2015 Jul 2;80(13):6609-18. doi: 10.1021/acs.joc.5b00716. Epub 2015 Jun 15.

PMID:
25942585
20.

Asymmetric Synthesis of Substituted anti-β-Fluorophenylalanines.

Davies SG, Fletcher AM, Frost AB, Roberts PM, Thomson JE.

Org Lett. 2015 May 1;17(9):2254-7. doi: 10.1021/acs.orglett.5b00880. Epub 2015 Apr 14.

PMID:
25871478
21.

Asymmetric syntheses of nakinadine D, nakinadine E, and nakinadine F: confirmation of their relative (RS,SR)-configurations and proposal of their absolute (2S,3R)-configurations.

Davies SG, Fletcher AM, Shah RS, Roberts PM, Thomson JE.

J Org Chem. 2015 Apr 17;80(8):4017-29. doi: 10.1021/acs.joc.5b00376. Epub 2015 Apr 7.

PMID:
25790266
22.

Asymmetric syntheses of (-)-3-epi-Fagomine, (2R,3S,4R)-dihydroxypipecolic acid, and several polyhydroxylated homopipecolic acids.

Csatayová K, Davies SG, Fletcher AM, Ford JG, Klauber DJ, Roberts PM, Thomson JE.

J Org Chem. 2014 Nov 21;79(22):10932-44. doi: 10.1021/jo501952t. Epub 2014 Oct 30.

PMID:
25337869
23.

The asymmetric syntheses of pyrrolizidines, indolizidines and quinolizidines via two sequential tandem ring-closure/N-debenzylation processes.

Davies SG, Fletcher AM, Foster EM, Houlsby IT, Roberts PM, Schofield TM, Thomson JE.

Org Biomol Chem. 2014 Dec 7;12(45):9223-35. doi: 10.1039/c4ob01737d.

PMID:
25300749
24.

Anterior skull-base surgery: current opinion.

Fletcher AM, Marentette L.

Curr Opin Otolaryngol Head Neck Surg. 2014 Aug;22(4):322-5. doi: 10.1097/MOO.0000000000000073. Review.

PMID:
24991746
25.

An efficient asymmetric synthesis of (-)-lupinine.

Davies SG, Fletcher AM, Foster EM, Houlsby IT, Roberts PM, Schofield TM, Thomson JE.

Chem Commun (Camb). 2014 Aug 7;50(61):8309-11. doi: 10.1039/c4cc02135e.

PMID:
24938152
26.

Calcitriol promotes augmented dopamine release in the lesioned striatum of 6-hydroxydopamine treated rats.

Cass WA, Peters LE, Fletcher AM, Yurek DM.

Neurochem Res. 2014 Aug;39(8):1467-76. doi: 10.1007/s11064-014-1331-1. Epub 2014 May 25.

27.

Hydrogen bond directed epoxidation: diastereoselective olefinic oxidation of allylic alcohols and amines.

Davies SG, Fletcher AM, Thomson JE.

Org Biomol Chem. 2014 Jul 14;12(26):4544-9. doi: 10.1039/c4ob00616j.

PMID:
24854106
28.

Diastereoselective Ireland-Claisen rearrangements of substituted allyl β-amino esters: applications in the asymmetric synthesis of C(5)-substituted transpentacins.

Davies SG, Fletcher AM, Lee JA, Roberts PM, Souleymanou MY, Thomson JE, Zammit CM.

Org Biomol Chem. 2014 May 7;12(17):2702-28. doi: 10.1039/c4ob00274a.

PMID:
24647746
29.

(-)-(2S,3R,Z)-Nakinadine A: first asymmetric synthesis and absolute configuration assignment.

Davies SG, Fletcher AM, Roberts PM, Shah RS, Thompson AL, Thomson JE.

Org Lett. 2014 Mar 7;16(5):1354-7. doi: 10.1021/ol500096r. Epub 2014 Feb 25.

30.

Reply: The alveolar macrophage and acute respiratory distress syndrome: a silent actor?

Barr LC, Brittan M, Morris AC, McAuley DF, McCormack C, Fletcher AM, Richardson H, Connell M, Patel D, Wallace WA, Rossi AG, Davidson DJ, Manson L, Turner M, Hirani N, Walsh TS, Anderson NH, Dhaliwal K, Simpson AJ.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):500-1. doi: 10.1164/rccm.201309-1725LE. No abstract available.

PMID:
24528325
31.

18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: a prospective clinical trial.

Joshi NV, Vesey AT, Williams MC, Shah AS, Calvert PA, Craighead FH, Yeoh SE, Wallace W, Salter D, Fletcher AM, van Beek EJ, Flapan AD, Uren NG, Behan MW, Cruden NL, Mills NL, Fox KA, Rudd JH, Dweck MR, Newby DE.

Lancet. 2014 Feb 22;383(9918):705-13. doi: 10.1016/S0140-6736(13)61754-7. Epub 2013 Nov 11.

32.

Occurrence of spontaneous pancreatic lesions in normal and diabetic rats: a potential confounding factor in the nonclinical assessment of GLP-1-based therapies.

Chadwick KD, Fletcher AM, Parrula MC, Bonner-Weir S, Mangipudy RS, Janovitz E, Graziano MJ, Roy D, Reilly TP.

Diabetes. 2014 Apr;63(4):1303-14. doi: 10.2337/db13-1268. Epub 2013 Nov 12.

33.

Long distance directional growth of dopaminergic axons along pathways of netrin-1 and GDNF.

Zhang C, Jin Y, Ziemba KS, Fletcher AM, Ghosh B, Truit E, Yurek DM, Smith GM.

Exp Neurol. 2013 Dec;250:156-64. doi: 10.1016/j.expneurol.2013.09.022. Epub 2013 Oct 4.

34.

Direct asymmetric syntheses of chiral aldehydes and ketones via N-acyl chiral auxiliary derivatives including chiral Weinreb amide equivalents.

Davies SG, Fletcher AM, Thomson JE.

Chem Commun (Camb). 2013 Oct 7;49(77):8586-98. doi: 10.1039/c3cc45463k.

PMID:
23959006
35.

Asymmetric syntheses of enantiopure C(5)-substituted transpentacins via diastereoselective Ireland-Claisen rearrangements.

Davies SG, Fletcher AM, Roberts PM, Thomson JE, Zammit CM.

Chem Commun (Camb). 2013 Aug 14;49(63):7037-9. doi: 10.1039/c3cc43250e.

PMID:
23821041
36.

A randomized controlled trial of peripheral blood mononuclear cell depletion in experimental human lung inflammation.

Barr LC, Brittan M, Morris AC, McAuley DF, McCormack C, Fletcher AM, Richardson H, Connell M, Patel D, Wallace WA, Rossi AG, Davidson DJ, Manson L, Turner M, Hirani N, Walsh TS, Anderson NH, Dhaliwal K, Simpson AJ.

Am J Respir Crit Care Med. 2013 Aug 15;188(4):449-55. doi: 10.1164/rccm.201212-2334OC.

PMID:
23627345
37.

Asymmetric syntheses of (-)-1-deoxymannojirimycin and (+)-1-deoxyallonojirimycin via a ring-expansion approach.

Davies SG, Figuccia AL, Fletcher AM, Roberts PM, Thomson JE.

Org Lett. 2013 Apr 19;15(8):2042-5. doi: 10.1021/ol400735z. Epub 2013 Apr 9.

PMID:
23570294
38.

Asymmetric synthesis of (-)-martinellic acid.

Davies SG, Fletcher AM, Lee JA, Lorkin TJ, Roberts PM, Thomson JE.

Org Lett. 2013 Apr 19;15(8):2050-3. doi: 10.1021/ol4007508. Epub 2013 Apr 4.

PMID:
23556476
39.

Asymmetric syntheses of APTO and AETD: the β-amino acid fragments within microsclerodermins C, D, and E.

Davies SG, Fletcher AM, Foster EM, Lee JA, Roberts PM, Thomson JE.

J Org Chem. 2013 Mar 15;78(6):2500-10. doi: 10.1021/jo302731m. Epub 2013 Feb 21.

PMID:
23379896
40.

An analysis of mercury exposures among the adult population in New York State.

Fletcher AM, Gelberg KH.

J Community Health. 2013 Jun;38(3):529-37. doi: 10.1007/s10900-012-9646-9.

PMID:
23264151
41.

Individualizing hemodynamic optimization during the management of circulatory collapse.

Fletcher AM, Andrews JCh, Frampton AE.

Expert Rev Cardiovasc Ther. 2012 Oct;10(10):1217-20. doi: 10.1586/erc.12.129.

PMID:
23190061
42.

A simultaneous voltammetric temperature and humidity sensor.

Xiong L, Fletcher AM, Davies SG, Norman SE, Hardacre C, Compton RG.

Analyst. 2012 Nov 7;137(21):4951-7. doi: 10.1039/c2an35939a. Epub 2012 Sep 24.

PMID:
23001184
43.

Ammonium-directed olefinic epoxidation: kinetic and mechanistic insights.

Brennan MB, Claridge TD, Compton RG, Davies SG, Fletcher AM, Henstridge MC, Hewings DS, Kurosawa W, Lee JA, Roberts PM, Schoonen AK, Thomson JE.

J Org Chem. 2012 Sep 7;77(17):7241-61. doi: 10.1021/jo3010556. Epub 2012 Aug 13.

PMID:
22827448
44.

Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension.

Fletcher AM, Greenlee JJ, Chang KE, Smoker WR, Kirby PA, O'Brien EK.

J Clin Neurosci. 2012 Jul;19(7):1048-9. doi: 10.1016/j.jocn.2011.11.016. Epub 2012 May 1.

PMID:
22555125
45.

Tuning solute redox potentials by varying the anion component of room temperature ionic liquids.

Xiong L, Fletcher AM, Davies SG, Norman SE, Hardacre C, Compton RG.

Chem Commun (Camb). 2012 Jun 11;48(46):5784-6. doi: 10.1039/c2cc32308g. Epub 2012 May 1.

PMID:
22549139
46.

An electrochemical thermometer: voltammetric measurement of temperature and its application to amperometric gas sensing.

Xiong L, Fletcher AM, Ernst S, Davies SG, Compton RG.

Analyst. 2012 Jun 7;137(11):2567-73. doi: 10.1039/c2an35336a. Epub 2012 Apr 26.

PMID:
22534882
47.

Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology.

Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, Richardson H, White A, McKillop G, van Beek EJ, Boon NA, Rudd JH, Newby DE.

J Am Coll Cardiol. 2012 Apr 24;59(17):1539-48. doi: 10.1016/j.jacc.2011.12.037.

48.

Polysubstituted piperidines via iodolactonization: application to the asymmetric synthesis of (+)-pseudodistomin D.

Davies SG, Fletcher AM, Lee JA, Roberts PM, Russell AJ, Taylor RJ, Thomson AD, Thomson JE.

Org Lett. 2012 Apr 6;14(7):1672-5. doi: 10.1021/ol300209s. Epub 2012 Mar 14.

PMID:
22416848
49.

Evoked dopamine overflow is augmented in the striatum of calcitriol treated rats.

Cass WA, Peters LE, Fletcher AM, Yurek DM.

Neurochem Int. 2012 Jan;60(2):186-91. doi: 10.1016/j.neuint.2011.11.010. Epub 2011 Nov 22.

50.

Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis.

Dweck MR, Jones C, Joshi NV, Fletcher AM, Richardson H, White A, Marsden M, Pessotto R, Clark JC, Wallace WA, Salter DM, McKillop G, van Beek EJ, Boon NA, Rudd JH, Newby DE.

Circulation. 2012 Jan 3;125(1):76-86. doi: 10.1161/CIRCULATIONAHA.111.051052. Epub 2011 Nov 16.

PMID:
22090163

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