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The tricellular vertex-specific adhesion molecule Sidekick facilitates polarised cell intercalation during Drosophila axis extension.

Finegan TM, Hervieux N, Nestor-Bergmann A, Fletcher AG, Blanchard GB, Sanson B.

PLoS Biol. 2019 Dec 5;17(12):e3000522. doi: 10.1371/journal.pbio.3000522. eCollection 2019 Dec.


Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model.

Scott JG, Maini PK, Anderson ARA, Fletcher AG.

Syst Biol. 2019 Oct 29. pii: syz070. doi: 10.1093/sysbio/syz070. [Epub ahead of print]


Conserved gene signalling and a derived patterning mechanism underlie the development of avian footpad scales.

Cooper RL, Lloyd VJ, Di-Poï N, Fletcher AG, Barrett PM, Fraser GJ.

Evodevo. 2019 Aug 13;10:19. doi: 10.1186/s13227-019-0130-9. eCollection 2019.


Experimental and Theoretical Evidence for Bidirectional Signaling via Core Planar Polarity Protein Complexes in Drosophila.

Fisher KH, Strutt D, Fletcher AG.

iScience. 2019 Jul 26;17:49-66. doi: 10.1016/j.isci.2019.06.021. Epub 2019 Jun 18.


Quantification of Crypt and Stem Cell Evolution in the Normal and Neoplastic Human Colon.

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SAC, Wright NA, Simons BD, Jansen M, Graham TA.

Cell Rep. 2019 May 21;27(8):2524. doi: 10.1016/j.celrep.2019.05.035. No abstract available.


Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation.

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C.

Cell Death Dis. 2019 Feb 6;10(2):108. doi: 10.1038/s41419-018-1275-5.


Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium.

Finegan TM, Na D, Cammarota C, Skeeters AV, Nádasi TJ, Dawney NS, Fletcher AG, Oakes PW, Bergstralh DT.

EMBO J. 2019 Feb 1;38(3). pii: e100072. doi: 10.15252/embj.2018100072. Epub 2018 Nov 26.


An ancient Turing-like patterning mechanism regulates skin denticle development in sharks.

Cooper RL, Thiery AP, Fletcher AG, Delbarre DJ, Rasch LJ, Fraser GJ.

Sci Adv. 2018 Nov 7;4(11):eaau5484. doi: 10.1126/sciadv.aau5484. eCollection 2018 Nov.


Deferoxamine-Soaked Suture Improves Angiogenesis and Repair Potential After Acute Injury of the Chicken Achilles Tendon.

Efird WM, Fletcher AG, Draeger RW, Spang JT, Dahners LE, Weinhold PS.

Orthop J Sports Med. 2018 Oct 23;6(10):2325967118802792. doi: 10.1177/2325967118802792. eCollection 2018 Oct.


Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

Muraro D, Parker A, Vaux L, Filippi S, Almet AA, Fletcher AG, Watson AJM, Pin C, Maini PK, Byrne HM.

J R Soc Interface. 2018 Aug;15(145). pii: 20180037. doi: 10.1098/rsif.2018.0037.


The devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.

Blanchard GB, Fletcher AG, Schumacher LJ.

Semin Cell Dev Biol. 2019 Sep;93:46-54. doi: 10.1016/j.semcdb.2018.06.003. Epub 2018 Jun 28. Review.


Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis.

Lambert B, MacLean AL, Fletcher AG, Combes AN, Little MH, Byrne HM.

J Math Biol. 2018 Jun;76(7):1673-1697. doi: 10.1007/s00285-018-1208-z. Epub 2018 Feb 1.


Approximate Bayesian computation reveals the importance of repeated measurements for parameterising cell-based models of growing tissues.

Kursawe J, Baker RE, Fletcher AG.

J Theor Biol. 2018 Apr 14;443:66-81. doi: 10.1016/j.jtbi.2018.01.020. Epub 2018 Jan 31.


An extended model for culture-dependent heterogenous gene expression and proliferation dynamics in mouse embryonic stem cells.

Godwin S, Ward D, Pedone E, Homer M, Fletcher AG, Marucci L.

NPJ Syst Biol Appl. 2017 Aug 3;3:19. doi: 10.1038/s41540-017-0020-5. eCollection 2017.


A hierarchical Bayesian model for understanding the spatiotemporal dynamics of the intestinal epithelium.

Maclaren OJ, Parker A, Pin C, Carding SR, Watson AJM, Fletcher AG, Byrne HM, Maini PK.

PLoS Comput Biol. 2017 Jul 28;13(7):e1005688. doi: 10.1371/journal.pcbi.1005688. eCollection 2017 Jul.


Morphological Plant Modeling: Unleashing Geometric and Topological Potential within the Plant Sciences.

Bucksch A, Atta-Boateng A, Azihou AF, Battogtokh D, Baumgartner A, Binder BM, Braybrook SA, Chang C, Coneva V, DeWitt TJ, Fletcher AG, Gehan MA, Diaz-Martinez DH, Hong L, Iyer-Pascuzzi AS, Klein LL, Leiboff S, Li M, Lynch JP, Maizel A, Maloof JN, Markelz RJC, Martinez CC, Miller LA, Mio W, Palubicki W, Poorter H, Pradal C, Price CA, Puttonen E, Reese JB, Rellán-Álvarez R, Spalding EP, Sparks EE, Topp CN, Williams JH, Chitwood DH.

Front Plant Sci. 2017 Jun 9;8:900. doi: 10.3389/fpls.2017.00900. eCollection 2017. Review.


Mechanocellular models of epithelial morphogenesis.

Fletcher AG, Cooper F, Baker RE.

Philos Trans R Soc Lond B Biol Sci. 2017 May 19;372(1720). pii: 20150519. doi: 10.1098/rstb.2015.0519. Review.


Comparing individual-based approaches to modelling the self-organization of multicellular tissues.

Osborne JM, Fletcher AG, Pitt-Francis JM, Maini PK, Gavaghan DJ.

PLoS Comput Biol. 2017 Feb 13;13(2):e1005387. doi: 10.1371/journal.pcbi.1005387. eCollection 2017 Feb.


Cell proliferation within small intestinal crypts is the principal driving force for cell migration on villi.

Parker A, Maclaren OJ, Fletcher AG, Muraro D, Kreuzaler PA, Byrne HM, Maini PK, Watson AJ, Pin C.

FASEB J. 2017 Feb;31(2):636-649. doi: 10.1096/fj.201601002. Epub 2016 Oct 20.


Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension.

Tetley RJ, Blanchard GB, Fletcher AG, Adams RJ, Sanson B.

Elife. 2016 May 16;5. pii: e12094. doi: 10.7554/eLife.12094.


A Computational Modeling Approach for Deriving Biomarkers to Predict Cancer Risk in Premalignant Disease.

Dhawan A, Graham TA, Fletcher AG.

Cancer Prev Res (Phila). 2016 Apr;9(4):283-95. doi: 10.1158/1940-6207.CAPR-15-0248. Epub 2016 Feb 5.


Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model.

Scott JG, Fletcher AG, Anderson AR, Maini PK.

PLoS Comput Biol. 2016 Jan 22;12(1):e1004712. doi: 10.1371/journal.pcbi.1004712. eCollection 2016 Jan.


Models, measurement and inference in epithelial tissue dynamics.

Maclaren OJ, Byrne HM, Fletcher AG, Maini PK.

Math Biosci Eng. 2015 Dec;12(6):1321-40. doi: 10.3934/mbe.2015.12.1321. Review.


Robust cell tracking in epithelial tissues through identification of maximum common subgraphs.

Kursawe J, Bardenet R, Zartman JJ, Baker RE, Fletcher AG.

J R Soc Interface. 2016 Nov;13(124). pii: 20160725. doi: 10.1098/rsif.2016.0725.


Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces.

Kursawe J, Brodskiy PA, Zartman JJ, Baker RE, Fletcher AG.

PLoS Comput Biol. 2015 Dec 29;11(12):e1004679. doi: 10.1371/journal.pcbi.1004679. eCollection 2015 Dec.


Migration and horizontal gene transfer divide microbial genomes into multiple niches.

Niehus R, Mitri S, Fletcher AG, Foster KR.

Nat Commun. 2015 Nov 23;6:8924. doi: 10.1038/ncomms9924.


Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance.

Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG.

PLoS Comput Biol. 2015 Sep 11;11(9):e1004493. doi: 10.1371/journal.pcbi.1004493. eCollection 2015 Sep.


Oxygen consumption dynamics in steady-state tumour models.

Grimes DR, Fletcher AG, Partridge M.

R Soc Open Sci. 2014 Sep 24;1(1):140080. doi: 10.1098/rsos.140080. eCollection 2014 Sep.


Ten simple rules for a successful cross-disciplinary collaboration.

Knapp B, Bardenet R, Bernabeu MO, Bordas R, Bruna M, Calderhead B, Cooper J, Fletcher AG, Groen D, Kuijper B, Lewis J, McInerny G, Minssen T, Osborne J, Paulitschke V, Pitt-Francis J, Todoric J, Yates CA, Gavaghan D, Deane CM.

PLoS Comput Biol. 2015 Apr 30;11(4):e1004214. doi: 10.1371/journal.pcbi.1004214. eCollection 2015 Apr. No abstract available.


A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy.

Scott JG, Fletcher AG, Maini PK, Anderson AR, Gerlee P.

Eur J Cancer. 2014 Nov;50(17):3068-75. doi: 10.1016/j.ejca.2014.08.019. Epub 2014 Oct 8.


Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.

Baker AM, Cereser B, Melton S, Fletcher AG, Rodriguez-Justo M, Tadrous PJ, Humphries A, Elia G, McDonald SA, Wright NA, Simons BD, Jansen M, Graham TA.

Cell Rep. 2014 Aug 21;8(4):940-7. doi: 10.1016/j.celrep.2014.07.019. Epub 2014 Aug 7. Erratum in: Cell Rep. 2019 May 21;27(8):2524.


Vertex models of epithelial morphogenesis.

Fletcher AG, Osterfield M, Baker RE, Shvartsman SY.

Biophys J. 2014 Jun 3;106(11):2291-304. doi: 10.1016/j.bpj.2013.11.4498. Review.


Modelling and analysis of bacterial tracks suggest an active reorientation mechanism in Rhodobacter sphaeroides.

Rosser G, Baker RE, Armitage JP, Fletcher AG.

J R Soc Interface. 2014 Aug 6;11(97):20140320. doi: 10.1098/rsif.2014.0320.


Ten simple rules for effective computational research.

Osborne JM, Bernabeu MO, Bruna M, Calderhead B, Cooper J, Dalchau N, Dunn SJ, Fletcher AG, Freeman R, Groen D, Knapp B, McInerny GJ, Mirams GR, Pitt-Francis J, Sengupta B, Wright DW, Yates CA, Gavaghan DJ, Emmott S, Deane C.

PLoS Comput Biol. 2014 Mar 27;10(3):e1003506. doi: 10.1371/journal.pcbi.1003506. eCollection 2014 Mar. No abstract available.


Novel methods for analysing bacterial tracks reveal persistence in Rhodobacter sphaeroides.

Rosser G, Fletcher AG, Wilkinson DA, de Beyer JA, Yates CA, Armitage JP, Maini PK, Baker RE.

PLoS Comput Biol. 2013 Oct;9(10):e1003276. doi: 10.1371/journal.pcbi.1003276. Epub 2013 Oct 24.


Implementing vertex dynamics models of cell populations in biology within a consistent computational framework.

Fletcher AG, Osborne JM, Maini PK, Gavaghan DJ.

Prog Biophys Mol Biol. 2013 Nov;113(2):299-326. doi: 10.1016/j.pbiomolbio.2013.09.003. Epub 2013 Oct 9. Review.


Mechanisms and mechanics of cell competition in epithelia.

Vincent JP, Fletcher AG, Baena-Lopez LA.

Nat Rev Mol Cell Biol. 2013 Sep;14(9):581-91. doi: 10.1038/nrm3639. Epub 2013 Aug 14. Review.


The effect of sampling rate on observed statistics in a correlated random walk.

Rosser G, Fletcher AG, Maini PK, Baker RE.

J R Soc Interface. 2013 Jun 5;10(85):20130273. doi: 10.1098/rsif.2013.0273. Print 2013 Aug 6.


Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment.

Lloyd-Lewis B, Fletcher AG, Dale TC, Byrne HM.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):391-407. doi: 10.1002/wsbm.1221. Epub 2013 Mar 29.


Chaste: an open source C++ library for computational physiology and biology.

Mirams GR, Arthurs CJ, Bernabeu MO, Bordas R, Cooper J, Corrias A, Davit Y, Dunn SJ, Fletcher AG, Harvey DG, Marsh ME, Osborne JM, Pathmanathan P, Pitt-Francis J, Southern J, Zemzemi N, Gavaghan DJ.

PLoS Comput Biol. 2013;9(3):e1002970. doi: 10.1371/journal.pcbi.1002970. Epub 2013 Mar 14.


A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis.

Dello Ioio R, Galinha C, Fletcher AG, Grigg SP, Molnar A, Willemsen V, Scheres B, Sabatini S, Baulcombe D, Maini PK, Tsiantis M.

Curr Biol. 2012 Sep 25;22(18):1699-704. doi: 10.1016/j.cub.2012.07.005. Epub 2012 Aug 16.


A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.

Mirams GR, Fletcher AG, Maini PK, Byrne HM.

J Theor Biol. 2012 Nov 7;312:143-56. doi: 10.1016/j.jtbi.2012.08.002. Epub 2012 Aug 10.


Mathematical modeling of monoclonal conversion in the colonic crypt.

Fletcher AG, Breward CJ, Jonathan Chapman S.

J Theor Biol. 2012 May 7;300:118-33. doi: 10.1016/j.jtbi.2012.01.021. Epub 2012 Jan 23.


Modelling the role of the basement membrane beneath a growing epithelial monolayer.

Dunn SJ, Fletcher AG, Chapman SJ, Gavaghan DJ, Osborne JM.

J Theor Biol. 2012 Apr 7;298:82-91. doi: 10.1016/j.jtbi.2011.12.013. Epub 2011 Dec 22.


Comparing a discrete and continuum model of the intestinal crypt.

Murray PJ, Walter A, Fletcher AG, Edwards CM, Tindall MJ, Maini PK.

Phys Biol. 2011 Apr;8(2):026011. doi: 10.1088/1478-3975/8/2/026011. Epub 2011 Mar 16.


A hybrid approach to multi-scale modelling of cancer.

Osborne JM, Walter A, Kershaw SK, Mirams GR, Fletcher AG, Pathmanathan P, Gavaghan D, Jensen OE, Maini PK, Byrne HM.

Philos Trans A Math Phys Eng Sci. 2010 Nov 13;368(1930):5013-28. doi: 10.1098/rsta.2010.0173.


Activation of a poised RNAPII-dependent promoter requires both SAGA and mediator.

Lee SK, Fletcher AG, Zhang L, Chen X, Fischbeck JA, Stargell LA.

Genetics. 2010 Mar;184(3):659-72. doi: 10.1534/genetics.109.113464. Epub 2010 Jan 4.


Spn1 regulates the recruitment of Spt6 and the Swi/Snf complex during transcriptional activation by RNA polymerase II.

Zhang L, Fletcher AG, Cheung V, Winston F, Stargell LA.

Mol Cell Biol. 2008 Feb;28(4):1393-403. Epub 2007 Dec 17.


Delayed recurrence of seminoma testis.

Tata HR, Fletcher AG Jr.

J Indian Med Assoc. 1981 Feb 16;76(4):64-5. No abstract available.


Delayed recurrence of seminoma testis.

Tata HR, Jayaramaih M, Fletcher AG Jr.

J Indian Med Assoc. 1980 Mar 16;74(6):117. No abstract available.


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