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Items: 1 to 50 of 150

1.

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma.

Gamble LD, Purgato S, Murray J, Xiao L, Yu DMT, Hanssen KM, Giorgi FM, Carter DR, Gifford AJ, Valli E, Milazzo G, Kamili A, Mayoh C, Liu B, Eden G, Sarraf S, Allan S, Di Giacomo S, Flemming CL, Russell AJ, Cheung BB, Oberthuer A, London WB, Fischer M, Trahair TN, Fletcher JI, Marshall GM, Ziegler DS, Hogarty MD, Burns MR, Perini G, Norris MD, Haber M.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.

PMID:
30700572
2.

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ.

Oncogene. 2019 May;38(20):3824-3842. doi: 10.1038/s41388-018-0666-5. Epub 2019 Jan 22.

PMID:
30670779
3.

Pathogen Survey of Pulp and Paper Mill Biosolids Compared with Soils, Composts, and Sewage Biosolids.

Flemming CA, Pileggi V, Chen S, Lee SS.

J Environ Qual. 2017 Sep;46(5):984-993. doi: 10.2134/jeq2016.12.0467.

PMID:
28991979
4.

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

Murray J, Valli E, Yu DMT, Truong AM, Gifford AJ, Eden GL, Gamble LD, Hanssen KM, Flemming CL, Tan A, Tivnan A, Allan S, Saletta F, Cheung L, Ruhle M, Schuetz JD, Henderson MJ, Byrne JA, Norris MD, Haber M, Fletcher JI.

Eur J Cancer. 2017 Sep;83:132-141. doi: 10.1016/j.ejca.2017.06.024. Epub 2017 Jul 20.

5.

Pathogen Characterization of Fresh and Stored Mesophilic Anaerobically Digested Biosolids.

Flemming CA, Simhon A, Odumeru JA.

Water Environ Res. 2017 Nov 1;89(11):2031-2042. doi: 10.2175/106143017X14839994522704. Epub 2017 Jan 13.

PMID:
28087921
6.

Towards a more accurate quantitative assessment of seasonal Cryptosporidium infection risks in surface waters using species and genotype information.

Lapen DR, Schmidt PJ, Thomas JL, Edge TA, Flemming C, Keithlin J, Neumann N, Pollari F, Ruecker N, Simhon A, Topp E, Wilkes G, Pintar KDM.

Water Res. 2016 Nov 15;105:625-637. doi: 10.1016/j.watres.2016.08.023. Epub 2016 Aug 13.

PMID:
27721171
7.

Direct observation of DNA threading in flap endonuclease complexes.

AlMalki FA, Flemming CS, Zhang J, Feng M, Sedelnikova SE, Ceska T, Rafferty JB, Sayers JR, Artymiuk PJ.

Nat Struct Mol Biol. 2016 Jul;23(7):640-6. doi: 10.1038/nsmb.3241. Epub 2016 Jun 6.

8.

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL.

Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13.

9.

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma.

Lau DT, Flemming CL, Gherardi S, Perini G, Oberthuer A, Fischer M, Juraeva D, Brors B, Xue C, Norris MD, Marshall GM, Haber M, Fletcher JI, Ashton LJ.

Oncotarget. 2015 Jun 20;6(17):15510-23.

10.

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Cheung L, Flemming CL, Watt F, Masada N, Yu DM, Huynh T, Conseil G, Tivnan A, Polinsky A, Gudkov AV, Munoz MA, Vishvanath A, Cooper DM, Henderson MJ, Cole SP, Fletcher JI, Haber M, Norris MD.

Biochem Pharmacol. 2014 Sep 1;91(1):97-108. doi: 10.1016/j.bcp.2014.05.023. Epub 2014 Jun 25.

PMID:
24973542
11.

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer.

Hedditch EL, Gao B, Russell AJ, Lu Y, Emmanuel C, Beesley J, Johnatty SE, Chen X, Harnett P, George J; Australian Ovarian Cancer Study Group, Williams RT, Flemming C, Lambrechts D, Despierre E, Lambrechts S, Vergote I, Karlan B, Lester J, Orsulic S, Walsh C, Fasching P, Beckmann MW, Ekici AB, Hein A, Matsuo K, Hosono S, Nakanishi T, Yatabe Y, Pejovic T, Bean Y, Heitz F, Harter P, du Bois A, Schwaab I, Hogdall E, Kjaer SK, Jensen A, Hogdall C, Lundvall L, Engelholm SA, Brown B, Flanagan J, Metcalf MD, Siddiqui N, Sellers T, Fridley B, Cunningham J, Schildkraut J, Iversen E, Weber RP, Berchuck A, Goode E, Bowtell DD, Chenevix-Trench G, deFazio A, Norris MD, MacGregor S, Haber M, Henderson MJ.

J Natl Cancer Inst. 2014 Jun 23;106(7). pii: dju149. doi: 10.1093/jnci/dju149. Print 2014 Jul.

12.

Fate of Clostridium difficile during wastewater treatment and incidence in Southern Ontario watersheds.

Xu C, Weese JS, Flemming C, Odumeru J, Warriner K.

J Appl Microbiol. 2014 Sep;117(3):891-904. doi: 10.1111/jam.12575. Epub 2014 Jul 7. Erratum in: J Appl Microbiol. 2014 Oct:117(4):1219.

13.

Suspected ventilator-associated respiratory infection in severely ill patients: a prospective observational study.

Shahin J, Bielinski M, Guichon C, Flemming C, Kristof AS.

Crit Care. 2013 Oct 22;17(5):R251. doi: 10.1186/cc13077.

15.
16.

The structure of Escherichia coli ExoIX--implications for DNA binding and catalysis in flap endonucleases.

Anstey-Gilbert CS, Hemsworth GR, Flemming CS, Hodskinson MR, Zhang J, Sedelnikova SE, Stillman TJ, Sayers JR, Artymiuk PJ.

Nucleic Acids Res. 2013 Sep;41(17):8357-67. doi: 10.1093/nar/gkt591. Epub 2013 Jul 2.

17.

Using Campylobacter spp. and Escherichia coli data and Bayesian microbial risk assessment to examine public health risks in agricultural watersheds under tile drainage management.

Schmidt PJ, Pintar KD, Fazil AM, Flemming CA, Lanthier M, Laprade N, Sunohara MD, Simhon A, Thomas JL, Topp E, Wilkes G, Lapen DR.

Water Res. 2013 Jun 15;47(10):3255-72. doi: 10.1016/j.watres.2013.02.002. Epub 2013 Feb 26.

PMID:
23623467
18.

Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets.

Mughini Gras L, Smid JH, Wagenaar JA, Koene MG, Havelaar AH, Friesema IH, French NP, Flemming C, Galson JD, Graziani C, Busani L, VAN Pelt W.

Epidemiol Infect. 2013 Dec;141(12):2526-35. doi: 10.1017/S0950268813000356. Epub 2013 Feb 28.

PMID:
23445833
19.

Molecular pathogen detection in biosolids with a focus on quantitative PCR using propidium monoazide for viable cell enumeration.

van Frankenhuyzen JK, Trevors JT, Lee H, Flemming CA, Habash MB.

J Microbiol Methods. 2011 Dec;87(3):263-72. doi: 10.1016/j.mimet.2011.09.007. Epub 2011 Sep 22. Review.

PMID:
21963489
20.

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

Henderson MJ, Haber M, Porro A, Munoz MA, Iraci N, Xue C, Murray J, Flemming CL, Smith J, Fletcher JI, Gherardi S, Kwek CK, Russell AJ, Valli E, London WB, Buxton AB, Ashton LJ, Sartorelli AC, Cohn SL, Schwab M, Marshall GM, Perini G, Norris MD.

J Natl Cancer Inst. 2011 Aug 17;103(16):1236-51. doi: 10.1093/jnci/djr256. Epub 2011 Jul 28.

21.

First evidence of genotypes Ad3a16 and Ad3a18 in North America, obtained by genetic analysis of infectious human adenovirus from wastewaters of two urban communities in Canada.

Vidovic S, Aly M, Flemming C, Springthorpe S, Sattar SA.

Appl Environ Microbiol. 2011 Jun;77(12):4256-9. doi: 10.1128/AEM.02795-10. Epub 2011 Apr 22.

22.

A novel selective growth medium-PCR assay to isolate and detect Sphingomonas in environmental samples.

Yim MS, Yau YC, Matlow A, So JS, Zou J, Flemming CA, Schraft H, Leung KT.

J Microbiol Methods. 2010 Jul;82(1):19-27. doi: 10.1016/j.mimet.2010.03.012. Epub 2010 Mar 30.

PMID:
20359508
23.

Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells.

Porro A, Haber M, Diolaiti D, Iraci N, Henderson M, Gherardi S, Valli E, Munoz MA, Xue C, Flemming C, Schwab M, Wong JH, Marshall GM, Della Valle G, Norris MD, Perini G.

J Biol Chem. 2010 Jun 18;285(25):19532-43. doi: 10.1074/jbc.M109.078584. Epub 2010 Mar 16.

24.

Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.

Burkhart CA, Watt F, Murray J, Pajic M, Prokvolit A, Xue C, Flemming C, Smith J, Purmal A, Isachenko N, Komarov PG, Gurova KV, Sartorelli AC, Marshall GM, Norris MD, Gudkov AV, Haber M.

Cancer Res. 2009 Aug 15;69(16):6573-80. doi: 10.1158/0008-5472.CAN-09-1075. Epub 2009 Aug 4.

25.

Out of America: ancient DNA evidence for a new world origin of late quaternary woolly mammoths.

Debruyne R, Chu G, King CE, Bos K, Kuch M, Schwarz C, Szpak P, Gröcke DR, Matheus P, Zazula G, Guthrie D, Froese D, Buigues B, de Marliave C, Flemming C, Poinar D, Fisher D, Southon J, Tikhonov AN, MacPhee RD, Poinar HN.

Curr Biol. 2008 Sep 9;18(17):1320-6. doi: 10.1016/j.cub.2008.07.061.

26.

Hospital standardized mortality ratio is a useful burning platform.

Zahn C, Baker M, MacNaughton J, Flemming C, Bell R.

Healthc Pap. 2008;8(4):50-3; discussion 69-75.

PMID:
18667871
27.

p53 determines multidrug sensitivity of childhood neuroblastoma.

Xue C, Haber M, Flemming C, Marshall GM, Lock RB, MacKenzie KL, Gurova KV, Norris MD, Gudkov AV.

Cancer Res. 2007 Nov 1;67(21):10351-60.

28.

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

Cheng AJ, Cheng NC, Ford J, Smith J, Murray JE, Flemming C, Lastowska M, Jackson MS, Hackett CS, Weiss WA, Marshall GM, Kees UR, Norris MD, Haber M.

Eur J Cancer. 2007 Jun;43(9):1467-75. Epub 2007 Apr 20.

29.

Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma.

Haber M, Smith J, Bordow SB, Flemming C, Cohn SL, London WB, Marshall GM, Norris MD.

J Clin Oncol. 2006 Apr 1;24(10):1546-53.

PMID:
16575006
30.

Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.

Norris MD, Smith J, Tanabe K, Tobin P, Flemming C, Scheffer GL, Wielinga P, Cohn SL, London WB, Marshall GM, Allen JD, Haber M.

Mol Cancer Ther. 2005 Apr;4(4):547-53.

31.

Challenges in operationalizing the DSM-IV clinical significance criterion.

Beals J, Novins DK, Spicer P, Orton HD, Mitchell CM, Barón AE, Manson SM, Big Crow CK, Buchwald D, Chambers B, Christensen ML, Dillard DA, DuBray K, Espinoza PA, Flemming CM, Frederick AW, Gurley D, Jervis LL, Jim SM, Kaufman CE, Keane EM, Klein SA, Lee D, McNutly MC, Middlebrook DL, Moore LA, Nez TD, Norton IM, Randall CJ, Sam A, Shore JH, Simpson SG, Yazzie LL; AI-SUPERPFP Team.

Arch Gen Psychiatry. 2004 Dec;61(12):1197-207.

PMID:
15583111
32.

MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma.

Manohar CF, Bray JA, Salwen HR, Madafiglio J, Cheng A, Flemming C, Marshall GM, Norris MD, Haber M, Cohn SL.

Oncogene. 2004 Jan 22;23(3):753-62.

PMID:
14737110
33.

Microtubule alterations and mutations induced by desoxyepothilone B: implications for drug-target interactions.

Verrills NM, Flemming CL, Liu M, Ivery MT, Cobon GS, Norris MD, Haber M, Kavallaris M.

Chem Biol. 2003 Jul;10(7):597-607.

PMID:
12890533
34.

The p53 pathway and its inactivation in neuroblastoma.

Tweddle DA, Pearson AD, Haber M, Norris MD, Xue C, Flemming C, Lunec J.

Cancer Lett. 2003 Jul 18;197(1-2):93-8. Review.

PMID:
12880966
35.

Dangerous Darwinism.

Flemming C, Goodall J.

Public Underst Sci. 2002 Jul;11(3):259-71.

PMID:
12430530
36.

Detection of Sphingomonas spp in soil by PCR and sphingolipid biomarker analysis.

Leung KT, Chang YJ, Gan YD, Peacock A, Macnaughton SJ, Stephen JR, Burkhalter RS, Flemming CA, White DC.

J Ind Microbiol Biotechnol. 1999 Oct;23(4-5):252-260.

PMID:
11423941
37.

Extinction: complexity of assessing risk.

MacPhee RD, Flemming C.

Science. 2001 Apr 13;292(5515):217-8. No abstract available.

PMID:
11305308
38.

Differentiation of Candida strains by lectin-mediated agglutination kinetics.

Nenoff P, Süss K, Flemming C, Haustein UF.

Mycoses. 2000;43(3-4):101-7.

PMID:
10907339
39.

Characterization of metal-resistant soil eubacteria by polymerase chain reaction--denaturing gradient gel electrophoresis with isolation of resistant strains.

Macnaughton S, Stephen JR, Chang YJ, Peacock A, Flemming CA, Leung KT, White DC.

Can J Microbiol. 1999 Feb;45(2):116-24.

PMID:
10380644
40.

Comparative study of the in vitro behavior of cord blood subpopulations after short-term cytokine exposure.

Rice A, Flemming C, Case J, Stevenson J, Gaudry L, Vowels M.

Bone Marrow Transplant. 1999 Feb;23(3):211-20.

41.

Effects of ammonium dinitramide on preimplantation embryos in Sprague-Dawley rats.

Graeter LJ, Wolfe RE, Kinkead ER, Flemming CD.

Toxicol Ind Health. 1998 Nov-Dec;14(6):789-98.

PMID:
9891911
42.

Effect of toxic metals on indigenous soil beta-subgroup proteobacterium ammonia oxidizer community structure and protection against toxicity by inoculated metal-resistant bacteria.

Stephen JR, Chang YJ, Macnaughton SJ, Kowalchuk GA, Leung KT, Flemming CA, White DC.

Appl Environ Microbiol. 1999 Jan;65(1):95-101.

43.
44.

Use of thymoglobulin induction therapy in the prevention of acute graft rejection episodes following liver transplantation.

Tchervenkov J, Flemming C, Guttmann RD, des Gachons G.

Transplant Proc. 1997 Nov;29(7A):13S-15S. No abstract available.

PMID:
9366919
45.

Sequential biological immunosuppression. Induction therapy with rabbit antithymocyte globulin.

Guttmann RD, Flemming C.

Clin Transplant. 1997 Jun;11(3):185-92.

PMID:
9193840
46.

Sarcoma cells engineered to secrete IFN-gamma or IL-2 acquire sensitization to immune cell killing via different mechanisms.

Flemming CL, Patel PM, Box G, Eccles SA, Collins MK.

Cytokine. 1997 May;9(5):328-32.

PMID:
9195131
47.

In vivo/in vitro comparison of the pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77).

Yu KO, Tillitt DE, Byczkowski JZ, Burton GA Jr, Channel SR, Drerup JM, Flemming CD, Fisher JW.

Toxicol Appl Pharmacol. 1996 Dec;141(2):434-8.

PMID:
8975768
48.

IL-12 stimulation but not B7 expression increases melanoma killing by patient cytotoxic T lymphocytes (CTL).

De Wit D, Flemming CL, Harris JD, Palmer KJ, Moore JS, Gore ME, Collins MK.

Clin Exp Immunol. 1996 Aug;105(2):353-9.

49.
50.

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