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Items: 1 to 50 of 112

1.

The role of pharmacology in drug discovery.

Fredholm BB, Fleming WW, Vanhoutte PM, Godfraind T.

Nat Rev Drug Discov. 2002 Mar;1(3):237-8. doi: 10.1038/nrd749. Review.

PMID:
12120508
2.
3.

Cellular depolarization of neurons in the locus ceruleus region of the guinea pig associated with the development of tolerance to opioids.

Kong JQ, Meng J, Biser PS, Fleming WW, Taylor DA.

J Pharmacol Exp Ther. 2001 Sep;298(3):909-16.

PMID:
11504784
4.

Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids.

Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 2001 Apr;297(1):11-8. Review.

PMID:
11259522
5.
6.

Quantification of the alpha(3) subunit of the Na(+)/K(+)-ATPase in developing rat cerebellum.

Biser PS, Thayne KA, Kong JQ, Fleming WW, Taylor DA.

Brain Res Dev Brain Res. 2000 Oct 28;123(2):165-72.

PMID:
11042345
7.

Cellular adaptation: journey from smooth muscle cells to neurons.

Fleming WW.

J Pharmacol Exp Ther. 1999 Dec;291(3):925-31.

PMID:
10565807
8.

The role of the sodium pump in the developmental regulation of membrane electrical properties of cerebellar Purkinje neurons of the rat.

Molnar LR, Thayne KA, Fleming WW, Taylor DA.

Brain Res Dev Brain Res. 1999 Feb 5;112(2):287-91.

PMID:
9878791
9.

Preparation and application of an isolated superior mesenteric arterial vascular preparation.

Caveney SW, Culhane JM, Taylor DA, Fleming WW.

J Cardiovasc Pharmacol. 1998 Nov;32(5):721-7.

PMID:
9821845
10.

The dose-response model for dioxin.

Byrd DM 3rd, Allen DO, Beamer RL, Besch HR Jr, Bylund DB, Doull J, Fleming WW, Fries A, Guengerich FP, Hornbrook R, Lasagna L, Lum BK, Michaelis EK, Morgan ET, Poland A, Rozman KK, Smith JB, Swanson HI, Waddell W, Wilson JD.

Risk Anal. 1998 Feb;18(1):1-2. No abstract available.

PMID:
9556441
11.
12.

Hyperpolarizing effects of morphine, clonidine and 2-chloroadenosine in myenteric neurons associated with tolerance to morphine.

Meng J, Malanga CJ, Kong JQ, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1997 Apr;281(1):41-7.

PMID:
9103478
13.

Mechanisms of adaptive supersensitivity: correlation of guinea pig atrial supersensitivity with modifications in adenylyl cyclase activity.

Roberts MI, Stadel JM, Torphy TJ, Fleming WW, Taylor DA.

Biochem Pharmacol. 1997 Feb 7;53(3):347-56.

PMID:
9065738
14.
15.

Chronic morphine treatment of guinea pigs induces nonspecific sensitivity changes in the nucleus tractus solitarius in vitro.

Malanga CJ, Meng J, Fleming WW, Taylor DA.

J Pharmacol Exp Ther. 1997 Jan;280(1):16-23.

PMID:
8996176
16.

The role of GABAA receptors in the subsensitivity of Purkinje neurons to GABA in genetic epilepsy prone rats.

Gould EM, Curto KA, Craig CR, Fleming WW, Taylor DA.

Brain Res. 1995 Nov 6;698(1-2):62-8.

PMID:
8581504
17.
18.

Sustained hypertension in Dahl rats. Negative correlation of agonist response to blood pressure.

Kong JQ, Taylor DA, Fleming WW.

Hypertension. 1995 Jan;25(1):139-45.

PMID:
7843745
19.

Functional distribution and role of alpha-1 adrenoceptor subtypes in the mesenteric vasculature of the rat.

Kong JQ, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1994 Mar;268(3):1153-9.

PMID:
7908049
20.

A quantitative method for assessing protein abundance using enhanced chemiluminescence.

Hershman KM, Fleming WW, Taylor DA.

Biotechniques. 1993 Nov;15(5):790, 792, 794 passim. No abstract available.

PMID:
8267963
22.

Adenylyl cyclase and guanine nucleotide-binding proteins in supersensitive guinea pig ventricles.

Roberts MI, Biser PS, Stadel JM, Taylor DA, Fleming WW.

Mol Pharmacol. 1992 Nov;42(5):784-91.

PMID:
1331761
23.

Membrane potential in myenteric neurons associated with tolerance and dependence to morphine.

Leedham JA, Kong JQ, Taylor DA, Johnson SM, Fleming WW.

J Pharmacol Exp Ther. 1992 Oct;263(1):15-9.

PMID:
1403780
24.

Effects of GABA in the morphine-tolerant longitudinal muscle, myenteric plexus preparation of the guinea pig.

Taylor DA, Leedham JA, Bennett LE, Fleming WW.

J Pharmacol Exp Ther. 1991 Dec;259(3):1094-101.

PMID:
1762064
25.

Sensitivity of cerebellar Purkinje neurons to neurotransmitters in genetically epileptic rats.

Gould EM, Craig CR, Fleming WW, Taylor DA.

J Pharmacol Exp Ther. 1991 Dec;259(3):1008-12.

PMID:
1684811
26.

Antagonism of norepinephrine by clonidine in the isolated rat mesenteric vascular bed.

Kong JQ, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1991 Nov;259(2):653-8.

PMID:
1941613
27.

Involvement of mu, delta and kappa receptors in morphine-induced tolerance in the guinea pig myenteric plexus.

Leedham JA, Bennett LE, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1991 Oct;259(1):295-301.

PMID:
1656024
28.

Mesenteric vascular responses of young spontaneously hypertensive rats.

Kong JQ, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1991 Jul 1;258(1):13-7.

PMID:
2072289
29.

Specific supersensitivity of the mesenteric vascular bed of Dahl salt-sensitive rats.

Kong JQ, Taylor DA, Fleming WW, Kotchen TA.

Hypertension. 1991 Mar;17(3):349-56.

PMID:
1847901
30.

Catecholamine and neuropeptide Y levels in tissues from young Dahl rats following 5 days low- or high-salt diet.

Kong JQ, Curto KA, Fleming WW, Kotchen TA, Taylor DA.

Blood Vessels. 1991;28(6):442-51.

PMID:
1782400
31.

Cyclic AMP and adaptive supersensitivity in guinea pig atria.

Fleming WW, Taylor DA.

J Neural Transm Suppl. 1991;34:179-85.

PMID:
1667870
32.

Mechanisms of cellular adaptive sensitivity changes: applications to opioid tolerance and dependence.

Johnson SM, Fleming WW.

Pharmacol Rev. 1989 Dec;41(4):435-88. Review. No abstract available.

PMID:
2700602
33.

Mechanisms of adaptive supersensitivity in smooth muscles vs cardiac muscle: a brief review.

Fleming WW.

Clin Exp Pharmacol Physiol. 1989 Jun;16(6):447-50. Review.

PMID:
2670351
34.
35.

Morphine tolerance and nonspecific subsensitivity of the longitudinal muscle myenteric plexus preparation of the guinea-pig to inhibitory agonists.

Taylor DA, Leedham JA, Doak N, Fleming WW.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Nov;338(5):553-9.

PMID:
2907611
36.

Sensitivity of caudal arteries and the mesenteric vascular bed to norepinephrine in DOCA-salt hypertension.

Longhurst PA, Rice PJ, Taylor DA, Fleming WW.

Hypertension. 1988 Aug;12(2):133-42.

PMID:
3410523
37.

Characteristics of adaptive supersensitivity in the left atrium of the guinea pig.

Hawthorn MH, Taylor DA, Fleming WW.

J Pharmacol Exp Ther. 1987 May;241(2):453-7.

PMID:
3572805
38.

Norepinephrine depletion and sensitivity changes in rat heart induced by pretreatment with reserpine.

Rice PJ, Taylor DA, Valinski WA, Head RJ, Fleming WW.

J Pharmacol Exp Ther. 1987 Mar;240(3):764-71.

PMID:
3559972
39.

Membrane potential and vascular smooth muscle sensitivity. A minireview.

Fleming WW.

Blood Vessels. 1987;24(3):108-12.

PMID:
3593973
40.

Airway epithelium modulates the reactivity of guinea-pig respiratory smooth muscle.

Hay DW, Farmer SG, Raeburn D, Robinson VA, Fleming WW, Fedan JS.

Eur J Pharmacol. 1986 Sep 23;129(1-2):11-8.

PMID:
3533569
41.

Epithelium modulates the reactivity of ovalbumin-sensitized guinea-pig airway smooth muscle.

Hay DW, Raeburn D, Farmer SG, Fleming WW, Fedan JS.

Life Sci. 1986 Jun 30;38(26):2461-8.

PMID:
3523095
42.

The effect of verapamil is reduced in isolated airway smooth muscle preparations lacking the epithelium.

Raeburn D, Hay DW, Robinson VA, Farmer SG, Fleming WW, Fedan JS.

Life Sci. 1986 Mar 3;38(9):809-16.

PMID:
3512945
43.

Sensitivity changes in the smooth muscle of the guinea-pig isolated vas deferens after treatment of animals with 6-hydroxydopamine.

Ice KS, Hay DW, Fleming WW, Robinson RL, Fedan JS.

J Pharmacol Exp Ther. 1985 Nov;235(2):349-53.

PMID:
2997431
44.

Surgical sympathectomy of the heart in rodents and its effect on sensitivity to agonists.

Goto K, Longhurst PA, Cassis LA, Head RJ, Taylor DA, Rice PJ, Fleming WW.

J Pharmacol Exp Ther. 1985 Jul;234(1):280-7.

PMID:
4009504
45.

Effect of postganglionic denervation and pretreatment with reserpine on alpha-adrenoceptors of the guinea-pig vas deferens.

Cowan FF Jr, Wong SK, Westfall DP, Fleming WW.

Pharmacology. 1985;30(5):289-95.

PMID:
2860677
46.

Cellular potentials, electrogenic sodium pumping and sensitivity in guinea-pig atria.

Schulz JC, Fleming WW, Westfall DP, Millecchia R.

J Pharmacol Exp Ther. 1984 Oct;231(1):181-8.

PMID:
6491974
47.
48.
49.

Mobility and function in elastin and collagen.

Torchia DA, Batchelder LS, Fleming WW, Jelinski LW, Sarkar SK, Sullivan CE.

Ciba Found Symp. 1983;93:98-115.

PMID:
6551234
50.

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