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RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.

Skinner M, Lumey LH, Fleming TP, Sapienza C, Hoyo C, Aronica L, Thompson J, Nichol PF.

JPEN J Parenter Enteral Nutr. 2019 Jul;43(5):627-637. doi: 10.1002/jpen.1536. Epub 2019 Apr 17.


Periconceptional environment and the developmental origins of disease

Velazquez MA, Fleming TP, Watkins AJ.

J Endocrinol. 2019 Feb 22;242(1):T33-T49. doi: 10.1530/JOE-18-0676. Review.


Preconception health - Authors' reply.

Stephenson J, Fleming TP, Godfrey KM, Barker M.

Lancet. 2018 Nov 24;392(10161):2267. doi: 10.1016/S0140-6736(18)32169-X. No abstract available.


The remarkable legacy of a father's diet on the health of his offspring.

Fleming TP.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):9827-9829. doi: 10.1073/pnas.1813731115. Epub 2018 Sep 14. No abstract available.


Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory.

Gould JM, Smith PJ, Airey CJ, Mort EJ, Airey LE, Warricker FDM, Pearson-Farr JE, Weston EC, Gould PJW, Semmence OG, Restall KL, Watts JA, McHugh PC, Smith SJ, Dewing JM, Fleming TP, Willaime-Morawek S.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7398-E7407. doi: 10.1073/pnas.1721876115. Epub 2018 Jun 25.


Origins of lifetime health around the time of conception: causes and consequences.

Fleming TP, Watkins AJ, Velazquez MA, Mathers JC, Prentice AM, Stephenson J, Barker M, Saffery R, Yajnik CS, Eckert JJ, Hanson MA, Forrester T, Gluckman PD, Godfrey KM.

Lancet. 2018 May 5;391(10132):1842-1852. doi: 10.1016/S0140-6736(18)30312-X. Epub 2018 Apr 16. Review.


Development of an adenovirus vector vaccine platform for targeting dendritic cells.

Sharma PK, Dmitriev IP, Kashentseva EA, Raes G, Li L, Kim SW, Lu ZH, Arbeit JM, Fleming TP, Kaliberov SA, Goedegebuure SP, Curiel DT, Gillanders WE.

Cancer Gene Ther. 2018 Feb;25(1-2):27-38. doi: 10.1038/s41417-017-0002-1. Epub 2017 Dec 15.


Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life.

Velazquez MA, Sheth B, Smith SJ, Eckert JJ, Osmond C, Fleming TP.

Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):590-600. doi: 10.1016/j.bbadis.2017.11.020. Epub 2017 Nov 28.


The Role of Maternal Nutrition During the Periconceptional Period and Its Effect on Offspring Phenotype.

Fleming TP, Eckert JJ, Denisenko O.

Adv Exp Med Biol. 2017;1014:87-105. doi: 10.1007/978-3-319-62414-3_5. Review.


Breast Cancer Neoantigens Can Induce CD8+ T-Cell Responses and Antitumor Immunity.

Zhang X, Kim S, Hundal J, Herndon JM, Li S, Petti AA, Soysal SD, Li L, McLellan MD, Hoog J, Primeau T, Myers N, Vickery TL, Sturmoski M, Hagemann IS, Miller CA, Ellis MJ, Mardis ER, Hansen T, Fleming TP, Goedegebuure SP, Gillanders WE.

Cancer Immunol Res. 2017 Jul;5(7):516-523. doi: 10.1158/2326-6066.CIR-16-0264. Epub 2017 Jun 15.


A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer.

Sankpal NV, Fleming TP, Sharma PK, Wiedner HJ, Gillanders WE.

Oncogene. 2017 Jun 29;36(26):3706-3717. doi: 10.1038/onc.2016.504. Epub 2017 Feb 13.


Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life.

Velazquez MA, Smith CG, Smyth NR, Osmond C, Fleming TP.

Hum Reprod. 2016 Sep;31(9):1970-80. doi: 10.1093/humrep/dew177. Epub 2016 Jul 7.


Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.

Denisenko O, Lucas ES, Sun C, Watkins AJ, Mar D, Bomsztyk K, Fleming TP.

Biochim Biophys Acta. 2016 Jul;1859(7):906-13. doi: 10.1016/j.bbagrm.2016.04.001. Epub 2016 Apr 7.


Maternal diabetes promotes mTORC1 downstream signalling in rabbit preimplantation embryos.

Gürke J, Schindler M, Pendzialek SM, Thieme R, Grybel KJ, Heller R, Spengler K, Fleming TP, Fischer B, Navarrete Santos A.

Reproduction. 2016 May;151(5):465-76. doi: 10.1530/REP-15-0523. Epub 2016 Feb 1.


Developing a clinical development paradigm for translation of a mammaglobin-A DNA vaccine.

Li L, Goedegebuure SP, Fleming TP, Gillanders WE.

Immunotherapy. 2015;7(7):709-11. doi: 10.2217/imt.15.40. Epub 2015 Aug 7. No abstract available.


Cell signalling during blastocyst morphogenesis.

Eckert JJ, Velazquez MA, Fleming TP.

Adv Exp Med Biol. 2015;843:1-21. doi: 10.1007/978-1-4939-2480-6_1. Review.


Embryos, DOHaD and David Barker.

Fleming TP, Velazquez MA, Eckert JJ.

J Dev Orig Health Dis. 2015 Oct;6(5):377-83. doi: 10.1017/S2040174415001105. Epub 2015 May 8. Review.


Maternal nutrition modifies trophoblast giant cell phenotype and fetal growth in mice.

Watkins AJ, Lucas ES, Marfy-Smith S, Bates N, Kimber SJ, Fleming TP.

Reproduction. 2015 Jun;149(6):563-75. doi: 10.1530/REP-14-0667. Epub 2015 Mar 9.


Do little embryos make big decisions? How maternal dietary protein restriction can permanently change an embryo's potential, affecting adult health.

Fleming TP, Watkins AJ, Sun C, Velazquez MA, Smyth NR, Eckert JJ.

Reprod Fertil Dev. 2015 May;27(4):684-92. doi: 10.1071/RD14455. Review.


Epigenetic regulation of histone modifications and Gata6 gene expression induced by maternal diet in mouse embryoid bodies in a model of developmental programming.

Sun C, Denisenko O, Sheth B, Cox A, Lucas ES, Smyth NR, Fleming TP.

BMC Dev Biol. 2015 Jan 21;15:3. doi: 10.1186/s12861-015-0053-1.


Searching for metastases in ovarian tissue before autotransplantation: a tailor-made approach.

Hoekman EJ, Smit VT, Fleming TP, Louwe LA, Fleuren GJ, Hilders CG.

Fertil Steril. 2015 Feb;103(2):469-77. doi: 10.1016/j.fertnstert.2014.11.001. Epub 2014 Dec 10.


Mouse early extra-embryonic lineages activate compensatory endocytosis in response to poor maternal nutrition.

Sun C, Velazquez MA, Marfy-Smith S, Sheth B, Cox A, Johnston DA, Smyth N, Fleming TP.

Development. 2014 Mar;141(5):1140-50. doi: 10.1242/dev.103952. Epub 2014 Feb 6.


Effect of maternal protein restriction during pregnancy and postweaning high-fat feeding on diet-induced thermogenesis in adult mouse offspring.

Sellayah D, Dib L, Anthony FW, Watkins AJ, Fleming TP, Hanson MA, Cagampang FR.

Eur J Nutr. 2014 Oct;53(7):1523-31. doi: 10.1007/s00394-014-0657-4. Epub 2014 Jan 31.


EpCAM modulates NF-κB signaling and interleukin-8 expression in breast cancer.

Sankpal NV, Fleming TP, Gillanders WE.

Mol Cancer Res. 2013 Apr;11(4):418-26. doi: 10.1158/1541-7786.MCR-12-0518. Epub 2013 Feb 1.


Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health.

Eckert JJ, Porter R, Watkins AJ, Burt E, Brooks S, Leese HJ, Humpherson PG, Cameron IT, Fleming TP.

PLoS One. 2012;7(12):e52791. doi: 10.1371/journal.pone.0052791. Epub 2012 Dec 27.


Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration.

Kimura TE, Merritt AJ, Lock FR, Eckert JJ, Fleming TP, Garrod DR.

Dev Biol. 2012 Sep 15;369(2):286-97. doi: 10.1016/j.ydbio.2012.06.025. Epub 2012 Jul 20.


Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination.

Li L, Kim S, Herndon JM, Goedegebuure P, Belt BA, Satpathy AT, Fleming TP, Hansen TH, Murphy KM, Gillanders WE.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12716-21. doi: 10.1073/pnas.1203468109. Epub 2012 Jul 16.


Mammaglobin-A cDNA vaccination of breast cancer patients induces antigen-specific cytotoxic CD4+ICOShi T cells.

Tiriveedhi V, Fleming TP, Goedegebuure PS, Naughton M, Ma C, Lockhart C, Gao F, Gillanders WE, Mohanakumar T.

Breast Cancer Res Treat. 2013 Feb;138(1):109-18. doi: 10.1007/s10549-012-2110-9. Epub 2012 Jun 8.


Adaptive responses of the embryo to maternal diet and consequences for post-implantation development.

Fleming TP, Lucas ES, Watkins AJ, Eckert JJ.

Reprod Fertil Dev. 2011;24(1):35-44. doi: 10.1071/RD11905. Review.


Nutrition of females during the peri-conceptional period and effects on foetal programming and health of offspring.

Fleming TP, Velazquez MA, Eckert JJ, Lucas ES, Watkins AJ.

Anim Reprod Sci. 2012 Feb;130(3-4):193-7. doi: 10.1016/j.anireprosci.2012.01.015. Epub 2012 Jan 25. Review.


Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age.

Watkins AJ, Lucas ES, Wilkins A, Cagampang FR, Fleming TP.

PLoS One. 2011;6(12):e28745. doi: 10.1371/journal.pone.0028745. Epub 2011 Dec 15.


Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion.

Sankpal NV, Mayfield JD, Willman MW, Fleming TP, Gillanders WE.

Breast Cancer Res. 2011;13(6):R124. doi: 10.1186/bcr3070. Epub 2011 Dec 1.


Identification of HLA-A24-restricted CD8(+) cytotoxic T-cell epitopes derived from mammaglobin-A, a human breast cancer-associated antigen.

Tiriveedhi V, Sarma NJ, Subramanian V, Fleming TP, Gillanders WE, Mohanakumar T.

Hum Immunol. 2012 Jan;73(1):11-6. doi: 10.1016/j.humimm.2011.10.017. Epub 2011 Oct 23.


Photoacoustic microscopy of tyrosinase reporter gene in vivo.

Krumholz A, Vanvickle-Chavez SJ, Yao J, Fleming TP, Gillanders WE, Wang LV.

J Biomed Opt. 2011 Aug;16(8):080503. doi: 10.1117/1.3606568.


Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring.

Williams CL, Teeling JL, Perry VH, Fleming TP.

BMC Biol. 2011 Jul 19;9:49. doi: 10.1186/1741-7007-9-49.


Tissue-specific selection of reference genes is required for expression studies in the mouse model of maternal protein undernutrition.

Lucas ES, Watkins AJ, Cox AL, Marfy-Smith SJ, Smyth N, Fleming TP.

Theriogenology. 2011 Aug;76(3):558-69. doi: 10.1016/j.theriogenology.2011.03.008. Epub 2011 May 7.


Cancer genome sequencing and its implications for personalized cancer vaccines.

Li L, Goedegebuure P, Mardis ER, Ellis MJ, Zhang X, Herndon JM, Fleming TP, Carreno BM, Hansen TH, Gillanders WE.

Cancers (Basel). 2011 Nov 25;3(4):4191-211. doi: 10.3390/cancers3044191.


Identification of immunodominant HLA-B7-restricted CD8+ cytotoxic T cell epitopes derived from mammaglobin-A expressed on human breast cancers.

Ilias Basha H, Tiriveedhi V, Fleming TP, Gillanders WE, Mohanakumar T.

Breast Cancer Res Treat. 2011 May;127(1):81-9. doi: 10.1007/s10549-010-0975-z. Epub 2010 Jun 11.


Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes.

Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR, McConnell J.

PLoS One. 2010 Apr 9;5(4):e10074. doi: 10.1371/journal.pone.0010074.


Impact of the periconceptional environment on the programming of adult disease.

Watkins AJ, Lucas ES, Fleming TP.

J Dev Orig Health Dis. 2010 Apr;1(2):87-95. doi: 10.1017/S2040174409990195.


Engineering superior DNA vaccines: MHC class I single chain trimers bypass antigen processing and enhance the immune response to low affinity antigens.

Li L, Herndon JM, Truscott SM, Hansen TH, Fleming TP, Goedegebuure P, Gillanders WE.

Vaccine. 2010 Feb 23;28(8):1911-8. doi: 10.1016/j.vaccine.2009.10.096.


Maternal low-protein diet during mouse pre-implantation development induces vascular dysfunction and altered renin-angiotensin-system homeostasis in the offspring.

Watkins AJ, Lucas ES, Torrens C, Cleal JK, Green L, Osmond C, Eckert JJ, Gray WP, Hanson MA, Fleming TP.

Br J Nutr. 2010 Jun;103(12):1762-70. doi: 10.1017/S0007114509993783. Epub 2010 Feb 4.


A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy.

Lin Y, Lin S, Watson M, Trinkaus KM, Kuo S, Naughton MJ, Weilbaecher K, Fleming TP, Aft RL.

Breast Cancer Res Treat. 2010 Oct;123(3):691-9. doi: 10.1007/s10549-009-0664-y. Epub 2009 Dec 6.


Dual expression lentiviral vectors for concurrent RNA interference and rescue.

Sankpal NV, Fleming TP, Gillanders WE.

J Surg Res. 2009 Sep;156(1):50-6. doi: 10.1016/j.jss.2009.02.004. Epub 2009 Mar 4.


Mammaglobin as a potential molecular target for breast cancer drug delivery.

Zuo L, Li L, Wang Q, Fleming TP, You S.

Cancer Cell Int. 2009 Mar 23;9:8. doi: 10.1186/1475-2867-9-8.


Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter.

Watkins AJ, Fleming TP.

J Anat. 2009 Jul;215(1):52-9. doi: 10.1111/j.1469-7580.2008.01033.x. Epub 2009 Feb 9. Review.


Transcriptional repression of epithelial cell adhesion molecule contributes to p53 control of breast cancer invasion.

Sankpal NV, Willman MW, Fleming TP, Mayfield JD, Gillanders WE.

Cancer Res. 2009 Feb 1;69(3):753-7. doi: 10.1158/0008-5472.CAN-08-2708. Epub 2009 Jan 13.


Tight junction protein ZO-2 expression and relative function of ZO-1 and ZO-2 during mouse blastocyst formation.

Sheth B, Nowak RL, Anderson R, Kwong WY, Papenbrock T, Fleming TP.

Exp Cell Res. 2008 Nov 1;314(18):3356-68. doi: 10.1016/j.yexcr.2008.08.021. Epub 2008 Sep 13.


Appetite regulatory mechanisms and food intake in mice are sensitive to mismatch in diets between pregnancy and postnatal periods.

Sellayah D, Sek K, Anthony FW, Watkins AJ, Osmond C, Fleming TP, Hanson MA, Cagampang FR.

Brain Res. 2008 Oct 27;1237:146-52. doi: 10.1016/j.brainres.2008.07.126. Epub 2008 Aug 13.


Tight junction biogenesis during early development.

Eckert JJ, Fleming TP.

Biochim Biophys Acta. 2008 Mar;1778(3):717-28. doi: 10.1016/j.bbamem.2007.09.031. Epub 2007 Oct 9. Review.

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