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Items: 1 to 50 of 82

1.

Lobe specificity of iron-binding to transferrin modulates murine erythropoiesis and iron homeostasis.

Parrow NL, Li Y, Feola M, Guerra A, Casu C, Prasad P, Mammen L, Ali F, Vaicikauskas E, Rivella S, Ginzburg YZ, Fleming RE.

Blood. 2019 Aug 21. pii: blood.2018893099. doi: 10.1182/blood.2018893099. [Epub ahead of print]

PMID:
31434707
2.

Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples.

Delaney KM, Guillet R, Fleming RE, Ru Y, Pressman EK, Vermeylen F, Nemeth E, O'Brien KO.

J Nutr. 2019 Mar 1;149(3):406-415. doi: 10.1093/jn/nxy286.

PMID:
30770543
3.

Tfr2 suppression benefits β-thalassemic erythropoiesis.

Ginzburg YZ, Fleming RE.

Blood. 2018 Nov 22;132(21):2215-2216. doi: 10.1182/blood-2018-10-876110. No abstract available.

4.

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry.

Parrow NL, Violet PC, Tu H, Nichols J, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M.

J Vis Exp. 2018 Jan 12;(131). doi: 10.3791/56910.

5.

Releasing the FKBP12 brake on hepcidin.

Parrow NL, Fleming RE.

Blood. 2017 Nov 9;130(19):2049-2050. doi: 10.1182/blood-2017-09-805390. No abstract available.

PMID:
29122771
6.

Iron Supplements for Infants at Risk for Iron Deficiency.

MacQueen BC, Baer VL, Scott DM, Ling CY, O'Brien EA, Boyer C, Henry E, Fleming RE, Christensen RD.

Glob Pediatr Health. 2017 Apr 25;4:2333794X17703836. doi: 10.1177/2333794X17703836. eCollection 2017.

7.

Measurements of red cell deformability and hydration reflect HbF and HbA2 in blood from patients with sickle cell anemia.

Parrow NL, Tu H, Nichols J, Violet PC, Pittman CA, Fitzhugh C, Fleming RE, Mohandas N, Tisdale JF, Levine M.

Blood Cells Mol Dis. 2017 Jun;65:41-50. doi: 10.1016/j.bcmd.2017.04.005. Epub 2017 Apr 18.

PMID:
28472705
8.

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice.

Li H, Choesang T, Bao W, Chen H, Feola M, Garcia-Santos D, Li J, Sun S, Follenzi A, Pham P, Liu J, Zhang J, Ponka P, An X, Mohandas N, Fleming RE, Rivella S, Li G, Ginzburg YZ.

Blood. 2017 Mar 16;129(11):1514-1526. doi: 10.1182/blood-2016-09-742387. Epub 2017 Feb 1. Erratum in: Blood. 2017 Dec 21;130(25):2809.

9.

Liver sinusoidal endothelial cells as iron sensors.

Parrow NL, Fleming RE.

Blood. 2017 Jan 26;129(4):397-398. doi: 10.1182/blood-2016-12-754499. No abstract available.

PMID:
28126953
10.

Improved Management of Harlequin Ichthyosis With Advances in Neonatal Intensive Care.

Glick JB, Craiglow BG, Choate KA, Kato H, Fleming RE, Siegfried E, Glick SA.

Pediatrics. 2017 Jan;139(1). pii: e20161003. doi: 10.1542/peds.2016-1003. Epub 2016 Dec 20. Review.

11.

The iron status at birth of neonates with risk factors for developing iron deficiency: a pilot study.

MacQueen BC, Christensen RD, Ward DM, Bennett ST, O'Brien EA, Sheffield MJ, Baer VL, Snow GL, Weaver Lewis KA, Fleming RE, Kaplan J.

J Perinatol. 2017 Apr;37(4):436-440. doi: 10.1038/jp.2016.234. Epub 2016 Dec 15.

12.

Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera.

Casu C, Oikonomidou PR, Chen H, Nandi V, Ginzburg Y, Prasad P, Fleming RE, Shah YM, Valore EV, Nemeth E, Ganz T, MacDonald B, Rivella S.

Blood. 2016 Jul 14;128(2):265-76. doi: 10.1182/blood-2015-10-676742. Epub 2016 May 6.

13.

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation.

Chen H, Choesang T, Li H, Sun S, Pham P, Bao W, Feola M, Westerman M, Li G, Follenzi A, Blanc L, Rivella S, Fleming RE, Ginzburg YZ.

Haematologica. 2016 Mar;101(3):297-308. doi: 10.3324/haematol.2015.127902. Epub 2015 Dec 3.

14.

Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis.

Lee SM, Loguinov A, Fleming RE, Vulpe CD.

Genes Nutr. 2015 Jan;10(1):443. doi: 10.1007/s12263-014-0443-1. Epub 2014 Nov 27.

15.

Bone morphogenetic proteins as regulators of iron metabolism.

Parrow NL, Fleming RE.

Annu Rev Nutr. 2014;34:77-94. doi: 10.1146/annurev-nutr-071813-105646. Epub 2014 Jun 6. Review.

PMID:
24995692
16.

Sequestration and scavenging of iron in infection.

Parrow NL, Fleming RE, Minnick MF.

Infect Immun. 2013 Oct;81(10):3503-14. doi: 10.1128/IAI.00602-13. Epub 2013 Jul 8.

17.

Associations of common variants in HFE and TMPRSS6 with iron parameters are independent of serum hepcidin in a general population: a replication study.

Galesloot TE, Geurts-Moespot AJ, den Heijer M, Sweep FC, Fleming RE, Kiemeney LA, Vermeulen SH, Swinkels DW.

J Med Genet. 2013 Sep;50(9):593-8. doi: 10.1136/jmedgenet-2013-101673. Epub 2013 Jun 21.

PMID:
23794717
18.

Smad6 and Smad7 are co-regulated with hepcidin in mouse models of iron overload.

Vujić Spasić M, Sparla R, Mleczko-Sanecka K, Migas MC, Breitkopf-Heinlein K, Dooley S, Vaulont S, Fleming RE, Muckenthaler MU.

Biochim Biophys Acta. 2013 Jan;1832(1):76-84. doi: 10.1016/j.bbadis.2012.08.013. Epub 2012 Aug 31.

19.

Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice.

Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE.

Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1397-404. doi: 10.1152/ajpgi.00020.2012. Epub 2012 Apr 19.

20.

Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling.

Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, Anderson ER, Shah YM, Li H, Ginzburg YZ, Fleming RE, Rivella S.

Blood. 2012 Mar 29;119(13):3187-9. doi: 10.1182/blood-2012-01-405563. No abstract available.

PMID:
22461476
21.

Iron overload in human disease.

Fleming RE, Ponka P.

N Engl J Med. 2012 Jan 26;366(4):348-59. doi: 10.1056/NEJMra1004967. Review. No abstract available. Erratum in: N Engl J Med. 2012 Feb 23;366(8):771.

PMID:
22276824
22.

Hepcidin in human iron disorders: diagnostic implications.

Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW.

Clin Chem. 2011 Dec;57(12):1650-69. doi: 10.1373/clinchem.2009.140053. Epub 2011 Oct 11. Review.

23.

Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe.

Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE.

Gastroenterology. 2011 Nov;141(5):1907-14. doi: 10.1053/j.gastro.2011.06.077. Epub 2011 Jul 13.

24.

Knockout mouse models of iron homeostasis.

Fleming RE, Feng Q, Britton RS.

Annu Rev Nutr. 2011 Aug 21;31:117-37. doi: 10.1146/annurev-nutr-072610-145117. Review.

PMID:
21548776
25.

Novel observations in hereditary hemochromatosis: potential implications for clinical strategies.

Swinkels DW, Fleming RE.

Haematologica. 2011 Apr;96(4):485-8. doi: 10.3324/haematol.2011.042036. No abstract available.

26.

Mass spectrometry analysis of hepcidin peptides in experimental mouse models.

Tjalsma H, Laarakkers CM, van Swelm RP, Theurl M, Theurl I, Kemna EH, van der Burgt YE, Venselaar H, Dutilh BE, Russel FG, Weiss G, Masereeuw R, Fleming RE, Swinkels DW.

PLoS One. 2011 Mar 8;6(3):e16762. doi: 10.1371/journal.pone.0016762.

27.

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice.

Castoldi M, Vujic Spasic M, Altamura S, Elmén J, Lindow M, Kiss J, Stolte J, Sparla R, D'Alessandro LA, Klingmüller U, Fleming RE, Longerich T, Gröne HJ, Benes V, Kauppinen S, Hentze MW, Muckenthaler MU.

J Clin Invest. 2011 Apr;121(4):1386-96. doi: 10.1172/JCI44883.

28.

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.

Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA.

Blood. 2010 Apr 22;115(16):3374-81. doi: 10.1182/blood-2009-09-245209. Epub 2010 Feb 22.

29.

Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis.

Chua AC, Delima RD, Morgan EH, Herbison CE, Tirnitz-Parker JE, Graham RM, Fleming RE, Britton RS, Bacon BR, Olynyk JK, Trinder D.

J Hepatol. 2010 Mar;52(3):425-31. doi: 10.1016/j.jhep.2009.12.010. Epub 2010 Jan 6.

30.

Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.

Rodriguez A, Luukkaala T, Fleming RE, Britton RS, Bacon BR, Parkkila S.

PLoS One. 2009 Sep 29;4(9):e7212. doi: 10.1371/journal.pone.0007212.

31.

Expression of iron-related genes in human brain and brain tumors.

Hänninen MM, Haapasalo J, Haapasalo H, Fleming RE, Britton RS, Bacon BR, Parkkila S.

BMC Neurosci. 2009 Apr 22;10:36. doi: 10.1186/1471-2202-10-36.

32.

Iron sensing as a partnership: HFE and transferrin receptor 2.

Fleming RE.

Cell Metab. 2009 Mar;9(3):211-2. doi: 10.1016/j.cmet.2009.02.004.

33.

Subendocardial infarction associated with ventricular hypertrophy in preterm infants with chronic lung disease.

Booth GR, Thornton K, Jureidini S, Fleming RE.

J Perinatol. 2008 Aug;28(8):580-3. doi: 10.1038/jp.2008.63.

PMID:
18668110
34.

Transferrin fails to provide protection against Fas-induced hepatic injury in mice with deletion of functional transferrin-receptor type 2.

Lesnikov V, Gorden N, Fausto N, Spaulding E, Campbell J, Shulman H, Fleming RE, Deeg HJ.

Apoptosis. 2008 Aug;13(8):1005-12. doi: 10.1007/s10495-008-0233-6.

35.

Iron and inflammation: cross-talk between pathways regulating hepcidin.

Fleming RE.

J Mol Med (Berl). 2008 May;86(5):491-4. doi: 10.1007/s00109-008-0349-8. No abstract available.

PMID:
18425494
36.

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.

Waheed A, Britton RS, Grubb JH, Sly WS, Fleming RE.

Arch Biochem Biophys. 2008 Jun 1;474(1):193-7. doi: 10.1016/j.abb.2008.02.041. Epub 2008 Mar 7.

PMID:
18353247
37.

Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse.

Rodriguez A, Hilvo M, Kytömäki L, Fleming RE, Britton RS, Bacon BR, Parkkila S.

BMC Genomics. 2007 Oct 19;8:379.

38.

Hepcidin activation during inflammation: make it STAT.

Fleming RE.

Gastroenterology. 2007 Jan;132(1):447-9. No abstract available.

PMID:
17241894
39.

Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3.

Drake SF, Morgan EH, Herbison CE, Delima R, Graham RM, Chua AC, Leedman PJ, Fleming RE, Bacon BR, Olynyk JK, Trinder D.

Am J Physiol Gastrointest Liver Physiol. 2007 Jan;292(1):G323-8. Epub 2006 Aug 24.

40.

Iron Imports. VI. HFE and regulation of intestinal iron absorption.

Fleming RE, Britton RS.

Am J Physiol Gastrointest Liver Physiol. 2006 Apr;290(4):G590-4. Review.

41.

Pathophysiology of hereditary hemochromatosis.

Fleming RE, Britton RS, Waheed A, Sly WS, Bacon BR.

Semin Liver Dis. 2005 Nov;25(4):411-9. Review.

42.

Orchestration of iron homeostasis.

Fleming RE, Bacon BR.

N Engl J Med. 2005 Apr 28;352(17):1741-4. No abstract available.

PMID:
15858181
43.

Advances in understanding the molecular basis for the regulation of dietary iron absorption.

Fleming RE.

Curr Opin Gastroenterol. 2005 Mar;21(2):201-6. Review.

PMID:
15711214
44.

Pathogenesis of hereditary hemochromatosis.

Fleming RE, Britton RS, Waheed A, Sly WS, Bacon BR.

Clin Liver Dis. 2004 Nov;8(4):755-73, vii. Review.

PMID:
15464654
45.

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis.

Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelly J, Umehara Y, Wano Y, Said JW, Koeffler HP.

Blood. 2005 Jan 1;105(1):376-81. Epub 2004 Sep 2.

PMID:
15345587
46.

Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis.

Tomatsu S, Orii KO, Fleming RE, Holden CC, Waheed A, Britton RS, Gutierrez MA, Velez-Castrillon S, Bacon BR, Sly WS.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15788-93. Epub 2003 Dec 12.

47.

Successful use of somatostatin in a case of neonatal chylothorax.

Au M, Weber TR, Fleming RE.

J Pediatr Surg. 2003 Jul;38(7):1106-7.

PMID:
12861552
48.

Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2.

Hannuksela J, Parkkila S, Waheed A, Britton RS, Fleming RE, Bacon BR, Sly WS.

Eur J Haematol. 2003 Apr;70(4):201-6.

PMID:
12656741
49.

Decreased liver hepcidin expression in the Hfe knockout mouse.

Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, Bacon BR, Sly WS, Fleming RE.

Blood Cells Mol Dis. 2002 Nov-Dec;29(3):361-6.

PMID:
12547226
50.

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis.

Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, Kawabata H, Britton RS, Bacon BR, Sly WS.

Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10653-8. Epub 2002 Jul 19.

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