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Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer.

Kesavan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I.

Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5923-5930. doi: 10.1073/pnas.1921381117. Epub 2020 Mar 2.


Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Peleli M, Bibli SI, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci M, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A.

Biochem Pharmacol. 2020 Feb 4:113833. doi: 10.1016/j.bcp.2020.113833. [Epub ahead of print]


Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome.

Dos Santos LRB, Fleming I.

Prostaglandins Other Lipid Mediat. 2019 Dec 31;148:106407. doi: 10.1016/j.prostaglandins.2019.106407. [Epub ahead of print] Review.


Selection for tandem stop codons in ciliate species with reassigned stop codons.

Fleming I, Cavalcanti ARO.

PLoS One. 2019 Nov 26;14(11):e0225804. doi: 10.1371/journal.pone.0225804. eCollection 2019.


Shear stress regulates cystathionine γ lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Bibli SI, Hu J, Leisegang MS, Wittig J, Zukunft S, Kapasakalidi A, Fisslthaler B, Tsilimigras D, Zografos G, Filis K, Brandes RP, Papapetropoulos A, Sigala F, Fleming I.

Redox Biol. 2020 Jan;28:101379. doi: 10.1016/j.redox.2019.101379. Epub 2019 Nov 13.


Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.

Marín-Juez R, El-Sammak H, Helker CSM, Kamezaki A, Mullapuli ST, Bibli SI, Foglia MJ, Fleming I, Poss KD, Stainier DYR.

Dev Cell. 2019 Nov 18;51(4):503-515.e4. doi: 10.1016/j.devcel.2019.10.019.


A role for spinal cord hypoxia in neurodegeneration.

Hernandez-Gerez E, Fleming IN, Parson SH.

Cell Death Dis. 2019 Nov 13;10(11):861. doi: 10.1038/s41419-019-2104-1. Review.


IL27Rα Deficiency Alters Endothelial Cell Function and Subverts Tumor Angiogenesis in Mammary Carcinoma.

Fink AF, Ciliberti G, Popp R, Sirait-Fischer E, Frank AC, Fleming I, Sekar D, Weigert A, Brüne B.

Front Oncol. 2019 Oct 4;9:1022. doi: 10.3389/fonc.2019.01022. eCollection 2019.


Regulation of calpain 2 expression by miR-223 and miR-145.

Siuda D, Randriamboavonjy V, Fleming I.

Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194438. doi: 10.1016/j.bbagrm.2019.194438. Epub 2019 Oct 18.


Reliability and Validity of Upper Extremity Patient-Reported Outcome Measures in Assessing Traumatic Finger Amputation Management.

Yoon AP, Kaur S, Chou CH, Chung KC, Malay S, Shauver M, Wang L, Zhong L, Sommers K, Hume K, Sawada H, Hsu CC, Tai-Jung T, Yang G, Zhang Z, Giladi A, Fleming I, Sabapathy SR, Kumaran MS, Ishiko T, Nishizuka T, Kawamura K, Sebastin S, Yong J, Jain S, Colvell K, Lacey M, Hillard C, Fowler J, Neumeister M, Lovel B, Kao D, Arif H, Spiess A, Grybowski D, Michelotti B, Costa B, Drolet B, Bueno RA Jr, Spear M, Woo SH, Kim YW, Moore A, Roth Bettlach C, Linkugel A, Dalton J; FRANCHISE Group.

Plast Reconstr Surg. 2020 Jan;145(1):94e-105e. doi: 10.1097/PRS.0000000000006326.


Relative Tissue Oxygenation and Temperature Changes for Detecting Early Upper Extremity Skin Ischemia.

Polfer EM, Sabino JM, Fleming IC, Means KR Jr.

Plast Reconstr Surg. 2019 Oct;144(4):907-910. doi: 10.1097/PRS.0000000000006024.


Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction in mice.

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim JI, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E.

Blood. 2019 Oct 24;134(17):1469-1479. doi: 10.1182/blood.2019001392.


Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity.

Hu J, Bibli SI, Wittig J, Zukunft S, Lin J, Hammes HP, Popp R, Fleming I.

J Clin Invest. 2019 Dec 2;129(12):5204-5218. doi: 10.1172/JCI123835.


New Lipid Mediators in Retinal Angiogenesis and Retinopathy.

Fleming I.

Front Pharmacol. 2019 Jul 5;10:739. doi: 10.3389/fphar.2019.00739. eCollection 2019. Review.


Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I.

EMBO J. 2019 Sep 2;38(17):e100938. doi: 10.15252/embj.2018100938. Epub 2019 Jul 22.


Relative Tissue Oxygenation and Temperature Changes for Detecting Early Upper Extremity Skin Ischemia.

Polfer EM, Sabino JM, Fleming IC, Means KR Jr.

Plast Reconstr Surg. 2019 Jun 27. doi: 10.1097/PRS.0000000000006024. [Epub ahead of print]


Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I.

Int J Mol Sci. 2019 Jun 19;20(12). pii: E3005. doi: 10.3390/ijms20123005.


Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.

Leisegang MS, Bibli SI, Günther S, Pflüger-Müller B, Oo JA, Höper C, Seredinski S, Yekelchyk M, Schmitz-Rixen T, Schürmann C, Hu J, Looso M, Sigala F, Boon RA, Fleming I, Brandes RP.

Eur Heart J. 2019 Aug 7;40(30):2523-2533. doi: 10.1093/eurheartj/ehz393.


Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S.

J Clin Invest. 2019 Jun 17;129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17.


AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I.

Acta Physiol (Oxf). 2020 Jan;228(1):e13325. doi: 10.1111/apha.13325. Epub 2019 Jun 21.


Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.

Vellecco V, Martelli A, Bibli IS, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Basso EM, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G.

Br J Pharmacol. 2020 Feb;177(4):810-823. doi: 10.1111/bph.14700. Epub 2019 May 3.


Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation.

Mudersbach T, Siuda D, Kohlstedt K, Fleming I.

PLoS One. 2019 May 1;14(5):e0216218. doi: 10.1371/journal.pone.0216218. eCollection 2019.


Estimating the relative fitness of escaped farmed salmon offspring in the wild and modelling the consequences of invasion for wild populations.

Sylvester EVA, Wringe BF, Duffy SJ, Hamilton LC, Fleming IA, Castellani M, Bentzen P, Bradbury IR.

Evol Appl. 2019 Jan 28;12(4):705-717. doi: 10.1111/eva.12746. eCollection 2019 Apr.


Chronic Hypoxia Enhances β-Oxidation-Dependent Electron Transport via Electron Transferring Flavoproteins.

Fuhrmann DC, Olesch C, Kurrle N, Schnütgen F, Zukunft S, Fleming I, Brüne B.

Cells. 2019 Feb 18;8(2). pii: E172. doi: 10.3390/cells8020172.


Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA).

Lowe PT, Dall'Angelo S, Fleming IN, Piras M, Zanda M, O'Hagan D.

Org Biomol Chem. 2019 Feb 6;17(6):1480-1486. doi: 10.1039/c8ob03150a.


Can variation in standard metabolic rate explain context-dependent performance of farmed Atlantic salmon offspring?

Robertsen G, Reid D, Einum S, Aronsen T, Fleming IA, Sundt-Hansen LE, Karlsson S, Kvingedal E, Ugedal O, Hindar K.

Ecol Evol. 2018 Dec 26;9(1):212-222. doi: 10.1002/ece3.4716. eCollection 2019 Jan. Erratum in: Ecol Evol. 2020 Jan 29;10(2):1093.


ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H.

J Immunol. 2019 Feb 15;202(4):1099-1111. doi: 10.4049/jimmunol.1800269. Epub 2019 Jan 16.


Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.

Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B.

Front Immunol. 2018 Dec 4;9:2858. doi: 10.3389/fimmu.2018.02858. eCollection 2018.


aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability.

Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher T, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöhner S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M.

Nat Commun. 2018 Dec 17;9(1):5357. doi: 10.1038/s41467-018-07739-0.


Association between arginase-containing platelet-derived microparticles and altered plasma arginine metabolism in polycystic ovary syndrome.

Kyselova A, Hinrichsmeyer H, Zukunft S, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V.

Metabolism. 2019 Jan;90:16-19. doi: 10.1016/j.metabol.2018.10.008. Epub 2018 Oct 24.


Extensive hybridization following a large escape of domesticated Atlantic salmon in the Northwest Atlantic.

Wringe BF, Jeffery NW, Stanley RRE, Hamilton LC, Anderson EC, Fleming IA, Grant C, Dempson JB, Veinott G, Duffy SJ, Bradbury IR.

Commun Biol. 2018 Aug 9;1:108. doi: 10.1038/s42003-018-0112-9. eCollection 2018.


Redox Regulation of Calpains: Consequences on Vascular Function.

Randriamboavonjy V, Kyselova A, Fleming I.

Antioxid Redox Signal. 2019 Mar 1;30(7):1011-1026. doi: 10.1089/ars.2018.7607. Epub 2018 Nov 15.


Endothelial AMP-Activated Kinase α1 Phosphorylates eNOS on Thr495 and Decreases Endothelial NO Formation.

Zippel N, Loot AE, Stingl H, Randriamboavonjy V, Fleming I, Fisslthaler B.

Int J Mol Sci. 2018 Sep 13;19(9). pii: E2753. doi: 10.3390/ijms19092753.


Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs.

Randriamboavonjy V, Fleming I.

Clin Sci (Lond). 2018 Sep 5;132(17):1875-1888. doi: 10.1042/CS20180580. Print 2018 Sep 14. Review.


Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug.

Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steven S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I.

Cardiovasc Res. 2019 Mar 1;115(3):625-636. doi: 10.1093/cvr/cvy222.


A selective and sensitive method for quantification of endogenous polysulfide production in biological samples.

Bibli SI, Luck B, Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I.

Redox Biol. 2018 Sep;18:295-304. doi: 10.1016/j.redox.2018.07.016. Epub 2018 Jul 21.


The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang MS.

Acta Physiol (Oxf). 2019 Jan;225(1):e13168. doi: 10.1111/apha.13168. Epub 2018 Aug 25.


Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy.

Nicolay JP, Thorn V, Daniel C, Amann K, Siraskar B, Lang F, Hillgruber C, Goerge T, Hoffmann S, Gorzelanny C, Huck V, Mess C, Obser T, Schneppenheim R, Fleming I, Schneider MF, Schneider SW.

Sci Rep. 2018 Jul 19;8(1):10945. doi: 10.1038/s41598-018-28961-2.


Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.

Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.


Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP.

Nat Commun. 2018 Jun 12;9(1):2292. doi: 10.1038/s41467-018-04602-0.


Angiogenesis and vascular stability in eicosanoids and cancer.

Hu J, Frömel T, Fleming I.

Cancer Metastasis Rev. 2018 Sep;37(2-3):425-438. doi: 10.1007/s10555-018-9732-2. Review.


Estimating degradation-related settlement in two landfill-reclaimed soils by sand-salt analogues.

McDougall JR, Fleming IR, Thiel R, Dewaele P, Parker D, Kelly D.

Waste Manag. 2018 Jul;77:294-303. doi: 10.1016/j.wasman.2018.04.013. Epub 2018 Apr 26.


Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells.

Cencioni C, Spallotta F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehage M, Sürün D, Siragusa M, Smith JG, Schnütgen F, von Melchner H, Rieger MA, Martelli F, Riccio A, Fleming I, Braun T, Zeiher AM, Farsetti A, Gaetano C.

Nat Commun. 2018 Mar 29;9(1):1281. doi: 10.1038/s41467-018-03668-0.


Role of the angiotensin-converting enzyme in the G-CSF-induced mobilization of progenitor cells.

Kohlstedt K, Trouvain C, Frömel T, Mudersbach T, Henschler R, Fleming I.

Basic Res Cardiol. 2018 Mar 17;113(3):18. doi: 10.1007/s00395-018-0677-y.


VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.

Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM.

J Cell Biol. 2018 Apr 2;217(4):1503-1519. doi: 10.1083/jcb.201702048. Epub 2018 Mar 5.


Characterization of Athabasca lean oil sands and mixed surficial materials: Comparison of capillary electrophoresis/low-resolution mass spectrometry and high-resolution mass spectrometry.

MacLennan MS, Peru KM, Swyngedouw C, Fleming I, Chen DDY, Headley JV.

Rapid Commun Mass Spectrom. 2018 May 15;32(9):695-702. doi: 10.1002/rcm.8093.


Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses.

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Schürmann C, Heringdorf DMZ, Geisslinger G, Fleming I, Brandes RP, Brüne B, Namgaladze D.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Apr;1863(4):433-446. doi: 10.1016/j.bbalip.2018.01.009.


Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning.

Köhler D, Bibli SI, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM, Rosenberger P.

Basic Res Cardiol. 2018 Jan 17;113(2):11. doi: 10.1007/s00395-018-0667-0.


Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy.

Hu J, Dziumbla S, Lin J, Bibli SI, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes HP, Popp R, Fleming I.

Nature. 2017 Dec 14;552(7684):248-252. doi: 10.1038/nature25013. Epub 2017 Dec 6.


The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Rezende F, Moll F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K.

Redox Biol. 2018 May;15:12-21. doi: 10.1016/j.redox.2017.11.014. Epub 2017 Nov 22.

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