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Items: 1 to 50 of 92

1.

A novel murine model for contact lens wear reveals clandestine IL-1R dependent corneal parainflammation and susceptibility to microbial keratitis upon inoculation with Pseudomonas aeruginosa.

Metruccio MME, Wan SJ, Horneman H, Kroken AR, Sullivan AB, Truong TN, Mun JJ, Tam CKP, Frith R, Welsh L, George MD, Morris CA, Evans DJ, Fleiszig SMJ.

Ocul Surf. 2019 Jan;17(1):119-133. doi: 10.1016/j.jtos.2018.11.006. Epub 2018 Nov 12.

PMID:
30439473
2.

Impact of topical corticosteroid pretreatment on susceptibility of the injured murine cornea to Pseudomonas aeruginosa colonization and infection.

Wu YT, Truong TN, Tam C, Mendoza MN, Zhu L, Evans DJ, Fleiszig SMJ.

Exp Eye Res. 2019 Feb;179:1-7. doi: 10.1016/j.exer.2018.10.010. Epub 2018 Oct 19.

PMID:
30343040
3.

IL-1R and MyD88 Contribute to the Absence of a Bacterial Microbiome on the Healthy Murine Cornea.

Wan SJ, Sullivan AB, Shieh P, Metruccio MME, Evans DJ, Bertozzi CR, Fleiszig SMJ.

Front Microbiol. 2018 May 29;9:1117. doi: 10.3389/fmicb.2018.01117. eCollection 2018.

4.
5.

Contributions of MyD88-dependent receptors and CD11c-positive cells to corneal epithelial barrier function against Pseudomonas aeruginosa.

Metruccio MME, Tam C, Evans DJ, Xie AL, Stern ME, Fleiszig SMJ.

Sci Rep. 2017 Oct 23;7(1):13829. doi: 10.1038/s41598-017-14243-w.

6.

Correction: Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa.

Li J, Metruccio MME, Smith BE, Evans DJ, Fleiszig SMJ.

PLoS Pathog. 2017 Sep 12;13(9):e1006612. doi: 10.1371/journal.ppat.1006612. eCollection 2017 Sep.

7.

Mucosal fluid glycoprotein DMBT1 suppresses twitching motility and virulence of the opportunistic pathogen Pseudomonas aeruginosa.

Li J, Metruccio MME, Evans DJ, Fleiszig SMJ.

PLoS Pathog. 2017 May 10;13(5):e1006392. doi: 10.1371/journal.ppat.1006392. eCollection 2017 May. Erratum in: PLoS Pathog. 2017 Sep 12;13(9):e1006612.

8.

Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding.

Jolly AL, Agarwal P, Metruccio MME, Spiciarich DR, Evans DJ, Bertozzi CR, Fleiszig SMJ.

FASEB J. 2017 Jun;31(6):2393-2404. doi: 10.1096/fj.201601198R. Epub 2017 Feb 21.

9.

Human Tear Fluid Reduces Culturability of Contact Lens-Associated Pseudomonas aeruginosa Biofilms but Induces Expression of the Virulence-Associated Type III Secretion System.

Wu YT, Tam C, Zhu LS, Evans DJ, Fleiszig SM.

Ocul Surf. 2017 Jan;15(1):88-96. doi: 10.1016/j.jtos.2016.09.001. Epub 2016 Sep 23.

10.

Pseudomonas aeruginosa Outer Membrane Vesicles Triggered by Human Mucosal Fluid and Lysozyme Can Prime Host Tissue Surfaces for Bacterial Adhesion.

Metruccio MM, Evans DJ, Gabriel MM, Kadurugamuwa JL, Fleiszig SM.

Front Microbiol. 2016 Jun 3;7:871. doi: 10.3389/fmicb.2016.00871. eCollection 2016.

11.

Pseudomonas aeruginosa Survival at Posterior Contact Lens Surfaces after Daily Wear.

Wu YT, Zhu LS, Tam KP, Evans DJ, Fleiszig SM.

Optom Vis Sci. 2015 Jun;92(6):659-64. doi: 10.1097/OPX.0000000000000597.

12.

Pseudomonas aeruginosa-induced bleb-niche formation in epithelial cells is independent of actinomyosin contraction and enhanced by loss of cystic fibrosis transmembrane-conductance regulator osmoregulatory function.

Jolly AL, Takawira D, Oke OO, Whiteside SA, Chang SW, Wen ER, Quach K, Evans DJ, Fleiszig SM.

MBio. 2015 Feb 24;6(2):e02533. doi: 10.1128/mBio.02533-14.

13.

The importance of the Pseudomonas aeruginosa type III secretion system in epithelium traversal depends upon conditions of host susceptibility.

Sullivan AB, Tam KP, Metruccio MM, Evans DJ, Fleiszig SM.

Infect Immun. 2015 Apr;83(4):1629-40. doi: 10.1128/IAI.02329-14. Epub 2015 Feb 9.

14.

Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolones.

Borkar DS, Acharya NR, Leong C, Lalitha P, Srinivasan M, Oldenburg CE, Cevallos V, Lietman TM, Evans DJ, Fleiszig SM.

BMC Ophthalmol. 2014 Apr 24;14:54. doi: 10.1186/1471-2415-14-54.

15.

Cornea and ocular surface disease: application of cutting-edge optometric research.

Robertson DM, Alexander LJ, Bonanno JA, Fleiszig SM, McNamara N.

Optom Vis Sci. 2014 Apr;91(4 Suppl 1):S3-16. doi: 10.1097/OPX.0000000000000226. Review.

16.

Pseudomonas aeruginosa utilizes the type III secreted toxin ExoS to avoid acidified compartments within epithelial cells.

Heimer SR, Evans DJ, Stern ME, Barbieri JT, Yahr T, Fleiszig SM.

PLoS One. 2013 Sep 18;8(9):e73111. doi: 10.1371/journal.pone.0073111. eCollection 2013.

17.

Surfactant protein D contributes to ocular defense against Pseudomonas aeruginosa in a murine model of dry eye disease.

Heimer SR, Evans DJ, Mun JJ, Stern ME, Fleiszig SM.

PLoS One. 2013 Jun 6;8(6):e65797. doi: 10.1371/journal.pone.0065797. Print 2013.

18.

Why does the healthy cornea resist Pseudomonas aeruginosa infection?

Evans DJ, Fleiszig SM.

Am J Ophthalmol. 2013 Jun;155(6):961-970.e2. doi: 10.1016/j.ajo.2013.03.001. Epub 2013 Apr 17.

19.

Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis.

Borkar DS, Fleiszig SM, Leong C, Lalitha P, Srinivasan M, Ghanekar AA, Tam C, Li WY, Zegans ME, McLeod SD, Lietman TM, Acharya NR.

JAMA Ophthalmol. 2013 Feb;131(2):147-53. doi: 10.1001/jamaophthalmol.2013.778.

20.

4. Contemporary research in contact lens care.

Morgan PB, Bright FV, Burke SE, Chalmers RL, Dobson C, Fleiszig SM, Hutter JC, Papas E, Peterson RC, Stapleton F.

Cont Lens Anterior Eye. 2013 Jan 15;36 Suppl 1:S22-7. doi: 10.1016/S1367-0484(13)60006-5.

PMID:
23347572
21.

3. Ocular surface health with contact lens wear.

Shovlin JP, Arg├╝eso P, Carnt N, Chalmers RL, Efron N, Fleiszig SM, Nichols JJ, Polse KA, Stapleton F, Wiley L, Willcox M, Bright FV, Efron N, Jones LW, Keir N, Peterson RC, Stapleton F.

Cont Lens Anterior Eye. 2013 Jan 15;36 Suppl 1:S14-21. doi: 10.1016/S1367-0484(13)60005-3.

PMID:
23347571
22.

Microbial keratitis: could contact lens material affect disease pathogenesis?

Evans DJ, Fleiszig SM.

Eye Contact Lens. 2013 Jan;39(1):73-8. doi: 10.1097/ICL.0b013e318275b473. Review.

23.

Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

Tam C, Mun JJ, Evans DJ, Fleiszig SM.

J Clin Invest. 2012 Oct;122(10):3665-77. doi: 10.1172/JCI64416. Epub 2012 Sep 24.

24.

Translocon-independent intracellular replication by Pseudomonas aeruginosa requires the ADP-ribosylation domain of ExoS.

Hritonenko V, Evans DJ, Fleiszig SM.

Microbes Infect. 2012 Dec;14(15):1366-73. doi: 10.1016/j.micinf.2012.08.007. Epub 2012 Aug 30.

25.

Modulation of epithelial immunity by mucosal fluid.

Mun JJ, Tam C, Evans DJ, Fleiszig SM.

Sci Rep. 2011;1:8. doi: 10.1038/srep00008. Epub 2011 Jun 14.

26.

Traversal of multilayered corneal epithelia by cytotoxic Pseudomonas aeruginosa requires the phospholipase domain of exoU.

Ramirez JC, Fleiszig SM, Sullivan AB, Tam C, Borazjani R, Evans DJ.

Invest Ophthalmol Vis Sci. 2012 Jan 25;53(1):448-53. doi: 10.1167/iovs.11-8999.

27.

3D quantitative imaging of unprocessed live tissue reveals epithelial defense against bacterial adhesion and subsequent traversal requires MyD88.

Tam C, LeDue J, Mun JJ, Herzmark P, Robey EA, Evans DJ, Fleiszig SM.

PLoS One. 2011;6(8):e24008. doi: 10.1371/journal.pone.0024008. Epub 2011 Aug 25.

28.

Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence.

Hritonenko V, Mun JJ, Tam C, Simon NC, Barbieri JT, Evans DJ, Fleiszig SM.

Microb Pathog. 2011 Nov;51(5):305-12. doi: 10.1016/j.micpath.2011.08.001. Epub 2011 Aug 9.

29.

Dynamics of Pseudomonas aeruginosa association with anionic hydrogel surfaces in the presence of aqueous divalent-cation salts.

Tran VB, Sung YS, Fleiszig SM, Evans DJ, Radke CJ.

J Colloid Interface Sci. 2011 Oct 1;362(1):58-66. doi: 10.1016/j.jcis.2011.06.012. Epub 2011 Jun 13.

30.

Dynamics of flagellum- and pilus-mediated association of Pseudomonas aeruginosa with contact lens surfaces.

Tran VB, Fleiszig SM, Evans DJ, Radke CJ.

Appl Environ Microbiol. 2011 Jun;77(11):3644-52. doi: 10.1128/AEM.02656-10. Epub 2011 Apr 15.

31.

Role of defensins in corneal epithelial barrier function against Pseudomonas aeruginosa traversal.

Augustin DK, Heimer SR, Tam C, Li WY, Le Due JM, Evans DJ, Fleiszig SM.

Infect Immun. 2011 Feb;79(2):595-605. doi: 10.1128/IAI.00854-10. Epub 2010 Nov 29.

32.

Factors impacting corneal epithelial barrier function against Pseudomonas aeruginosa traversal.

Alarcon I, Tam C, Mun JJ, LeDue J, Evans DJ, Fleiszig SM.

Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1368-77. doi: 10.1167/iovs.10-6125.

33.

The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells.

Angus AA, Evans DJ, Barbieri JT, Fleiszig SM.

Infect Immun. 2010 Nov;78(11):4500-10. doi: 10.1128/IAI.00417-10. Epub 2010 Aug 23.

34.

Pathogenesis of contact lens-associated microbial keratitis.

Fleiszig SM, Evans DJ.

Optom Vis Sci. 2010 Apr;87(4):225-32. doi: 10.1097/OPX.0b013e3181d408ee. Review.

35.

The impact of inoculation parameters on the pathogenesis of contact lens-related infectious keratitis.

Tam C, Mun JJ, Evans DJ, Fleiszig SM.

Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3100-6. doi: 10.1167/iovs.09-4593. Epub 2010 Feb 3.

36.

Role of the corneal epithelial basement membrane in ocular defense against Pseudomonas aeruginosa.

Alarcon I, Kwan L, Yu C, Evans DJ, Fleiszig SM.

Infect Immun. 2009 Aug;77(8):3264-71. doi: 10.1128/IAI.00111-09. Epub 2009 Jun 8.

37.

Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model.

Mun JJ, Tam C, Kowbel D, Hawgood S, Barnett MJ, Evans DJ, Fleiszig SM.

Infect Immun. 2009 Jun;77(6):2392-8. doi: 10.1128/IAI.00173-09. Epub 2009 Apr 6.

38.

The role of twitching motility in Pseudomonas aeruginosa exit from and translocation of corneal epithelial cells.

Alarcon I, Evans DJ, Fleiszig SM.

Invest Ophthalmol Vis Sci. 2009 May;50(5):2237-44. doi: 10.1167/iovs.08-2785. Epub 2009 Jan 10.

39.

Pathogenic phenotype and genotype of Pseudomonas aeruginosa isolates from spontaneous canine ocular infections.

Ledbetter EC, Mun JJ, Kowbel D, Fleiszig SM.

Invest Ophthalmol Vis Sci. 2009 Feb;50(2):729-36. doi: 10.1167/iovs.08-2358. Epub 2008 Oct 3.

40.

Expression of surfactant protein D in human corneal epithelial cells is upregulated by Pseudomonas aeruginosa.

Ni M, Tam C, Verma A, Ramphal R, Hawgood S, Evans DJ, Fleiszig SM.

FEMS Immunol Med Microbiol. 2008 Nov;54(2):177-84. doi: 10.1111/j.1574-695X.2008.00461.x. Epub 2008 Jul 22.

41.

Pseudomonas aeruginosa induces membrane blebs in epithelial cells, which are utilized as a niche for intracellular replication and motility.

Angus AA, Lee AA, Augustin DK, Lee EJ, Evans DJ, Fleiszig SM.

Infect Immun. 2008 May;76(5):1992-2001. doi: 10.1128/IAI.01221-07. Epub 2008 Mar 3.

42.
43.

Life at the front: dissecting bacterial-host interactions at the ocular surface.

Evans DJ, McNamara NA, Fleiszig SM.

Ocul Surf. 2007 Jul;5(3):213-27. Review.

PMID:
17660895
44.

Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa.

Maltseva IA, Fleiszig SM, Evans DJ, Kerr S, Sidhu SS, McNamara NA, Basbaum C.

Exp Eye Res. 2007 Jul;85(1):142-53. Epub 2007 Apr 14.

PMID:
17531223
45.

Human tear fluid protects against Pseudomonas aeruginosa keratitis in a murine experimental model.

Kwong MS, Evans DJ, Ni M, Cowell BA, Fleiszig SM.

Infect Immun. 2007 May;75(5):2325-32. Epub 2007 Feb 26.

46.
47.
48.

Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.

Cowell BA, Evans DJ, Fleiszig SM.

FEMS Microbiol Lett. 2005 Sep 1;250(1):71-6.

49.

Mutation of retS, encoding a putative hybrid two-component regulatory protein in Pseudomonas aeruginosa, attenuates multiple virulence mechanisms.

Zolfaghar I, Angus AA, Kang PJ, To A, Evans DJ, Fleiszig SM.

Microbes Infect. 2005 Oct;7(13):1305-16. Epub 2005 Jun 13.

PMID:
16027020
50.

Interaction of Pseudomonas aeruginosa with human tear fluid components.

McNamara NA, Andika R, Kwong M, Sack RA, Fleiszig SM.

Curr Eye Res. 2005 Jul;30(7):517-25.

PMID:
16020285

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