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Items: 8

1.

Transient Telomerase Inhibition with Imetelstat Impacts DNA Damage Signals and Cell-Cycle Kinetics.

Thompson CAH, Gu A, Yang SY, Mathew V, Fleisig HB, Wong JMY.

Mol Cancer Res. 2018 Aug;16(8):1215-1225. doi: 10.1158/1541-7786.MCR-17-0772. Epub 2018 May 14.

PMID:
29759988
2.

Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability.

Fleisig HB, Hukezalie KR, Thompson CA, Au-Yeung TT, Ludlow AT, Zhao CR, Wong JM.

Oncogene. 2016 Jan 14;35(2):218-27. doi: 10.1038/onc.2015.75. Epub 2015 Apr 20.

PMID:
25893297
3.

The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita.

Zeng XL, Thumati NR, Fleisig HB, Hukezalie KR, Savage SA, Giri N, Alter BP, Wong JM.

Hum Mol Genet. 2012 Feb 15;21(4):721-9. doi: 10.1093/hmg/ddr504. Epub 2011 Nov 4.

4.

Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells.

Fleisig HB, Wong JM.

Oncogene. 2012 Feb 23;31(8):954-65. doi: 10.1038/onc.2011.292. Epub 2011 Jul 11.

PMID:
21743490
5.

Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.

Tamakawa RA, Fleisig HB, Wong JM.

Cancer Res. 2010 Nov 1;70(21):8684-94. doi: 10.1158/0008-5472.CAN-10-2227. Epub 2010 Sep 13.

6.

Adenoviral oncoprotein E1B55K mediates colocalization of SSBP2 and PML in response to stress.

Fleisig HB, Liang H, Nagarajan L.

J Mol Signal. 2010 Jun 11;5:6. doi: 10.1186/1750-2187-5-6.

7.

Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes.

Fleisig HB, Orazio NI, Liang H, Tyler AF, Adams HP, Weitzman MD, Nagarajan L.

Oncogene. 2007 Jul 19;26(33):4797-805. Epub 2007 Feb 19.

PMID:
17311003
8.

Telomerase as a clinical target: current strategies and potential applications.

Fleisig HB, Wong JM.

Exp Gerontol. 2007 Jan-Feb;42(1-2):102-12. Epub 2006 Jun 30. Review.

PMID:
16814507

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