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Tsitologiia. 1996;38(10):1118-23.

[The use of pluripotent mouse embryo stem cells for the production of chimeric animals].

[Article in Russian]


Embryonic stem (ES) cells derived from pluripotent cells of the early mouse embryos provide a powerful tool for genome manipulation in mammals. Conditions for maintaining and preservation of pluripotent properties of embryonic stem (ES) cells in culture using different tests are described. A simple aggregation of pluripotent ES cells with morulae-stage embryos for derivation of chimaeras is considered.

[Indexed for MEDLINE]

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