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Items: 1 to 50 of 167

1.

Optogenetic stimulation of Gs-signaling in the heart with high spatio-temporal precision.

Makowka P, Bruegmann T, Dusend V, Malan D, Beiert T, Hesse M, Fleischmann BK, Sasse P.

Nat Commun. 2019 Mar 20;10(1):1281. doi: 10.1038/s41467-019-09322-7.

2.

Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility.

Andrié RP, Beiert T, Knappe V, Linhart M, Stöckigt F, Klein AM, Ghanem A, Lübkemeier I, Röll W, Nickenig G, Fleischmann BK, Schrickel JW.

PLoS One. 2019 Feb 14;14(2):e0208301. doi: 10.1371/journal.pone.0208301. eCollection 2019.

3.

Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.

Krebs KM, Pfeil EM, Simon K, Grundmann M, Häberlein F, Bautista-Aguilera OM, Gütschow M, Weaver CD, Fleischmann BK, Kostenis E.

ACS Omega. 2018 Nov 30;3(11):14814-14823. doi: 10.1021/acsomega.8b02254. Epub 2018 Nov 5.

4.

PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.

Winkler F, Herz K, Rieck S, Kimura K, Hu T, Röll W, Hesse M, Fleischmann BK, Wenzel D.

Sci Rep. 2018 Dec 4;8(1):17582. doi: 10.1038/s41598-018-36039-2.

5.

Midbody Positioning and Distance Between Daughter Nuclei Enable Unequivocal Identification of Cardiomyocyte Cell Division in Mice.

Hesse M, Doengi M, Becker A, Kimura K, Voeltz N, Stein V, Fleischmann BK.

Circ Res. 2018 Oct 12;123(9):1039-1052. doi: 10.1161/CIRCRESAHA.118.312792.

PMID:
30355161
6.

Pathobiology, pathology and genetics of pulmonary hypertension: Update from the Cologne Consensus Conference 2018.

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kuebler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Int J Cardiol. 2018 Dec 1;272S:4-10. doi: 10.1016/j.ijcard.2018.09.070. Epub 2018 Sep 20. Review.

PMID:
30314839
7.

A Novel iRFP-Incorporated in vivo Murine Atherosclerosis Imaging System.

Kulathunga K, Hamada M, Hiraishi Y, Otake M, Tran MTN, Cheng O, Tanaka J, Sakasai T, Sakaguchi S, Sugiyama Y, Fleischmann BK, Takahashi S, Miwa Y.

Sci Rep. 2018 Sep 28;8(1):14515. doi: 10.1038/s41598-018-32456-5.

8.

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.

Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BK, Yamada M, Finkel T.

J Mol Cell Cardiol. 2018 Oct;123:180-184. doi: 10.1016/j.yjmcc.2018.09.005. Epub 2018 Sep 17.

PMID:
30236923
9.

The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.

Rommel C, Rösner S, Lother A, Barg M, Schwaderer M, Gilsbach R, Bömicke T, Schnick T, Mayer S, Doll S, Hesse M, Kretz O, Stiller B, Neumann FJ, Mann M, Krane M, Fleischmann BK, Ravens U, Hein L.

Circ Res. 2018 Aug 17;123(5):550-563. doi: 10.1161/CIRCRESAHA.118.313036.

PMID:
29930145
10.

Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling.

Roell W, Klein AM, Breitbach M, Becker TS, Parikh A, Lee J, Zimmermann K, Reining S, Gabris B, Ottersbach A, Doran R, Engelbrecht B, Schiffer M, Kimura K, Freitag P, Carls E, Geisen C, Duerr GD, Sasse P, Welz A, Pfeifer A, Salama G, Kotlikoff M, Fleischmann BK.

Sci Rep. 2018 May 8;8(1):7145. doi: 10.1038/s41598-018-25147-8.

11.

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction.

Loyer X, Zlatanova I, Devue C, Yin M, Howangyin KY, Klaihmon P, Guerin CL, Kheloufi M, Vilar J, Zannis K, Fleischmann BK, Hwang DW, Park J, Lee H, Menasché P, Silvestre JS, Boulanger CM.

Circ Res. 2018 Jun 22;123(1):100-106. doi: 10.1161/CIRCRESAHA.117.311326. Epub 2018 Mar 28.

12.

Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.

Deutsch MA, Doppler SA, Li X, Lahm H, Santamaria G, Cuda G, Eichhorn S, Ratschiller T, Dzilic E, Dreßen M, Eckart A, Stark K, Massberg S, Bartels A, Rischpler C, Gilsbach R, Hein L, Fleischmann BK, Wu SM, Lange R, Krane M.

Cardiovasc Res. 2018 Jul 1;114(8):1098-1114. doi: 10.1093/cvr/cvy069.

13.

In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche.

Breitbach M, Kimura K, Luis TC, Fuegemann CJ, Woll PS, Hesse M, Facchini R, Rieck S, Jobin K, Reinhardt J, Ohneda O, Wenzel D, Geisen C, Kurts C, Kastenmüller W, Hölzel M, Jacobsen SEW, Fleischmann BK.

Cell Stem Cell. 2018 Feb 1;22(2):262-276.e7. doi: 10.1016/j.stem.2018.01.008.

14.

Visualization of endothelial cell cycle dynamics in mouse using the Flt-1/eGFP-anillin system.

Herz K, Becker A, Shi C, Ema M, Takahashi S, Potente M, Hesse M, Fleischmann BK, Wenzel D.

Angiogenesis. 2018 May;21(2):349-361. doi: 10.1007/s10456-018-9601-1. Epub 2018 Feb 7.

PMID:
29417260
15.

Improved heart repair upon myocardial infarction: Combination of magnetic nanoparticles and tailored magnets strongly increases engraftment of myocytes.

Ottersbach A, Mykhaylyk O, Heidsieck A, Eberbeck D, Rieck S, Zimmermann K, Breitbach M, Engelbrecht B, Brügmann T, Hesse M, Welz A, Sasse P, Wenzel D, Plank C, Gleich B, Hölzel M, Bloch W, Pfeifer A, Fleischmann BK, Roell W.

Biomaterials. 2018 Feb;155:176-190. doi: 10.1016/j.biomaterials.2017.11.012. Epub 2017 Nov 15.

PMID:
29179133
16.

PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy.

Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z.

Circ Res. 2017 Dec 8;121(12):1370-1378. doi: 10.1161/CIRCRESAHA.117.311456. Epub 2017 Sep 19.

17.

Targeted inhibition of Gq signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D.

Sci Transl Med. 2017 Sep 13;9(407). pii: eaag2288. doi: 10.1126/scitranslmed.aag2288.

PMID:
28904224
18.

Heart regeneration and the cardiomyocyte cell cycle.

Hesse M, Welz A, Fleischmann BK.

Pflugers Arch. 2018 Feb;470(2):241-248. doi: 10.1007/s00424-017-2061-4. Epub 2017 Aug 28. Review.

19.

Cardiomyocyte Regeneration: A Consensus Statement.

Eschenhagen T, Bolli R, Braun T, Field LJ, Fleischmann BK, Frisén J, Giacca M, Hare JM, Houser S, Lee RT, Marbán E, Martin JF, Molkentin JD, Murry CE, Riley PR, Ruiz-Lozano P, Sadek HA, Sussman MA, Hill JA.

Circulation. 2017 Aug 15;136(7):680-686. doi: 10.1161/CIRCULATIONAHA.117.029343. Epub 2017 Jul 6. Review. No abstract available.

20.

Visualization of Cell Cycle Variations and Determination of Nucleation in Postnatal Cardiomyocytes.

Raulf A, Voeltz N, Korzus D, Fleischmann BK, Hesse M.

J Vis Exp. 2017 Feb 24;(120). doi: 10.3791/55204.

21.

Intercellular transfer of miR-126-3p by endothelial microparticles reduces vascular smooth muscle cell proliferation and limits neointima formation by inhibiting LRP6.

Jansen F, Stumpf T, Proebsting S, Franklin BS, Wenzel D, Pfeifer P, Flender A, Schmitz T, Yang X, Fleischmann BK, Nickenig G, Werner N.

J Mol Cell Cardiol. 2017 Mar;104:43-52. doi: 10.1016/j.yjmcc.2016.12.005. Epub 2017 Jan 28.

PMID:
28143713
22.

Engineered Context-Sensitive Agonism: Tissue-Selective Drug Signaling through a G Protein-Coupled Receptor.

Seemann WK, Wenzel D, Schrage R, Etscheid J, Bödefeld T, Bartol A, Warnken M, Sasse P, Klöckner J, Holzgrabe U, DeAmici M, Schlicker E, Racké K, Kostenis E, Meyer R, Fleischmann BK, Mohr K.

J Pharmacol Exp Ther. 2017 Feb;360(2):289-299. doi: 10.1124/jpet.116.237149. Epub 2016 Nov 15.

PMID:
28082514
23.

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice.

Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M, Burgos JI, Vila-Petroff M, Dutra FF, Bozza MT, Paiva CN, Carvalho AB, Bonomo A, Fleischmann BK, de Carvalho ACC, Medei E.

Nat Commun. 2016 Nov 24;7:13344. doi: 10.1038/ncomms13344.

24.

[Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016].

Olschewski A, Berghausen EM, Eichstaedt CA, Fleischmann BK, Grünig E, Grünig G, Hansmann G, Harbaum L, Hennigs JK, Jonigk D, Kübler WM, Kwapiszewska G, Pullamsetti SS, Stacher E, Weissmann N, Wenzel D, Schermuly RT.

Dtsch Med Wochenschr. 2016 Oct;141(S 01):S4-S9. Epub 2016 Oct 19. German.

PMID:
27760444
25.

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Kathage B, Gehlert S, Ulbricht A, Lüdecke L, Tapia VE, Orfanos Z, Wenzel D, Bloch W, Volkmer R, Fleischmann BK, Fürst DO, Höhfeld J.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):62-75. doi: 10.1016/j.bbamcr.2016.10.007. Epub 2016 Oct 15.

26.

Improvement of vascular function by magnetic nanoparticle-assisted circumferential gene transfer into the native endothelium.

Vosen S, Rieck S, Heidsieck A, Mykhaylyk O, Zimmermann K, Plank C, Gleich B, Pfeifer A, Fleischmann BK, Wenzel D.

J Control Release. 2016 Nov 10;241:164-173. doi: 10.1016/j.jconrel.2016.09.024. Epub 2016 Sep 22.

PMID:
27667178
27.

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

Bruegmann T, Boyle PM, Vogt CC, Karathanos TV, Arevalo HJ, Fleischmann BK, Trayanova NA, Sasse P.

J Clin Invest. 2016 Oct 3;126(10):3894-3904. doi: 10.1172/JCI88950. Epub 2016 Sep 12.

28.

Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.

Howangyin KY, Zlatanova I, Pinto C, Ngkelo A, Cochain C, Rouanet M, Vilar J, Lemitre M, Stockmann C, Fleischmann BK, Mallat Z, Silvestre JS.

Circulation. 2016 Mar 1;133(9):826-39. doi: 10.1161/CIRCULATIONAHA.115.020857. Epub 2016 Jan 27.

29.

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

Malan D, Zhang M, Stallmeyer B, Müller J, Fleischmann BK, Schulze-Bahr E, Sasse P, Greber B.

Basic Res Cardiol. 2016 Mar;111(2):14. doi: 10.1007/s00395-016-0530-0. Epub 2016 Jan 23.

30.

Tissue-Mimicking Geometrical Constraints Stimulate Tissue-Like Constitution and Activity of Mouse Neonatal and Human-Induced Pluripotent Stem Cell-Derived Cardiac Myocytes.

Pilarczyk G, Raulf A, Gunkel M, Fleischmann BK, Lemor R, Hausmann M.

J Funct Biomater. 2016 Jan 7;7(1). pii: E1. doi: 10.3390/jfb7010001.

31.

Vascular Repair by Circumferential Cell Therapy Using Magnetic Nanoparticles and Tailored Magnets.

Vosen S, Rieck S, Heidsieck A, Mykhaylyk O, Zimmermann K, Bloch W, Eberbeck D, Plank C, Gleich B, Pfeifer A, Fleischmann BK, Wenzel D.

ACS Nano. 2016 Jan 26;10(1):369-76. doi: 10.1021/acsnano.5b04996. Epub 2016 Jan 6.

PMID:
26736067
32.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

33.

Differential Expression Levels of Integrin α6 Enable the Selective Identification and Isolation of Atrial and Ventricular Cardiomyocytes.

Wiencierz AM, Kernbach M, Ecklebe J, Monnerat G, Tomiuk S, Raulf A, Christalla P, Malan D, Hesse M, Bosio A, Fleischmann BK, Eckardt D.

PLoS One. 2015 Nov 30;10(11):e0143538. doi: 10.1371/journal.pone.0143538. eCollection 2015.

34.

Integrin Based Isolation Enables Purification of Murine Lineage Committed Cardiomyocytes.

Tarnawski L, Xian X, Monnerat G, Macaulay IC, Malan D, Borgman A, Wu SM, Fleischmann BK, Jovinge S.

PLoS One. 2015 Aug 31;10(8):e0135880. doi: 10.1371/journal.pone.0135880. eCollection 2015.

35.

Deciphering the Epigenetic Code of Cardiac Myocyte Transcription.

Preissl S, Schwaderer M, Raulf A, Hesse M, Grüning BA, Köbele C, Backofen R, Fleischmann BK, Hein L, Gilsbach R.

Circ Res. 2015 Aug 14;117(5):413-23. doi: 10.1161/CIRCRESAHA.115.306337. Epub 2015 Jun 23.

PMID:
26105955
36.

Optogenetic control of contractile function in skeletal muscle.

Bruegmann T, van Bremen T, Vogt CC, Send T, Fleischmann BK, Sasse P.

Nat Commun. 2015 Jun 2;6:7153. doi: 10.1038/ncomms8153.

37.

Transgenic systems for unequivocal identification of cardiac myocyte nuclei and analysis of cardiomyocyte cell cycle status.

Raulf A, Horder H, Tarnawski L, Geisen C, Ottersbach A, Röll W, Jovinge S, Fleischmann BK, Hesse M.

Basic Res Cardiol. 2015 May;110(3):33. doi: 10.1007/s00395-015-0489-2. Epub 2015 Apr 30.

38.

Systemic gene transfer enables optogenetic pacing of mouse hearts.

Vogt CC, Bruegmann T, Malan D, Ottersbach A, Roell W, Fleischmann BK, Sasse P.

Cardiovasc Res. 2015 May 1;106(2):338-43. doi: 10.1093/cvr/cvv004. Epub 2015 Jan 12.

PMID:
25587047
39.

Human Connexin43E42K mutation from a sudden infant death victim leads to impaired ventricular activation and neonatal death in mice.

Lübkemeier I, Bosen F, Kim JS, Sasse P, Malan D, Fleischmann BK, Willecke K.

Circ Cardiovasc Genet. 2015 Feb;8(1):21-9. doi: 10.1161/CIRCGENETICS.114.000793. Epub 2014 Dec 10.

PMID:
25504652
40.

CB2 receptor-mediated effects of pro-inflammatory macrophages influence survival of cardiomyocytes.

Heinemann JC, Duerr GD, Keppel K, Breitbach M, Fleischmann BK, Zimmer A, Wehner S, Welz A, Dewald O.

Life Sci. 2015 Oct 1;138:18-28. doi: 10.1016/j.lfs.2014.11.027. Epub 2014 Dec 9.

PMID:
25497711
41.

MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization.

Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T, Boettger T.

PLoS One. 2014 Nov 21;9(11):e113449. doi: 10.1371/journal.pone.0113449. eCollection 2014.

42.

Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease.

Gilsbach R, Preissl S, Grüning BA, Schnick T, Burger L, Benes V, Würch A, Bönisch U, Günther S, Backofen R, Fleischmann BK, Schübeler D, Hein L.

Nat Commun. 2014 Oct 22;5:5288. doi: 10.1038/ncomms6288.

43.

Comment on "Do neonatal mouse hearts regenerate following heart apex resection"?

Kotlikoff MI, Hesse M, Fleischmann BK.

Stem Cell Reports. 2014 Jul 8;3(1):2. doi: 10.1016/j.stemcr.2014.06.010. eCollection 2014 Jul 8. No abstract available.

44.

A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation.

Schmitz AL, Schrage R, Gaffal E, Charpentier TH, Wiest J, Hiltensperger G, Morschel J, Hennen S, Häußler D, Horn V, Wenzel D, Grundmann M, Büllesbach KM, Schröder R, Brewitz HH, Schmidt J, Gomeza J, Galés C, Fleischmann BK, Tüting T, Imhof D, Tietze D, Gütschow M, Holzgrabe U, Sondek J, Harden TK, Mohr K, Kostenis E.

Chem Biol. 2014 Jul 17;21(7):890-902. doi: 10.1016/j.chembiol.2014.06.003.

45.

The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy.

Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O.

Basic Res Cardiol. 2014 Jul;109(4):425. doi: 10.1007/s00395-014-0425-x. Epub 2014 Jul 1.

PMID:
24980781
46.

HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis.

Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J.

Mol Biol Cell. 2014 Aug 1;25(15):2260-71. doi: 10.1091/mbc.E14-02-0742. Epub 2014 Jun 4.

47.

Concise review: The role of C-kit expressing cells in heart repair at the neonatal and adult stage.

Hesse M, Fleischmann BK, Kotlikoff MI.

Stem Cells. 2014 Jul;32(7):1701-12. doi: 10.1002/stem.1696. Review.

48.

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T.

Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.

PMID:
24572365
49.

FACS-based isolation, propagation and characterization of mouse embryonic cardiomyocytes based on VCAM-1 surface marker expression.

Pontén A, Walsh S, Malan D, Xian X, Schéele S, Tarnawski L, Fleischmann BK, Jovinge S.

PLoS One. 2013 Dec 30;8(12):e82403. doi: 10.1371/journal.pone.0082403. eCollection 2013.

50.

Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes.

Zhang J, Dublin P, Griemsmann S, Klein A, Brehm R, Bedner P, Fleischmann BK, Steinhäuser C, Theis M.

PLoS One. 2013 Dec 9;8(12):e82818. doi: 10.1371/journal.pone.0082818. eCollection 2013.

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