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Donor-specific anti-HLA antibodies in unrelated hematopoietic cell transplantation for non-malignant disorders.

Woolfrey A, Wang T, Lee SJ, Haagenson MD, Chen G, Fleischhauer K, Horan J, Hsu K, Verneris M, Spellman SR, Fernandez-Vina M.

Bone Marrow Transplant. 2018 Sep 19. doi: 10.1038/s41409-018-0334-y. [Epub ahead of print] No abstract available.


Common and well-documented HLA alleles of German stem cell donors by haplotype frequency estimation.

Eberhard HP, Schmidt AH, Mytilineos J, Fleischhauer K, Müller C.

HLA. 2018 Aug 17. doi: 10.1111/tan.13378. [Epub ahead of print]


In silico prediction of nonpermissive HLA-DPB1 mismatches in unrelated HCT by functional distance.

Arrieta-Bolaños E, Crivello P, Shaw BE, Ahn KW, Wang HL, Verneris MR, Hsu KC, Pidala J, Lee SJ, Fleischhauer K, Spellman SR.

Blood Adv. 2018 Jul 24;2(14):1773-1783. doi: 10.1182/bloodadvances.2018019620.


Relative Impact of HLA Matching and Non-HLA Donor Characteristics on Outcomes of Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome.

Ayuk F, Beelen DW, Bornhäuser M, Stelljes M, Zabelina T, Finke J, Kobbe G, Wolff D, Wagner EM, Christopeit M, Schmid C, Ottinger H, Groth C, Faul C, Bertz H, Rachlis E, Wolschke C, Schetelig J, Horn PA, Mytilineos J, Guellstorf M, Kelsch R, Fleischhauer K, Kröger N, Bethge W.

Biol Blood Marrow Transplant. 2018 Jul 24. pii: S1083-8791(18)30365-3. doi: 10.1016/j.bbmt.2018.06.026. [Epub ahead of print]


Prevention of relapse after allogeneic hematopoietic cell transplantation by donor and cell source selection.

Fleischhauer K, Hsu KC, Shaw BE.

Bone Marrow Transplant. 2018 May 24. doi: 10.1038/s41409-018-0218-1. [Epub ahead of print] Review.


Immune monitoring in allogeneic hematopoietic stem cell transplant recipients: a survey from the EBMT-CTIWP.

Greco R, Ciceri F, Noviello M, Bondanza A, Vago L, Oliveira G, Peccatori J, Cieri N, Ruggeri A, Koehl U, Fleischhauer K, Rocha V, Dazzi F, van der Werf SM, Eikema DJ, Terwel SR, Kuball J, Toubert A, Chabannon C, Bonini C; EBMT Cellular Therapy and Immunobiology Working Party (CTIWP).

Bone Marrow Transplant. 2018 Sep;53(9):1201-1205. doi: 10.1038/s41409-018-0167-8. Epub 2018 Apr 17. No abstract available.


Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies.

Chabannon C, Kuball J, Bondanza A, Dazzi F, Pedrazzoli P, Toubert A, Ruggeri A, Fleischhauer K, Bonini C.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaap9630. doi: 10.1126/scitranslmed.aap9630. Review.


Alloreactive T Cell Receptor Diversity against Structurally Similar or Dissimilar HLA-DP Antigens Assessed by Deep Sequencing.

Arrieta-Bolaños E, Crivello P, Metzing M, Meurer T, Ahci M, Rytlewski J, Vignali M, Yusko E, van Balen P, Horn PA, Falkenburg JHF, Fleischhauer K.

Front Immunol. 2018 Feb 19;9:280. doi: 10.3389/fimmu.2018.00280. eCollection 2018.


Development of an Unrelated Donor Selection Score Predictive of Survival after HCT: Donor Age Matters Most.

Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, Hurley C, Barker J, Maiers M, Dehn J, Wang H, Haagenson M, Porter D, Petersdorf EW, Woolfrey A, Horowitz MM, Verneris M, Hsu KC, Fleischhauer K, Lee SJ.

Biol Blood Marrow Transplant. 2018 May;24(5):1049-1056. doi: 10.1016/j.bbmt.2018.02.006. Epub 2018 Feb 14.


Evaluation of a Machine Learning-Based Prognostic Model for Unrelated Hematopoietic Cell Transplantation Donor Selection.

Buturovic L, Shelton J, Spellman SR, Wang T, Friedman L, Loftus D, Hesterberg L, Woodring T, Fleischhauer K, Hsu KC, Verneris MR, Haagenson M, Lee SJ.

Biol Blood Marrow Transplant. 2018 Jun;24(6):1299-1306. doi: 10.1016/j.bbmt.2018.01.038. Epub 2018 Feb 2.


Prediction of absolute risk of acute graft-versus-host disease following hematopoietic cell transplantation.

Lee C, Haneuse S, Wang HL, Rose S, Spellman SR, Verneris M, Hsu KC, Fleischhauer K, Lee SJ, Abdi R.

PLoS One. 2018 Jan 18;13(1):e0190610. doi: 10.1371/journal.pone.0190610. eCollection 2018.


Implementation of the Single European Code in a Multi-Tissue Bank.

Schroeter J, Schulz T, Schroeter B, Fleischhauer K, Pruß A.

Transfus Med Hemother. 2017 Nov;44(6):396-400. doi: 10.1159/000481145. Epub 2017 Nov 22. Review.


The impact of HLA matching on outcomes of unmanipulated haploidentical HSCT is modulated by GVHD prophylaxis.

Lorentino F, Labopin M, Fleischhauer K, Ciceri F, Mueller CR, Ruggeri A, Shimoni A, Bornhäuser M, Bacigalupo A, Gülbas Z, Koc Y, Arcese W, Bruno B, Tischer J, Blaise D, Messina G, Beelen DW, Nagler A, Mohty M.

Blood Adv. 2017 Apr 21;1(11):669-680. doi: 10.1182/bloodadvances.2017006429. eCollection 2017 Apr 25.


No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia.

Gadalla SM, Wang T, Loftus D, Friedman L, Dagnall C, Haagenson M, Spellman SR, Buturovic L, Blauwkamp M, Shelton J, Fleischhauer K, Hsu KC, Verneris MR, Krstajic D, Hicks B, Jones K, Lee SJ, Savage SA.

Bone Marrow Transplant. 2018 Apr;53(4):383-391. doi: 10.1038/s41409-017-0029-9. Epub 2017 Dec 21.


Jon van Rood (1926-2017).

Mueller C, Bonini C, Foeken L, Chabannon C, Bondanza A, Fleischhauer K, Velardi A, Kröger N, Kuball J, Mohty M.

Bone Marrow Transplant. 2017 Dec;52(12):1587. doi: 10.1038/bmt.2017.242. No abstract available.


Impact of HLA Alleles on Outcomes of Allogeneic Transplantation for B Cell Non-Hodgkin Lymphomas: A Center for International Blood and Marrow Transplant Research Analysis.

William BM, Wang T, Haagenson MD, Fleischhauer K, Verneris M, Hsu KC, de Lima MJ, Fernandez-Viña M, Spellman SR, Lee SJ, Hill BT.

Biol Blood Marrow Transplant. 2018 Apr;24(4):827-831. doi: 10.1016/j.bbmt.2017.11.003. Epub 2017 Nov 16.


Impact of HLA-G polymorphism on the outcome of allogeneic hematopoietic stem cell transplantation for metastatic renal cell carcinoma.

Crocchiolo R, Ringden O, Bay JO, Blaise D, Omasic B, Mazzi B, Picard C, Trinca S, Barkholt L, Peccatori J, Gregori S, Amodio G, Fleischhauer K, Ciceri F, Bregni M.

Bone Marrow Transplant. 2018 Feb;53(2):213-218. doi: 10.1038/bmt.2017.243. Epub 2017 Nov 13.


αβ-T-cell depleted donor lymphocyte infusion for leukemia relapse after allogeneic stem cell transplantation.

Kordelas L, Buttkereit U, Lindemann M, Koldehoff M, Klisanin V, Horn PA, Fleischhauer K, Beelen DW.

Bone Marrow Transplant. 2017 Dec;52(12):1668-1670. doi: 10.1038/bmt.2017.185. Epub 2017 Sep 4. No abstract available.


HLA-DP in unrelated hematopoietic cell transplantation revisited: challenges and opportunities.

Fleischhauer K, Shaw BE.

Blood. 2017 Aug 31;130(9):1089-1096. doi: 10.1182/blood-2017-03-742346. Epub 2017 Jun 30. Review.


A new tool for rapid and reliable diagnosis of HLA loss relapses after HSCT.

Ahci M, Toffalori C, Bouwmans E, Crivello P, Brambati C, Pultrone C, Stempelmann K, Bost D, Mazzi B, Beelen DW, Ciceri F, Mulder W, Fleischhauer K, Vago L.

Blood. 2017 Sep 7;130(10):1270-1273. doi: 10.1182/blood-2017-05-784306. Epub 2017 Jun 27. No abstract available.


Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis.

Eapen M, Wang T, Veys PA, Boelens JJ, St Martin A, Spellman S, Bonfim CS, Brady C, Cant AJ, Dalle JH, Davies SM, Freeman J, Hsu KC, Fleischhauer K, Kenzey C, Kurtzberg J, Michel G, Orchard PJ, Paviglianiti A, Rocha V, Veneris MR, Volt F, Wynn R, Lee SJ, Horowitz MM, Gluckman E, Ruggeri A.

Lancet Haematol. 2017 Jul;4(7):e325-e333. doi: 10.1016/S2352-3026(17)30104-7. Epub 2017 Jun 13.


Clinical Utility of Quantitative PCR for Chimerism and Engraftment Monitoring after Allogeneic Stem Cell Transplantation for Hematologic Malignancies.

Ahci M, Stempelmann K, Buttkereit U, Crivello P, Trilling M, Heinold A, Steckel NK, Koldehoff M, Horn PA, Beelen DW, Fleischhauer K.

Biol Blood Marrow Transplant. 2017 Oct;23(10):1658-1668. doi: 10.1016/j.bbmt.2017.05.031. Epub 2017 Jun 8.


Directionality of non-permissive HLA-DPB1 T-cell epitope group mismatches does not improve clinical risk stratification in 8/8 matched unrelated donor hematopoietic cell transplantation.

Fleischhauer K, Ahn KW, Wang HL, Zito L, Crivello P, Müller C, Verneris M, Shaw BE, Pidala J, Oudshorn M, Lee SJ, Spellman SR.

Bone Marrow Transplant. 2017 Sep;52(9):1280-1287. doi: 10.1038/bmt.2017.96. Epub 2017 Jun 5.


Investigating the Association of Genetic Admixture and Donor/Recipient Genetic Disparity with Transplant Outcomes.

Madbouly A, Wang T, Haagenson M, Paunic V, Vierra-Green C, Fleischhauer K, Hsu KC, Verneris MR, Majhail NS, Lee SJ, Spellman SR, Maiers M.

Biol Blood Marrow Transplant. 2017 Jun;23(6):1029-1037. doi: 10.1016/j.bbmt.2017.02.019. Epub 2017 Mar 2.


Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation.

Lindsley RC, Saber W, Mar BG, Redd R, Wang T, Haagenson MD, Grauman PV, Hu ZH, Spellman SR, Lee SJ, Verneris MR, Hsu K, Fleischhauer K, Cutler C, Antin JH, Neuberg D, Ebert BL.

N Engl J Med. 2017 Feb 9;376(6):536-547. doi: 10.1056/NEJMoa1611604.


Common and well-documented HLA alleles over all of Europe and within European sub-regions: A catalogue from the European Federation for Immunogenetics.

Sanchez-Mazas A, Nunes JM, Middleton D, Sauter J, Buhler S, McCabe A, Hofmann J, Baier DM, Schmidt AH, Nicoloso G, Andreani M, Grubic Z, Tiercy JM, Fleischhauer K.

HLA. 2017 Feb;89(2):104-113. doi: 10.1111/tan.12956.


MHC Class I Chain-Related Gene A (MICA) Donor-Recipient Mismatches and MICA-129 Polymorphism in Unrelated Donor Hematopoietic Cell Transplantations Has No Impact on Outcomes in Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, or Myelodysplastic Syndrome: A Center for International Blood and Marrow Transplant Research Study.

Askar M, Sobecks R, Wang T, Haagenson M, Majhail N, Madbouly A, Thomas D, Zhang A, Fleischhauer K, Hsu K, Verneris M, Lee SJ, Spellman SR, Fernández-Viña M.

Biol Blood Marrow Transplant. 2017 Mar;23(3):436-444. doi: 10.1016/j.bbmt.2016.11.021. Epub 2016 Dec 14.


Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD.

Carapito R, Jung N, Kwemou M, Untrau M, Michel S, Pichot A, Giacometti G, Macquin C, Ilias W, Morlon A, Kotova I, Apostolova P, Schmitt-Graeff A, Cesbron A, Gagne K, Oudshoorn M, van der Holt B, Labalette M, Spierings E, Picard C, Loiseau P, Tamouza R, Toubert A, Parissiadis A, Dubois V, Lafarge X, Maumy-Bertrand M, Bertrand F, Vago L, Ciceri F, Paillard C, Querol S, Sierra J, Fleischhauer K, Nagler A, Labopin M, Inoko H, von dem Borne PA, Kuball J, Ota M, Katsuyama Y, Michallet M, Lioure B, Peffault de Latour R, Blaise D, Cornelissen JJ, Yakoub-Agha I, Claas F, Moreau P, Milpied N, Charron D, Mohty M, Zeiser R, Socié G, Bahram S.

Blood. 2016 Oct 13;128(15):1979-1986. Epub 2016 Aug 22.


YKL-40 in allogeneic hematopoietic cell transplantation after AML and myelodysplastic syndrome.

Kornblit B, Wang T, Lee SJ, Spellman SR, Zhu X, Fleischhauer K, Müller C, Verneris MR, Müller K, Johansen JS, Vindelov L, Garred P.

Bone Marrow Transplant. 2016 Dec;51(12):1556-1560. doi: 10.1038/bmt.2016.192. Epub 2016 Jul 18.


Functional distance between recipient and donor HLA-DPB1 determines nonpermissive mismatches in unrelated HCT.

Crivello P, Heinold A, Rebmann V, Ottinger HD, Horn PA, Beelen DW, Fleischhauer K.

Blood. 2016 Jul 7;128(1):120-9. doi: 10.1182/blood-2015-12-686238. Epub 2016 May 9. Erratum in: Blood. 2016 Dec 8;128(23 ):2744.


Validation Study Failed to Confirm an Association between Genetic Variants in the Base Excision Repair Pathway and Transplant-Related Mortality and Relapse after Hematopoietic Cell Transplantation.

Arora M, Lee SJ, Spellman SR, Weisdorf DJ, Guan W, Haagenson M, Wang T, Horowitz MH, Verneris MR, Fleischhauer K, Hsu K, Thyagarajan B.

Biol Blood Marrow Transplant. 2016 Aug;22(8):1531-1532. doi: 10.1016/j.bbmt.2016.04.020. Epub 2016 May 4. No abstract available.


High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine Model.

Gassa A, Kalkavan H, Jian F, Duhan V, Khairnar V, Shaabani N, Honke N, Carpinteiro A, Botezatu L, Crivello P, Dolff S, Ferencik S, Häussinger D, Khandanpour C, Fleischhauer K, Witzke O, Wahlers T, Hardt C, Lang PA, Lang KS.

Cell Physiol Biochem. 2016;38(4):1343-53. doi: 10.1159/000443078. Epub 2016 Mar 24.


HLA mismatching as a strategy to reduce relapse after alternative donor transplantation.

Fleischhauer K, Beelen DW.

Semin Hematol. 2016 Apr;53(2):57-64. doi: 10.1053/j.seminhematol.2016.01.010. Epub 2016 Jan 15. Review.


T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes.

Mennonna D, Maccalli C, Romano MC, Garavaglia C, Capocefalo F, Bordoni R, Severgnini M, De Bellis G, Sidney J, Sette A, Gori A, Longhi R, Braga M, Ghirardelli L, Baldari L, Orsenigo E, Albarello L, Zino E, Fleischhauer K, Mazzola G, Ferrero N, Amoroso A, Casorati G, Parmiani G, Dellabona P.

Gut. 2017 Mar;66(3):454-463. doi: 10.1136/gutjnl-2015-309453. Epub 2015 Dec 17.


Immunogenetics of HLA-DP--A New View of Permissible Mismatches.

Fleischhauer K.

N Engl J Med. 2015 Aug 13;373(7):669-72. doi: 10.1056/NEJMe1505539. No abstract available.


The impact of amino acid variability on alloreactivity defines a functional distance predictive of permissive HLA-DPB1 mismatches in hematopoietic stem cell transplantation.

Crivello P, Zito L, Sizzano F, Zino E, Maiers M, Mulder A, Toffalori C, Naldini L, Ciceri F, Vago L, Fleischhauer K.

Biol Blood Marrow Transplant. 2015 Feb;21(2):233-41. doi: 10.1016/j.bbmt.2014.10.017. Epub 2014 Oct 23.


Incidence, risk factors and clinical outcome of leukemia relapses with loss of the mismatched HLA after partially incompatible hematopoietic stem cell transplantation.

Crucitti L, Crocchiolo R, Toffalori C, Mazzi B, Greco R, Signori A, Sizzano F, Chiesa L, Zino E, Lupo Stanghellini MT, Assanelli A, Carrabba MG, Marktel S, Marcatti M, Bordignon C, Corti C, Bernardi M, Peccatori J, Bonini C, Fleischhauer K, Ciceri F, Vago L.

Leukemia. 2015 May;29(5):1143-52. doi: 10.1038/leu.2014.314. Epub 2014 Nov 5.


BAT2 and BAT3 polymorphisms as novel genetic risk factors for rejection after HLA-related SCT.

Piras IS, Angius A, Andreani M, Testi M, Lucarelli G, Floris M, Marktel S, Ciceri F, La Nasa G, Fleischhauer K, Roncarolo MG, Bulfone A, Gregori S, Bacchetta R.

Bone Marrow Transplant. 2014 Nov;49(11):1400-1404. doi: 10.1038/bmt.2014.177. Epub 2014 Aug 11. Erratum in: Bone Marrow Transplant. 2014 Nov;49(11):1452. Nasa, G La [corrected to La Nasa, G].


Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1.

Fleischhauer K, Fernandez-Viña MA, Wang T, Haagenson M, Battiwalla M, Baxter-Lowe LA, Ciceri F, Dehn J, Gajewski J, Hale GA, Heemskerk MB, Marino SR, McCarthy PL, Miklos D, Oudshoorn M, Pollack MS, Reddy V, Senitzer D, Shaw BE, Waller EK, Lee SJ, Spellman SR.

Bone Marrow Transplant. 2014 Sep;49(9):1176-83. doi: 10.1038/bmt.2014.122. Epub 2014 Jun 23.


Sirolimus-based graft-versus-host disease prophylaxis promotes the in vivo expansion of regulatory T cells and permits peripheral blood stem cell transplantation from haploidentical donors.

Peccatori J, Forcina A, Clerici D, Crocchiolo R, Vago L, Stanghellini MT, Noviello M, Messina C, Crotta A, Assanelli A, Marktel S, Olek S, Mastaglio S, Giglio F, Crucitti L, Lorusso A, Guggiari E, Lunghi F, Carrabba M, Tassara M, Battaglia M, Ferraro A, Carbone MR, Oliveira G, Roncarolo MG, Rossini S, Bernardi M, Corti C, Marcatti M, Patriarca F, Zecca M, Locatelli F, Bordignon C, Fleischhauer K, Bondanza A, Bonini C, Ciceri F.

Leukemia. 2015 Feb;29(2):396-405. doi: 10.1038/leu.2014.180. Epub 2014 Jun 4.


Experts' considerations on HLA-haploidentical stem cell transplantation.

Patriarca F, Luznik L, Medeot M, Zecca M, Bacigalupo A, Di Bartolomeo P, Arcese W, Corradini P, Ciceri F, Vago L, Kanakry CG, Fleischhauer K, Martelli MF, Bosi A, Rambaldi A, Cesaro S, Russo D, Fanin R.

Eur J Haematol. 2014 Sep;93(3):187-97. doi: 10.1111/ejh.12322. Epub 2014 Apr 26.


Allorecognition of HLA-DP by CD4+ T cells is affected by polymorphism in its alpha chain.

Lauterbach N, Crivello P, Wieten L, Zito L, Groeneweg M, Voorter CE, Fleischhauer K, Tilanus MG.

Mol Immunol. 2014 May;59(1):19-29. doi: 10.1016/j.molimm.2013.12.006. Epub 2014 Jan 22.


Molecular modelling of HLA-B*35:132.

Longhi E, Crivello P, Mantovani M, Frison S, Fleischhauer K, Crespiatico L, Piccolo G, Poli F.

Int J Immunogenet. 2014 Jun;41(3):195-7. doi: 10.1111/iji.12105. Epub 2014 Jan 9.


Translating the HLA-DPB1 T-cell epitope-matching algorithm into clinical practice.

Shaw BE, Robinson J, Fleischhauer K, Madrigal JA, Marsh SG.

Bone Marrow Transplant. 2013 Nov;48(12):1510-2. doi: 10.1038/bmt.2013.91. Epub 2013 Jul 1. No abstract available.


Effects of transmembrane region variability on cell surface expression and allorecognition of HLA-DP3.

Crivello P, Lauterbach N, Zito L, Sizzano F, Toffalori C, Marcon J, Curci L, Mulder A, Wieten L, Zino E, Voorter CE, Tilanus MG, Fleischhauer K.

Hum Immunol. 2013 Aug;74(8):970-7. doi: 10.1016/j.humimm.2013.04.014. Epub 2013 Apr 23.


Common and well-documented HLA alleles: 2012 update to the CWD catalogue.

Mack SJ, Cano P, Hollenbach JA, He J, Hurley CK, Middleton D, Moraes ME, Pereira SE, Kempenich JH, Reed EF, Setterholm M, Smith AG, Tilanus MG, Torres M, Varney MD, Voorter CE, Fischer GF, Fleischhauer K, Goodridge D, Klitz W, Little AM, Maiers M, Marsh SG, Müller CR, Noreen H, Rozemuller EH, Sanchez-Mazas A, Senitzer D, Trachtenberg E, Fernandez-Vina M.

Tissue Antigens. 2013 Apr;81(4):194-203. doi: 10.1111/tan.12093.


Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene.

Casucci M, Perna SK, Falcone L, Camisa B, Magnani Z, Bernardi M, Crotta A, Tresoldi C, Fleischhauer K, Ponzoni M, Gregori S, Caligaris Cappio F, Ciceri F, Bordignon C, Cignetti A, Bondanza A, Bonini C.

Mol Ther. 2013 Feb;21(2):466-75. doi: 10.1038/mt.2012.227. Epub 2012 Nov 13.


16th IHIW: international histocompatibility working group in hematopoietic cell transplantation.

Petersdorf EW, Malkki M, Hsu K, Bardy P, Cesbron A, Dickinson A, Dubois V, Fleischhauer K, Kawase T, Madrigal A, Morishima Y, Shaw B, Spellman S, Spierings E, Stern M, Tiercy JM, Velardi A, Gooley T; International Histocompatibility Working Group in Hematopoietic Cell Transplantation.

Int J Immunogenet. 2013 Feb;40(1):2-10. doi: 10.1111/iji.12022. Epub 2012 Dec 28.


Genomic loss of mismatched human leukocyte antigen and leukemia immune escape from haploidentical graft-versus-leukemia.

Vago L, Toffalori C, Ciceri F, Fleischhauer K.

Semin Oncol. 2012 Dec;39(6):707-15. doi: 10.1053/j.seminoncol.2012.09.009. Review.


Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3.

Hilton HG, Vago L, Older Aguilar AM, Moesta AK, Graef T, Abi-Rached L, Norman PJ, Guethlein LA, Fleischhauer K, Parham P.

J Immunol. 2012 Aug 1;189(3):1418-30. doi: 10.4049/jimmunol.1100431. Epub 2012 Jul 6.

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