Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 89

1.

Barriers to 3-Hydroxypropionate-Dependent Growth of Rhodobacter sphaeroides by Distinct Disruptions of the Ethylmalonyl Coenzyme A Pathway.

Carlson SJ, Fleig A, Baron MK, Berg IA, Alber BE.

J Bacteriol. 2019 Jan 28;201(4). pii: e00556-18. doi: 10.1128/JB.00556-18. Print 2019 Feb 15.

PMID:
30455284
2.

TRPM7 channels play a role in high glucose-induced endoplasmic reticulum stress and neuronal cell apoptosis.

Huang Y, Leng TD, Inoue K, Yang T, Liu M, Horgen FD, Fleig A, Li J, Xiong ZG.

J Biol Chem. 2018 Sep 14;293(37):14393-14406. doi: 10.1074/jbc.RA117.001032. Epub 2018 Aug 3.

PMID:
30076216
3.

The TRPM7 kinase limits receptor-induced calcium release by regulating heterotrimeric G-proteins.

Suzuki S, Lis A, Schmitz C, Penner R, Fleig A.

Cell Mol Life Sci. 2018 Aug;75(16):3069-3078. doi: 10.1007/s00018-018-2786-z. Epub 2018 Mar 2.

PMID:
29500477
4.

Scalaradial Is a Potent Inhibitor of Transient Receptor Potential Melastatin 2 (TRPM2) Ion Channels.

Starkus JG, Poerzgen P, Layugan K, Kawabata KG, Goto JI, Suzuki S, Myers G, Kelly M, Penner R, Fleig A, Horgen FD.

J Nat Prod. 2017 Oct 27;80(10):2741-2750. doi: 10.1021/acs.jnatprod.7b00515. Epub 2017 Oct 11.

PMID:
29019677
5.

Erratum to: Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.

Huang J, Furuya H, Faouzi M, Zhang Z, Monteilh-Zoller M, Kawabata KG, David Horgen F, Kawamori T, Penner R, Fleig A.

Cell Commun Signal. 2017 Sep 11;15(1):31. doi: 10.1186/s12964-017-0188-8. No abstract available.

6.

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice.

Huang J, Furuya H, Faouzi M, Zhang Z, Monteilh-Zoller M, Kawabata KG, Horgen FD, Kawamori T, Penner R, Fleig A.

Cell Commun Signal. 2017 Aug 15;15(1):30. doi: 10.1186/s12964-017-0187-9. Erratum in: Cell Commun Signal. 2017 Sep 11;15(1):31.

7.

New insights into Ca2+ channel function in health and disease.

Fleig A, Parekh AB.

J Physiol. 2017 May 15;595(10):2997-2998. doi: 10.1113/JP274289. No abstract available.

8.

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion.

Sisquella X, Nebl T, Thompson JK, Whitehead L, Malpede BM, Salinas ND, Rogers K, Tolia NH, Fleig A, O'Neill J, Tham WH, David Horgen F, Cowman AF.

Elife. 2017 Feb 22;6. pii: e21083. doi: 10.7554/eLife.21083.

9.

The TRPM7 channel kinase regulates store-operated calcium entry.

Faouzi M, Kilch T, Horgen FD, Fleig A, Penner R.

J Physiol. 2017 May 15;595(10):3165-3180. doi: 10.1113/JP274006. Epub 2017 Mar 10.

10.

The coiled-coil domain of zebrafish TRPM7 regulates Mg·nucleotide sensitivity.

Jansen C, Sahni J, Suzuki S, Horgen FD, Penner R, Fleig A.

Sci Rep. 2016 Sep 15;6:33459. doi: 10.1038/srep33459.

11.

Human CNNM2 is not a Mg(2+) transporter per se.

Sponder G, Mastrototaro L, Kurth K, Merolle L, Zhang Z, Abdulhanan N, Smorodchenko A, Wolf K, Fleig A, Penner R, Iotti S, Aschenbach JR, Vormann J, Kolisek M.

Pflugers Arch. 2016 Jul;468(7):1223-40. doi: 10.1007/s00424-016-1816-7. Epub 2016 Apr 11.

PMID:
27068403
12.

TRPM7 kinase activity regulates murine mast cell degranulation.

Zierler S, Sumoza-Toledo A, Suzuki S, Dúill FÓ, Ryazanova LV, Penner R, Ryazanov AG, Fleig A.

J Physiol. 2016 Jun 1;594(11):2957-70. doi: 10.1113/JP271564. Epub 2016 Jan 27.

13.

Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice.

Ryazanova LV, Hu Z, Suzuki S, Chubanov V, Fleig A, Ryazanov AG.

Sci Rep. 2014 Dec 23;4:7599. doi: 10.1038/srep07599.

14.

TRPM7 Regulates Axonal Outgrowth and Maturation of Primary Hippocampal Neurons.

Turlova E, Bae CYJ, Deurloo M, Chen W, Barszczyk A, Horgen FD, Fleig A, Feng ZP, Sun HS.

Mol Neurobiol. 2016 Jan;53(1):595-610. doi: 10.1007/s12035-014-9032-y. Epub 2014 Dec 11.

15.

N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation.

Zhang Z, Faouzi M, Huang J, Geerts D, Yu H, Fleig A, Penner R.

Oncotarget. 2014 Sep 15;5(17):7625-34.

16.

Regulation of endogenous and heterologous Ca²⁺ release-activated Ca²⁺ currents by pH.

Beck A, Fleig A, Penner R, Peinelt C.

Cell Calcium. 2014 Sep;56(3):235-43. doi: 10.1016/j.ceca.2014.07.011. Epub 2014 Aug 2.

17.

TRPM7.

Fleig A, Chubanov V.

Handb Exp Pharmacol. 2014;222:521-46. doi: 10.1007/978-3-642-54215-2_21. Review.

18.

Bacterial itaconate degradation promotes pathogenicity.

Sasikaran J, Ziemski M, Zadora PK, Fleig A, Berg IA.

Nat Chem Biol. 2014 May;10(5):371-7. doi: 10.1038/nchembio.1482. Epub 2014 Mar 23.

PMID:
24657929
19.

The TRPM6 kinase domain determines the Mg·ATP sensitivity of TRPM7/M6 heteromeric ion channels.

Zhang Z, Yu H, Huang J, Faouzi M, Schmitz C, Penner R, Fleig A.

J Biol Chem. 2014 Feb 21;289(8):5217-27. doi: 10.1074/jbc.M113.512285. Epub 2014 Jan 2.

20.

Solute Carrier Family SLC41, what do we really know about it?

Fleig A, Schweigel-Röntgen M, Kolisek M.

Wiley Interdiscip Rev Membr Transp Signal. 2013;2(6). doi: 10.1002/wmts.95.

21.

TRPM7 triggers Ca2+ sparks and invadosome formation in neuroblastoma cells.

Visser D, Langeslag M, Kedziora KM, Klarenbeek J, Kamermans A, Horgen FD, Fleig A, van Leeuwen FN, Jalink K.

Cell Calcium. 2013 Dec;54(6):404-15. doi: 10.1016/j.ceca.2013.09.003. Epub 2013 Oct 16.

22.

Factors influencing physical functional status in intensive care unit survivors two years after discharge.

Haas JS, Teixeira C, Cabral CR, Fleig AH, Freitas AP, Treptow EC, Rizzotto MI, Machado AS, Balzano PC, Hetzel MP, Dallegrave DM, Oliveira RP, Savi A, Vieira SR.

BMC Anesthesiol. 2013 Jun 18;13:11. doi: 10.1186/1471-2253-13-11. eCollection 2013.

23.

TRPM2 channels are not required for acute airway inflammation in OVA-induced severe allergic asthma in mice.

Sumoza-Toledo A, Fleig A, Penner R.

J Inflamm (Lond). 2013 May 1;10(1):19. doi: 10.1186/1476-9255-10-19.

24.

TRPM7 is regulated by halides through its kinase domain.

Yu H, Zhang Z, Lis A, Penner R, Fleig A.

Cell Mol Life Sci. 2013 Aug;70(15):2757-71. doi: 10.1007/s00018-013-1284-6. Epub 2013 Mar 8.

25.

Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels.

Zierler S, Yao G, Zhang Z, Kuo WC, Pörzgen P, Penner R, Horgen FD, Fleig A.

J Biol Chem. 2011 Nov 11;286(45):39328-35. doi: 10.1074/jbc.M111.264341. Epub 2011 Sep 16.

26.

Patients admitted to the ICU for acute exacerbation of COPD: two-year mortality and functional status.

Teixeira C, Cabral Cda R, Hass JS, Oliveira RP, Vargas MA, Freitas AP, Fleig AH, Treptow EC, Rizzotto MI.

J Bras Pneumol. 2011 May-Jun;37(3):334-40. English, Portuguese.

27.

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release.

Sumoza-Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, Penner R, Partida-Sánchez S.

FASEB J. 2011 Oct;25(10):3529-42. doi: 10.1096/fj.10-178483. Epub 2011 Jul 13.

28.

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating.

Lis A, Zierler S, Peinelt C, Fleig A, Penner R.

J Gen Physiol. 2010 Dec;136(6):673-86. doi: 10.1085/jgp.201010484.

29.

TRPM7 is essential for Mg(2+) homeostasis in mammals.

Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Yamaguchi TP, Mazur A, Fleig A, Ryazanov AG.

Nat Commun. 2010 Nov 2;1:109.

30.

Activation of store-operated I(CRAC) by hydrogen peroxide.

Grupe M, Myers G, Penner R, Fleig A.

Cell Calcium. 2010 Jul;48(1):1-9. doi: 10.1016/j.ceca.2010.05.005. Epub 2010 Jun 19.

31.

Development and optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors.

Castillo B, Pörzgen P, Penner R, Horgen FD, Fleig A.

J Biomol Screen. 2010 Jun;15(5):498-507. doi: 10.1177/1087057110368294. Epub 2010 Apr 22.

32.

TRPM5 regulates glucose-stimulated insulin secretion.

Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D.

Pflugers Arch. 2010 Jun;460(1):69-76. doi: 10.1007/s00424-010-0835-z.

33.

Thoracic aortic aneurysms.

Fleig A, Seitz K.

Ultraschall Med. 2010 Apr;31(2):122-40; quiz 141-3. doi: 10.1055/s-0029-1245288. Epub 2010 Mar 19. Review. English, German. No abstract available.

PMID:
20306379
34.

The calcium-permeable non-selective cation channel TRPM2 is modulated by cellular acidification.

Starkus JG, Fleig A, Penner R.

J Physiol. 2010 Apr 15;588(Pt 8):1227-40. doi: 10.1113/jphysiol.2010.187476. Epub 2010 Mar 1.

35.

Two novel 2-aminoethyl diphenylborinate (2-APB) analogues differentially activate and inhibit store-operated Ca(2+) entry via STIM proteins.

Goto J, Suzuki AZ, Ozaki S, Matsumoto N, Nakamura T, Ebisui E, Fleig A, Penner R, Mikoshiba K.

Cell Calcium. 2010 Jan;47(1):1-10. doi: 10.1016/j.ceca.2009.10.004. Epub 2009 Nov 27.

36.

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R.

Sci Signal. 2009 May 19;2(71):ra23. doi: 10.1126/scisignal.2000278.

37.

IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC).

Peinelt C, Beck A, Monteilh-Zoller MK, Penner R, Fleig A.

Cell Calcium. 2009 Apr;45(4):326-30. doi: 10.1016/j.ceca.2008.12.001. Epub 2009 Jan 20.

38.

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO.

PLoS One. 2008;3(12):e4009. doi: 10.1371/journal.pone.0004009. Epub 2008 Dec 23.

39.

Synergistic regulation of endogenous TRPM2 channels by adenine dinucleotides in primary human neutrophils.

Lange I, Penner R, Fleig A, Beck A.

Cell Calcium. 2008 Dec;44(6):604-15. doi: 10.1016/j.ceca.2008.05.001. Epub 2008 Jun 24.

40.

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.

Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.

Nat Med. 2008 Jul;14(7):738-47. doi: 10.1038/nm1758. Epub 2008 Jun 8.

41.

2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels.

Peinelt C, Lis A, Beck A, Fleig A, Penner R.

J Physiol. 2008 Jul 1;586(13):3061-73. doi: 10.1113/jphysiol.2008.151365. Epub 2008 Apr 10.

42.

SLC41A1 is a novel mammalian Mg2+ carrier.

Kolisek M, Launay P, Beck A, Sponder G, Serafini N, Brenkus M, Froschauer EM, Martens H, Fleig A, Schweigel M.

J Biol Chem. 2008 Jun 6;283(23):16235-47. doi: 10.1074/jbc.M707276200. Epub 2008 Mar 25.

44.

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation.

Parvez S, Beck A, Peinelt C, Soboloff J, Lis A, Monteilh-Zoller M, Gill DL, Fleig A, Penner R.

FASEB J. 2008 Mar;22(3):752-61. Epub 2007 Sep 28.

45.

Regulation of TRPM2 by extra- and intracellular calcium.

Starkus J, Beck A, Fleig A, Penner R.

J Gen Physiol. 2007 Oct;130(4):427-40.

46.

TRPM7 channel is sensitive to osmotic gradients in human kidney cells.

Bessac BF, Fleig A.

J Physiol. 2007 Aug 1;582(Pt 3):1073-86. Epub 2007 May 17.

47.

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.

Lis A, Peinelt C, Beck A, Parvez S, Monteilh-Zoller M, Fleig A, Penner R.

Curr Biol. 2007 May 1;17(9):794-800. Epub 2007 Apr 19.

48.

The Mg2+ and Mg(2+)-nucleotide-regulated channel-kinase TRPM7.

Penner R, Fleig A.

Handb Exp Pharmacol. 2007;(179):313-28. Review.

49.

Cell cycle-dependent regulation of store-operated I(CRAC) and Mg2+-nucleotide-regulated MagNuM (TRPM7) currents.

Tani D, Monteilh-Zoller MK, Fleig A, Penner R.

Cell Calcium. 2007 Mar;41(3):249-60. Epub 2006 Oct 24.

50.

CRACM1 multimers form the ion-selective pore of the CRAC channel.

Vig M, Beck A, Billingsley JM, Lis A, Parvez S, Peinelt C, Koomoa DL, Soboloff J, Gill DL, Fleig A, Kinet JP, Penner R.

Curr Biol. 2006 Oct 24;16(20):2073-9. Epub 2006 Sep 14.

Supplemental Content

Support Center