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Items: 25

1.

Physiological factors leading to a successful vaccination: A computational approach.

Maderazo DL, Flegg JA, Neeland MR, de Veer MJ, Flegg MB.

J Theor Biol. 2018 Jun 19;454:215-230. doi: 10.1016/j.jtbi.2018.06.008. [Epub ahead of print]

PMID:
29894721
2.

Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II.

Zhang QH, Yuen WS, Adhikari D, Flegg JA, FitzHarris G, Conti M, Sicinski P, Nabti I, Marangos P, Carroll J.

J Cell Biol. 2017 Oct 2;216(10):3133-3143. doi: 10.1083/jcb.201607111. Epub 2017 Aug 17.

3.

Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda.

Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD, Dorsey G, Rosenthal PJ.

Open Forum Infect Dis. 2016 Oct 25;4(1):ofw229. doi: 10.1093/ofid/ofw229. eCollection 2017 Winter.

4.

Optimal health and disease management using spatial uncertainty: a geographic characterization of emergent artemisinin-resistant Plasmodium falciparum distributions in Southeast Asia.

Grist EP, Flegg JA, Humphreys G, Mas IS, Anderson TJ, Ashley EA, Day NP, Dhorda M, Dondorp AM, Faiz MA, Gething PW, Hien TT, Hlaing TM, Imwong M, Kindermans JM, Maude RJ, Mayxay M, McDew-White M, Menard D, Nair S, Nosten F, Newton PN, Price RN, Pukrittayakamee S, Takala-Harrison S, Smithuis F, Nguyen NT, Tun KM, White NJ, Witkowski B, Woodrow CJ, Fairhurst RM, Sibley CH, Guerin PJ.

Int J Health Geogr. 2016 Oct 24;15(1):37.

5.

On the mathematical modeling of wound healing angiogenesis in skin as a reaction-transport process.

Flegg JA, Menon SN, Maini PK, McElwain DL.

Front Physiol. 2015 Sep 30;6:262. doi: 10.3389/fphys.2015.00262. eCollection 2015. Review.

6.

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.

WWARN Parasite Clearance Study Group, Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D'Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA.

Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.

7.

Healing of venous ulcers using compression therapy: Predictions of a mathematical model.

Flegg JA, Kasza J, Darby I, Weller CD.

J Theor Biol. 2015 Aug 21;379:1-9. doi: 10.1016/j.jtbi.2015.04.028. Epub 2015 May 6.

PMID:
25957521
8.

Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach.

White LJ, Flegg JA, Phyo AP, Wiladpai-ngern JH, Bethell D, Plowe C, Anderson T, Nkhoma S, Nair S, Tripura R, Stepniewska K, Pan-Ngum W, Silamut K, Cooper BS, Lubell Y, Ashley EA, Nguon C, Nosten F, White NJ, Dondorp AM.

PLoS Med. 2015 Apr 28;12(4):e1001823. doi: 10.1371/journal.pmed.1001823. eCollection 2015 Apr.

9.

The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.

WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Brasseur P, Bukirwa H, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Desai M, Diap G, Djimde AA, Dorsey G, Doumbo OK, Espié E, Etard JF, Fanello CI, Faucher JF, Faye B, Flegg JA, Gaye O, Gething PW, González R, Grandesso F, Guerin PJ, Guthmann JP, Hamour S, Hasugian AR, Hay SI, Humphreys GS, Jullien V, Juma E, Kamya MR, Karema C, Kiechel JR, Kremsner PG, Krishna S, Lameyre V, Ibrahim LM, Lee SJ, Lell B, Mårtensson A, Massougbodji A, Menan H, Ménard D, Menéndez C, Meremikwu M, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Nikiema F, Nsanzabana C, Ntoumi F, Ogutu BR, Olliaro P, Osorio L, Ouédraogo JB, Penali LK, Pene M, Pinoges L, Piola P, Price RN, Roper C, Rosenthal PJ, Rwagacondo CE, Same-Ekobo A, Schramm B, Seck A, Sharma B, Sibley CH, Sinou V, Sirima SB, Smith JJ, Smithuis F, Somé FA, Sow D, Staedke SG, Stepniewska K, Swarthout TD, Sylla K, Talisuna AO, Tarning J, Taylor WR, Temu EA, Thwing JI, Tjitra E, Tine RC, Tinto H, Vaillant MT, Valecha N, Van den Broek I, White NJ, Yeka A, Zongo I.

BMC Med. 2015 Mar 31;13:66. doi: 10.1186/s12916-015-0301-z.

10.

Bayesian hierarchical regression on clearance rates in the presence of "lag" and "tail" phases with an application to malaria parasites.

Fogarty CB, Fay MP, Flegg JA, Stepniewska K, Fairhurst RM, Small DS.

Biometrics. 2015 Sep;71(3):751-9. doi: 10.1111/biom.12307. Epub 2015 Apr 7.

11.

Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker.

Tun KM, Imwong M, Lwin KM, Win AA, Hlaing TM, Hlaing T, Lin K, Kyaw MP, Plewes K, Faiz MA, Dhorda M, Cheah PY, Pukrittayakamee S, Ashley EA, Anderson TJ, Nair S, McDew-White M, Flegg JA, Grist EP, Guerin P, Maude RJ, Smithuis F, Dondorp AM, Day NP, Nosten F, White NJ, Woodrow CJ.

Lancet Infect Dis. 2015 Apr;15(4):415-21. doi: 10.1016/S1473-3099(15)70032-0. Epub 2015 Feb 20.

12.

Spread of artemisinin resistance in Plasmodium falciparum malaria.

Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, Sreng S, Anderson JM, Mao S, Sam B, Sopha C, Chuor CM, Nguon C, Sovannaroth S, Pukrittayakamee S, Jittamala P, Chotivanich K, Chutasmit K, Suchatsoonthorn C, Runcharoen R, Hien TT, Thuy-Nhien NT, Thanh NV, Phu NH, Htut Y, Han KT, Aye KH, Mokuolu OA, Olaosebikan RR, Folaranmi OO, Mayxay M, Khanthavong M, Hongvanthong B, Newton PN, Onyamboko MA, Fanello CI, Tshefu AK, Mishra N, Valecha N, Phyo AP, Nosten F, Yi P, Tripura R, Borrmann S, Bashraheil M, Peshu J, Faiz MA, Ghose A, Hossain MA, Samad R, Rahman MR, Hasan MM, Islam A, Miotto O, Amato R, MacInnis B, Stalker J, Kwiatkowski DP, Bozdech Z, Jeeyapant A, Cheah PY, Sakulthaew T, Chalk J, Intharabut B, Silamut K, Lee SJ, Vihokhern B, Kunasol C, Imwong M, Tarning J, Taylor WJ, Yeung S, Woodrow CJ, Flegg JA, Das D, Smith J, Venkatesan M, Plowe CV, Stepniewska K, Guerin PJ, Dondorp AM, Day NP, White NJ; Tracking Resistance to Artemisinin Collaboration (TRAC).

N Engl J Med. 2014 Jul 31;371(5):411-23. doi: 10.1056/NEJMoa1314981. Erratum in: N Engl J Med. 2014 Aug 21;371(8):786.

13.

Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections.

Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR, Rosenthal PJ, Dorsey G, Sibley CH, Guerin PJ, Holmes CC.

Malar J. 2014 Mar 17;13:102. doi: 10.1186/1475-2875-13-102.

14.

Optimal sampling designs for estimation of Plasmodium falciparum clearance rates in patients treated with artemisinin derivatives.

Flegg JA, Guérin PJ, Nosten F, Ashley EA, Phyo AP, Dondorp AM, Fairhurst RM, Socheat D, Borrmann S, Björkman A, Mårtensson A, Mayxay M, Newton PN, Bethell D, Se Y, Noedl H, Diakite M, Djimde AA, Hien TT, White NJ, Stepniewska K.

Malar J. 2013 Nov 13;12:411. doi: 10.1186/1475-2875-12-411.

15.

Surveillance of travellers: an additional tool for tracking antimalarial drug resistance in endemic countries.

Gharbi M, Flegg JA, Pradines B, Berenger A, Ndiaye M, Djimdé AA, Roper C, Hubert V, Kendjo E, Venkatesan M, Brasseur P, Gaye O, Offianan AT, Penali L, Le Bras J, Guérin PJ; Members of the French National Reference Center for Imported Malaria Study.

PLoS One. 2013 Oct 30;8(10):e77775. doi: 10.1371/journal.pone.0077775. eCollection 2013.

16.

Trends in antimalarial drug use in Africa.

Flegg JA, Metcalf CJ, Gharbi M, Venkatesan M, Shewchuk T, Hopkins Sibley C, Guerin PJ.

Am J Trop Med Hyg. 2013 Nov;89(5):857-65. doi: 10.4269/ajtmh.13-0129. Epub 2013 Sep 9.

17.

Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum.

Flegg JA, Patil AP, Venkatesan M, Roper C, Naidoo I, Hay SI, Sibley CH, Guerin PJ.

Malar J. 2013 Jul 17;12:249. doi: 10.1186/1475-2875-12-249.

18.

High-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.

Woodrow CJ, Dahlström S, Cooksey R, Flegg JA, Le Nagard H, Mentré F, Murillo C, Ménard D, Nosten F, Sriprawat K, Musset L, Quashie NB, Lim P, Fairhurst RM, Nsobya SL, Sinou V, Noedl H, Pradines B, Johnson JD, Guerin PJ, Sibley CH, Le Bras J.

Antimicrob Agents Chemother. 2013 Jul;57(7):3121-30. doi: 10.1128/AAC.02350-12. Epub 2013 Apr 22.

19.

Growth of confined cancer spheroids: a combined experimental and mathematical modelling approach.

Loessner D, Flegg JA, Byrne HM, Clements JA, Hutmacher DW.

Integr Biol (Camb). 2013 Mar;5(3):597-605. doi: 10.1039/c3ib20252f.

PMID:
23388834
20.

Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011.

Gharbi M, Flegg JA, Hubert V, Kendjo E, Metcalf JE, Bertaux L, Guérin PJ, Le Bras J; Members of the French National Reference Centre for Imported Malaria Study, Aboubaca A, Agnamey P, Angoulvant A, Barbut P, Basset D, Belkadi G, Bellanger AP, Bemba D, Benoit-Vica F, Berry A, Bigel ML, Bonhomme J, Botterel F, Bouchaud O, Bougnoux ME, Bourée P, Bourgeois N, Branger C, Bret L, Buret B, Casalino E, Chevrier S, Conquere de Monbrison F, Cuisenier B, Danis M, Darde ML, De Gentile L, Delarbre JM, Delaunay P, Delaval A, Desoubeaux G, Develoux M, Dunand J, Durand R, Eloy O, Fauchet N, Faugere B, Faye A, Fenneteau O, Flori P, Fontrouge M, Garabedian C, Gayandrieu F, Godineau N, Houzé P, Houzé S, Hurst JP, Ichou H, Lachaud L, Lebuisson A, Lefevre M, LeGuern AS, Le Moal G, Lusina D, Machouart MC, Malvy D, Matheron S, Maubon D, Mechali D, Megarbane B, Menard G, Millon L, Aiach MM, Minodier P, Morelle C, Nevez G, Parola P, Parzy D, Patey O, Patoz P, Penn P, Perignon A, Picot S, Pilo JE, Poilane I, Pons D, Poupart M, Pradines B, Raffenot D, Rapp C, Receveur MC, Sarfati C, Senghor Y, Simon F, Siriez JY, Taudon N, Thellier M, Thouvenin M, Toubas D.

Malar J. 2013 Jan 25;12:35. doi: 10.1186/1475-2875-12-35.

21.

Modelling the interaction of keratinocytes and fibroblasts during normal and abnormal wound healing processes.

Menon SN, Flegg JA, McCue SW, Schugart RC, Dawson RA, McElwain DL.

Proc Biol Sci. 2012 Aug 22;279(1741):3329-38. doi: 10.1098/rspb.2012.0319. Epub 2012 May 23.

22.

Wound healing angiogenesis: the clinical implications of a simple mathematical model.

Flegg JA, Byrne HM, Flegg MB, McElwain DL.

J Theor Biol. 2012 May 7;300:309-16. doi: 10.1016/j.jtbi.2012.01.043. Epub 2012 Feb 4.

PMID:
22326476
23.

Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator.

Flegg JA, Guerin PJ, White NJ, Stepniewska K.

Malar J. 2011 Nov 10;10:339. doi: 10.1186/1475-2875-10-339.

24.

Mathematical model of hyperbaric oxygen therapy applied to chronic diabetic wounds.

Flegg JA, Byrne HM, McElwain DL.

Bull Math Biol. 2010 Oct;72(7):1867-91. doi: 10.1007/s11538-010-9514-7. Epub 2010 Mar 5.

PMID:
20204711
25.

A three species model to simulate application of Hyperbaric Oxygen Therapy to chronic wounds.

Flegg JA, McElwain DL, Byrne HM, Turner IW.

PLoS Comput Biol. 2009 Jul;5(7):e1000451. doi: 10.1371/journal.pcbi.1000451. Epub 2009 Jul 31.

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