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Items: 44

1.

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.

Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.

J Clin Invest. 2019 Jul 1;129(7):2980. doi: 10.1172/JCI130874. Epub 2019 Jul 1. No abstract available.

2.

Enterotoxigenic Escherichia coli Infections.

Fleckenstein JM, Kuhlmann FM.

Curr Infect Dis Rep. 2019 Mar 4;21(3):9. doi: 10.1007/s11908-019-0665-x. Review.

PMID:
30830466
3.

Molecular Determinants of Enterotoxigenic Escherichia coli Heat-Stable Toxin Secretion and Delivery.

Zhu Y, Luo Q, Davis SM, Westra C, Vickers TJ, Fleckenstein JM.

Infect Immun. 2018 Oct 25;86(11). pii: e00526-18. doi: 10.1128/IAI.00526-18. Print 2018 Nov.

4.

Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development.

Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM.

J Infect Dis. 2018 Sep 22;218(9):1436-1446. doi: 10.1093/infdis/jiy312.

PMID:
29800314
5.

Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.

Kumar P, Kuhlmann FM, Chakraborty S, Bourgeois AL, Foulke-Abel J, Tumala B, Vickers TJ, Sack DA, DeNearing B, Harro CD, Wright WS, Gildersleeve JC, Ciorba MA, Santhanam S, Porter CK, Gutierrez RL, Prouty MG, Riddle MS, Polino A, Sheikh A, Donowitz M, Fleckenstein JM.

J Clin Invest. 2018 Aug 1;128(8):3298-3311. doi: 10.1172/JCI97659. Epub 2018 Jun 25. Erratum in: J Clin Invest. 2019 Jul 1;129(7):2980.

6.

A Role for Salivary Peptides in the Innate Defense Against Enterotoxigenic Escherichia coli.

Brown JW, Badahdah A, Iticovici M, Vickers TJ, Alvarado DM, Helmerhorst EJ, Oppenheim FG, Mills JC, Ciorba MA, Fleckenstein JM, Bullitt E.

J Infect Dis. 2018 Apr 11;217(9):1435-1441. doi: 10.1093/infdis/jiy032.

7.

Comparative genomics and transcriptomics of Escherichia coli isolates carrying virulence factors of both enteropathogenic and enterotoxigenic E. coli.

Hazen TH, Michalski J, Luo Q, Shetty AC, Daugherty SC, Fleckenstein JM, Rasko DA.

Sci Rep. 2017 Jun 14;7(1):3513. doi: 10.1038/s41598-017-03489-z.

8.

Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology.

Sahl JW, Sistrunk JR, Baby NI, Begum Y, Luo Q, Sheikh A, Qadri F, Fleckenstein JM, Rasko DA.

Sci Rep. 2017 Jun 13;7(1):3402. doi: 10.1038/s41598-017-03631-x.

9.

Providing Structure to Enterotoxigenic Escherichia coli Vaccine Development.

Fleckenstein JM.

J Infect Dis. 2017 Jul 1;216(1):1-3. doi: 10.1093/infdis/jix146. No abstract available.

10.

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.

Sheikh A, Rashu R, Begum YA, Kuhlman FM, Ciorba MA, Hultgren SJ, Qadri F, Fleckenstein JM.

PLoS Negl Trop Dis. 2017 May 22;11(5):e0005586. doi: 10.1371/journal.pntd.0005586. eCollection 2017 May.

11.

Dynamic Interactions of a Conserved Enterotoxigenic Escherichia coli Adhesin with Intestinal Mucins Govern Epithelium Engagement and Toxin Delivery.

Kumar P, Kuhlmann FM, Bhullar K, Yang H, Vallance BA, Xia L, Luo Q, Fleckenstein JM.

Infect Immun. 2016 Nov 18;84(12):3608-3617. Print 2016 Dec.

12.

Immunogenicity and Protective Efficacy against Enterotoxigenic Escherichia coli Colonization following Intradermal, Sublingual, or Oral Vaccination with EtpA Adhesin.

Luo Q, Vickers TJ, Fleckenstein JM.

Clin Vaccine Immunol. 2016 Jul 5;23(7):628-37. doi: 10.1128/CVI.00248-16. Print 2016 Jul.

13.

Blood Group O-Dependent Cellular Responses to Cholera Toxin: Parallel Clinical and Epidemiological Links to Severe Cholera.

Kuhlmann FM, Santhanam S, Kumar P, Luo Q, Ciorba MA, Fleckenstein JM.

Am J Trop Med Hyg. 2016 Aug 3;95(2):440-3. doi: 10.4269/ajtmh.16-0161. Epub 2016 May 9.

14.

Overcoming Enterotoxigenic Escherichia coli Pathogen Diversity: Translational Molecular Approaches to Inform Vaccine Design.

Fleckenstein JM, Rasko DA.

Methods Mol Biol. 2016;1403:363-83. doi: 10.1007/978-1-4939-3387-7_19.

15.

Examination of the Enterotoxigenic Escherichia coli Population Structure during Human Infection.

Sahl JW, Sistrunk JR, Fraser CM, Hine E, Baby N, Begum Y, Luo Q, Sheikh A, Qadri F, Fleckenstein JM, Rasko DA.

MBio. 2015 Jun 9;6(3):e00501. doi: 10.1128/mBio.00501-15.

16.

Conservation and immunogenicity of novel antigens in diverse isolates of enterotoxigenic Escherichia coli.

Luo Q, Qadri F, Kansal R, Rasko DA, Sheikh A, Fleckenstein JM.

PLoS Negl Trop Dis. 2015 Jan 28;9(1):e0003446. doi: 10.1371/journal.pntd.0003446. eCollection 2015 Jan. Erratum in: PLoS Negl Trop Dis. 2015 Jun;9(6):e0003858.

17.

Contribution of the highly conserved EaeH surface protein to enterotoxigenic Escherichia coli pathogenesis.

Sheikh A, Luo Q, Roy K, Shabaan S, Kumar P, Qadri F, Fleckenstein JM.

Infect Immun. 2014 Sep;82(9):3657-66. doi: 10.1128/IAI.01890-14. Epub 2014 Jun 16.

18.

Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli.

Fleckenstein JM, Sheikh A.

Toxins (Basel). 2014 Jun 10;6(6):1799-812. doi: 10.3390/toxins6061799. Review.

19.

Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.

Luo Q, Kumar P, Vickers TJ, Sheikh A, Lewis WG, Rasko DA, Sistrunk J, Fleckenstein JM.

Infect Immun. 2014 Feb;82(2):509-21. doi: 10.1128/IAI.01106-13. Epub 2013 Nov 18.

20.

EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin.

Kumar P, Luo Q, Vickers TJ, Sheikh A, Lewis WG, Fleckenstein JM.

Infect Immun. 2014 Feb;82(2):500-8. doi: 10.1128/IAI.01078-13. Epub 2013 Nov 11.

21.

Enterotoxigenic Escherichia coli: Orchestrated host engagement.

Fleckenstein JM, Munson GM, Rasko DA.

Gut Microbes. 2013 Sep-Oct;4(5):392-6. doi: 10.4161/gmic.25861. Epub 2013 Jul 25.

22.

Transcriptional modulation of enterotoxigenic Escherichia coli virulence genes in response to epithelial cell interactions.

Kansal R, Rasko DA, Sahl JW, Munson GP, Roy K, Luo Q, Sheikh A, Kuhne KJ, Fleckenstein JM.

Infect Immun. 2013 Jan;81(1):259-70. doi: 10.1128/IAI.00919-12. Epub 2012 Oct 31.

23.
24.

Directed evaluation of enterotoxigenic Escherichia coli autotransporter proteins as putative vaccine candidates.

Harris JA, Roy K, Woo-Rasberry V, Hamilton DJ, Kansal R, Qadri F, Fleckenstein JM.

PLoS Negl Trop Dis. 2011 Dec;5(12):e1428. doi: 10.1371/journal.pntd.0001428. Epub 2011 Dec 6.

25.

Outer membrane vesicles induce immune responses to virulence proteins and protect against colonization by enterotoxigenic Escherichia coli.

Roy K, Hamilton DJ, Munson GP, Fleckenstein JM.

Clin Vaccine Immunol. 2011 Nov;18(11):1803-8. doi: 10.1128/CVI.05217-11. Epub 2011 Sep 7.

26.

Adhesin degradation accelerates delivery of heat-labile toxin by enterotoxigenic Escherichia coli.

Roy K, Kansal R, Bartels SR, Hamilton DJ, Shaaban S, Fleckenstein JM.

J Biol Chem. 2011 Aug 26;286(34):29771-9. doi: 10.1074/jbc.M111.251546. Epub 2011 Jul 8.

27.

Infectious agents of food- and water-borne illnesses.

Fleckenstein JM, Bartels SR, Drevets PD, Bronze MS, Drevets DA.

Am J Med Sci. 2010 Sep;340(3):238-46. doi: 10.1097/MAJ.0b013e3181e99893. Review.

PMID:
20823701
28.

Lingual leishmaniasis complicating visceral disease.

Mazumder SA, Pandey S, Brewer SC, Baselski VS, Weina PJ, Land MA, Fleckenstein JM.

J Travel Med. 2010 May-Jun;17(3):212-4. doi: 10.1111/j.1708-8305.2010.00403.x.

29.

Enterotoxigenic Escherichia coli elicits immune responses to multiple surface proteins.

Roy K, Bartels S, Qadri F, Fleckenstein JM.

Infect Immun. 2010 Jul;78(7):3027-35. doi: 10.1128/IAI.00264-10. Epub 2010 May 10.

30.

Molecular mechanisms of enterotoxigenic Escherichia coli infection.

Fleckenstein JM, Hardwidge PR, Munson GP, Rasko DA, Sommerfelt H, Steinsland H.

Microbes Infect. 2010 Feb;12(2):89-98. doi: 10.1016/j.micinf.2009.10.002. Epub 2009 Oct 31. Review.

PMID:
19883790
31.

Purification of recombinant high molecular weight two-partner secretion proteins from Escherichia coli.

Fleckenstein JM, Roy K.

Nat Protoc. 2009;4(7):1083-92. doi: 10.1038/nprot.2009.87. Epub 2009 Jul 2.

PMID:
19707189
32.

Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model.

Roy K, Hamilton D, Ostmann MM, Fleckenstein JM.

Vaccine. 2009 Jul 23;27(34):4601-8. doi: 10.1016/j.vaccine.2009.05.076. Epub 2009 Jun 11.

PMID:
19523914
33.

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells.

Roy K, Hilliard GM, Hamilton DJ, Luo J, Ostmann MM, Fleckenstein JM.

Nature. 2009 Jan 29;457(7229):594-8. doi: 10.1038/nature07568. Epub 2008 Dec 7.

34.

Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells.

Johnson AM, Kaushik RS, Francis DH, Fleckenstein JM, Hardwidge PR.

J Bacteriol. 2009 Jan;191(1):178-86. doi: 10.1128/JB.00822-08. Epub 2008 Oct 31.

35.

The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection.

Roy K, Hamilton D, Allen KP, Randolph MP, Fleckenstein JM.

Infect Immun. 2008 May;76(5):2106-12. doi: 10.1128/IAI.01304-07. Epub 2008 Feb 19.

36.

Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli.

Dorsey FC, Fischer JF, Fleckenstein JM.

Cell Microbiol. 2006 Sep;8(9):1516-27.

PMID:
16922869
37.

Identification of a two-partner secretion locus of enterotoxigenic Escherichia coli.

Fleckenstein JM, Roy K, Fischer JF, Burkitt M.

Infect Immun. 2006 Apr;74(4):2245-58.

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41.

Breaching the mucosal barrier by stealth: an emerging pathogenic mechanism for enteroadherent bacterial pathogens.

Fleckenstein JM, Kopecko DJ.

J Clin Invest. 2001 Jan;107(1):27-30. Review. No abstract available.

42.
43.

Molecular characterization of the tia invasion locus from enterotoxigenic Escherichia coli.

Fleckenstein JM, Kopecko DJ, Warren RL, Elsinghorst EA.

Infect Immun. 1996 Jun;64(6):2256-65.

44.

Cryptococcal skull infection: a case report with review of the literature.

Armonda RA, Fleckenstein JM, Brandvold B, Ondra SL.

Neurosurgery. 1993 Jun;32(6):1034-6; discussion 1036. Review.

PMID:
8327080

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