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Items: 1 to 50 of 1312

1.

hnRNPA2B1: a nuclear DNA sensor in antiviral immunity.

Zhang X, Flavell RA, Li HB.

Cell Res. 2019 Aug 30. doi: 10.1038/s41422-019-0226-8. [Epub ahead of print] No abstract available.

PMID:
31471560
2.

Author Correction: Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.

Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA.

Nature. 2019 Sep;573(7773):E2. doi: 10.1038/s41586-019-1490-y.

PMID:
31447485
3.

Publisher Correction: HER2 joins AKT to inhibit STING immunity.

Odell ID, Flavell RA.

Nat Cell Biol. 2019 Oct;21(10):1301. doi: 10.1038/s41556-019-0395-1.

PMID:
31444402
4.

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.

Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA.

Cell. 2019 Aug 22;178(5):1176-1188.e15. doi: 10.1016/j.cell.2019.07.032.

PMID:
31442406
5.

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity.

Solis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA.

Nature. 2019 Sep;573(7772):69-74. doi: 10.1038/s41586-019-1485-8. Epub 2019 Aug 21.

PMID:
31435009
6.

Publisher Correction: Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, Lin LL, Gilfillan S, Flavell RA, Shan L, Artyomov MN, Bowman M, Oltz EM, Jelinsky SA, Colonna M.

Nat Immunol. 2019 Oct;20(10):1405. doi: 10.1038/s41590-019-0474-2.

PMID:
31388149
7.

Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.

Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR.

Mol Pharm. 2019 Sep 3;16(9):3831-3841. doi: 10.1021/acs.molpharmaceut.9b00464. Epub 2019 Aug 16.

PMID:
31381351
8.

HER2 joins AKT to inhibit STING immunity.

Odell ID, Flavell RA.

Nat Cell Biol. 2019 Aug;21(8):917-918. doi: 10.1038/s41556-019-0368-4. No abstract available. Erratum in: Nat Cell Biol. 2019 Oct;21(10):1301.

PMID:
31371829
9.

Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.

Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR.

Chemistry. 2019 Sep 12;25(51):11842-11846. doi: 10.1002/chem.201902771. Epub 2019 Aug 20.

PMID:
31338914
10.

Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance.

Korenchan DE, Flavell RR.

Cancers (Basel). 2019 Jul 20;11(7). pii: E1026. doi: 10.3390/cancers11071026. Review.

11.

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.

Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA.

Nature. 2019 Jul;571(7765):403-407. doi: 10.1038/s41586-019-1311-3. Epub 2019 Jun 19. Erratum in: Nature. 2019 Sep;573(7773):E2.

PMID:
31217581
12.

Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.

Cella M, Gamini R, Sécca C, Collins PL, Zhao S, Peng V, Robinette ML, Schettini J, Zaitsev K, Gordon W, Bando JK, Yomogida K, Cortez V, Fronick C, Fulton R, Lin LL, Gilfillan S, Flavell RA, Shan L, Artyomov MN, Bowman M, Oltz EM, Jelinsky SA, Colonna M.

Nat Immunol. 2019 Aug;20(8):980-991. doi: 10.1038/s41590-019-0425-y. Epub 2019 Jun 17. Erratum in: Nat Immunol. 2019 Aug 6;:.

PMID:
31209406
13.

Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis.

Tang P, Low HB, Png CW, Torta F, Kumar JK, Lim HY, Zhou Y, Yang H, Angeli V, Shabbir A, Tai ES, Flavell RA, Dong C, Wenk MR, Yang DY, Zhang Y.

Hepatol Commun. 2019 Mar 1;3(6):748-762. doi: 10.1002/hep4.1324. eCollection 2019 Jun.

14.

Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.

Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR.

Magn Reson Med. 2019 Sep;82(3):959-972. doi: 10.1002/mrm.27780. Epub 2019 May 3.

PMID:
31050049
15.

Single-Center Prospective Evaluation of 68Ga-PSMA-11 PET in Biochemical Recurrence of Prostate Cancer.

Lawhn-Heath C, Flavell RR, Behr SC, Yohannan T, Greene KL, Feng F, Carroll PR, Hope TA.

AJR Am J Roentgenol. 2019 Aug;213(2):266-274. doi: 10.2214/AJR.18.20699. Epub 2019 Apr 30.

PMID:
31039025
16.

Quantitative and Qualitative Improvement of Low-Count [68Ga]Citrate and [90Y]Microspheres PET Image Reconstructions Using Block Sequential Regularized Expectation Maximization Algorithm.

Seo Y, Khalighi MM, Wangerin KA, Deller TW, Wang YH, Jivan S, Kohi MP, Aggarwal R, Flavell RR, Behr SC, Evans MJ.

Mol Imaging Biol. 2019 Apr 15. doi: 10.1007/s11307-019-01347-0. [Epub ahead of print]

PMID:
30993558
17.

miR-181a/b downregulation exerts a protective action on mitochondrial disease models.

Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez-Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao-Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B.

EMBO Mol Med. 2019 May;11(5). pii: e8734. doi: 10.15252/emmm.201708734.

18.

Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial.

Fendler WP, Calais J, Eiber M, Flavell RR, Mishoe A, Feng FY, Nguyen HG, Reiter RE, Rettig MB, Okamoto S, Emmett L, Zacho HD, Ilhan H, Wetter A, Rischpler C, Schoder H, Burger IA, Gartmann J, Smith R, Small EJ, Slavik R, Carroll PR, Herrmann K, Czernin J, Hope TA.

JAMA Oncol. 2019 Jun 1;5(6):856-863. doi: 10.1001/jamaoncol.2019.0096.

19.

Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis.

Barger SR, Reilly NS, Shutova MS, Li Q, Maiuri P, Heddleston JM, Mooseker MS, Flavell RA, Svitkina T, Oakes PW, Krendel M, Gauthier NC.

Nat Commun. 2019 Mar 19;10(1):1249. doi: 10.1038/s41467-019-09104-1.

20.

Breeding progress and preparedness for mass-scale deployment of perennial lignocellulosic biomass crops switchgrass, miscanthus, willow and poplar.

Clifton-Brown J, Harfouche A, Casler MD, Dylan Jones H, Macalpine WJ, Murphy-Bokern D, Smart LB, Adler A, Ashman C, Awty-Carroll D, Bastien C, Bopper S, Botnari V, Brancourt-Hulmel M, Chen Z, Clark LV, Cosentino S, Dalton S, Davey C, Dolstra O, Donnison I, Flavell R, Greef J, Hanley S, Hastings A, Hertzberg M, Hsu TW, Huang LS, Iurato A, Jensen E, Jin X, Jørgensen U, Kiesel A, Kim DS, Liu J, McCalmont JP, McMahon BG, Mos M, Robson P, Sacks EJ, Sandu A, Scalici G, Schwarz K, Scordia D, Shafiei R, Shield I, Slavov G, Stanton BJ, Swaminathan K, Taylor G, Torres AF, Trindade LM, Tschaplinski T, Tuskan GA, Yamada T, Yeon Yu C, Zalesny RS Jr, Zong J, Lewandowski I.

Glob Change Biol Bioenergy. 2019 Jan;11(1):118-151. doi: 10.1111/gcbb.12566. Epub 2018 Oct 23.

21.

Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT.

Raghavan K, Wen KW, Small EJ, Ha P, Flavell RR.

Clin Nucl Med. 2019 May;44(5):e367-e369. doi: 10.1097/RLU.0000000000002507.

PMID:
30829856
22.

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response.

Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS.

Science. 2019 Mar 1;363(6430):993-998. doi: 10.1126/science.aat7186.

23.

The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.

Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P.

Cancers (Basel). 2019 Feb 22;11(2). pii: E257. doi: 10.3390/cancers11020257.

24.

Role of IL-10 Receptor Signaling in the Function of CD4+ T-Regulatory Type 1 cells: T-Cell Therapy in Patients with Inflammatory Bowel Disease.

Soukou S, Brockmann L, Bedke T, Gagliani N, Flavell RA, Huber S.

Crit Rev Immunol. 2018;38(5):415-431. doi: 10.1615/CritRevImmunol.2018026850. Review.

PMID:
30806217
25.

Immunity, microbiota and kidney disease.

Knauf F, Brewer JR, Flavell RA.

Nat Rev Nephrol. 2019 May;15(5):263-274. doi: 10.1038/s41581-019-0118-7. Review.

PMID:
30796361
26.

Antiviral immunity: a link to bile acids.

Wang J, Flavell RA, Li HB.

Cell Res. 2019 Mar;29(3):177-178. doi: 10.1038/s41422-019-0148-5. No abstract available.

PMID:
30778178
27.

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.

Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.

Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x.

28.

Heterogeneous Uptake of 18F-FDG and 68Ga-PSMA-11 in Hepatocellular Carcinoma.

Perez PM, Flavell RR, Kelley RK, Umetsu S, Behr SC.

Clin Nucl Med. 2019 Mar;44(3):e133-e135. doi: 10.1097/RLU.0000000000002452.

PMID:
30624275
29.

Collecting wild Miscanthus germplasm in Asia for crop improvement and conservation in Europe whilst adhering to the guidelines of the United Nations' Convention on Biological Diversity.

Huang LS, Flavell R, Donnison IS, Chiang YC, Hastings A, Hayes C, Heidt C, Hong H, Hsu TW, Humphreys M, Jackson J, Norris J, Schwarz KU, Squance M, Swaller T, Thomas ID, Van Assche W, Xi Q, Yamada T, Youell S, Clifton-Brown J.

Ann Bot. 2018 Dec 22. doi: 10.1093/aob/mcy231. [Epub ahead of print]

PMID:
30596965
30.

Molecular and functional heterogeneity of IL-10-producing CD4+ T cells.

Brockmann L, Soukou S, Steglich B, Czarnewski P, Zhao L, Wende S, Bedke T, Ergen C, Manthey C, Agalioti T, Geffken M, Seiz O, Parigi SM, Sorini C, Geginat J, Fujio K, Jacobs T, Roesch T, Izbicki JR, Lohse AW, Flavell RA, Krebs C, Gustafsson JA, Antonson P, Roncarolo MG, Villablanca EJ, Gagliani N, Huber S.

Nat Commun. 2018 Dec 21;9(1):5457. doi: 10.1038/s41467-018-07581-4.

31.

The translation of non-canonical open reading frames controls mucosal immunity.

Jackson R, Kroehling L, Khitun A, Bailis W, Jarret A, York AG, Khan OM, Brewer JR, Skadow MH, Duizer C, Harman CCD, Chang L, Bielecki P, Solis AG, Steach HR, Slavoff S, Flavell RA.

Nature. 2018 Dec;564(7736):434-438. doi: 10.1038/s41586-018-0794-7. Epub 2018 Dec 12.

PMID:
30542152
32.

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.

Calcinotto A, Brevi A, Chesi M, Ferrarese R, Garcia Perez L, Grioni M, Kumar S, Garbitt VM, Sharik ME, Henderson KJ, Tonon G, Tomura M, Miwa Y, Esplugues E, Flavell RA, Huber S, Canducci F, Rajkumar VS, Bergsagel PL, Bellone M.

Nat Commun. 2018 Dec 3;9(1):4832. doi: 10.1038/s41467-018-07305-8.

33.

Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.

Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y.

J Nucl Med. 2019 Jul;60(7):910-916. doi: 10.2967/jnumed.118.220715. Epub 2018 Nov 21.

PMID:
30464040
34.

Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells.

Ding S, Zhu S, Ren L, Feng N, Song Y, Ge X, Li B, Flavell RA, Greenberg HB.

Elife. 2018 Nov 21;7. pii: e39494. doi: 10.7554/eLife.39494.

35.

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells.

Mathies F, Steffens N, Kleinschmidt D, Stuhlmann F, Huber FJ, Roy U, Meyer T, Luetgehetmann M, von Petersdorff M, Seiz O, Herkel J, Schramm C, Flavell RA, Gagliani N, Krebs C, Panzer U, Abdullah Z, Strowig T, Bedke T, Huber S.

J Immunol. 2018 Dec 15;201(12):3558-3568. doi: 10.4049/jimmunol.1800711. Epub 2018 Nov 16.

PMID:
30446566
36.

A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain.

Ding Y, Sohn JH, Kawczynski MG, Trivedi H, Harnish R, Jenkins NW, Lituiev D, Copeland TP, Aboian MS, Mari Aparici C, Behr SC, Flavell RR, Huang SY, Zalocusky KA, Nardo L, Seo Y, Hawkins RA, Hernandez Pampaloni M, Hadley D, Franc BL.

Radiology. 2019 Feb;290(2):456-464. doi: 10.1148/radiol.2018180958. Epub 2018 Nov 6.

PMID:
30398430
37.

Intertumoral Heterogeneity of 18F-FDG and 68Ga-PSMA Uptake in Prostate Cancer Pulmonary Metastases.

Perez PM, Hope TA, Behr SC, van Zante A, Small EJ, Flavell RR.

Clin Nucl Med. 2019 Jan;44(1):e28-e32. doi: 10.1097/RLU.0000000000002367.

PMID:
30394930
38.

Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.

Chen HM, van der Touw W, Wang YS, Kang K, Mai S, Zhang J, Alsina-Beauchamp D, Duty JA, Mungamuri SK, Zhang B, Moran T, Flavell R, Aaronson S, Hu HM, Arase H, Ramanathan S, Flores R, Pan PY, Chen SH.

J Clin Invest. 2018 Dec 3;128(12):5647-5662. doi: 10.1172/JCI97570. Epub 2018 Oct 22.

39.

cGAS activation in phased droplets.

Liu Y, Li HB, Flavell RA.

Cell Res. 2018 Oct;28(10):967-968. doi: 10.1038/s41422-018-0087-6. No abstract available.

40.

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease.

Tye H, Yu CH, Simms LA, de Zoete MR, Kim ML, Zakrzewski M, Penington JS, Harapas CR, Souza-Fonseca-Guimaraes F, Wockner LF, Preaudet A, Mielke LA, Wilcox SA, Ogura Y, Corr SC, Kanojia K, Kouremenos KA, De Souza DP, McConville MJ, Flavell RA, Gerlic M, Kile BT, Papenfuss AT, Putoczki TL, Radford-Smith GL, Masters SL.

Nat Commun. 2018 Sep 13;9(1):3728. doi: 10.1038/s41467-018-06125-0.

41.

Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells.

Shehata HM, Khan S, Chen E, Fields PE, Flavell RA, Sanjabi S.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8939-E8947. doi: 10.1073/pnas.1808320115. Epub 2018 Aug 20.

42.

RNA m6A modification and its function in diseases.

Tong J, Flavell RA, Li HB.

Front Med. 2018 Aug;12(4):481-489. doi: 10.1007/s11684-018-0654-8. Epub 2018 Aug 10. Review.

PMID:
30097961
43.

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development.

Stefanski HE, Xing Y, Taylor PA, Maio S, Henao-Meija J, Williams A, Flavell RA, Hollander GA, Blazar BR.

PLoS One. 2018 Jun 27;13(6):e0198871. doi: 10.1371/journal.pone.0198871. eCollection 2018.

44.

Detection of Metastatic Meningioma to the Liver Using 68Ga-DOTA-Octreotate PET/CT.

Villanueva-Meyer JE, Magill ST, Lee JC, Umetsu SE, Flavell RR.

Clin Nucl Med. 2018 Sep;43(9):e338-e340. doi: 10.1097/RLU.0000000000002183.

PMID:
29939957
45.

IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN.

Diefenhardt P, Nosko A, Kluger MA, Richter JV, Wegscheid C, Kobayashi Y, Tiegs G, Huber S, Flavell RA, Stahl RAK, Steinmetz OM.

J Am Soc Nephrol. 2018 Jul;29(7):1825-1837. doi: 10.1681/ASN.2017091044. Epub 2018 Jun 4.

46.

Family-based study reveals decreased abundance of sputum Granulicatella in asthmatics.

Wang L, de Ángel Solá D, Mao Y, Bielecki P, Zhu Y, Sun Z, Shan L, Flavell RA, Bazzy-Asaad A, DeWan A.

Allergy. 2018 Sep;73(9):1918-1921. doi: 10.1111/all.13493. Epub 2018 Jun 25. No abstract available.

47.

Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes.

Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM.

Sci Rep. 2018 May 21;8(1):7928. doi: 10.1038/s41598-018-26296-6.

48.

Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.

Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR.

Chem Commun (Camb). 2018 May 17;54(41):5233-5236. doi: 10.1039/c8cc02246a.

49.

[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.

Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM.

ACS Infect Dis. 2018 Jul 13;4(7):1067-1072. doi: 10.1021/acsinfecdis.8b00061. Epub 2018 May 8.

50.

Antigen-mediated regulation in monoclonal gammopathies and myeloma.

Nair S, Sng J, Boddupalli CS, Seckinger A, Chesi M, Fulciniti M, Zhang L, Rauniyar N, Lopez M, Neparidze N, Parker T, Munshi NC, Sexton R, Barlogie B, Orlowski R, Bergsagel L, Hose D, Flavell RA, Mistry PK, Meffre E, Dhodapkar MV.

JCI Insight. 2018 Apr 19;3(8). pii: 98259. doi: 10.1172/jci.insight.98259. eCollection 2018 Apr 19.

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