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Potential pitfalls in analyzing structural uncoupling of eNOS: aging is not associated with increased enzyme monomerization.

Chang F, Flavahan S, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H80-H88. doi: 10.1152/ajpheart.00506.2018. Epub 2018 Oct 5.


Superoxide inhibition restores endothelium-dependent dilatation in aging arteries by enhancing impaired adherens junctions.

Chang F, Flavahan S, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2018 Apr 1;314(4):H805-H811. doi: 10.1152/ajpheart.00681.2017. Epub 2018 Jan 12.


Impaired activity of adherens junctions contributes to endothelial dilator dysfunction in ageing rat arteries.

Chang F, Flavahan S, Flavahan NA.

J Physiol. 2017 Aug 1;595(15):5143-5158. doi: 10.1113/JP274189. Epub 2017 Jun 30.


In Development-A New Paradigm for Understanding Vascular Disease.

Flavahan NA.

J Cardiovasc Pharmacol. 2017 May;69(5):248-263. doi: 10.1097/FJC.0000000000000480. Review.


Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41.

Natarajan N, Hori D, Flavahan S, Steppan J, Flavahan NA, Berkowitz DE, Pluznick JL.

Physiol Genomics. 2016 Nov 1;48(11):826-834. doi: 10.1152/physiolgenomics.00089.2016. Epub 2016 Sep 23.


Raynaud's Phenomenon.

Wigley FM, Flavahan NA.

N Engl J Med. 2016 Aug 11;375(6):556-65. doi: 10.1056/NEJMra1507638. Review. No abstract available.


Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries.

Flavahan S, Chang F, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H849-54. doi: 10.1152/ajpheart.00422.2016. Epub 2016 Jul 15.


Immature endothelial cells initiate endothelin-mediated constriction of newborn arteries.

Chang F, Flavahan S, Flavahan NA.

J Physiol. 2016 Sep 1;594(17):4933-44. doi: 10.1113/JP272176. Epub 2016 Jun 16.


A vascular mechanistic approach to understanding Raynaud phenomenon.

Flavahan NA.

Nat Rev Rheumatol. 2015 Mar;11(3):146-58. doi: 10.1038/nrrheum.2014.195. Epub 2014 Dec 23. Review.


Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.

Zhao Y, Flavahan S, Leung SW, Xu A, Vanhoutte PM, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2015 Feb 15;308(4):H358-63. doi: 10.1152/ajpheart.00775.2014. Epub 2014 Dec 5.


The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling.

Flavahan S, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H628-32. doi: 10.1152/ajpheart.00327.2014. Epub 2014 Jun 20.


Exercise, vascular stiffness, and tissue transglutaminase.

Steppan J, Sikka G, Jandu S, Barodka V, Halushka MK, Flavahan NA, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L.

J Am Heart Assoc. 2014 Apr 10;3(2):e000599. doi: 10.1161/JAHA.113.000599.


Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.

Motawea HK, Jeyaraj SC, Eid AH, Mitra S, Unger NT, Ahmed AA, Flavahan NA, Chotani MA.

Am J Physiol Cell Physiol. 2013 Oct 15;305(8):C829-45. doi: 10.1152/ajpcell.00221.2012. Epub 2013 Jul 17.


Pressure-induced maturation of endothelial cells on newborn mouse carotid arteries.

Flavahan S, Mozayan MM, Lindgren I, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H321-9. doi: 10.1152/ajpheart.00099.2013. Epub 2013 May 24.


Cyclic AMP-Rap1A signaling activates RhoA to induce α(2c)-adrenoceptor translocation to the cell surface of microvascular smooth muscle cells.

Jeyaraj SC, Unger NT, Eid AH, Mitra S, Paul El-Dahdah N, Quilliam LA, Flavahan NA, Chotani MA.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C499-511. doi: 10.1152/ajpcell.00461.2011. Epub 2012 May 23.


Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension.

Yang XR, Lin AH, Hughes JM, Flavahan NA, Cao YN, Liedtke W, Sham JS.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L555-68. doi: 10.1152/ajplung.00005.2011. Epub 2011 Dec 29.


Nitric oxide regulates tissue transglutaminase localization and function in the vasculature.

Jandu SK, Webb AK, Pak A, Sevinc B, Nyhan D, Belkin AM, Flavahan NA, Berkowitz DE, Santhanam L.

Amino Acids. 2013 Jan;44(1):261-9. doi: 10.1007/s00726-011-1090-0. Epub 2011 Oct 8.


Intracellular α(2C)-adrenoceptors: storage depot, stunted development or signaling domain?

Chotani MA, Flavahan NA.

Biochim Biophys Acta. 2011 Aug;1813(8):1495-503. doi: 10.1016/j.bbamcr.2011.05.006. Epub 2011 May 14. Review.


Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3.

Zhu JH, Chen CL, Flavahan S, Harr J, Su B, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1770-80. doi: 10.1152/ajpheart.00535.2010. Epub 2010 Dec 17.


Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea.

Patt BT, Jarjoura D, Haddad DN, Sen CK, Roy S, Flavahan NA, Khayat RN.

Am J Respir Crit Care Med. 2010 Dec 15;182(12):1540-5. doi: 10.1164/rccm.201002-0162OC. Epub 2010 Jul 23.


Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.

Goel A, Su B, Flavahan S, Lowenstein CJ, Berkowitz DE, Flavahan NA.

Circ Res. 2010 Jul 23;107(2):242-51. doi: 10.1161/CIRCRESAHA.109.210229. Epub 2010 Jun 3.


Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness.

Santhanam L, Tuday EC, Webb AK, Dowzicky P, Kim JH, Oh YJ, Sikka G, Kuo M, Halushka MK, Macgregor AM, Dunn J, Gutbrod S, Yin D, Shoukas A, Nyhan D, Flavahan NA, Belkin AM, Berkowitz DE.

Circ Res. 2010 Jul 9;107(1):117-25. doi: 10.1161/CIRCRESAHA.109.215228. Epub 2010 May 20. Erratum in: Circ Res. 2011 Apr 29;108(9):e12.


Acute dilation to alpha(2)-adrenoceptor antagonists uncovers dual constriction and dilation mediated by arterial alpha(2)-adrenoceptors.

Crassous PA, Flavahan S, Flavahan NA.

Br J Pharmacol. 2009 Nov;158(5):1344-55. doi: 10.1111/j.1476-5381.2009.00403.x. Epub 2009 Sep 28.


Increased oxidant activity mediates vascular dysfunction in vibration injury.

Hughes JM, Wirth O, Krajnak K, Miller R, Flavahan S, Berkowitz DE, Welcome D, Flavahan NA.

J Pharmacol Exp Ther. 2009 Jan;328(1):223-30. doi: 10.1124/jpet.108.144618. Epub 2008 Oct 27.


Cyclic AMP acts through Rap1 and JNK signaling to increase expression of cutaneous smooth muscle alpha2C-adrenoceptors.

Eid AH, Chotani MA, Mitra S, Miller TJ, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H266-72. doi: 10.1152/ajpheart.00084.2008. Epub 2008 May 16.


Latency associated peptide has in vitro and in vivo immune effects independent of TGF-beta1.

Ali NA, Gaughan AA, Orosz CG, Baran CP, McMaken S, Wang Y, Eubank TD, Hunter M, Lichtenberger FJ, Flavahan NA, Lawler J, Marsh CB.

PLoS One. 2008 Apr 2;3(4):e1914. doi: 10.1371/journal.pone.0001914.


Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.

Flavahan NA.

Rheum Dis Clin North Am. 2008 Feb;34(1):81-7; vii. doi: 10.1016/j.rdc.2007.12.005. Review.


Estrogen increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced constriction of cutaneous arteries.

Eid AH, Maiti K, Mitra S, Chotani MA, Flavahan S, Bailey SR, Thompson-Torgerson CS, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1955-61. Epub 2007 Jul 20.


In vivo endothelial denudation disrupts smooth muscle caveolae and differentially impairs agonist-induced constriction in small arteries.

Bailey SR, Mitra S, Flavahan S, Bergdall VK, Flavahan NA.

J Cardiovasc Pharmacol. 2007 Apr;49(4):183-90.


Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin.

Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H30-6. Epub 2007 Apr 6.


Balancing prostanoid activity in the human vascular system.

Flavahan NA.

Trends Pharmacol Sci. 2007 Mar;28(3):106-10. Epub 2007 Feb 5. Review. Erratum in: Trends Pharmacol Sci. 2007 Jun;28(6):251.


Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.

Thompson-Torgerson CS, Holowatz LA, Flavahan NA, Kenney WL.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1700-5. Epub 2006 Dec 15.


Hypertension caused by transgenic overexpression of Rac1.

Hassanain HH, Gregg D, Marcelo ML, Zweier JL, Souza HP, Selvakumar B, Ma Q, Moustafa-Bayoumi M, Binkley PF, Flavahan NA, Morris M, Dong C, Goldschmidt-Clermont PJ.

Antioxid Redox Signal. 2007 Jan;9(1):91-100.


Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells.

Yang EV, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Yeh PE, Lemeshow S, Glaser R.

Cancer Res. 2006 Nov 1;66(21):10357-64.


A farewell kiss triggers a broken heart?

Flavahan NA.

Circ Res. 2006 May 12;98(9):1117-9. Review. No abstract available.


Increased expression of cyclooxygenase-2 mediates enhanced contraction to endothelin ETA receptor stimulation in endothelial nitric oxide synthase knockout mice.

Zhou Y, Mitra S, Varadharaj S, Parinandi N, Zweier JL, Flavahan NA.

Circ Res. 2006 Jun 9;98(11):1439-45. Epub 2006 Apr 27.


The effect of phenotype on mechanical stretch-induced vascular smooth muscle cell apoptosis.

Su BY, Shontz KM, Flavahan NA, Nowicki PT.

J Vasc Res. 2006;43(3):229-37. Epub 2006 Jan 23.


Acute vibration increases alpha2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries.

Krajnak K, Dong RG, Flavahan S, Welcome D, Flavahan NA.

J Appl Physiol (1985). 2006 Apr;100(4):1230-7. Epub 2005 Dec 8.


Acetylcholine causes endothelium-dependent contraction of mouse arteries.

Zhou Y, Varadharaj S, Zhao X, Parinandi N, Flavahan NA, Zweier JL.

Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H1027-32. Epub 2005 May 6.


Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries.

Bailey SR, Mitra S, Flavahan S, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H243-50. Epub 2005 Mar 11.


Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors.

Flavahan NA.

J Pharmacol Exp Ther. 2005 Apr;313(1):432-9. Epub 2004 Dec 17.


Imaging remodeling of the actin cytoskeleton in vascular smooth muscle cells after mechanosensitive arteriolar constriction.

Flavahan NA, Bailey SR, Flavahan WA, Mitra S, Flavahan S.

Am J Physiol Heart Circ Physiol. 2005 Feb;288(2):H660-9. Epub 2004 Sep 23.


Distinct cAMP signaling pathways differentially regulate alpha2C-adrenoceptor expression: role in serum induction in human arteriolar smooth muscle cells.

Chotani MA, Mitra S, Eid AH, Han SA, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H69-76. Epub 2004 Sep 2.


The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing.

Wilgus TA, Bergdall VK, Tober KL, Hill KJ, Mitra S, Flavahan NA, Oberyszyn TM.

Am J Pathol. 2004 Sep;165(3):753-61.


Rho kinase mediates cold-induced constriction of cutaneous arteries: role of alpha2C-adrenoceptor translocation.

Bailey SR, Eid AH, Mitra S, Flavahan S, Flavahan NA.

Circ Res. 2004 May 28;94(10):1367-74. Epub 2004 Apr 15.


Fas-mediated apoptosis in accelerated graft arteriosclerosis.

Moldovan NI, Qian Z, Chen Y, Dong C, Ying A, Hruban RH, Flavahan NA, Baldwin III WM, Sanfilippo F, Goldschmidt-Clermont PJ.

Angiogenesis. 1998;2(3):245-54.


Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.

Chotani MA, Mitra S, Su BY, Flavahan S, Eid AH, Clark KR, Montague CR, Paris H, Handy DE, Flavahan NA.

Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H59-67. Epub 2003 Aug 28.


The vasculopathy of Raynaud's phenomenon and scleroderma.

Flavahan NA, Flavahan S, Mitra S, Chotani MA.

Rheum Dis Clin North Am. 2003 May;29(2):275-91, vi. Review.


Activated monocytes induce smooth muscle cell death: role of macrophage colony-stimulating factor and cell contact.

Seshiah PN, Kereiakes DJ, Vasudevan SS, Lopes N, Su BY, Flavahan NA, Goldschmidt-Clermont PJ.

Circulation. 2002 Jan 15;105(2):174-80.


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